Revisión de los ensayos clínicos sobre prevención del daño neurológico en el traumatismo craneoencefálico grave y análisis de su fracaso terapéutico
Overview of the recent clinical triáis in severe head injury and analysis of their therapeutic failure
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"apellidos" => "Caldera-Duarte" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147305704322?idApp=UINPBA00004B" "url" => "/11301473/0000001600000001/v1_201305151233/S1130147305704322/v1_201305151233/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Revisión de los ensayos clínicos sobre prevención del daño neurológico en el traumatismo craneoencefálico grave y análisis de su fracaso terapéutico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "39" "paginaFinal" => "49" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "G.R. Boto, P.A. Gómez, R.D. Lobato" "autores" => array:3 [ 0 => array:3 [ "nombre" => "G.R." "apellidos" => "Boto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "P.A." "apellidos" => "Gómez" ] 2 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Neurocirugía. Hospital 12 de Octubre. Madrid" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Avda. Dr. García Tapia, 159. Escalera D. 4°-B. 28030 Madrid." ] ] ] 1 => array:3 [ "autoresLista" => "J. De la Cruz" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "De la Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Unidad de Epidemiología Clínica. Hospital 12 de Octubre. Madrid" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Overview of the recent clinical triáis in severe head injury and analysis of their therapeutic failure" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-01-08" "fechaAceptado" => "2004-11-12" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158731" "palabras" => array:3 [ 0 => "Ensayos clínicos" 1 => "Traumatismo craneoencefálico grave" 2 => "Neuroprotección" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec158730" "palabras" => array:3 [ 0 => "Clinical triáis" 1 => "Severe head injury" 2 => "Neuroprotection" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En la pasada “Década del Cerebro” se han sometido a ensayo clínico distintos fármacos neuroprotectores frente al traumatismo craneoencefálico grave (TCEG) sin que ninguno de ellos haya mejorado de manera significativa el pronóstico final de estos pacientes. La eficacia neuroprotectora de estas sustancias, confirmada en los modelos animales, no ha podido trasladarse al ámbito clínico, creando gran decepción en la comunidad científica.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Este trabajo se ha estructurado en tres partes: en la primera, se resumen los mecanismos fisiopatológicos involucrados en el TCEG, diana de los fármacos neuroprotectores. En la segunda parte se revisan cuáles han sido los ensayos clínicos más importantes sobre TCEG llevados a cabo en estos últimos años y en la tercera, se analizan los motivos que pueden explicar el “fracaso” terapéutico de estos fármacos.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">During the past “Decade of the Brain” several neuroprotective agents have been tested in phase III clinical triáis for severe head injury (SHI) but unfortu-nately none of them significantly improved the outcome of these patients. In contrast to the success achieved by these drugs in animal laboratory studies, the results in terms of neuroprotection in the clinical setting have been disappointing.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This paper has been divided in three parts: in the first one, we summarize the pathophysiological mecha-nisms related to SHI, targeted by the neuroprotective agents. In the second part we review the main clinical triáis carried out for SHI to date, and in the third one, we analyze the possible reasons that explain why these agents have failed to show efficacy.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Boto, G.R.; Gómez, P.A.; De la Cruz, J.; Lobato, R.D.: Revisión de los ensayos clínicos sobre prevención del daño neurológico en el traumatismo craneoencefálico grave y análisis de su fracaso terapéutico. Neurocirugía 2005; 16: 39–49.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:55 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 3 | 1 | 4 |
| 2018 Marzo | 1 | 2 | 3 |
| 2018 Febrero | 19 | 3 | 22 |
| 2018 Enero | 14 | 7 | 21 |
| 2017 Diciembre | 14 | 10 | 24 |
| 2017 Noviembre | 17 | 10 | 27 |
| 2017 Octubre | 10 | 11 | 21 |
| 2017 Septiembre | 11 | 9 | 20 |
| 2017 Agosto | 12 | 6 | 18 |
| 2017 Julio | 14 | 6 | 20 |
| 2017 Junio | 21 | 5 | 26 |
| 2017 Mayo | 15 | 8 | 23 |
| 2017 Abril | 13 | 11 | 24 |
| 2017 Marzo | 8 | 7 | 15 |
| 2017 Febrero | 10 | 4 | 14 |
| 2017 Enero | 11 | 19 | 30 |
| 2016 Diciembre | 51 | 4 | 55 |
| 2016 Noviembre | 37 | 4 | 41 |
| 2016 Octubre | 38 | 12 | 50 |
| 2016 Septiembre | 38 | 10 | 48 |
| 2016 Agosto | 41 | 9 | 50 |
| 2016 Julio | 33 | 18 | 51 |
| 2016 Mayo | 1 | 0 | 1 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Agosto | 1 | 0 | 1 |
| 2015 Julio | 1 | 0 | 1 |
| 2015 Junio | 13 | 8 | 21 |
| 2015 Mayo | 47 | 18 | 65 |
| 2015 Abril | 37 | 11 | 48 |
| 2015 Marzo | 37 | 17 | 54 |
| 2015 Febrero | 22 | 15 | 37 |
| 2015 Enero | 16 | 11 | 27 |
| 2014 Diciembre | 14 | 15 | 29 |
| 2014 Noviembre | 18 | 10 | 28 |
| 2014 Octubre | 28 | 17 | 45 |
| 2014 Septiembre | 15 | 22 | 37 |
| 2014 Agosto | 12 | 17 | 29 |
| 2014 Julio | 15 | 12 | 27 |
| 2014 Junio | 21 | 22 | 43 |
| 2014 Mayo | 22 | 29 | 51 |
| 2014 Abril | 23 | 15 | 38 |
| 2014 Marzo | 27 | 21 | 48 |
| 2014 Febrero | 17 | 21 | 38 |
| 2014 Enero | 21 | 14 | 35 |
| 2013 Diciembre | 15 | 18 | 33 |
| 2013 Noviembre | 18 | 12 | 30 |
| 2013 Octubre | 24 | 8 | 32 |
| 2013 Septiembre | 22 | 13 | 35 |
| 2013 Agosto | 28 | 25 | 53 |
| 2013 Julio | 25 | 20 | 45 |
| 2013 Junio | 16 | 25 | 41 |
| 2013 Mayo | 20 | 22 | 42 |
| 2013 Abril | 18 | 12 | 30 |
| 2013 Marzo | 17 | 16 | 33 |
| 2013 Febrero | 13 | 17 | 30 |
| 2013 Enero | 13 | 13 | 26 |
| 2012 Diciembre | 24 | 13 | 37 |
| 2012 Noviembre | 0 | 8 | 8 |
| 2012 Octubre | 0 | 1 | 1 |
| 2012 Septiembre | 0 | 1 | 1 |
| 2012 Enero | 22 | 0 | 22 |
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