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specialists have relied on the pattern of bleeding distribution within the cisterns to predict the location of the aneurysm&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Indeed&#44; several studies based on <span class="elsevierStyleItalic">de visu</span> assessment of non-contrast computed tomography images &#40;NCCT&#41; have reported acceptable predicting rates for aneurysms sitting in the middle cerebral &#40;MCA&#41; or the anterior communicating &#40;ACom&#41; arteries&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> However&#44; this does not hold true for other locations&#46; In addition&#44; the human eye has its boundaries in discriminating the grey colour range&#44; which hampers the evaluation of cases in which the differences in the amount of haemorrhage among the cisterns is small&#46; To overcome this limitation&#44; the development of computer-based software can provide reliable quantification of blood and its distribution within the subarachnoid space regions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We have tested the hypothesis that machine-based quantification of blood volumes stratified according to the distribution in a set of subarachnoid regions could predict the location of the ruptured aneurysm after spontaneous SAH&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patient selection</span><p id="par0020" class="elsevierStylePara elsevierViewall">This study is part of a larger project evaluating the utility of Radiomics in improving the diagnostic and prognostic yield of NCCT for spontaneous SAH&#46; Sampling consisted in the consecutive inclusion of adult subjects admitted to our tertiary neurovascular centre with spontaneous SAH&#44; between January 2012 and December 2018&#46; Inclusion criteria required admission within 72&#160;h of symptom onset and the performance of CTA and&#47;or DSA&#46; Exclusion criteria involved the absence of aneurysm in the vascular imaging and&#44; conversely&#44; the presence of more than one aneurysm or the presence of an intracerebral hematoma&#46; Subjects whose CT imaging had insufficient quality for running the quantification software were also excluded&#46; The first 30 subjects were used to develop the automatized method and for training purposes&#46; These and the subsequent subjects were included for the formal analysis&#46; Imaging data were codified to prevent individual identification&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The study protocol was approved by the institution&#8217;s Clinical Research Ethics Committee &#40;HCB&#47;2019&#47;0930&#41; and complies with national legislation of biomedical research&#44; the protection of personal data &#40;15&#47;1999&#41;&#44; the standards of Good Clinical Practice and the Helsinki Declaration &#40;1975 and 1983 revisions&#41;&#46; Patient informed consent was waived by the ethics committee&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Imaging protocol</span><p id="par0030" class="elsevierStylePara elsevierViewall">Whole-brain NCCT was performed in two scanners&#44; SOMATOM Sensation 64 and SOMATOM Definition Flash 128 &#40;Siemens&#44; Erlangen&#44; Germany&#41;&#44; with the following parameters&#58; 120&#160;kV&#44; 380&#160;mAs&#44; reconstruction kernel H40s&#44; and 2&#46;5&#160;mm pitch&#46; All cases were reconstructed to 5&#160;mm slices parallel to the orbitomeatal plane&#44; which was used as a reference for segmentation purposes&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Volumetric analysis and segmentation</span><p id="par0035" class="elsevierStylePara elsevierViewall">The method of blood detection and quantification is based on the relative density increase in NCCT attributed to the presence of blood&#46; Manual segmentation of the areas of blood distribution was performed in 3DSlicer by three experienced neuroradiologists&#44; according to anatomic references&#46; Doubtful cases were solved by consensus between two of them&#46; A threshold-paint tool with HU set in the range 50&#8211;150 was used&#46; The specified range permits identification and differentiation of densities other than blood &#40;i&#46;e&#46;&#44; grey matter&#44; white matter and cerebrospinal fluid and bone&#41;&#44; which were not considered for quantification&#46; Five areas were considered to quantitatively describe the distribution of blood in the SAH patients &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These were&#58; Perimesencephalic &#40;including the perimesencephalic and prepontine cisterns&#41;&#44; Interhemispheric &#40;within the interhemispheric fissure&#41;&#44; Right hemisphere &#40;within the right Silvian fissure and the cortical sulcus adjacent to it&#41;&#44; Left hemisphere and Intraventricular &#40;inside the ventricular system&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The quantity of blood present in each area was adjusted to the total amount of blood present intracranially&#46; To this aim&#44; the blood present in each area is expressed as the ratio between the quantity of blood in that given area per the total amount of blood&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Other features of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">Besides the quantification of blood and its distribution&#44; other features of interest were&#58; demographic variables&#44; World Federation of Neurosurgical Societies &#40;WFNS&#41; score at admission&#44; modified Fisher grade &#40;mF&#41;&#44; location of the aneurysm according to the DSA&#44; presence of clinically relevant hydrocephalus &#40;requiring an external ventricular drain&#44; EVD&#41;&#44; development of chronic hydrocephalus &#40;requiring a ventriculo-peritoneal shunt&#44; VP shunt&#41;&#44; presence of angiographic vasospasm and delayed cerebral ischemia &#40;DCI&#41;&#44; and modified Rankin Scale &#40;mRS&#41; at three months&#46; DCI was defined as a neurological worsening &#40;increase in &#8805; 2 points on NIHSS scale or decrease in &#8805; 2 points on Glasgow Coma Scale&#41;&#44; happening 48&#160;h after the initial haemorrhage&#44; lasting for at least one hour&#44; and without other attributable causes&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Statistical analysis of the data was performed with SPSS statistics version 27 &#40;IBM&#41;&#46; Graphics were constructed with Excel calculation software &#40;Microsoft Office&#41; version 2019&#46; Data were summarised by means&#160;&#177;&#160;standard deviation or proportions&#46; Continuous variables were analysed with Student <span class="elsevierStyleItalic">t</span>-test or ANOVA&#46; A p-value of &#60; 0&#46;05 was considered an indicator of statistical significance&#46; Internal validation of the predictive patterns was represented in a receiver operating characteristic &#40;ROC&#41; curve &#40;SPSS statistics&#41;&#46; The Youden Index was used to determine the optimal cut-off value of each diagnostic test&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">Between 2012 and 2018&#44; 322 patients suffering from spontaneous SAH were admitted to our institution within 72&#160;h from symptom onset&#46; CTA and DSA were performed to identify the bleeding source&#46; Of all&#44; 24 patients were excluded because of harbouring multiple aneurysms&#44; in 40 no aneurysms were found&#44; 75 had a concomitant intraparenchymal hematoma and 2 patients died before CTA or DSA was performed&#46; Additionally&#44; 113 subjects had to be excluded as they were referred from peripheral centres and their NCCT could not be run in our software&#46; In the end&#44; 68 patients were included for the analysis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Data on patient and aneurysm characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Aneurysm location and bleeding distribution</span><p id="par0060" class="elsevierStylePara elsevierViewall">The location of the aneurysms in the sample was representative of both anterior and posterior circulation and&#44; particularly&#44; included&#58; 23 &#40;35&#37;&#41; anterior communicating artery &#40;ACom&#41;&#44; 1 &#40;1&#37;&#41; anterior cerebral artery &#40;ACA&#41;&#44; 7 &#40;10&#37;&#41; middle cerebral artery &#40;MCA&#41;&#44; 7 &#40;10&#37;&#41; internal carotid artery &#40;ICA&#41;&#44; 16 &#40;24&#37;&#41; posterior communicating artery &#40;PCom&#41;&#44; 2 &#40;3&#37;&#41; posterior cerebral artery &#40;PCA&#41;&#44; 5 &#40;7&#37;&#41; posteroinferior cerebellar artery &#40;PICA&#41;&#44; 2 &#40;2&#37;&#41; anteroinferior cerebellar artery &#40;AICA&#41;&#44; 1 &#40;1&#37;&#41; superior cerebellar artery &#40;SCA&#41;&#44; and 4 &#40;6&#37;&#41; basilar artery &#40;BA&#41; aneurysms&#46; Mean volumetric values of the total blood and regional bleeding distribution according to the location of the ruptured aneurysm are displayed in Supplementary Table S1&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Association between bleeding pattern and aneurysm site</span><p id="par0065" class="elsevierStylePara elsevierViewall">To uniformly define the bleeding pattern&#44; in every case the volume of blood present in each of the five pre-specified regions of distribution was compensated by the global amount of blood &#40;ratio regional blood&#47;total blood&#41;&#46; Overall&#44; univariate analysis showed a strong association between the distribution of blood and the aneurysm location &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; Meanwhile&#44; the total amount of blood was not associated with aneurysm location &#40;p&#160;&#61;&#160;0&#46;918&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Certain bleeding patterns were associated with specific sites of aneurysm rupture &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; ACom rupture was predominantly distributed within the interhemispheric fissure &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; while MCA bleed preferentially towards the ipsilateral hemisphere &#40;i&#46;e&#46;&#44; Silvian fissure and sulcus of the lateral convexity&#41; &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; and ICA affected both the ipsilateral hemisphere and the perimesencephalic cisterns &#40;p&#160;&#60;&#160;0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The PCom bleeding distribution affected the ipsilateral hemisphere&#44; perimesencephalic and intraventricular spaces &#40;p&#160;&#61;&#160;0&#46;019&#41;&#59; and that of the PICA was predominantly perimesencephalic and intraventricular &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; Nonetheless&#44; a significant correlation between the bleeding vessel and the distribution could not be demonstrated for other posterior circulation aneurysms&#44; like the AICA and the BA &#40;p&#160;&#62;&#160;0&#46;05&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarizes the associations between each specific pattern of blood distribution and the location of the aneurysm found in our sample&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The internal value of the predictive model was analysed with ROC curves and cut-off values are provided in ratios &#40;regional blood&#47;total blood&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; According to the Youden Index&#44; the best cut-off point for an interhemispheric pattern to predict an ACom aneurysm was 0&#46;134 &#40;AUROC 0&#46;891&#44; CI 0&#46;803&#8722;0&#46;979&#44; sensitivity 87&#37; and specificity 82&#37;&#41;&#46; For an ipsilateral hemispheric pattern to predict an MCA aneurysm was 0&#46;482 &#40;AUROC 0&#46;981&#44; CI 0&#46;951&#8211;1&#46;000&#44; sensitivity 100&#37; and specificity 92&#37;&#41;&#46; A cut-off of 0&#46;656 was obtained for the combined ipsilateral hemispheric and perimesencephalic pattern to predict an ICA aneurysm &#40;AUROC 0&#46;836&#44; CI 0&#46;819&#8722;0&#46;989&#44; sensitivity 86&#37; and specificity 84&#37;&#41;&#46; In posterior circulation&#44; the cut-off point for a PCom aneurysm was 0&#46;743 with a combined ipsilateral hemispheric&#44; perimesencephalic and intraventricular pattern &#40;AUROC 0&#46;616&#44; CI 0&#46;482&#8722;0&#46;750&#44; sensitivity 60&#37; and specificity 60&#37;&#41;&#59; and that for a PICA aneurysm was 0&#46;740 with a perimesencephalic and intraventricular pattern &#40;AUROC 0&#46;929&#44; CI 0&#46;863&#8722;0&#46;995&#44; sensitivity 100&#37; and specificity 87&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Bleeding pattern and clinical outcomes</span><p id="par0080" class="elsevierStylePara elsevierViewall">The association between blood quantity and distribution in the subarachnoid space and clinical outcomes was a secondary objective in this study&#46; The total volume of blood was associated with worse clinical status at admission &#40;WFNS 4&#8722;5&#44; p&#160;&#61;&#160;0&#46;030&#41; and also with worse performance status at three months &#40;mRS&#160;&#62;&#160;2&#44; p&#160;&#60;&#160;0&#46;001&#41;&#46; A non-significant trend was found in acute hydrocephalus &#40;p&#160;&#61;&#160;0&#46;059&#41; and delayed cerebral ischemia &#40;p&#160;&#61;&#160;0&#46;085&#41;&#46; No association was found between the bleeding pattern and the development of chronic hydrocephalus &#40;VP shunt&#41; or the occurrence of asymptomatic angiographic vasospasm &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Regarding the bleeding distribution&#44; intraventricular haemorrhage was indeed associated with the development of acute hydrocephalus &#40;p&#160;&#61;&#160;0&#46;012&#41;&#46; Neither the intraventricular nor the perimesencephalic bleeding volumes seemed to correlate with DCI &#40;p&#160;&#61;&#160;0&#46;191 and p&#160;&#61;&#160;0&#46;129&#44; respectively&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">In the present study&#44; a semi-automatic computerized volumetric software was used to quantify and determine in detail the bleeding pattern after aneurysmal subarachnoid haemorrhage&#46; This tool could accurately predict the location of the ruptured aneurysm&#44; with high sensitivity and specificity values&#46; A potential application in the emergency setting may be pursued&#44; provided that speed and simplicity