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array:22 [ "pii" => "S1130147391709111" "issn" => "11301473" "doi" => "10.1016/S1130-1473(91)70911-1" "estado" => "S300" "fechaPublicacion" => "1991-01-01" "aid" => "70911" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1991" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1991;2:313-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1646 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 770 "PDF" => 864 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147391709123" "issn" => "11301473" "doi" => "10.1016/S1130-1473(91)70912-3" "estado" => "S300" "fechaPublicacion" => "1991-01-01" "aid" => "70912" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1991;2:323-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2036 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 875 "PDF" => 1150 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Astrocitomas de ventrículo lateral" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "323" "paginaFinal" => "328" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Isla, F. Alvarez, C. Morales, J. Muñoz, R. Frutos, M.G. Blázquez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Isla" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Alvarez" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Morales" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Muñoz" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Frutos" ] 5 => array:2 [ "nombre" => "M.G." "apellidos" => "Blázquez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147391709123?idApp=UINPBA00004B" "url" => "/11301473/0000000200000004/v1_201305151330/S1130147391709123/v1_201305151330/es/main.assets" ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Lesiones isquémicas en la fase aguda de los traumatismos craneoencefálicos graves (lesiones difusas)" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "313" "paginaFinal" => "322" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J. Sahuquillo, M.A. Poca, E. Rubio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Sahuquillo" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Poca" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Rubio" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía, Unidad de Vigilancia Intensiva Hospital de Traumatología. Barcelona" ] ] ] 1 => array:3 [ "autoresLista" => "A. Robles, M. Baguena, C. Triginer, M.C. Pelegri" "autores" => array:4 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Robles" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">+</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Baguena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">+</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Triginer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">+</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.C." "apellidos" => "Pelegri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Bioquímica. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">+</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Hospital Vall d’Hebron. Barcelona" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0015" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec160486" "palabras" => array:5 [ 0 => "Traumatismo craneoencefálico" 1 => "Lesión difusa" 2 => "Isquemia" 3 => "Diferencias arteriovenosas de oxígeno" 4 => "Metabolismo cerebral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec160487" "palabras" => array:5 [ 0 => "Head injury" 1 => "Diffuse brain injuy" 2 => "Ischemia" 3 => "Brain metabolismo Arteriovenous differences of oxygen" 4 => "Jugular bulbo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La incidencia de lesiones isquémicas no se ha reducido de forma significativa en los traumatismos cranoencefálicos graves (TCEG) a pesar de mejoras evidentes en la recogida, traslado y atenciones prehospitalarias. Estas lesiones secundarias, sobreañadidas a la lesión de impacto, contribuyen a aumentar la tasa de morbi/mortalidad que estos pacientes presentan. Durante un período consecutivo de 6 meses hemos seleccionado 15 pacientes afectos de un TCEG (Glasgow inferior o igual a 8) en los cuales el examen tomodensitométrico demostraba una lesión difusa de severidad variable. La edad media de los pacientes fue de 25.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11 años, con una mortalidad del 33% y unos malos resultados, valorados de acuerdo con la escala de resultados de Glasgow del 53%.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En todos los casos, se procedió a la colocación de un cateter retrógrado en el bulbo de la yugular derecha para la determinación de diferencias arteriovenosas de oxígeno (AVDO 2) y de lactatos (AVDL). A partir de estos parámetros efectuamos una estimación del flujo sanguíneo cerebral y determinamos la existencia o no de un metabolismo anaerobio incrementado dentro de las primeras 24 horas del traumatismo. Dentro de este intervalo de tiempo, 2 pacientes presentaban un índice lactato-oxígeno (LOI) superior o igual a 0.08, traduciendo la existencia de un metabolismo anaerobio considerablemente incrementado y por Jo tanto la existencia de una lesión isquémica precoz. En los 13 casos en que el LOI fue inferior a 0.08, las AVDO2 demostraron un flujo aumentado (hiperemia) en 2 pacientes (AVDO2 < 1.3<span class="elsevierStyleHsp" style=""></span>μmol/ml), normal en 8 (AVDO2 entre 1.3 – 3.0<span class="elsevierStyleHsp" style=""></span>μmol/ml) y un patrón de hipoperfusión compensada (AVDO2 > 3.0<span class="elsevierStyleHsp" style=""></span>μmol/ml) en 3.