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                    0 => array:2 [
                      "titulo" => "The site&#44; structure and frequency of intracranial aneurysms&#44; angiomas and arteriovenous abnormalities"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;G&#46; Berry"
                            1 => "B&#46;J&#46; Alpers"
                            2 => "J&#46;C&#46; White"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Res Pub Assoc Res Nerv Ment Dis"
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                        "volumen" => "41"
                        "paginaInicial" => "40"
                        "paginaFinal" => "72"
                      ]
                    ]
                  ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial cavernous angiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;M&#46; Bicknell"
                            1 => "T&#46;J&#46; Carlow"
                            2 => "M&#46; Kornfeld"
                            3 => "J&#46; Stovring"
                            4 => "P&#46; Turner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "1978"
                        "volumen" => "35"
                        "paginaInicial" => "746"
                        "paginaFinal" => "749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/718473"
                            "web" => "Medline"
                          ]
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                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Bruhlmann"
                            1 => "N&#46; De Tribolet"
                            2 => "J&#46; Berney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurochirurgie"
                        "fecha" => "1985"
                        "volumen" => "31"
                        "paginaInicial" => "271"
                        "paginaFinal" => "279"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4088398"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib4"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial occurrence of cavernous angiomata of the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;V&#46; Clark"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "1970"
                        "volumen" => "33"
                        "paginaInicial" => "871"
                        "paginaFinal" => "876"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5531907"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Formes familiales des h&#233;mangiomes caverneux intracr&#226;niens&#58; &#224; propos de 5 cas dans deux familles"
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                        0 => array:2 [
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                            2 => "A&#46; Biondi"
                            3 => "M&#46; Combelles-Pruvot"
                            4 => "G&#46; Szikla"
                            5 => "J&#46;L&#46; Christiaens"
                          ]
                        ]
                      ]
                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Neurochirurgie"
                        "fecha" => "1983"
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                        "paginaInicial" => "263"
                        "paginaFinal" => "269"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6633773"
                            "web" => "Medline"
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                  ]
                ]
              ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An analysis of the natural history of cavernous angiomas"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Del Curling"
                            1 => "D&#46;L&#46; Kelly"
                            2 => "A&#46;D&#46; Elster"
                            3 => "T&#46;E&#46; Craven"
                          ]
                        ]
                      ]
                    ]
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                      "doi" => "10.3171/jns.1991.75.5.0702"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1991"
                        "volumen" => "75"
                        "paginaInicial" => "702"
                        "paginaFinal" => "708"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1919691"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Cavernous angiomatosis of the Central Nervous System&#58; Usefullness of screening the family"
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                          "etal" => false
                          "autores" => array:2 [
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurol Scand"
                        "fecha" => "1993"
                        "volumen" => "88"
                        "paginaInicial" => "259"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8256569"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
            ]
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                      "titulo" => "Familial cavernous malformations of the central nervous system and retina"
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                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46;B&#46; Dobyns"
                            1 => "V&#46;V&#46; Michels"
                            2 => "R&#46;V&#46; Groover"
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                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1002/ana.410210609"
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                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1987"
                        "volumen" => "21"
                        "paginaInicial" => "578"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3606045"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                      "titulo" => "A gene responsable for cavernous malformations of the brain maps to chromosome 7q"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:7 [
                            0 => "J&#46; Dubovsky"
                            1 => "J&#46;M&#46; Zabramski"
                            2 => "J&#46; Kurth"
                            3 => "R&#46;P&#46; Spetzler"
                            4 => "S&#46;S&#46; Rich"
                            5 => "H&#46;T&#46; Orr"
                            6 => "J&#46;L&#46; Weber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Mol Genet"
                        "fecha" => "1995"
                        "volumen" => "4"
                        "paginaInicial" => "453"
                        "paginaFinal" => "458"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7795602"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                      "titulo" => "Angiographically occult vascular malformations in childhood"