are attained with full automatization of the process&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">About 20&#37; of patients with spontaneous SAH have multiple aneurysms in the admission vascular imaging studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Moreover&#44; in an additional 10&#37;&#8211;30&#37; of patients no aneurysms are initially detected&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> In these cases&#44; identification of the actual point of bleeding is essential to guide treatment and prevent complications&#46; In fact&#44; predicting the aneurysm location is a recurrent topic in the literature&#44; given its implications&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Conventionally&#44; experts have relied on the pattern of blood distribution within the subarachnoid spaces to determine the probable source of bleeding&#46; With the irruption of the digital era&#44; fallible visual-based methods of prediction<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8&#44;12</span></a> were challenged by machine-based tools&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a> Yet&#44; to date&#44; these novel predictive models are based in parameters other than the widely accepted bleeding pattern&#44; like patient characteristics&#44; aneurysm morphology and haemodynamic factors&#46; The latter two require a CTA or a DSA reconstruction and the careful assessment by experienced neuroradiologists&#44; which limit their applicability in the busy emergency setting and in non-stroke referral centres&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The method that we propose is an upgrade of the well-established procedure of prediction by which the location of the ruptured aneurysm can be predicted by looking at the distribution of blood within the different subarachnoid cisterns&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;16</span></a> In fact&#44; our results could be regarded as a contemporary confirmation of the effectiveness of tradition regarding SAH patterns of bleeding and aneurysm site determination&#46; With this favourable background&#44; our automatised tool provides a reliable and rigorous method for volumetric quantification of the regional distribution of blood&#44; with specific cut-off values to predict the aneurysm-site&#44; all of which are obtained in a timely and convenient manner&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Of note&#44; the predictive value of our model was internally robust for most of anterior and posterior circulation lesions&#46; As shown in <a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#44; the AUROC for ACom&#44; MCA&#44; ICA and PICA were roughly 0&#46;900 or above&#44; therefore conferring a high sensitivity and specificity for this pattern-based diagnostic tool&#46; For PCom aneurysms&#44; the predictive value was moderate &#40;AUROC 0&#46;616&#41;&#44; but still acceptable&#46; As we objectively demonstrated&#44; ACom rupture is predominantly distributed within the interhemispheric fissure&#44; while MCA bleeds preferentially towards the ipsilateral hemisphere&#44; and ICA affects both the hemisphere and the perimesencephalic cisterns&#46; PICA aneurysms showed the higher relative volumes of intraventricular haemorrhage&#44; as previously described&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> and the combined presence of intraventricular and perimesencephalic bleeding was predictive of a PICA location of the aneurysm&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">It seems that the main limitation to the automatized method is actually shared with the conventional visual assessment&#44; and that is the determination of posterior circulation aneurysm location&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> We were not able to predict BA&#44; SCA or AICA locations&#44; however the limited number of these cases in our sample might have precluded the detection of such association&#46; Other possible explanations are the lower resolution of CT scan to evaluate the posterior fossa&#44; and also&#44; the difficulty in delineating regions of bleeding distribution within the basal cisterns&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A potential bias in the validation of a rupture prediction model is the selection of the diagnostic technique used as a reference for determining the location of the ruptured aneurysm&#46; In our study&#44; we used CTA or DSA for defining the ruptured aneurysm&#46; However&#44; to date&#44; only visual inspection of the aneurysm sac and surrounding parenchyma&#44; by means of intraoperative observation sac or postmortem studies&#44; allow a true confirmation of the rupture status&#46; To avoid this plausible bias&#44; we decided to exclude patients with multiple aneurysms&#46; While this simplified in testing the accuracy of the prediction capacity&#44; it also hampered its validation in these cases of difficult diagnosis&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">As a secondary objective in this study&#44; the volume and distribution of blood was tested as a predictor of clinical outcomes&#46; The otherwise common agreement that the amount of blood is a major determinant of neurological presentation and evolution<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#8211;23</span></a> was confirmed in our set&#44; where both poor WFNS at admission and unfavourable mRS at three months were associated with the total blood volume quantification&#46; In this line&#44; automatised measurements&#44; rather than classic visual scales<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a> decrease the interobserver variability and provide a quantitative metric for comparison&#46; Our results increase the validation yield established by Boers et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> from MCA aneurysms to a diversity of aneurysm locations&#46; While Boers et al&#46; centred their study on MCA aneurysms&#44; we included a variety of locations&#59; still&#44; it is worth remarking that we excluded patients with concomitant intraparenchymal hematomas and therefore an underrepresentation of MCA aneurysms can be expected in our sample&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">An exhaustive analysis of the bleeding distribution and the development of vasospasm and DCI is out of the scope of this study&#46; Despite&#44; in our sample&#44; a non-significant trend was found between higher volumes of blood and the incidence of DCI&#59; this was not the case for angiographic vasospasm&#46; None of the specific regions of blood spread seemed to elicit DCI&#46; Interestingly&#44; Friedman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> also used a software-based tool to precisely quantify the bleeding in Fisher grade 3 SAH and found DCI to be associated with larger cisternal and total haemorrhage volumes&#44; yet no regional volume alone was predictive of DCI in their study&#46; Similar results were obtained by van der Steen et al&#46; in 2018&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Potential applications of the volumetric examination tool that we present are objectively and accurately determining the source of bleeding in cases of multiple aneurysms&#44; and estimating the most probable location of an aneurysm in cases of non-perimesencephalic &#40;classic&#41; pattern of SAH with negative CTA and DSA&#46; These two particular subtypes of SAH patients &#8211; multiple aneurysms and no aneurysms &#8211; were excluded in our study so as to test this novel tool in cases with a definitive diagnosis of aneurysm location&#46; Provided that the proposed tool is well-powered and reliable&#44; an extrapolation to these more complex situations should be sought&#46; In the end&#44; performing this volumetric test systematically could increase the pre-test probability when undergoing a repeated diagnostic DSA&#46; Moreover&#44; in the bustling emergency setting&#44; the use of this rapid and simple method could accelerate the decision making and serve as a reassurance in case of peripheral centres lacking an expert neuroradiologist&#46; The use of heat maps to represent the differences in density &#40;regional amount of blood&#41; could make the software more user-friendly and facilitate the visual estimation of aneurysm location&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Weaknesses of the study include the limited sample size and the heterogeneous numeric representation of the aneurysm sites&#44; though this reflects the epidemiology of the disease&#46; Moreover&#44; the apparent loss of 113 candidates must be addressed&#58; these were patients referred to our tertiary institution&#44; in which the initial CT was done in peripheral centres and could not be run in our software&#46; Prospective studies in larger cohorts could increase the predictive yield in certain vessel locations&#44; especially in posterior circulation aneurysms&#46; As previously stated&#44; confirmation of the rupture status is only possible with direct inspection&#59; therefore&#44; a prospective series of surgical cases exclusively would confirm the validity of the method&#46; Still&#44; this would require either a multicentric cooperation or a lengthy study period&#46; On the other hand&#44; the generalization of these results and the applicability of the method rely on the availability of the volumetric software among the different institutions&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conclusion</span><p id="par0145" class="elsevierStylePara elsevierViewall">Computer-based semi-automatic volumetric analysis seems a reliable and objective tool to quantify and describe the distribution of blood within the subarachnoid and intraventricular spaces after spontaneous subarachnoid haemorrhage&#46; We provide a pattern-based diagnostic tool to accurately predict the aneurysm location after spontaneous SAH&#46; For anterior communicating&#44; middle cerebral&#44; internal carotid and posteroinferior cerebellar artery aneurysms&#44; this model is well-powered &#40;AUROC&#160;&#8805;&#160;0&#46;900&#41;&#59; however&#44; its value in posterior communication artery and other posterior circulation aneurysms deserves further optimization&#46; Prospective studies are encouraged to determine the external validation of the proposed tool&#44; particularly in the cases of difficult diagnosis&#44; like the in the presence of multiple aneurysms or in those cases with negative DSA&#46; Also of interest would be to estimate the impact of the software in the emergency department workflow&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Statements and declarations</span><p id="par0150" class="elsevierStylePara elsevierViewall">Nothing to disclose&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Funding</span><p id="par0155" class="elsevierStylePara elsevierViewall">We thank the Spanish <span class="elsevierStyleGrantSponsor" id="gs0005">Ministry of Economy and Competitiveness</span> for the grant given to SA and RT &#40;project PI19&#47;00936 funded by <span class="elsevierStyleGrantSponsor" id="gs0010">Instituto de Salud Carlos III</span> and co-funded by the <span class="elsevierStyleGrantSponsor" id="gs0015">European Regional Development Fund</span> &#91;ERDF&#93;&#41;&#46;</p></span></span>"
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            0 => "Subarachnoid haemorrhage"
            1 => "Bleeding pattern"
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          "palabras" => array:23 [
            0 => "ACA"
            1 => "ACom"
            2 => "BA"
            3 => "CI"
            4 => "CT"
            5 => "CTA"
            6 => "DSA"
            7 => "DCI"
            8 => "EVD"
            9 => "ICA"
            10 => "MCA"
            11 => "mFisher"
            12 => "mRS"
            13 => "NCCT"
            14 => "PCA"
            15 => "PCom"
            16 => "PICA"
            17 => "ROC"
            18 => "SAH"
            19 => "SCA"
            20 => "SD"
            21 => "VP shunt"
            22 => "WFNS"
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            2 => "Aneurisma"
            3 => "Volumetr&#237;a"
