Inmunoterapia en astrocitomas de alto grado: principios y estado actual

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"apellidos" => "Mateo-Sierra" ] 2 => array:2 [ "nombre" => "F.A." "apellidos" => "Gutiérrez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Fernández-Carballal" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Carrillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital General Universitario Gregorio Marañón. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Servicio de Neuro-cirugía. Hospital General Universitario Gregorio Marañón. C/Dr. Esquerdo 46. 28007 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Immunotherapy in high grade astrocytomas: principles and current state" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-09-29" "fechaAceptado" => "2004-11-19" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158985" "palabras" => array:4 [ 0 => "Inmunoterapia" 1 => "Tratamiento de gliomas" 2 => "Citoquina" 3 => "Linfocitos" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec158983" "palabras" => array:19 [ 0 => "ADCC" 1 => "APC" 2 => "ASL" 3 => "BCG" 4 => "BHE" 5 => "CMH" 6 => "EFGr" 7 => "GM-CSF" 8 => "HLA" 9 => "IFN" 10 => "IGF" 11 => "IL" 12 => "LAK" 13 => "MAK" 14 => "NK" 15 => "TGF" 16 => "Th" 17 => "TIL" 18 => "TNF" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec158984" "palabras" => array:3 [ 0 => "Immunotherapy" 1 => "Glioma treatment" 2 => "Interleukin Lymphocytes" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Desde hace tiempo se conoce que la presencia de un tumor origina en el organismo una reacción del sistema inmune enfocada a eliminar la amenaza que el desarrollo tumoral implica. Sin embargo, se van averiguando diferentes mecanismos por los cuales los tumores provocan un estado de inmunosupresión que dificulta el desa-rrollo de una reacción inmunitaria eficaz. La utilización del sistema inmune como arma frente a los astrocitomas de alto grado constituye una de las principales estrategias de investigación desde los primeros ensayos de Bloom en 1960, siendo hoy en día una práctica habitual en la terapia antineoplásica de múltiples disciplinas médicas.El objetivo de este estudio es describir las características de las reacciones inmunológicas del sistema nervioso central, los mecanismos utilizados por los tumores astrocitarios para despistar las defensas del organismo y las diferentes líneas de investigación llevadas a cabo hasta la fecha, mostrando sus bases fisiopatológicas y los resultados obtenidos, basándonos en una extensa revisión bibliográfica." ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "It is generally accepted that tumour development promotes a systemic response leading to protect the host against cancer. However, tumours may as well elicit a partial immunodeficiency to avoid the development of a complete and active immune response. Since Bloom's first studies on immunotherapy to treat high grade gliomas in 1960, many attempts have been made from different medical specialties to use the immune system as a weapon against a great diversity of cancers.Main objective of this study is to outline the basic features of the immune response inside the Central Nervous System, the strategies employed by astrocytic tumours to evade body defences, and to provide an extended literature review on research on immunotherapy, especially concerning its patho-physiology and the clinical results achieved till date." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Pinilla-Arias, D.; Mateo Sierra, O.; Gutiérrez, F.A.; Fernández-Carballal, C.; Carrillo, R.: Inmunoterapia en astrocitomas de alto grado: principios y estado actual. 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Immunotherapy in high grade astrocytomas: principles and current state

D. Pinilla-Arias

, O. Mateo-Sierra, F.A. Gutiérrez, C. Fernández-Carballal, R. Carrillo

Servicio de Neurocirugía. Hospital General Universitario Gregorio Marañón. Madrid

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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Desde hace tiempo se conoce que la presencia de un tumor origina en el organismo una reacci&#243;n del sistema inmune enfocada a eliminar la amenaza que el desarrollo tumoral implica&#46; Sin embargo&#44; se van averiguando diferentes mecanismos por los cuales los tumores provocan un estado de inmunosupresi&#243;n que dificulta el desa-rrollo de una reacci&#243;n inmunitaria eficaz&#46; La utilizaci&#243;n del sistema inmune como arma frente a los astrocitomas de alto grado constituye una de las principales estrategias de investigaci&#243;n desde los primeros ensayos de Bloom en 1960&#44; siendo hoy en d&#237;a una pr&#225;ctica habitual en la terapia antineopl&#225;sica de m&#250;ltiples disciplinas m&#233;dicas&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio es describir las caracter&#237;sticas de las reacciones inmunol&#243;gicas del sistema nervioso central&#44; los mecanismos utilizados por los tumores astrocitarios para despistar las defensas del organismo y las diferentes l&#237;neas de investigaci&#243;n llevadas a cabo hasta la fecha&#44; mostrando sus bases fisiopatol&#243;gicas y los resultados obtenidos&#44; bas&#225;ndonos en una extensa revisi&#243;n bibliogr&#225;fica&#46;</p>"
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        "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">It is generally accepted that tumour development promotes a systemic response leading to protect the host against cancer&#46; However&#44; tumours may as well elicit a partial immunodeficiency to avoid the development of a complete and active immune response&#46; Since Bloom&#39;s first studies on immunotherapy to treat high grade gliomas in 1960&#44; many attempts have been made from different medical specialties to use the immune system as a weapon against a great diversity of cancers&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Main objective of this study is to outline the basic features of the immune response inside the Central Nervous System&#44; the strategies employed by astrocytic tumours to evade body defences&#44; and to provide an extended literature review on research on immunotherapy&#44; especially concerning its patho-physiology and the clinical results achieved till date&#46;</p>"
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Información del artículo

ISSN: 11301473
Idioma original: Español

DOI:10.1016/S1130-1473(05)70401-2

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