Perspectivas en el tratamiento del vasospasmo cerebral inducido por hemorragia subaracnoidea

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"apellidos" => "Landolt" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamentos de Neurocirugía. Hospital Cantonal de Aarau. Aarau. Suiza" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Neurocirugía. Hospital Cantonal de Aarau. Aarau. Suiza" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamentos de Cuidado Intensivo. Hospital Cantonal de Aarau. Aarau. Suiza" "etiqueta" => "***" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: M.D. Department of Neurosurgery University Hospital Bern. 3010 Bern. Switzerland." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-01-20" "fechaAceptado" => "2006-05-16" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec159501" "palabras" => array:6 [ 0 => "Hemorragia subaracnoidea" 1 => "Vasospasmo cerebral" 2 => "Angioplastia" 3 => "Donadores de óxido nítrico" 4 => "Estatinas" 5 => "Antagonistas de los receptores de la endotelina" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec159500" "palabras" => array:23 [ 0 => "ACT" 1 => "ACV" 2 => "ARM" 3 => "CBF" 4 => "CD11 a/CD18" 5 => "CD11 b/CD18" 6 => "DIND" 7 => "EDRF" 8 => "ET" 9 => "ETA" 10 => "ETB" 11 => "HSA" 12 => "ICAM-1" 13 => "LCR" 14 => "NA" 15 => "NO" 16 => "NOS" 17 => "PPV" 18 => "TCD" 19 => "t-PA" 20 => "UK" 21 => "VC" 22 => "VCAM-1" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec159502" "palabras" => array:6 [ 0 => "Subarachnoid hemorrhage" 1 => "Cerebral vasospasm" 2 => "Angioplasty" 3 => "NO donors" 4 => "Statins" 5 => "Endothelin receptors antagonists" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El vasospasmo cerebral sigue siendo la causa más importante de invalidez y muerte posterior a la ruptura de aneurismas saculares intracerebrales. Las estrategias terapéuticas en el vasospasmo inducido por la hemorragia subaracnoidea pueden ser agrupadas en cuatro categorías a saber: 1) terapias de prevención; 2) terapias de reversión; 3) terapias para el aumento de la perfusión cerebral; y 4) terapias de neuroprotección y rescate. Estudios experimentales recientes han permitido la realización de estudios clínicos fase II que sugieren resultados positivos con medicamentos que incluyen estatinas (simvastatina y pravastatina) y antagonistas de receptores tipo A de la endotelina-1 (clasozentan). De igual manera, evidencias experimentales y clínicas han mostrado las ventajas del drenaje de líquido cefalorraquídeo, administración intratecal de donadores de óxido nítrico, y los efectos desinhibidores de la Ca2+ Protein Kinasa C (Fasudil) y catecolaminas sobre la vascularización cerebral. Este artículo resume el estado de investigación actual de posibles agentes y estrategias terapéuticas relevantes en el tratamiento del vasospasmo cerebral." ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "Cerebral vasospasm is still the most important cause of death and disability after rupture of intracranial aneurysms. The therapeutic strategies in the treatment of subarachnoid hemorrhage induced vasospasm include four groups: 1) prevention of vasospasm; 2) reversion of vasospasm; 3) improvement of cerebral perfusion; and 4) neuroprotection and rescue therapies. Recent experimental studies allowed the design of phase II clinical studies which demonstrated positive results with medications and compounds such as statins (simvastatin and pravastatin) and endothelin-1 receptor antagonists (clasozentan). Moreover, experimental and clinical evidences showed the advantages of early cerebrospinal fluid drainage, intrathecal administration of NO-donors, effects of Ca2+ protein kinase inhibitor (Fasudil) and catecholamines on the cerebral vessels. This review article summarizes the stage of investigation of these medications and therapeutic strategies which will be relevant in the treatment of cerebral vasospasm... I would caution that vasospasm is still around, it is still alive and living in every neurosurgical unit. Hence my plea that our scientists not falter or lose interest for a final understanding and solution”C.G. Drake, 19909" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Fandino, J.; Fathi, A.R.; Graupner, T.; Jakob, S.; Landolt,H.: Perspectivas en el tratamiento del vasospasmo cerebral inducido por hemorragia subaracnoidea. 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Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm

J. Fandino*,**,***,

, A.R. Fathi*, T. Graupner*, S. Jacob***, H. Landolt**

* Departamentos de Neurocirugía. Hospital Cantonal de Aarau. Aarau. Suiza

** Departamento de Neurocirugía. Hospital Cantonal de Aarau. Aarau. Suiza

*** Departamentos de Cuidado Intensivo. Hospital Cantonal de Aarau. Aarau. Suiza

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        "titulo" => "Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El vasospasmo cerebral sigue siendo la causa m&#225;s importante de invalidez y muerte posterior a la ruptura de aneurismas saculares intracerebrales&#46; Las estrategias terap&#233;uticas en el vasospasmo inducido por la hemorragia subaracnoidea pueden ser agrupadas en cuatro categor&#237;as a saber&#58; 1&#41; terapias de prevenci&#243;n&#59; 2&#41; terapias de reversi&#243;n&#59; 3&#41; terapias para el aumento de la perfusi&#243;n cerebral&#59; y 4&#41; terapias de neuroprotecci&#243;n y rescate&#46; Estudios experimentales recientes han permitido la realizaci&#243;n de estudios cl&#237;nicos fase II que sugieren resultados positivos con medicamentos que incluyen estatinas &#40;simvastatina y pravastatina&#41; y antagonistas de receptores tipo A de la endotelina-1 &#40;clasozentan&#41;&#46; De igual manera&#44; evidencias experimentales y cl&#237;nicas han mostrado las ventajas del drenaje de l&#237;quido cefalorraqu&#237;deo&#44; administraci&#243;n intratecal de donadores de &#243;xido n&#237;trico&#44; y los efectos desinhibidores de la Ca2&#43; Protein Kinasa C &#40;Fasudil&#41; y catecolaminas sobre la vascularizaci&#243;n cerebral&#46; Este art&#237;culo resume el estado de investigaci&#243;n actual de posibles agentes y estrategias terap&#233;uticas relevantes en el tratamiento del vasospasmo cerebral&#46;</p>"
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        "titulo" => "Summary"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cerebral vasospasm is still the most important cause of death and disability after rupture of intracranial aneurysms&#46; The therapeutic strategies in the treatment of subarachnoid hemorrhage induced vasospasm include four groups&#58; 1&#41; prevention of vasospasm&#59; 2&#41; reversion of vasospasm&#59; 3&#41; improvement of cerebral perfusion&#59; and 4&#41; neuroprotection and rescue therapies&#46; Recent experimental studies allowed the design of phase II clinical studies which demonstrated positive results with medications and compounds such as statins &#40;simvastatin and pravastatin&#41; and endothelin-1 receptor antagonists &#40;clasozentan&#41;&#46; Moreover&#44; experimental and clinical evidences showed the advantages of early cerebrospinal fluid drainage&#44; intrathecal administration of NO-donors&#44; effects of Ca2&#43; protein kinase inhibitor &#40;Fasudil&#41; and catecholamines on the cerebral vessels&#46; This review article summarizes the stage of investigation of these medications and therapeutic strategies which will be relevant in the treatment of cerebral vasospasm&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">&#46;&#46; I would caution that vasospasm is still around&#44; it is still alive and living in every neurosurgical unit&#46; Hence my plea that our scientists not falter or lose interest for a final understanding and solution&#8221;</span></p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">C&#46;G&#46; Drake&#44; 1990<span class="elsevierStyleSup">9</span></p>"
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      0 => array:2 [
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        "nota" => "<p class="elsevierStyleNotepara">Fandino&#44; J&#46;&#59; Fathi&#44; A&#46;R&#46;&#59; Graupner&#44; T&#46;&#59; Jakob&#44; S&#46;&#59; Landolt&#44;H&#46;&#58; Perspectivas en el tratamiento del vasospasmo cerebral inducido por hemorragia subaracnoidea&#46; Neurocirug&#237;a 2007&#59; 18&#58; 16&#8211;27&#46;</p>"
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Información del artículo

ISSN: 11301473
Idioma original: Español

DOI:10.1016/S1130-1473(07)70304-4

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