            4 => "Cuantificaci&#243;n"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">In spontaneous subarachnoid haemorrhage &#40;SAH&#41; accurate determination of the bleeding source is paramount to guide treatment&#46; Traditionally&#44; the bleeding pattern has been used to predict the aneurysm location&#46; Here&#44; we have tested a software-based tool&#44; which quantifies the volume of intracranial blood and stratifies it according to the regional distribution&#44; to predict the location of the ruptured aneurysm&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">A consecutive series of SAH patients admitted to a single tertiary centre between 2012&#8211;2018&#44; within 72&#160;h of onset&#44; harbouring a single intracranial aneurysm&#46; A semi-automatized method of blood quantification&#44; based on the relative density increase&#44; was applied to initial non-contrast CTs&#46; Five regions were used to define the bleeding patterns and to correlate them with aneurysm location&#58; perimesencephalic&#44; interhemispheric&#44; right&#47;left hemisphere and intraventricular&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">68 patients were included for analysis&#46; There was a strong association between the distribution of blood and the aneurysm location &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; In particular&#58; ACom and interhemispheric fissure &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; MCA and ipsilateral hemisphere &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; ICA and ipsilateral hemisphere and perimesencephalic cisterns &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; PCom and hemispheric&#44; perimesencephalic and intraventricular &#40;p&#160;&#61;&#160;0&#46;019&#41;&#44; and PICA and perimesencephalic and intraventricular &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; The internal diagnostic value was high &#40;AUROC&#160;&#8805;&#160;0&#46;900&#41; for these locations&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Regional automatised volumetry seems a reliable and objective tool to quantify and describe the distribution of blood within the subarachnoid spaces&#46; This tool accurately predicts the location of the ruptured aneurysm&#59; its use may be prospectively considered in the emergency setting when speed and simplicity are attained&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Background"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">En la hemorragia subaracnoidea espont&#225;nea &#40;HAS&#41;&#44; la determinaci&#243;n fehaciente del punto de sangrado es fundamental para guiar el tratamiento&#46; De forma tradicional&#44; la determinaci&#243;n de la localizaci&#243;n del aneurisma se basa en el patr&#243;n de sangrado&#46; En el presente estudio&#44; evaluamos una herramienta computarizada&#44; capaz de cuantificar el volumen de sangre intracraneal y de estratificarlo seg&#250;n la distribuci&#243;n regional&#44; con el objetivo de predecir la localizaci&#243;n del aneurisma roto&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Una serie consecutiva de pacientes ingresados en nuestro centro terciario durante el periodo 2012&#8211;2018&#44; con hemorragia subaracnoidea de debut en &#60; 72&#160;h y con aneurisma &#250;nico&#46; Se aplic&#243; el m&#233;todo cuantitativo semiautomatizado a las tomograf&#237;as computarizadas basales de dichos pacientes&#46; La detecci&#243;n del sistema se basa en el aumento relativo de densidad atribuido a la presencia de sangre&#46; Se contemplaron cinco regiones para definir los patrones de sangrado y para su posterior correlaci&#243;n con la localizaci&#243;n del aneurisma&#58; perimesencef&#225;lico&#44; interhemisf&#233;rico&#44; hemisf&#233;rico derecho&#47;izquierdo e intraventricular&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">El an&#225;lisis incluy&#243; 68 pacientes&#46; Se detect&#243; una fuerte asociaci&#243;n entre el patr&#243;n de sangrado y la localizaci&#243;n del aneurisma &#40;p&#160;&#60;&#160;0&#44;001&#41;&#46; En concreto&#58; ACom con la distribuci&#243;n interhemisf&#233;rica &#40;p&#160;&#60;&#160;0&#44;001&#41;&#59; ACM con la hemisf&#233;rica ipsilateral &#40;p&#160;&#60;&#160;0&#44;001&#41;&#59; ACI con la hemisf&#233;rica ipsilateral y perimesencef&#225;lica &#40;p&#160;&#60;&#160;0&#44;001&#41;&#59; ACoP la hemisf&#233;rica ipsilateral&#44; perimesencef&#225;lica e intraventricular &#40;p&#160;&#61;&#160;0&#44;019&#41;&#59; ACPI con la perimesencef&#225;lica e intraventricular &#40;p&#160;&#60;&#160;0&#44;001&#41;&#46; El valor diagn&#243;stico interno del modelo fue elevado para estas localizaciones &#40;AUROC&#160;&#8805;&#160;0&#46;900&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">La volumetr&#237;a regional automatizada parece una herramienta fiable y objetiva para cuantificar y describir la distribuci&#243;n de sangre en los espacios subaracnoideos&#46; Este m&#233;todo es capaz de predecir de forma precisa la localizaci&#243;n del aneurisma roto&#59; su aplicaci&#243;n prospectiva es en la medicina de urgencias&#44; una vez asegurada la agilidad y simplicidad del funcionamiento&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Antecedentes"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0165" class="elsevierStylePara elsevierViewall">The following is Supplementary data to this article&#58;<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0085"
          ]
        ]
      ]
    ]
    "multimedia" => array:9 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2107
            "Ancho" => 3341
            "Tamanyo" => 695514
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Semi-automatized method of regional segmentation of blood distribution&#46; Five areas are distinguished&#58; 1&#44; Perimesencephalic&#59; 2&#44; Interhemispheric&#59; 3&#44; Right hemisphere&#59; 4&#44; Left hemisphere&#59; 5&#44; Intraventricular&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1406
            "Ancho" => 1675
            "Tamanyo" => 127478
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        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diagram of the sampling process&#46; Flowchart of the study&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Fig&#46; 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1489
            "Ancho" => 2508
            "Tamanyo" => 223689
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Blood distribution according to the site of the aneurysm&#46; Blood quantification is expressed as the ratio between the amounts of blood in a given region per the total amount of intracranial blood&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "fig0020"
        "etiqueta" => "Fig&#46; 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1321
            "Ancho" => 1675
            "Tamanyo" => 172878
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Schematic representation of the bleeding distribution according to the location of the ruptured aneurysm&#46; &#40;&#42;&#42;&#41; denote statistically significant associations found in our sample&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "fig0025"
        "etiqueta" => "Fig&#46; 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 1285
            "Ancho" => 3341
            "Tamanyo" => 256922
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Sensitivity and specificity values&#44; plotted on a receiver operating characteristic curve&#44; of each bleeding pattern to predict a certain aneurysm location&#46; The AUROC&#44; CI&#44; Youden Index&#44; Sensivity and Specificity values are summarized in the accessory table beneath&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0030"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">ACom&#44; anterior communicating artery&#59; ACA&#44; anterior cerebral artery&#59; MCA&#44; middle cerebral artery&#59; ICA&#44; internal carotid artery&#59; PCA&#44; posterior cerebral artery&#59; PCom&#44; posterior communicating artery&#59; PICA&#44; posteroinferior cerebellar artery&#59; SCA&#44; superior cerebellar artery&#59; BA&#44; basilar artery&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SAH patients &#40;N&#160;&#61;&#160;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex female&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WFNS&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8722;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&#8722;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modified Fisher&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aneurysm location&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MCA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MCA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCom right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCom left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PICA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PICA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AICA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AICA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SCA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3525745.png"
              ]
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          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics of the sample of patients with spontaneous subarachnoid haemorrhage and a single ruptured aneurysm&#46;</p>"
        ]
      ]
      6 => array:8 [
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        "etiqueta" => "Table 2"
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          0 => array:3 [
            "identificador" => "at0035"
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          ]
        ]
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          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">ACom&#44; anterior communicating artery&#59; ACA&#44; anterior cerebral artery&#59; MCA&#44; middle cerebral artery&#59; ICA&#44; internal carotid artery&#59; PCA&#44; posterior cerebral artery&#59; PCom&#44; posterior communicating artery&#59; PICA&#44; posteroinferior cerebellar artery&#59; SCA&#44; superior cerebellar artery&#59; BA&#44; basilar artery&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Aneurysm location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bleeding pattern&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Interhemispheric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Interhemispheric &#38; perimesencephalic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;437&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemisphere &#40;ipsilateral&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemisphere &#40;ipsilateral&#41; &#38; perimesencephalic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemisphere &#40;ipsilateral&#41;&#44; perimesencephalic &#38; IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perimesencephalic &#38; IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perimesencephalic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perimesencephalic&#44; interhemispheric &#38; IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;258&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Association between the location of the ruptured aneurysm and the pattern of blood distribution&#46; The specific combinations of regions of blood distribution were initially obtained after the observation of relative ratios of bleeding distribution according to aneurysm site&#46; After the multivariate analysis confirmed the association between bleeding distribution and aneurysm site&#44; a post-hoc analysis was performed to establish the individual correlations between site of rupture and bleeding pattern&#46;</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
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          0 => array:3 [
            "identificador" => "at0040"
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          ]
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">VP&#44; ventriculo-peritoneal&#59; mRS&#44; modified Rankin scale&#46;</p>"
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Amount of blood &#40;cm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WFNS admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8722;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;638 &#40;12&#44;249&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&#8722;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;763 &#40;17&#44;523&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acute hydrocephalus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;974 &#40;14&#44;487&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;893 &#40;12&#44;463&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic hydrocephalus &#40;VP shunt&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;556&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;112 &#40;12&#44;847&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;112 &#40;15&#44;622&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rebleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;325&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183&#44;680&#47;20&#44;220&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;914 &#40;14&#44;345&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Angiographic vasospasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;820&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;209 &#40;14&#44;564&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;074 &#40;16&#44;117&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Delayed cerebral ischemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;085&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;728 &#40;19&#44;326&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;897 &#40;13&#44;854&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">mRS 3-months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0&#8722;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;985 &#40;11&#44;458&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&#8722;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;967 &#40;6305&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;154 &#40;18&#44;808&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3525743.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Association between the total amount of blood assessed by volumetric quantification and the primary clinical outcomes in SAH patients&#46; The amount of blood is expressed as mean &#40;standard deviation&#41; in squared centimetres&#46;</p>"
        ]
      ]
      8 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.docx"
          "ficheroTamanyo" => 22163
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:26 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history of unruptured intracranial aneurysms&#58; a long-term follow-up study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Juvela"
                            1 => "K&#46; Poussa"
                            2 => "H&#46; Lehto"
                            3 => "M&#46; Porras"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "doi" => "10.1161/STROKEAHA.113.001838"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "2013"
                        "volumen" => "44"
                        "paginaInicial" => "2414"
                        "paginaFinal" => "2421"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23868274"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and outcome of multiple intracranial aneurysms in a defined population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kaminogo"
                            1 => "M&#46; Yonekura"
                            2 => "S&#46; Shibata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.str.0000046763.48330.ad"
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                        "tituloSerie" => "Stroke"
                        "fecha" => "2002"
                        "volumen" => "34"
                        "paginaInicial" => "16"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12511744"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors and outcomes associated with early and delayed aneurysm treatment in subarachnoid hemorrhage patients in the United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Siddiq"
