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array:22 [ "pii" => "S1130147398709984" "issn" => "11301473" "doi" => "10.1016/S1130-1473(98)70998-4" "estado" => "S300" "fechaPublicacion" => "1998-01-01" "aid" => "70998" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1998" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1998;9:199-208" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1851 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 965 "PDF" => 869 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147398709996" "issn" => "11301473" "doi" => "10.1016/S1130-1473(98)70999-6" "estado" => "S300" "fechaPublicacion" => "1998-01-01" "aid" => "70999" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1998;9:209-19" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3072 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 1021 "PDF" => 2034 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Artrodesis por vía posterior en las luxaciones cervicales altas en pacientes con artritis reumatoide" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "209" "paginaFinal" => "219" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Posterior arthrodesis of the unstable upper cervical spine in rheumatoid arthritis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. Pardo, J. Molet, J.M. Fernández Villa, P. Tresserras, B. Oliver, P. Parés, F. Bartumeus" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Pardo" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Molet" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Fernández Villa" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Tresserras" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Oliver" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Parés" ] 6 => array:2 [ "nombre" => "F." "apellidos" => "Bartumeus" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147398709996?idApp=UINPBA00004B" "url" => "/11301473/0000000900000003/v1_201305151511/S1130147398709996/v1_201305151511/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Consideraciones sobre la citogenética y los factores de proliferación celular en la oncogénesis de los astrocitomas anaplásicos y glioblastoma multiforme" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "199" "paginaFinal" => "208" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J.L. Gil-Salú, J.M. González-Darder" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Gil-Salú" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "González-Darder" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sección de Neurocirugía. Hospital General de Castellón" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Oncogenesis of anaplastic astrocytoma and glioblastoma. Citogenetics and proliferating cell factors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163329" "palabras" => array:3 [ 0 => "Gliomas malignos" 1 => "Citocinética tumoral" 2 => "Control de crecimiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163328" "palabras" => array:3 [ 0 => "Malignant gliomas" 1 => "Tumoral citocinetics" 2 => "Growth control" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Todas las modalidades terapéuticas de que disponemos en la actualidad sobre los astrocitomas anaplásicos y glioblastoma multiforme son paliativas. La finalidad de dichos tratamientos es la de conseguir los más largos períodos de supervivencia con buena calidad de vida, pero incluso la combinación de los distintos tratamientos consigue resultados de supervivencia desalentadores.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En la actualidad, gracias al auge de los estudios citogenéticos y de biología molecular, nuevas perspectivas en la actividad investigadora nos abren futuras estrategias de tratamiento. Estas técnicas nos muestran cómo la iniciación y progresión de un tumor neuroepitelial es el resultado de la expresión inadecuada y exagerada de proto-oncogenes, a partir de los cuales se ponen en marcha sistemas con actividad biológica que conducen a la desdiferenciación y proliferación celular.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Por otro lado, las técnicas inmunohistológicas empleando anticuerpos monoclonales de alta especificidad, que nos valoran la cinética tumoral, nos permiten evaluar el pronóstico de los pacientes y la eficacia de las diversas opciones terapéuticas.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La presentación de los mecanismos implicados en la fisiopatología, diagnóstico y técnicas de estudio histológicas de los tumores anaplásicos neuroepiteliales del adulto y cómo dichos mecanismos convergen a nivel molecular repercutiendo en el conocimiento de la biología del ciclo celular, son el objetivo del presente artículo.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">All currently available therapies on anaplastic astrocytomas and glioblastoma multiforme are palliative. The goal of treatment is to provide the longest period of good quality life but the setup treatment achieve discouraging results.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Now, by the neurogenetics and the molecular biology of human brain tumors studies new approaches of research activity shows future treatment strategies. So, the initiation and progression of a neuroepithelial tumor is the result of inappropiate expresion of protooncogen, which encoding systems with biological activities that influence cell differentiation and proliferation.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">With the production of monoclonal antibodies with high specific binding characteristics, inmunohistology, tumoral cytocinetics studies became the preferable method by which to evaluate the prognosis and treatment options. In this article, the pathogenesis and diagnosis technics are reviewed and we can appreciate Iike in cell cycle, all oncogenic influences must converge.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Gil-Salú, J.; González-Darder, J.: Consideraciones sobre la citogenética y los factores de proliferación celular en la oncogénesis de los astrocitomas anaplásicos y glioblastoma multiforme. Neurocirugía 1998; 9: 199–208.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:73 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oncogenes: cause or consequence in the development of glial tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Akbasak" 1 => "B. 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