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                          "autores" => array:4 [
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                            3 => "D&#46;G&#46; McLone"
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                      ]
                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1987"
                        "volumen" => "20"
                        "paginaInicial" => "759"
                        "paginaFinal" => "766"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3601023"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Cerebral Cavernous Angiomas"
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                          "etal" => false
                          "autores" => array:6 [
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                            1 => "F&#46; Maiuri"
                            2 => "P&#46; Donati"
                            3 => "G&#46; Cinalli"
                            4 => "M&#46; De Caro"
                            5 => "L&#46; Sigona"
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                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:5 [
                        "tituloSerie" => "Neurol Reseach"
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                        "paginaInicial" => "131"
                        "paginaFinal" => "136"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cavemous angiomas of the brain account of fourteen personal cases review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Giombini"
                            1 => "G&#46; Morello"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1978"
                        "volumen" => "40"
                        "paginaInicial" => "61"
                        "paginaFinal" => "82"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mapping of a gene causing cerebral cavernous malforma tion to 7q11&#46;2-q21"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Gunel"
                            1 => "I&#46;A&#46; Awad"
                            2 => "J&#46; Ansonj"
                            3 => "R&#46;P&#46; Lifton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci USA"
                        "fecha" => "1995"
                        "volumen" => "92"
                        "paginaInicial" => "6620"
                        "paginaFinal" => "6624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7604043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A founder mutation as a cause of cerebral cavemous malformation in hispanic americans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Gunel"
                            1 => "L&#46;A&#46; Awad"
                            2 => "K&#46; Finberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199604113341503"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1996"
                        "volumen" => "334"
                        "paginaInicial" => "946"
                        "paginaFinal" => "951"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8596595"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial cavernous angiomas&#58; natural history and genetic study over a 5-year period"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46;A&#46; Hayman"
                            1 => "R&#46;A&#46; Evans"
                            2 => "R&#46;E&#46; Ferrell"
                            3 => "L&#46;M&#46; Fahr"
                            4 => "P&#46; Ostrow"
                            5 => "V&#46;M&#46; Riccardi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ajmg.1320110205"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Genet"
                        "fecha" => "1982"
                        "volumen" => "11"
                        "paginaInicial" => "147"
                        "paginaFinal" => "160"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6950664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral angiomata in an Iceland family"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;A&#46; Kidd"
                            1 => "J&#46;N&#46; Cumings"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1947"
                        "volumen" => "1"
                        "paginaInicial" => "747"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2895270"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Uber heredofamiliare Angiomatose des Gehims und der Retina ihre Beziehungen zueinander und zur Angiomatose der Haut"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Kufs"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Z Neurol Psychiatr"
                        "fecha" => "1928"
                        "volumen" => "113"
                        "paginaInicial" => "651"
                        "paginaFinal" => "686"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cavernomes intracraniens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Lechevalier"
                            1 => "J&#46;P&#46; Houtteville"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Neurol &#40;Par&#237;s&#41;"
                        "fecha" => "1992"
                        "volumen" => "148"
                        "paginaInicial" => "173"
                        "paginaFinal" => "179"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Formes familiales des cavernomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; Lejeune"
                            1 => "G&#46; Combelles"
                            2 => "J&#46;L&#46; Christiaens"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurochirurgie"
                        "fecha" => "1989"
                        "volumen" => "35"
                        "paginaInicial" => "111"
                        "paginaFinal" => "112"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2674749"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical&#44; radiological&#44; and pathological spectrum of angiographically occult intracranial vascular malformations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Lobato"
                            1 => "C&#46; P&#233;rez"
                            2 => "J&#46;J&#46; Rivas"
                            3 => "F&#46; Cordob&#233;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1988.68.4.0518"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1988"
                        "volumen" => "68"
                        "paginaInicial" => "518"
                        "paginaFinal" => "531"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3280747"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Progressive vision loss&#46; Arare manifestation of familial cavernous angiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Malik"
                            1 => "B&#46;H&#46; Cohen"