                            1 => "S&#46;A&#46; Chaudhry"
                            2 => "R&#46;P&#46; Tummala"
                            3 => "M&#46;F&#46; Suri"
                            4 => "A&#46;I&#46; Qureshi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1227/NEU.0b013e318261749b"
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "2012"
                        "volumen" => "71"
                        "paginaInicial" => "670"
                        "paginaFinal" => "677"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "False localization of rupture site in patients with multiple cerebral aneurysms and subarachnoid hemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Hino"
                            1 => "M&#46; Fujimoto"
                            2 => "Y&#46; Iwamoto"
                            3 => "T&#46; Yamaki"
                            4 => "T&#46; Katsumori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00006123-200004000-00011"
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "2000"
                        "volumen" => "46"
                        "paginaInicial" => "825"
                        "paginaFinal" => "830"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aneurysm rebleeding after poor-grade aneurysmal subarachnoid hemorrhage&#58; predictors and impact on clinical outcomes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Zhao"
                            1 => "Y&#46; Fan"
                            2 => "Y&#46; Xiong"
                            3 => "R&#46; Yin"
                            4 => "K&#46; Zheng"
                            5 => "Z&#46; Li"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2016.10.020"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2016"
                        "volumen" => "371"
                        "paginaInicial" => "62"
                        "paginaFinal" => "66"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27871451"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple intracranial aneurysms&#58; determining the site of rupture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;G&#46; Nehls"
                            1 => "R&#46;A&#46; Flom"
                            2 => "L&#46;P&#46; Carter"
                            3 => "R&#46;F&#46; Spetzler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1985.63.3.0342"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1985"
                        "volumen" => "63"
                        "paginaInicial" => "342"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4020459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic decisi&#243;n and management of aneurysmal subarachnoid haemorrhage base don computed tomographic angiography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;R&#46; Dehdashti"
                            1 => "D&#46;A&#46; Rufenacht"
                            2 => "J&#46; Delavelle"
                            3 => "A&#46; Reverdin"
                            4 => "N&#46; de Tribolet"
                            5 => "A&#46;R&#46; Dehdashti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Neurosurg"
                        "fecha" => "2003"
                        "volumen" => "17"
                        "numero" => "1"
                        "paginaInicial" => "46"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12779201"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accuracy in identifying the source of subarachnoid hemorrhage in the setting of multiple intracranial aneurysms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Orning"
                            1 => "S&#46;F&#46; Shakur"
                            2 => "A&#46; Alaraj"
                            3 => "M&#46; Behbahani"
                            4 => "F&#46;T&#46; Charbel"
                            5 => "V&#46;A&#46; Aletich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/neuros/nyx339"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "2018"
                        "volumen" => "83"
                        "numero" => "1"
                        "paginaInicial" => "62"
                        "paginaFinal" => "68"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ruptured cerebral aneurysms missed by initial angiographic study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Iwanaga"
                            1 => "S&#46; Wakai"
                            2 => "C&#46; Ochiai"
                            3 => "J&#46; Narita"
                            4 => "S&#46; Inoh"
                            5 => "M&#46; Nagai"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00006123-199007000-00006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1990"
                        "volumen" => "27"
                        "paginaInicial" => "45"
                        "paginaFinal" => "51"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2377280"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spontaneous subarachnoid haemorrhage with negative initial angiography&#58; a review of 143 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;Y&#46; Jung"
                            1 => "Y&#46;B&#46; Kim"
                            2 => "J&#46;W&#46; Lee"
                            3 => "S&#46;K&#46; Huh"
                            4 => "K&#46;C&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jocn.2005.09.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Neurosci"
                        "fecha" => "2006"
                        "volumen" => "13"
                        "paginaInicial" => "1011"
                        "paginaFinal" => "1017"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16931020"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeat digital subtraction angiography after a negative baseline assessment in nonperimesencephalic subarachnoid hemorrhage&#58; a pooled data meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;A&#46; Bakker"
                            1 => "R&#46;J&#46; Groen"
                            2 => "M&#46; Foumani"
                            3 => "M&#46; Uyttenboogaart"
                            4 => "O&#46;S&#46; Eshghi"
                            5 => "J&#46;D&#46; Metzemaekers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/2013.9.JNS131337"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "2014"
                        "volumen" => "120"
                        "numero" => "1"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24160474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validity of prediction of the site of ruptured intracranial aneurysms with CT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; van der Jagt"
                            1 => "D&#46; Hasan"
                            2 => "H&#46;W&#46; Bijvoet"
                            3 => "H&#46; Pieterman"
                            4 => "D&#46;W&#46; Dippel"
                            5 => "F&#46;H&#46; Vermeij"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1212/wnl.52.1.34"
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "34"
                        "paginaFinal" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel models for identification of the ruptured aneurysm in patients with subarachnoid hemorrhage with multiple aneurysms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Rajabzadeh-Oghaz"
                            1 => "J&#46; Wang"
                            2 => "N&#46; Varble"
                            3 => "S&#46;I&#46; Sugiyama"
                            4 => "A&#46; Shimizu"
                            5 => "L&#46; Jing"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3174/ajnr.A6259"
                      "Revista" => array:7 [
                        "tituloSerie" => "AJNR Am J Neuroradiol"
                        "fecha" => "2019"
                        "volumen" => "40"
                        "numero" => "11"
                        "paginaInicial" => "1939"
                        "paginaFinal" => "1946"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31649161"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rupture resemblance score &#40;RRS&#41;&#58; toward risk stratification of unruptured intracranial aneurysms using hemodynamic-morphological discriminants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Xiang"
                            1 => "J&#46; Yu"
                            2 => "H&#46; Choi"
                            3 => "J&#46;M&#46; Dolan Fox"
                            4 => "K&#46;V&#46; Snyder"
                            5 => "E&#46;I&#46; Lev"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/neurintsurg-2014-011218"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurointerv Surg"
                        "fecha" => "2015"
                        "volumen" => "7"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24811740"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple aneurysms in subarachnoid hemorrhage &#8211; identification of the ruptured aneurysm&#44; when the bleeding pattern is not self-explanatory &#8211; development of a novel prediction score"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "P&#46; Schuss"
                            2 => "S&#46; Brandecker"
                            3 => "T&#46; Welchowski"
                            4 => "M&#46; Schmid"
                            5 => "H&#46; Vatter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12883-020-01655-x"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Neurol"
                        "fecha" => "2020"
                        "volumen" => "20"
                        "numero" => "1"
                        "paginaInicial" => "70"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "False localization of rupture by computed tomography in bilateral internal carotid artery aneurysms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;C&#46; Lee"
                            1 => "J&#46;Y&#46; Joo"
                            2 => "K&#46;S&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0090-3019(95)00409-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Neurol"
                        "fecha" => "1996"
                        "volumen" => "45"
                        "paginaInicial" => "435"
                        "paginaFinal" => "441"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8629243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patterns of hemorrhage with ruptured posterior inferior cerebellar artery aneurysms&#58; CT findings in 44 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;F&#46; Kallmes"
                            1 => "G&#46; Lanzino"
                            2 => "J&#46;E&#46; Dix"
                            3 => "J&#46;E&#46; Dion"
                            4 => "H&#46; Do"
                            5 => "R&#46;J&#46; Woodcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.169.4.9308484"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "1997"
                        "volumen" => "169"
                        "paginaInicial" => "1169"
                        "paginaFinal" => "1171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9308484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of the quantity and distribution of subarachnoid haemorrhage on CT in the localization of a ruptured cerebral aneurysm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;I&#46; Karttunen"
                            1 => "P&#46;H&#46; Jartti"
                            2 => "V&#46;A&#46; Ukkola"
                            3 => "J&#46; Sajanti"
                            4 => "M&#46; Haapea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00701-003-0080-8"
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "2003"
                        "volumen" => "145"
                        "numero" => "8"
                        "paginaInicial" => "655"
                        "paginaFinal" => "661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14520544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subarachnoid hemorrhage grading scales&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Rosen"
                            1 => "R&#46;L&#46; Macdonald"
                          ]
                        ]
                      ]
                    ]
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                        "link" => array:1 [
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                            "web" => "Medline"
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                ]
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                        "link" => array:1 [
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                            "web" => "Medline"
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                    ]
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                ]
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                        "paginaFinal" => "2286"
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                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Volumetric quantification of Fisher Grade 3 aneurysmal subarachnoid hemorrhage&#58; a novel method to predict symptomatic vasospasm on admission computerized tomography scans"
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                        "paginaFinal" => "407"
                        "link" => array:1 [
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Clinical Research
Aneurysmal subarachnoid haemorrhage: Volumetric quantification of the blood distribution pattern to accurately predict the ruptured aneurysm location
Hemorragia subaracnoidea aneurismática: cuantificación volumétrica del patrón de distribución hemática en la predicción del aneurisma índice
Alejandra Mosteiroa, Diego Culebrasa, Alberto Vargas Solanob, Javier Luis Moreno Negreteb, Antonio López-Ruedab, Laura Llullc, Daniel Santanac, Leire Pedrosad, Sergio Amaroc,d, Ramón Tornéa,d,
Autor para correspondencia
torne@clinic.cat

Corresponding author.
