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Vol. 3. Issue 3.
Pages 206-211 (January 1992)
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Vol. 3. Issue 3.
Pages 206-211 (January 1992)
Tumores cerebrales experimentales inducidos por etil-nitrosourea en la rata Wistar
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J. Vaquero, A. Arias, M. Zurita, S. Coca, S. Oya, C. Morales
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro y Departamento de Biología Celular, Universidad Complutense, Madrid
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Resumen

Se muestra la experiencia obtenida en la inducción de tumores experimentales del Sistema Nervioso en la rata Wistar, tras la exposición a etil-nitrosourea (ENU) durante el período fetal. En las condiciones experimentales utilizadas (inyección IP de 50mg/kg de ENU en el día 17 de gestación), se obtuvieron schwanomas, generalmente del trigémino y/o ganglio de Gasser, con una latencia que osciló entre 4 y 7 meses, y tumores intracerebrales con aspecto morfológico de oligodendrogliomas, tras una latencia que osciló entre 7 y 10 meses tras la exposición al carcinógeno. El estudio inmunohistoquímico de ambos tipos de tumores mostró una clara positividad a la sinaptofisina, y en menor grado a la vimentina, lo que sugiere que, independientemente de su aspecto histológico, las neoplasias experimentales inducidas por ENU deben ser consideradas como tumores neuroectodérmicos primitivos.

Palabras clave:
Tumores cerebrales experimentales
ENU
Tumores neuroectodérrnicos primitivos
Sinaptofisina
Schwanomas
Oligodendrogliomas
Summary

The experience with experimental brain tumors, induced in the Wistar rat after transplacental administration (50mg/kg, 17 day of gestafion) of ethyl-nitrosourea (ENU) is presented. Malignant schwannomas, arising from the trigeminal nerves or Gasserian ganglia, were found after a latency between 4–7 months. Oligodendroglioma-like tumors appeared between 7–10 months after ENU administration. Imunohistochemical study of the ENU-induced tumors showed that most of them expressed strong positivity to synaptophysin and, to a lesser degree, to vimentin, suggesting their interpretation as primitive neuroectodermal tumors.

Key words:
Experimental brain tumors
ENU
Primitive neuroectoderrnal tumors
Synaptophysin
Schwannoma
Oligodendroglioma

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