                            2 => "J&#46; Robinson"
                            3 => "A&#46; Fried"
                            4 => "C&#46;A&#46; Sila"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "1992"
                        "volumen" => "49"
                        "paginaInicial" => "170"
                        "paginaFinal" => "173"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1736851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A locus for cerebral cavernous malformations maps to chromosome 7q in two families"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;A&#46; Marchuk"
                            1 => "C&#46;J&#46; Gallione"
                            2 => "L&#46;A&#46; Morrisson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Genomics"
                        "fecha" => "1995"
                        "volumen" => "28"
                        "paginaInicial" => "311"
                        "paginaFinal" => "313"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8530042"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology and grading of intracranial malformations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Martin"
                            1 => "H&#46; Vinters"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Intracranial vascular malformations&#46; Neurosurgical topics"
                        "paginaInicial" => "1"
                        "paginaFinal" => "30"
                        "serieFecha" => "1990"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial cavernous angiomas of the brain in an Hispanic family"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Mason"
                            1 => "J&#46;M&#46; Aase"
                            2 => "W&#46;W&#46; Orrison"
                            3 => "J&#46;D&#46; Wicks"
                            4 => "R&#46;S&#46; Seigel"
                            5 => "J&#46;M&#46; Bicknell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1988"
                        "volumen" => "38"
                        "paginaInicial" => "324"
                        "paginaFinal" => "326"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3340304"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of vascular malformations of the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;F&#46; McCormick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Intracranial artcriovenous malformations"
                        "paginaInicial" => "44"
                        "paginaFinal" => "63"
                        "serieFecha" => "1984"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple teleangiectases of the brain&#58; a discussion of hereditary factors in their development"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;C&#46; Michael"
                            1 => "P&#46;M&#46; Levin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Neurol Psychiatry"
                        "fecha" => "1936"
                        "volumen" => "36"
                        "paginaInicial" => "514"
                        "paginaFinal" => "529"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cavernomatose c&#233;r&#233;brale familiale"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Mouly"
                            1 => "L&#46; Cohen"
                            2 => "D&#46; Laplane"
                            3 => "C&#46; Pierrot-Deseilligny"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Neurol &#40;Paris&#41;"
                        "fecha" => "1996"
                        "volumen" => "152"
                        "paginaInicial" => "752"
                        "paginaFinal" => "754"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Growth&#44; subsequent bleeding&#44; and De No- Neurocirug&#237;a vo appearance of cerebral cavernous angiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Pozzati"
                            1 => "N&#46; Acciari"
                            2 => "F&#46; Tognetti"
                            3 => "F&#46; Marliani"
                            4 => "F&#46; Giangaspero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1996"
                        "volumen" => "38"
                        "paginaInicial" => "662"
                        "paginaFinal" => "670"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8692382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The growth of cerebral cavernous angiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Pozzati"
                            1 => "G&#46; Giuliani"
                            2 => "G&#46;K&#46; Nuzzo"
                            3 => "M&#46; Poppi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1989"
                        "volumen" => "25"
                        "paginaInicial" => "92"
                        "paginaFinal" => "97"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2755587"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The MRI appearance of cavernous malformations &#40;angiomas&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D&#46; Rigamonti"
                            1 => "B&#46;P&#46; Drayer"
                            2 => "P&#46;C&#46; Johnson"
                            3 => "M&#46;N&#46; Hadley"
                            4 => "J&#46; Zabramski"
                            5 => "R&#46;F&#46; Spetzler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.67.4.0518"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1987"
                        "volumen" => "67"
                        "paginaInicial" => "518"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3655889"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral cavernous malformation&#58; incidence and familial occurrence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Rigamonti"
                            1 => "M&#46;N&#46; Hadley"
                            2 => "B&#46;P&#46; Drayer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Eng J Med"
                        "fecha" => "1988"
                        "volumen" => "319"
                        "paginaInicial" => "343"
                        "paginaFinal" => "347"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cavernous angiomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Russell"
                            1 => "L&#46;J&#46; Rubinstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "titulo" => "Pathology of tumours of the nervous system"
                        "fecha" => "1989"
                        "editorial" => "Williams &#38; Wilkins"
                        "editorialLocalizacion" => "Ed&#46; V&#46; Baltimore"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intramedullary cavernous angioma with trigeminal neuralgia&#58; a case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Saito"