, Joaquim Enseñata,d
a Department of Neurosurgery, Hospital Clínic of Barcelona, University of Barcelona, Spain
b Department of Radiology, Hospital Clínic of Barcelona, University of Barcelona, Spain
c Comprehensive Stroke Center, Department of Neurology, Hospital Clínic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
d August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Semi-automatized method of regional segmentation of blood distribution&#46; Five areas are distinguished&#58; 1&#44; Perimesencephalic&#59; 2&#44; Interhemispheric&#59; 3&#44; Right hemisphere&#59; 4&#44; Left hemisphere&#59; 5&#44; Intraventricular&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In the diagnostic workup after spontaneous subarachnoid haemorrhage &#40;SAH&#41;&#44; multiple aneurysms are found in about 20&#37; of the cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> In such a context&#44; accurate identification of the source of rupture is paramount to guide treatment&#44; as inappropriate aneurysm selection could have devastating consequences due to rebleeding&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5</span></a> In fact&#44; the need for certainty has become even more relevant with the change in trend in the treatment technique&#44; for open surgery provides direct confirmation of the rupture status of the aneurysm while endovascular approaches do not&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Traditionally&#44; specialists have relied on the pattern of bleeding distribution within the cisterns to predict the location of the aneurysm&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Indeed&#44; several studies based on <span class="elsevierStyleItalic">de visu</span> assessment of non-contrast computed tomography images &#40;NCCT&#41; have reported acceptable predicting rates for aneurysms sitting in the middle cerebral &#40;MCA&#41; or the anterior communicating &#40;ACom&#41; arteries&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> However&#44; this does not hold true for other locations&#46; In addition&#44; the human eye has its boundaries in discriminating the grey colour range&#44; which hampers the evaluation of cases in which the differences in the amount of haemorrhage among the cisterns is small&#46; To overcome this limitation&#44; the development of computer-based software can provide reliable quantification of blood and its distribution within the subarachnoid space regions&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">We have tested the hypothesis that machine-based quantification of blood volumes stratified according to the distribution in a set of subarachnoid regions could predict the location of the ruptured aneurysm after spontaneous SAH&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Patient selection</span><p id="par0020" class="elsevierStylePara elsevierViewall">This study is part of a larger project evaluating the utility of Radiomics in improving the diagnostic and prognostic yield of NCCT for spontaneous SAH&#46; Sampling consisted in the consecutive inclusion of adult subjects admitted to our tertiary neurovascular centre with spontaneous SAH&#44; between January 2012 and December 2018&#46; Inclusion criteria required admission within 72&#160;h of symptom onset and the performance of CTA and&#47;or DSA&#46; Exclusion criteria involved the absence of aneurysm in the vascular imaging and&#44; conversely&#44; the presence of more than one aneurysm or the presence of an intracerebral hematoma&#46; Subjects whose CT imaging had insufficient quality for running the quantification software were also excluded&#46; The first 30 subjects were used to develop the automatized method and for training purposes&#46; These and the subsequent subjects were included for the formal analysis&#46; Imaging data were codified to prevent individual identification&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The study protocol was approved by the institution&#8217;s Clinical Research Ethics Committee &#40;HCB&#47;2019&#47;0930&#41; and complies with national legislation of biomedical research&#44; the protection of personal data &#40;15&#47;1999&#41;&#44; the standards of Good Clinical Practice and the Helsinki Declaration &#40;1975 and 1983 revisions&#41;&#46; Patient informed consent was waived by the ethics committee&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Imaging protocol</span><p id="par0030" class="elsevierStylePara elsevierViewall">Whole-brain NCCT was performed in two scanners&#44; SOMATOM Sensation 64 and SOMATOM Definition Flash 128 &#40;Siemens&#44; Erlangen&#44; Germany&#41;&#44; with the following parameters&#58; 120&#160;kV&#44; 380&#160;mAs&#44; reconstruction kernel H40s&#44; and 2&#46;5&#160;mm pitch&#46; All cases were reconstructed to 5&#160;mm slices parallel to the orbitomeatal plane&#44; which was used as a reference for segmentation purposes&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Volumetric analysis and segmentation</span><p id="par0035" class="elsevierStylePara elsevierViewall">The method of blood detection and quantification is based on the relative density increase in NCCT attributed to the presence of blood&#46; Manual segmentation of the areas of blood distribution was performed in 3DSlicer by three experienced neuroradiologists&#44; according to anatomic references&#46; Doubtful cases were solved by consensus between two of them&#46; A threshold-paint tool with HU set in the range 50&#8211;150 was used&#46; The specified range permits identification and differentiation of densities other than blood &#40;i&#46;e&#46;&#44; grey matter&#44; white matter and cerebrospinal fluid and bone&#41;&#44; which were not considered for quantification&#46; Five areas were considered to quantitatively describe the distribution of blood in the SAH patients &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These were&#58; Perimesencephalic &#40;including the perimesencephalic and prepontine cisterns&#41;&#44; Interhemispheric &#40;within the interhemispheric fissure&#41;&#44; Right hemisphere &#40;within the right Silvian fissure and the cortical sulcus adjacent to it&#41;&#44; Left hemisphere and Intraventricular &#40;inside the ventricular system&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The quantity of blood present in each area was adjusted to the total amount of blood present intracranially&#46; To this aim&#44; the blood present in each area is expressed as the ratio between the quantity of blood in that given area per the total amount of blood&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Other features of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">Besides the quantification of blood and its distribution&#44; other features of interest were&#58; demographic variables&#44; World Federation of Neurosurgical Societies &#40;WFNS&#41; score at admission&#44; modified Fisher grade &#40;mF&#41;&#44; location of the aneurysm according to the DSA&#44; presence of clinically relevant hydrocephalus &#40;requiring an external ventricular drain&#44; EVD&#41;&#44; development of chronic hydrocephalus &#40;requiring a ventriculo-peritoneal shunt&#44; VP shunt&#41;&#44; presence of angiographic vasospasm and delayed cerebral ischemia &#40;DCI&#41;&#44; and modified Rankin Scale &#40;mRS&#41; at three months&#46; DCI was defined as a neurological worsening &#40;increase in &#8805; 2 points on NIHSS scale or decrease in &#8805; 2 points on Glasgow Coma Scale&#41;&#44; happening 48&#160;h after the initial haemorrhage&#44; lasting for at least one hour&#44; and without other attributable causes&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Statistical analysis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Statistical analysis of the data was performed with SPSS statistics version 27 &#40;IBM&#41;&#46; Graphics were constructed with Excel calculation software &#40;Microsoft Office&#41; version 2019&#46; Data were summarised by means&#160;&#177;&#160;standard deviation or proportions&#46; Continuous variables were analysed with Student <span class="elsevierStyleItalic">t</span>-test or ANOVA&#46; A p-value of &#60; 0&#46;05 was considered an indicator of statistical significance&#46; Internal validation of the predictive patterns was represented in a receiver operating characteristic &#40;ROC&#41; curve &#40;SPSS statistics&#41;&#46; The Youden Index was used to determine the optimal cut-off value of each diagnostic test&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">Between 2012 and 2018&#44; 322 patients suffering from spontaneous SAH were admitted to our institution within 72&#160;h from symptom onset&#46; CTA and DSA were performed to identify the bleeding source&#46; Of all&#44; 24 patients were excluded because of harbouring multiple aneurysms&#44; in 40 no aneurysms were found&#44; 75 had a concomitant intraparenchymal hematoma and 2 patients died before CTA or DSA was performed&#46; Additionally&#44; 113 subjects had to be excluded as they were referred from peripheral centres and their NCCT could not be run in our software&#46; In the end&#44; 68 patients were included for the analysis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Data on patient and aneurysm characteristics are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Aneurysm location and bleeding distribution</span><p id="par0060" class="elsevierStylePara elsevierViewall">The location of the aneurysms in the sample was representative of both anterior and posterior circulation and&#44; particularly&#44; included&#58; 23 &#40;35&#37;&#41; anterior communicating artery &#40;ACom&#41;&#44; 1 &#40;1&#37;&#41; anterior cerebral artery &#40;ACA&#41;&#44; 7 &#40;10&#37;&#41; middle cerebral artery &#40;MCA&#41;&#44; 7 &#40;10&#37;&#41; internal carotid artery &#40;ICA&#41;&#44; 16 &#40;24&#37;&#41; posterior communicating artery &#40;PCom&#41;&#44; 2 &#40;3&#37;&#41; posterior cerebral artery &#40;PCA&#41;&#44; 5 &#40;7&#37;&#41; posteroinferior cerebellar artery &#40;PICA&#41;&#44; 2 &#40;2&#37;&#41; anteroinferior cerebellar artery &#40;AICA&#41;&#44; 1 &#40;1&#37;&#41; superior cerebellar artery &#40;SCA&#41;&#44; and 4 &#40;6&#37;&#41; basilar artery &#40;BA&#41; aneurysms&#46; Mean volumetric values of the total blood and regional bleeding distribution according to the location of the ruptured aneurysm are displayed in Supplementary Table S1&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Association between bleeding pattern and aneurysm site</span><p id="par0065" class="elsevierStylePara elsevierViewall">To uniformly define the bleeding pattern&#44; in every case the volume of blood present in each of the five pre-specified regions of distribution was compensated by the global amount of blood &#40;ratio regional blood&#47;total blood&#41;&#46; Overall&#44; univariate analysis showed a strong association between the distribution of blood and the aneurysm location &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; Meanwhile&#44; the total amount of blood was not associated with aneurysm location &#40;p&#160;&#61;&#160;0&#46;918&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Certain bleeding patterns were associated with specific sites of aneurysm rupture &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; ACom rupture was predominantly distributed within the interhemispheric fissure &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; while MCA bleed preferentially towards the ipsilateral hemisphere &#40;i&#46;e&#46;&#44; Silvian fissure and sulcus of the lateral convexity&#41; &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; and ICA affected both the ipsilateral hemisphere and the perimesencephalic cisterns &#40;p&#160;&#60;&#160;0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; The PCom bleeding distribution affected the ipsilateral hemisphere&#44; perimesencephalic and intraventricular spaces &#40;p&#160;&#61;&#160;0&#46;019&#41;&#59; and that of the PICA was predominantly perimesencephalic and intraventricular &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; Nonetheless&#44; a significant correlation between the bleeding vessel and the distribution could not be demonstrated for other posterior circulation aneurysms&#44; like the AICA and the BA &#40;p&#160;&#62;&#160;0&#46;05&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarizes the associations between each specific pattern of blood distribution and the location of the aneurysm found in our sample&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">The internal value of the predictive model was analysed with ROC curves and cut-off values are provided in ratios &#40;regional blood&#47;total blood&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; According to the Youden Index&#44; the best cut-off point for an interhemispheric pattern to predict an ACom aneurysm was 0&#46;134 &#40;AUROC 0&#46;891&#44; CI 0&#46;803&#8722;0&#46;979&#44; sensitivity 87&#37; and specificity 82&#37;&#41;&#46; For an ipsilateral hemispheric pattern to predict an MCA aneurysm was 0&#46;482 &#40;AUROC 0&#46;981&#44; CI 0&#46;951&#8211;1&#46;000&#44; sensitivity 100&#37; and specificity 92&#37;&#41;&#46; A cut-off of 0&#46;656 was obtained for the combined ipsilateral hemispheric and perimesencephalic pattern to predict an ICA aneurysm &#40;AUROC 0&#46;836&#44; CI 0&#46;819&#8722;0&#46;989&#44; sensitivity 86&#37; and specificity 84&#37;&#41;&#46; In posterior circulation&#44; the cut-off point for a PCom aneurysm was 0&#46;743 with a combined ipsilateral hemispheric&#44; perimesencephalic and intraventricular pattern &#40;AUROC 0&#46;616&#44; CI 0&#46;482&#8722;0&#46;750&#44; sensitivity 60&#37; and specificity 60&#37;&#41;&#59; and that for a PICA aneurysm was 0&#46;740 with a perimesencephalic and intraventricular pattern &#40;AUROC 0&#46;929&#44; CI 0&#46;863&#8722;0&#46;995&#44; sensitivity 100&#37; and specificity 87&#37;&#41;&#46;</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Bleeding pattern and clinical outcomes</span><p id="par0080" class="elsevierStylePara elsevierViewall">The association between blood quantity and distribution in the subarachnoid space and clinical outcomes was a secondary objective in this study&#46; The