Tumores cerebrales experimentales inducidos por etil-nitrosourea en la rata Wistar
J. Vaquero, A. Arias, M. Zurita, S. Coca, S. Oya, C. Morales
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro y Departamento de Biología Celular, Universidad Complutense, Madrid
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"apellidos" => "Oya" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Morales" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro y Departamento de Biología Celular, Universidad Complutense, Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162261" "palabras" => array:6 [ 0 => "Tumores cerebrales experimentales" 1 => "ENU" 2 => "Tumores neuroectodérrnicos primitivos" 3 => "Sinaptofisina" 4 => "Schwanomas" 5 => "Oligodendrogliomas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162262" "palabras" => array:6 [ 0 => "Experimental brain tumors" 1 => "ENU" 2 => "Primitive neuroectoderrnal tumors" 3 => "Synaptophysin" 4 => "Schwannoma" 5 => "Oligodendroglioma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se muestra la experiencia obtenida en la inducción de tumores experimentales del Sistema Nervioso en la rata Wistar, tras la exposición a etil-nitrosourea (ENU) durante el período fetal. En las condiciones experimentales utilizadas (inyección IP de 50<span class="elsevierStyleHsp" style=""></span>mg/kg de ENU en el día 17 de gestación), se obtuvieron schwanomas, generalmente del trigémino y/o ganglio de Gasser, con una latencia que osciló entre 4 y 7 meses, y tumores intracerebrales con aspecto morfológico de oligodendrogliomas, tras una latencia que osciló entre 7 y 10 meses tras la exposición al carcinógeno. El estudio inmunohistoquímico de ambos tipos de tumores mostró una clara positividad a la sinaptofisina, y en menor grado a la vimentina, lo que sugiere que, independientemente de su aspecto histológico, las neoplasias experimentales inducidas por ENU deben ser consideradas como tumores neuroectodérmicos primitivos.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The experience with experimental brain tumors, induced in the Wistar rat after transplacental administration (50<span class="elsevierStyleHsp" style=""></span>mg/kg, 17 day of gestafion) of ethyl-nitrosourea (ENU) is presented. Malignant schwannomas, arising from the trigeminal nerves or Gasserian ganglia, were found after a latency between 4–7 months. Oligodendroglioma-like tumors appeared between 7–10 months after ENU administration. Imunohistochemical study of the ENU-induced tumors showed that most of them expressed strong positivity to synaptophysin and, to a lesser degree, to vimentin, suggesting their interpretation as primitive neuroectodermal tumors.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Vaquero, J.; Arias, A.; Zurita, M.; Coca, S.; Oya, S.; Morales, c.: Tumores cerebrales experimentales inducidos por etil-nitrosurea en la rata Wistar. Neurocirugía 1992; 3: 206–211.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Short and long-tenn effects of methyl-and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. II. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2023 March | 2 | 1 | 3 |
| 2018 February | 8 | 10 | 18 |
| 2018 January | 8 | 6 | 14 |
| 2017 December | 10 | 15 | 25 |
| 2017 November | 37 | 21 | 58 |
| 2017 October | 7 | 9 | 16 |
| 2017 September | 13 | 24 | 37 |
| 2017 August | 10 | 16 | 26 |
| 2017 July | 10 | 13 | 23 |
| 2017 June | 19 | 21 | 40 |
| 2017 May | 13 | 28 | 41 |
| 2017 April | 13 | 11 | 24 |
| 2017 March | 13 | 25 | 38 |
| 2017 February | 2 | 8 | 10 |
| 2017 January | 9 | 12 | 21 |
| 2016 December | 29 | 21 | 50 |
| 2016 November | 22 | 21 | 43 |
| 2016 October | 27 | 18 | 45 |
| 2016 September | 36 | 29 | 65 |
| 2016 August | 42 | 19 | 61 |
| 2016 July | 40 | 29 | 69 |
| 2015 December | 2 | 0 | 2 |
| 2015 July | 0 | 4 | 4 |
| 2015 June | 13 | 9 | 22 |
| 2015 May | 20 | 18 | 38 |
| 2015 April | 17 | 14 | 31 |
| 2015 March | 19 | 26 | 45 |
| 2015 February | 18 | 28 | 46 |
| 2015 January | 17 | 21 | 38 |
| 2014 December | 10 | 29 | 39 |
| 2014 November | 12 | 19 | 31 |
| 2014 October | 10 | 32 | 42 |
| 2014 September | 13 | 27 | 40 |
| 2014 August | 20 | 29 | 49 |
| 2014 July | 8 | 19 | 27 |
| 2014 June | 16 | 23 | 39 |
| 2014 May | 18 | 21 | 39 |
| 2014 April | 12 | 25 | 37 |
| 2014 March | 17 | 29 | 46 |
| 2014 February | 20 | 35 | 55 |
| 2014 January | 14 | 13 | 27 |
| 2013 December | 11 | 17 | 28 |
| 2013 November | 14 | 26 | 40 |
| 2013 October | 17 | 22 | 39 |
| 2013 September | 17 | 30 | 47 |
| 2013 August | 14 | 29 | 43 |
| 2013 July | 20 | 37 | 57 |
| 2013 June | 15 | 30 | 45 |
| 2013 May | 19 | 24 | 43 |
| 2013 April | 16 | 29 | 45 |
| 2013 March | 14 | 38 | 52 |
| 2013 February | 12 | 22 | 34 |
| 2013 January | 16 | 12 | 28 |
| 2012 December | 9 | 25 | 34 |
| 2012 November | 0 | 23 | 23 |
| 2012 October | 0 | 5 | 5 |
| 2012 September | 0 | 2 | 2 |
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