                            1 => "K&#46; Yamakawa"
                            2 => "T&#46; Sasaki"
                            3 => "l&#46; Saito"
                            4 => "K&#46; Takakura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1989"
                        "volumen" => "25"
                        "paginaInicial" => "467"
                        "paginaFinal" => "474"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracerebral venous angioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Sarwar"
                            1 => "W&#46;F&#46; McCormick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "1978"
                        "volumen" => "35"
                        "paginaInicial" => "323"
                        "paginaFinal" => "325"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/646686"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial cavernous hemangiomas&#58; neuroradiologic review of 36 operated cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Savoiardo"
                            1 => "L&#46; Strada"
                            2 => "A&#46; Passerini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "AJNR"
                        "fecha" => "1983"
                        "volumen" => "4"
                        "paginaInicial" => "945"
                        "paginaFinal" => "950"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6410879"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cavernous angioma&#58; a review of 126 collected and 12 new clinical cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;M&#46; Simard"
                            1 => "F&#46; Garc&#237;a-Bengoechea"
                            2 => "W&#46;E&#46; Ballinger Jr&#46;"
                            3 => "J&#46;P&#46; Mickle"
                            4 => "R&#46;G&#46; Quislingj"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1986"
                        "volumen" => "18"
                        "paginaInicial" => "162"
                        "paginaFinal" => "172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3960293"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial cavernous angiomas of the brain&#58; observation in a four generation family"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Steichen-Gersdof"
                            1 => "S&#46; Felber"
                            2 => "W&#46; Fuchs"
                            3 => "L&#46; Russeger"
                            4 => "K&#46; Twerdy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Pediatr"
                        "fecha" => "1992"
                        "volumen" => "151"
                        "paginaInicial" => "861"
                        "paginaFinal" => "863"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1468464"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial cavernous angioma&#58; presentation and management"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Tagle"
                            1 => "J&#46; Huete"
                            2 => "J&#46; M&#233;ndez"
                            3 => "S&#46; Del Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1986.64.5.0720"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1986"
                        "volumen" => "64"
                        "paginaInicial" => "720"
                        "paginaFinal" => "723"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3701420"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cavernomas of the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46; Vaquero"
                            1 => "G&#46; Leunda"
                            2 => "R&#46; Mart&#237;nez"
                            3 => "G&#46; Bravo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1983"
                        "volumen" => "12"
                        "paginaInicial" => "208"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6835502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral cavernous haemangiomas or cavernomas Incidence&#44; pathology&#44; localization&#44; diagnosis&#44; clinical features and treatment&#46; Review of the literature and report of an unusual case"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Voigt"
                            1 => "M&#46;G&#46; Yasargil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0028-1090391"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurochirurgia"
                        "fecha" => "1976"
                        "volumen" => "19"
                        "paginaInicial" => "59"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1264322"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The natural history of familial cavernous malformations&#58; results of an ongoing study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;M&#46; Zabramski"
                            1 => "T&#46;M&#46; Wascher"
                            2 => "R&#46;F&#46; Spetzler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1994.80.3.0422"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1994"
                        "volumen" => "80"
                        "paginaInicial" => "422"
                        "paginaFinal" => "432"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8113854"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 9. Núm. 4.
Páginas 312-315 (enero 1998)
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Vol. 9. Núm. 4.
Páginas 312-315 (enero 1998)
Cavernomatosis cerebral familiar
Familial cerebral cavernous angiomatosis
Visitas
4145
A. Gómez Sierra, A. Rodríguez de Lope, O. Mateo Sierra, V. Martín Velaseo, J.M. Pérez Calvo, R. Carrillo Yagüe
Servicio de Neurocirugía. Hospisafftal General Universitario Gregario Marañón. Madrid
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Resumen

Presentamos 3 pacientes con historia de crisis epilépticas de larga evolución y la presencia de cavernomatosis familiar. En 2 de ellos, se resecaron 3 angiomas cavernosos. En esta forma de la enfermedad, los cavernomas son múltiples y diseminados por el cerebro. La indicación quirúrgica debe tomarse en base a la accesibilidad de la lesión y la respuesta al tratamiento médico.

Palabras clave:
Cavernoma
Malformación familiar
Angioma
Summary

Three patients with familial cavernous angiomatosis presenting with long lasting variable epilepsy are presented. In two patients, three cavernous angiomas were resected. Familial cerebral cavernous angiomas are often numerous and disseminated in the brain. Neurosurgical treatment should be planned according to the accesibility of the lesions and the response to medical treatment in patients presenting with epilepsy.

Key words:
Cavernous malformation
Familial malformation
Angioma

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