total volume of blood was associated with worse clinical status at admission &#40;WFNS 4&#8722;5&#44; p&#160;&#61;&#160;0&#46;030&#41; and also with worse performance status at three months &#40;mRS&#160;&#62;&#160;2&#44; p&#160;&#60;&#160;0&#46;001&#41;&#46; A non-significant trend was found in acute hydrocephalus &#40;p&#160;&#61;&#160;0&#46;059&#41; and delayed cerebral ischemia &#40;p&#160;&#61;&#160;0&#46;085&#41;&#46; No association was found between the bleeding pattern and the development of chronic hydrocephalus &#40;VP shunt&#41; or the occurrence of asymptomatic angiographic vasospasm &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Regarding the bleeding distribution&#44; intraventricular haemorrhage was indeed associated with the development of acute hydrocephalus &#40;p&#160;&#61;&#160;0&#46;012&#41;&#46; Neither the intraventricular nor the perimesencephalic bleeding volumes seemed to correlate with DCI &#40;p&#160;&#61;&#160;0&#46;191 and p&#160;&#61;&#160;0&#46;129&#44; respectively&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">In the present study&#44; a semi-automatic computerized volumetric software was used to quantify and determine in detail the bleeding pattern after aneurysmal subarachnoid haemorrhage&#46; This tool could accurately predict the location of the ruptured aneurysm&#44; with high sensitivity and specificity values&#46; A potential application in the emergency setting may be pursued&#44; provided that speed and simplicity are attained with full automatization of the process&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">About 20&#37; of patients with spontaneous SAH have multiple aneurysms in the admission vascular imaging studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Moreover&#44; in an additional 10&#37;&#8211;30&#37; of patients no aneurysms are initially detected&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a> In these cases&#44; identification of the actual point of bleeding is essential to guide treatment and prevent complications&#46; In fact&#44; predicting the aneurysm location is a recurrent topic in the literature&#44; given its implications&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#8211;5</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Conventionally&#44; experts have relied on the pattern of blood distribution within the subarachnoid spaces to determine the probable source of bleeding&#46; With the irruption of the digital era&#44; fallible visual-based methods of prediction<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6&#8211;8&#44;12</span></a> were challenged by machine-based tools&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#8211;15</span></a> Yet&#44; to date&#44; these novel predictive models are based in parameters other than the widely accepted bleeding pattern&#44; like patient characteristics&#44; aneurysm morphology and haemodynamic factors&#46; The latter two require a CTA or a DSA reconstruction and the careful assessment by experienced neuroradiologists&#44; which limit their applicability in the busy emergency setting and in non-stroke referral centres&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The method that we propose is an upgrade of the well-established procedure of prediction by which the location of the ruptured aneurysm can be predicted by looking at the distribution of blood within the different subarachnoid cisterns&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;16</span></a> In fact&#44; our results could be regarded as a contemporary confirmation of the effectiveness of tradition regarding SAH patterns of bleeding and aneurysm site determination&#46; With this favourable background&#44; our automatised tool provides a reliable and rigorous method for volumetric quantification of the regional distribution of blood&#44; with specific cut-off values to predict the aneurysm-site&#44; all of which are obtained in a timely and convenient manner&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Of note&#44; the predictive value of our model was internally robust for most of anterior and posterior circulation lesions&#46; As shown in <a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#44; the AUROC for ACom&#44; MCA&#44; ICA and PICA were roughly 0&#46;900 or above&#44; therefore conferring a high sensitivity and specificity for this pattern-based diagnostic tool&#46; For PCom aneurysms&#44; the predictive value was moderate &#40;AUROC 0&#46;616&#41;&#44; but still acceptable&#46; As we objectively demonstrated&#44; ACom rupture is predominantly distributed within the interhemispheric fissure&#44; while MCA bleeds preferentially towards the ipsilateral hemisphere&#44; and ICA affects both the hemisphere and the perimesencephalic cisterns&#46; PICA aneurysms showed the higher relative volumes of intraventricular haemorrhage&#44; as previously described&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> and the combined presence of intraventricular and perimesencephalic bleeding was predictive of a PICA location of the aneurysm&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">It seems that the main limitation to the automatized method is actually shared with the conventional visual assessment&#44; and that is the determination of posterior circulation aneurysm location&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> We were not able to predict BA&#44; SCA or AICA locations&#44; however the limited number of these cases in our sample might have precluded the detection of such association&#46; Other possible explanations are the lower resolution of CT scan to evaluate the posterior fossa&#44; and also&#44; the difficulty in delineating regions of bleeding distribution within the basal cisterns&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">A potential bias in the validation of a rupture prediction model is the selection of the diagnostic technique used as a reference for determining the location of the ruptured aneurysm&#46; In our study&#44; we used CTA or DSA for defining the ruptured aneurysm&#46; However&#44; to date&#44; only visual inspection of the aneurysm sac and surrounding parenchyma&#44; by means of intraoperative observation sac or postmortem studies&#44; allow a true confirmation of the rupture status&#46; To avoid this plausible bias&#44; we decided to exclude patients with multiple aneurysms&#46; While this simplified in testing the accuracy of the prediction capacity&#44; it also hampered its validation in these cases of difficult diagnosis&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">As a secondary objective in this study&#44; the volume and distribution of blood was tested as a predictor of clinical outcomes&#46; The otherwise common agreement that the amount of blood is a major determinant of neurological presentation and evolution<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#8211;23</span></a> was confirmed in our set&#44; where both poor WFNS at admission and unfavourable mRS at three months were associated with the total blood volume quantification&#46; In this line&#44; automatised measurements&#44; rather than classic visual scales<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a> decrease the interobserver variability and provide a quantitative metric for comparison&#46; Our results increase the validation yield established by Boers et al&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> from MCA aneurysms to a diversity of aneurysm locations&#46; While Boers et al&#46; centred their study on MCA aneurysms&#44; we included a variety of locations&#59; still&#44; it is worth remarking that we excluded patients with concomitant intraparenchymal hematomas and therefore an underrepresentation of MCA aneurysms can be expected in our sample&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">An exhaustive analysis of the bleeding distribution and the development of vasospasm and DCI is out of the scope of this study&#46; Despite&#44; in our sample&#44; a non-significant trend was found between higher volumes of blood and the incidence of DCI&#59; this was not the case for angiographic vasospasm&#46; None of the specific regions of blood spread seemed to elicit DCI&#46; Interestingly&#44; Friedman et al&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> also used a software-based tool to precisely quantify the bleeding in Fisher grade 3 SAH and found DCI to be associated with larger cisternal and total haemorrhage volumes&#44; yet no regional volume alone was predictive of DCI in their study&#46; Similar results were obtained by van der Steen et al&#46; in 2018&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">Potential applications of the volumetric examination tool that we present are objectively and accurately determining the source of bleeding in cases of multiple aneurysms&#44; and estimating the most probable location of an aneurysm in cases of non-perimesencephalic &#40;classic&#41; pattern of SAH with negative CTA and DSA&#46; These two particular subtypes of SAH patients &#8211; multiple aneurysms and no aneurysms &#8211; were excluded in our study so as to test this novel tool in cases with a definitive diagnosis of aneurysm location&#46; Provided that the proposed tool is well-powered and reliable&#44; an extrapolation to these more complex situations should be sought&#46; In the end&#44; performing this volumetric test systematically could increase the pre-test probability when undergoing a repeated diagnostic DSA&#46; Moreover&#44; in the bustling emergency setting&#44; the use of this rapid and simple method could accelerate the decision making and serve as a reassurance in case of peripheral centres lacking an expert neuroradiologist&#46; The use of heat maps to represent the differences in density &#40;regional amount of blood&#41; could make the software more user-friendly and facilitate the visual estimation of aneurysm location&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Weaknesses of the study include the limited sample size and the heterogeneous numeric representation of the aneurysm sites&#44; though this reflects the epidemiology of the disease&#46; Moreover&#44; the apparent loss of 113 candidates must be addressed&#58; these were patients referred to our tertiary institution&#44; in which the initial CT was done in peripheral centres and could not be run in our software&#46; Prospective studies in larger cohorts could increase the predictive yield in certain vessel locations&#44; especially in posterior circulation aneurysms&#46; As previously stated&#44; confirmation of the rupture status is only possible with direct inspection&#59; therefore&#44; a prospective series of surgical cases exclusively would confirm the validity of the method&#46; Still&#44; this would require either a multicentric cooperation or a lengthy study period&#46; On the other hand&#44; the generalization of these results and the applicability of the method rely on the availability of the volumetric software among the different institutions&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conclusion</span><p id="par0145" class="elsevierStylePara elsevierViewall">Computer-based semi-automatic volumetric analysis seems a reliable and objective tool to quantify and describe the distribution of blood within the subarachnoid and intraventricular spaces after spontaneous subarachnoid haemorrhage&#46; We provide a pattern-based diagnostic tool to accurately predict the aneurysm location after spontaneous SAH&#46; For anterior communicating&#44; middle cerebral&#44; internal carotid and posteroinferior cerebellar artery aneurysms&#44; this model is well-powered &#40;AUROC&#160;&#8805;&#160;0&#46;900&#41;&#59; however&#44; its value in posterior communication artery and other posterior circulation aneurysms deserves further optimization&#46; Prospective studies are encouraged to determine the external validation of the proposed tool&#44; particularly in the cases of difficult diagnosis&#44; like the in the presence of multiple aneurysms or in those cases with negative DSA&#46; Also of interest would be to estimate the impact of the software in the emergency department workflow&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Statements and declarations</span><p id="par0150" class="elsevierStylePara elsevierViewall">Nothing to disclose&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Funding</span><p id="par0155" class="elsevierStylePara elsevierViewall">We thank the Spanish <span class="elsevierStyleGrantSponsor" id="gs0005">Ministry of Economy and Competitiveness</span> for the grant given to SA and RT &#40;project PI19&#47;00936 funded by <span class="elsevierStyleGrantSponsor" id="gs0010">Instituto de Salud Carlos III</span> and co-funded by the <span class="elsevierStyleGrantSponsor" id="gs0015">European Regional Development Fund</span> &#91;ERDF&#93;&#41;&#46;</p></span></span>"
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              "titulo" => "Other features of interest"
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              "identificador" => "sec0045"
              "titulo" => "Aneurysm location and bleeding distribution"
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              "titulo" => "Association between bleeding pattern and aneurysm site"
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              "titulo" => "Bleeding pattern and clinical outcomes"
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    "fechaRecibido" => "2023-06-08"
    "fechaAceptado" => "2023-11-24"
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            0 => "Subarachnoid haemorrhage"
            1 => "Bleeding pattern"
            2 => "Aneurysm"
            3 => "Volumetric"
            4 => "Quantification"
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        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec1815914"
          "palabras" => array:23 [
            0 => "ACA"
            1 => "ACom"
            2 => "BA"
            3 => "CI"
            4 => "CT"
            5 => "CTA"
            6 => "DSA"
            7 => "DCI"
            8 => "EVD"
            9 => "ICA"
            10 => "MCA"
            11 => "mFisher"
