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array:23 [ "pii" => "S1130147396707418" "issn" => "11301473" "doi" => "10.1016/S1130-1473(96)70741-8" "estado" => "S300" "fechaPublicacion" => "1996-01-01" "aid" => "70741" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1996" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1996;7:100-10" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1949 "formatos" => array:3 [ "EPUB" => 14 "HTML" => 843 "PDF" => 1092 ] ] "itemSiguiente" => array:18 [ "pii" => "S113014739670742X" "issn" => "11301473" "doi" => "10.1016/S1130-1473(96)70742-X" "estado" => "S300" "fechaPublicacion" => "1996-01-01" "aid" => "70742" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1996;7:111-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3558 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 958 "PDF" => 2584 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Meningiomas petroclivales gigantes" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "111" "paginaFinal" => "118" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "J. Piquer, G. Bataller, H. Pérez Garrigues, R. Villanueva, F. Cortés, J. Navarro, P. Riesgo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Piquer" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Bataller" ] 2 => array:2 [ "nombre" => "H." "apellidos" => "Pérez Garrigues" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Villanueva" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Cortés" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Navarro" ] 6 => array:2 [ "nombre" => "P." "apellidos" => "Riesgo" ] ] ] 1 => array:2 [ "autoresLista" => "V. Vázquez Añón" "autores" => array:1 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Vázquez Añón" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739670742X?idApp=UINPBA00004B" "url" => "/11301473/0000000700000002/v1_201305151451/S113014739670742X/v1_201305151451/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147396707406" "issn" => "11301473" "doi" => "10.1016/S1130-1473(96)70740-6" "estado" => "S300" "fechaPublicacion" => "1996-01-01" "aid" => "70740" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1996;7:89-99" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2105 "formatos" => array:3 [ "EPUB" => 14 "HTML" => 911 "PDF" => 1180 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Atornillado anterior en las fracturas agudas de la odontoides" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "89" "paginaFinal" => "99" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Martín Ferrer, J. Rimbau Muñoz, R. Feliu Tatay" "autores" => array:3 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Martín Ferrer" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Rimbau Muñoz" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Feliu Tatay" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147396707406?idApp=UINPBA00004B" "url" => "/11301473/0000000700000002/v1_201305151451/S1130147396707406/v1_201305151451/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Aspectos inmunológicos en los gliomas: infiltrado celular y características de la célula tumoral" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "100" "paginaFinal" => "110" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J.A. Gómez-Moreta, F. Morales" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Gómez-Moreta" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Morales" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital Virgen de la Vega. Salamanca" ] ] ] 1 => array:3 [ "autoresLista" => "M.A. Piris, Mª.P. Galindo, J. Broseta" "autores" => array:3 [ 0 => array:3 [ "nombre" => "M.A." "apellidos" => "Piris" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Mª.P." "apellidos" => "Galindo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Broseta" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Patología. Sección de Inmunohistoquimia. Hospital Virgen de la Salud. Toledo" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Departamento de Estadística y Matemática Aplicadas. Universidad de Salamanca. Salamanca" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] 2 => array:3 [ "entidad" => "Cátedra de Neurocirugía. Facultad de Medicina. Universidad de Salamanca. Salamanca" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162957" "palabras" => array:5 [ 0 => "Complejos de histocompatibilidad" 1 => "Glioma" 2 => "Inmunidad" 3 => "Célula linfoide" 4 => "Macrófago" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162958" "palabras" => array:5 [ 0 => "Glioma" 1 => "Histocompatibility complexo" 2 => "Immunity" 3 => "Gliomas, Limphoid cell" 4 => "Macrophage" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se estudian las características inmunológicas de 32 gliomas clasificados en dos grupos según su histología y siguiendo la escala en grados de Kernohan: los de baja agresividad (grados I y II) Ylos filiados como malignos (grados III y IV). En 21 ocasiones el tumor correspondió al primero de los grupos y en 11 al segundo. La investigación inmunohistoquímica se realizó sobre material congelado a −70 °C utilizando casi siempre técnica FAAFA (fosfatasa alcalina-antifosfatasa alcalina); en algún caso se utilizó técnica PAP (peroxidasa- antiperoxidasa). El estudio abarca la caracterización funcional del infiltrado linfomonocitario y la de la propia célula tumoral en cuanto a la existencia o no de determinantes de histocompatibiliad (CHM) de clase I y II. Se determina también la capacidad proliferativa del tumor utilizando el índice Ki-67. La tipificación del infiltrado permite concluir la presencia de macrófagos (CD68+) en todos los casos, en gran cantidad y difusamente distribuidos entre las células tumorales, siendo más abundantes en tumores con CHM II (28.8% de media) que en los que carecen de estos determinantes antigénicos (19.3% de media). Se identificaron linfocitos T (CD3+) en 30 ocasiones, linfocitos T-facilitadores (CD4+) en 29 y linfocitos T-supresores/citotóxicos (CD8+) en 25, situándose predominantemente en los espacios perivasculares. Otras poblaciones: linfocitos B (CD19+), células plasmáticas (CD38+), células con antígenos de activación (CD25+) y células con actividad killer (CD57+), se identificaron en pocos gliomas y siempre en escasa cantidad. La subpoblación T más abundante fue la T-facilitadora (CD4+) siendo más numerosa en tumores altamente agresivos (7.7% de media) que en los filiados como grados I-II (4.6% de media).</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A study is made of the immunological characteristics of 32 gliomas classified into two groups according to their histology and following the grading scale of Kernohan.; those of low aggressiveness (grades I and II) and those deemed malignant (grades III and IV). 21 cases, corresponded to the first group and 11 to the second. Immunohistochemical study was performed on material frozen at −70 °C, almost always using APAAP (alkaline phosphatase-antialkaline phosphatase) technique, although in sorne cases the PAP (peroxidase- antiperoxidase) technique was employed. The study addressed the functional characterization of lymphomonocyte infiltration and of tumor cellularity itself in regard to the existence or not of classes I and II histocompatibility determinants (MHC). The proliferative capacity of the tumors, was also determined using the Ki-67 indexo Infiltrate typing showed that in all the cases macrophages (CD68+) were distributed diffusely in large amounts among the tumor cells. They were more abundant in tumors with MHC II (mean, 28.8%) than in those lacking these antigen determinants (mean, 19.3%). T lymphocytes (CD3+) were identified in thirty cases, helper/inducer T lymphocytes in 29 and suppressor/cytotoxic T limphocytes (CD8+) in 25; these cells were predominantly located in the perivascular space. Other populations, including B cells (CD19+), plasma cells (CD38+), cells displaying activation antigens (CD25+) and cells with killer activity (CD57+) were only identified in a few gliomas and always at low levels. The most abundant T subset wasT-helper/inducer (CD4+), this being more numerous in the strongly aggressive tumors (mean, 7.7%) than in those belonging to grade I-II (mean, 4.6%).</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Gómez-Moreta, J.A.; Piris, M.A.; Galindo, Mª. P.; Broseta, J.; Morales, F.: Aspectos inmunológicos en los gliomas: infiltrado celular y características de la célula tumoral. Neurocirugía 1996; 7: 100–110.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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