            12 => "mRS"
            13 => "NCCT"
            14 => "PCA"
            15 => "PCom"
            16 => "PICA"
            17 => "ROC"
            18 => "SAH"
            19 => "SCA"
            20 => "SD"
            21 => "VP shunt"
            22 => "WFNS"
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          "palabras" => array:5 [
            0 => "Hemorragia subaracnoidea"
            1 => "Patr&#243;n de sangrado"
            2 => "Aneurisma"
            3 => "Volumetr&#237;a"
            4 => "Cuantificaci&#243;n"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">In spontaneous subarachnoid haemorrhage &#40;SAH&#41; accurate determination of the bleeding source is paramount to guide treatment&#46; Traditionally&#44; the bleeding pattern has been used to predict the aneurysm location&#46; Here&#44; we have tested a software-based tool&#44; which quantifies the volume of intracranial blood and stratifies it according to the regional distribution&#44; to predict the location of the ruptured aneurysm&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">A consecutive series of SAH patients admitted to a single tertiary centre between 2012&#8211;2018&#44; within 72&#160;h of onset&#44; harbouring a single intracranial aneurysm&#46; A semi-automatized method of blood quantification&#44; based on the relative density increase&#44; was applied to initial non-contrast CTs&#46; Five regions were used to define the bleeding patterns and to correlate them with aneurysm location&#58; perimesencephalic&#44; interhemispheric&#44; right&#47;left hemisphere and intraventricular&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">68 patients were included for analysis&#46; There was a strong association between the distribution of blood and the aneurysm location &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; In particular&#58; ACom and interhemispheric fissure &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; MCA and ipsilateral hemisphere &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; ICA and ipsilateral hemisphere and perimesencephalic cisterns &#40;p&#160;&#60;&#160;0&#46;001&#41;&#44; PCom and hemispheric&#44; perimesencephalic and intraventricular &#40;p&#160;&#61;&#160;0&#46;019&#41;&#44; and PICA and perimesencephalic and intraventricular &#40;p&#160;&#60;&#160;0&#46;001&#41;&#46; The internal diagnostic value was high &#40;AUROC&#160;&#8805;&#160;0&#46;900&#41; for these locations&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Regional automatised volumetry seems a reliable and objective tool to quantify and describe the distribution of blood within the subarachnoid spaces&#46; This tool accurately predicts the location of the ruptured aneurysm&#59; its use may be prospectively considered in the emergency setting when speed and simplicity are attained&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Antecedentes</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">En la hemorragia subaracnoidea espont&#225;nea &#40;HAS&#41;&#44; la determinaci&#243;n fehaciente del punto de sangrado es fundamental para guiar el tratamiento&#46; De forma tradicional&#44; la determinaci&#243;n de la localizaci&#243;n del aneurisma se basa en el patr&#243;n de sangrado&#46; En el presente estudio&#44; evaluamos una herramienta computarizada&#44; capaz de cuantificar el volumen de sangre intracraneal y de estratificarlo seg&#250;n la distribuci&#243;n regional&#44; con el objetivo de predecir la localizaci&#243;n del aneurisma roto&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Una serie consecutiva de pacientes ingresados en nuestro centro terciario durante el periodo 2012&#8211;2018&#44; con hemorragia subaracnoidea de debut en &#60; 72&#160;h y con aneurisma &#250;nico&#46; Se aplic&#243; el m&#233;todo cuantitativo semiautomatizado a las tomograf&#237;as computarizadas basales de dichos pacientes&#46; La detecci&#243;n del sistema se basa en el aumento relativo de densidad atribuido a la presencia de sangre&#46; Se contemplaron cinco regiones para definir los patrones de sangrado y para su posterior correlaci&#243;n con la localizaci&#243;n del aneurisma&#58; perimesencef&#225;lico&#44; interhemisf&#233;rico&#44; hemisf&#233;rico derecho&#47;izquierdo e intraventricular&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">El an&#225;lisis incluy&#243; 68 pacientes&#46; Se detect&#243; una fuerte asociaci&#243;n entre el patr&#243;n de sangrado y la localizaci&#243;n del aneurisma &#40;p&#160;&#60;&#160;0&#44;001&#41;&#46; En concreto&#58; ACom con la distribuci&#243;n interhemisf&#233;rica &#40;p&#160;&#60;&#160;0&#44;001&#41;&#59; ACM con la hemisf&#233;rica ipsilateral &#40;p&#160;&#60;&#160;0&#44;001&#41;&#59; ACI con la hemisf&#233;rica ipsilateral y perimesencef&#225;lica &#40;p&#160;&#60;&#160;0&#44;001&#41;&#59; ACoP la hemisf&#233;rica ipsilateral&#44; perimesencef&#225;lica e intraventricular &#40;p&#160;&#61;&#160;0&#44;019&#41;&#59; ACPI con la perimesencef&#225;lica e intraventricular &#40;p&#160;&#60;&#160;0&#44;001&#41;&#46; El valor diagn&#243;stico interno del modelo fue elevado para estas localizaciones &#40;AUROC&#160;&#8805;&#160;0&#46;900&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">La volumetr&#237;a regional automatizada parece una herramienta fiable y objetiva para cuantificar y describir la distribuci&#243;n de sangre en los espacios subaracnoideos&#46; Este m&#233;todo es capaz de predecir de forma precisa la localizaci&#243;n del aneurisma roto&#59; su aplicaci&#243;n prospectiva es en la medicina de urgencias&#44; una vez asegurada la agilidad y simplicidad del funcionamiento&#46;</p></span>"
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            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Semi-automatized method of regional segmentation of blood distribution&#46; Five areas are distinguished&#58; 1&#44; Perimesencephalic&#59; 2&#44; Interhemispheric&#59; 3&#44; Right hemisphere&#59; 4&#44; Left hemisphere&#59; 5&#44; Intraventricular&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Diagram of the sampling process&#46; Flowchart of the study&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Blood distribution according to the site of the aneurysm&#46; Blood quantification is expressed as the ratio between the amounts of blood in a given region per the total amount of intracranial blood&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Schematic representation of the bleeding distribution according to the location of the ruptured aneurysm&#46; &#40;&#42;&#42;&#41; denote statistically significant associations found in our sample&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Sensitivity and specificity values&#44; plotted on a receiver operating characteristic curve&#44; of each bleeding pattern to predict a certain aneurysm location&#46; The AUROC&#44; CI&#44; Youden Index&#44; Sensivity and Specificity values are summarized in the accessory table beneath&#46;</p>"
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          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">ACom&#44; anterior communicating artery&#59; ACA&#44; anterior cerebral artery&#59; MCA&#44; middle cerebral artery&#59; ICA&#44; internal carotid artery&#59; PCA&#44; posterior cerebral artery&#59; PCom&#44; posterior communicating artery&#59; PICA&#44; posteroinferior cerebellar artery&#59; SCA&#44; superior cerebellar artery&#59; BA&#44; basilar artery&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SAH patients &#40;N&#160;&#61;&#160;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&#44; mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex female&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WFNS&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8722;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&#8722;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Modified Fisher&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aneurysm location&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MCA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MCA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCom right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCom left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PICA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PICA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AICA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AICA left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SCA right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3525745.png"
              ]
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Baseline characteristics of the sample of patients with spontaneous subarachnoid haemorrhage and a single ruptured aneurysm&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0035"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">ACom&#44; anterior communicating artery&#59; ACA&#44; anterior cerebral artery&#59; MCA&#44; middle cerebral artery&#59; ICA&#44; internal carotid artery&#59; PCA&#44; posterior cerebral artery&#59; PCom&#44; posterior communicating artery&#59; PICA&#44; posteroinferior cerebellar artery&#59; SCA&#44; superior cerebellar artery&#59; BA&#44; basilar artery&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Aneurysm location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bleeding pattern&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Interhemispheric&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Interhemispheric &#38; perimesencephalic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;437&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemisphere &#40;ipsilateral&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemisphere &#40;ipsilateral&#41; &#38; perimesencephalic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PCom&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemisphere &#40;ipsilateral&#41;&#44; perimesencephalic &#38; IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perimesencephalic &#38; IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>AICA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perimesencephalic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;400&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>BA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perimesencephalic&#44; interhemispheric &#38; IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;258&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Association between the location of the ruptured aneurysm and the pattern of blood distribution&#46; The specific combinations of regions of blood distribution were initially obtained after the observation of relative ratios of bleeding distribution according to aneurysm site&#46; After the multivariate analysis confirmed the association between bleeding distribution and aneurysm site&#44; a post-hoc analysis was performed to establish the individual correlations between site of rupture and bleeding pattern&#46;</p>"
        ]
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        "etiqueta" => "Table 3"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">VP&#44; ventriculo-peritoneal&#59; mRS&#44; modified Rankin scale&#46;</p>"
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            0 => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Amount of blood &#40;cm<span class="elsevierStyleSup">3</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WFNS admission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;030&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1&#8722;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;638 &#40;12&#44;249&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>4&#8722;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;763 &#40;17&#44;523&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Acute hydrocephalus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;059&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;974 &#40;14&#44;487&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;893 &#40;12&#44;463&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chronic hydrocephalus &#40;VP shunt&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;556&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;112 &#40;12&#44;847&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;112 &#40;15&#44;622&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rebleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;325&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">183&#44;680&#47;20&#44;220&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;914 &#40;14&#44;345&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Angiographic vasospasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;820&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;209 &#40;14&#44;564&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;074 &#40;16&#44;117&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Delayed cerebral ischemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;085&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;728 &#40;19&#44;326&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">13&#44;897 &#40;13&#44;854&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">mRS 3-months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">13&#44;967 &#40;6305&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">29&#44;154 &#40;18&#44;808&#41;&nbsp;\t\t\t\t\t\t\n
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                        "paginaFinal" => "2421"
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              "identificador" => "bib0010"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidence and outcome of multiple intracranial aneurysms in a defined population"
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                          "etal" => false
                          "autores" => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors and outcomes associated with early and delayed aneurysm treatment in subarachnoid hemorrhage patients in the United States"
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                        "fecha" => "2016"
                        "volumen" => "371"
                        "paginaInicial" => "62"
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                        "link" => array:1 [
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                      "doi" => "10.3171/jns.1985.63.3.0342"
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                      "titulo" => "Therapeutic decisi&#243;n and management of aneurysmal subarachnoid haemorrhage base don computed tomographic angiography"
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                          "etal" => true
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                            3 => "M&#46; Behbahani"
                            4 => "F&#46;T&#46; Charbel"
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                            3 => "J&#46; Narita"
                            4 => "S&#46; Inoh"
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                      "titulo" => "Spontaneous subarachnoid haemorrhage with negative initial angiography&#58; a review of 143 cases"
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                          "etal" => false
                          "autores" => array:5 [
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                            2 => "J&#46;W&#46; Lee"
                            3 => "S&#46;K&#46; Huh"
                            4 => "K&#46;C&#46; Lee"
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                    0 => array:2 [
                      "doi" => "10.1016/j.jocn.2005.09.007"
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                        "tituloSerie" => "J Clin Neurosci"
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                        "paginaInicial" => "1011"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeat digital subtraction angiography after a negative baseline assessment in nonperimesencephalic subarachnoid hemorrhage&#58; a pooled data meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;A&#46; Bakker"
                            1 => "R&#46;J&#46; Groen"
                            2 => "M&#46; Foumani"
                            3 => "M&#46; Uyttenboogaart"
                            4 => "O&#46;S&#46; Eshghi"
                            5 => "J&#46;D&#46; Metzemaekers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/2013.9.JNS131337"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "2014"
                        "volumen" => "120"
                        "numero" => "1"
                        "paginaInicial" => "99"
                        "paginaFinal" => "103"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24160474"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validity of prediction of the site of ruptured intracranial aneurysms with CT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; van der Jagt"
                            1 => "D&#46; Hasan"
                            2 => "H&#46;W&#46; Bijvoet"
                            3 => "H&#46; Pieterman"
                            4 => "D&#46;W&#46; Dippel"
                            5 => "F&#46;H&#46; Vermeij"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1212/wnl.52.1.34"
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "1999"
                        "volumen" => "52"
                        "paginaInicial" => "34"
                        "paginaFinal" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel models for identification of the ruptured aneurysm in patients with subarachnoid hemorrhage with multiple aneurysms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46; Rajabzadeh-Oghaz"
                            1 => "J&#46; Wang"
                            2 => "N&#46; Varble"
                            3 => "S&#46;I&#46; Sugiyama"
                            4 => "A&#46; Shimizu"
                            5 => "L&#46; Jing"
                          ]
                        ]
                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.3174/ajnr.A6259"
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                        "tituloSerie" => "AJNR Am J Neuroradiol"
                        "fecha" => "2019"
                        "volumen" => "40"
                        "numero" => "11"
                        "paginaInicial" => "1939"
                        "paginaFinal" => "1946"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31649161"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0070"
              "etiqueta" => "14"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rupture resemblance score &#40;RRS&#41;&#58; toward risk stratification of unruptured intracranial aneurysms using hemodynamic-morphological discriminants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Xiang"
                            1 => "J&#46; Yu"
                            2 => "H&#46; Choi"
                            3 => "J&#46;M&#46; Dolan Fox"
                            4 => "K&#46;V&#46; Snyder"
                            5 => "E&#46;I&#46; Lev"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/neurintsurg-2014-011218"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurointerv Surg"
                        "fecha" => "2015"
                        "volumen" => "7"
                        "paginaInicial" => "490"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24811740"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple aneurysms in subarachnoid hemorrhage &#8211; identification of the ruptured aneurysm&#44; when the bleeding pattern is not self-explanatory &#8211; development of a novel prediction score"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Hadjiathanasiou"
                            1 => "P&#46; Schuss"
                            2 => "S&#46; Brandecker"
                            3 => "T&#46; Welchowski"
                            4 => "M&#46; Schmid"
                            5 => "H&#46; Vatter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12883-020-01655-x"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Neurol"
                        "fecha" => "2020"
                        "volumen" => "20"
                        "numero" => "1"
                        "paginaInicial" => "70"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "False localization of rupture by computed tomography in bilateral internal carotid artery aneurysms"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;C&#46; Lee"
                            1 => "J&#46;Y&#46; Joo"
                            2 => "K&#46;S&#46; Lee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0090-3019(95)00409-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Neurol"
                        "fecha" => "1996"
                        "volumen" => "45"
                        "paginaInicial" => "435"
                        "paginaFinal" => "441"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8629243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patterns of hemorrhage with ruptured posterior inferior cerebellar artery aneurysms&#58; CT findings in 44 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;F&#46; Kallmes"
                            1 => "G&#46; Lanzino"
                            2 => "J&#46;E&#46; Dix"
                            3 => "J&#46;E&#46; Dion"
                            4 => "H&#46; Do"
                            5 => "R&#46;J&#46; Woodcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.169.4.9308484"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "1997"
                        "volumen" => "169"
                        "paginaInicial" => "1169"
                        "paginaFinal" => "1171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9308484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of the quantity and distribution of subarachnoid haemorrhage on CT in the localization of a ruptured cerebral aneurysm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46;I&#46; Karttunen"
                            1 => "P&#46;H&#46; Jartti"
                            2 => "V&#46;A&#46; Ukkola"
                            3 => "J&#46; Sajanti"
                            4 => "M&#46; Haapea"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00701-003-0080-8"
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "2003"
                        "volumen" => "145"
                        "numero" => "8"
                        "paginaInicial" => "655"
                        "paginaFinal" => "661"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14520544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subarachnoid hemorrhage grading scales&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Rosen"
                            1 => "R&#46;L&#46; Macdonald"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1385/NCC:2:2:110"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurocrit Care"
                        "fecha" => "2005"
                        "volumen" => "2"
                        "paginaInicial" => "110"
                        "paginaFinal" => "118"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16159052"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Computed tomography in aneurysmal subarachnoid haemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;A&#46; Bell"
                            1 => "B&#46;E&#46; Kendall"
                            2 => "L&#46; Symon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.43.6.522"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "1980"
                        "volumen" => "43"
                        "paginaInicial" => "522"
                        "paginaFinal" => "524"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Fisher"
                            1 => "J&#46; Kistler"
                            2 => "J&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1227/00006123-198001000-00001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1980"
                        "volumen" => "6"
                        "paginaInicial" => "1"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7354892"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Grading the amount of blood on computed tomograms after subarachnoid hemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Hijdra"
                            1 => "P&#46;J&#46; Brouwers"
                            2 => "M&#46; Vermeulen"
                            3 => "J&#46; van Gijn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/01.str.21.8.1156"
                      "Revista" => array:6 [
                        "tituloSerie" => "Stroke"
                        "fecha" => "1990"
                        "volumen" => "21"
                        "paginaInicial" => "1156"
                        "paginaFinal" => "1161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2389295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subarachnoid haemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46; van Gijn"
                            1 => "R&#46;S&#46; Kerr"
                            2 => "G&#46;J&#46; Rinkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(07)60153-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2007"
                        "volumen" => "369"
                        "paginaInicial" => "306"
                        "paginaFinal" => "318"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17258671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Automatic quantification of subarachnoid hemorrhage on noncontrast CT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Boers"
                            1 => "I&#46;A&#46; Zijlstra"
                            2 => "C&#46;S&#46; Gathier"
                            3 => "R&#46; van den Berg"
                            4 => "C&#46;H&#46; Slump"
                            5 => "H&#46;A&#46; Marquering"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3174/ajnr.A4042"
                      "Revista" => array:7 [
                        "tituloSerie" => "AJNR Am J Neuroradiol"
                        "fecha" => "2014"
                        "volumen" => "35"
                        "numero" => "12"
                        "paginaInicial" => "2279"
                        "paginaFinal" => "2286"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25104292"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Volumetric quantification of Fisher Grade 3 aneurysmal subarachnoid hemorrhage&#58; a novel method to predict symptomatic vasospasm on admission computerized tomography scans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46;J&#46; Goerss"
                            2 => "F&#46;B&#46; Meyer"
                            3 => "D&#46;G&#46; Piepgras"
                            4 => "M&#46;A&#46; Pichelmann"
                            5 => "J&#46;I&#46; McIver"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.3171/jns.2002.97.2.0401"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "2002"
                        "volumen" => "97"
                        "numero" => "2"
                        "paginaInicial" => "401"
                        "paginaFinal" => "407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12186469"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "26"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of quantified location-specific blood volumes with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "I&#46;A&#46; Zijlstra"
                            2 => "D&#46; Verbaan"
                            3 => "A&#46;M&#46;M&#46; Boers"
                            4 => "C&#46;S&#46; Gathier"
                            5 => "R&#46; van den Berg"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.3174/ajnr.A5626"
                      "Revista" => array:7 [
                        "tituloSerie" => "AJNR Am J Neuroradiol"
                        "fecha" => "2018"
                        "volumen" => "39"
                        "numero" => "6"
                        "paginaInicial" => "1059"
                        "paginaFinal" => "1064"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29650786"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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