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se discuten los resultados, haciendo énfasis en el probable desarrollo intrahospitalario de estas lesiones secundarias y en la importancia que tiene la detección precoz de los patrones de hipoperfusión compensada por su potencial reversibilidad. Discutimos el valor que la monitorización precoz puede tener de las AVDO2 y AVDL en el manejo global de los pacientes con un TCEG y en especial en laslesiones difusas.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In spite of better transportation and prehospital care of severe head injury patients, recent neuropathological work has shown that the incidence of ischemic brain lesions has not been significantly reduced. This type of secondary lesions contributes considerably to the poor outcome of patients with traumatic brain injuries.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">During a consecutive period of six months we selected for the study 15 patients (mean age =25.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11 yrs) with severe head injury (score of 8 points or less in the Glasgow Coma Scale) showing difusse brain damage of variable importance in the admission CT scan. The mortality rate in this group of patients was 33% and 53% of them had a poor coutcome (Glasgow Outcome Scale).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">All patients had a catheter inserted in the right juguiar bulb to measure the arteriovenous differences of oxygen (AVDO2) and lactates (AVDL). Cerebral blood flow and metabolism were estimated from these data. AVDO2 and AVDL allowed to evidenciate the existence of an increased anaerobic metabolism within 24 hours of impact. Two patients had a lactate-oxygen index (LOI) above or equal to 0.08 within this period of time indicating the presence of an early ischemic brain insulto In the 13 patients showing a LOI inferior to 0.08 the AVDO2 revealed an increased cerebral blood flow (hyperemia) in 2 (AVDO2 < 1.3<span class="elsevierStyleHsp" style=""></span>μmol/ml), a normal cerebral blood flow in 8 (AVDO2 =1.3-3<span class="elsevierStyleHsp" style=""></span>μmol/ml) and a state of compensated hypoperfusion in 3 (AVDO > 3<span class="elsevierStyleHsp" style=""></span>μmol/ml).</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that many ischemic lesions develop after admission of the patient into the neurosurgical unit. The importance of an early diagnosis of the compensated hypoperfusion pattern is discussed, and the value of early monitoring of AVDO2 and AVDL in the management of severe head injury patients, especially in those suffering diffuse brain damage, emphasized.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:29 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed brain injury: Secondary insults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.R. Cooper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Central Nervous System Trauma Status Report" "paginaInicial" => "217" "paginaFinal" => "228" "serieFecha" => "1985" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypoxic insults in acute brain injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Cruz" 1 => "S.J. Allen" 2 => "M.E. Miner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit. Care Med" "fecha" => "1985" "volumen" => "13" "paginaInicial" => "284" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modulating cerebral oxygen delivery and extraction in acute traumatic coma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Cruz" 1 => "M.E. Miner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurotrauma 1. Treatment, Rehabilitation an Related lssues" "paginaInicial" => "55" "paginaFinal" => "72" "serieFecha" => "1986" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous monitoring of cerebral oxygenation in acute brain injury: injection of mannitol during hyperventilation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Cruz" 1 => "M.E. Miner" 2 => "S.J. Aller" 3 => "W.M. Alves" 4 => "T.A. Gennarelli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1990.73.5.0725" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1990" "volumen" => "73" "paginaInicial" => "725" "paginaFinal" => "730" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2120395" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimation of CBF by cerebral venous oxygen difference (letter)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Gilbert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1989" "volumen" => "71" "paginaInicial" => "790" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2809735" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcranial doppler ultrasound flollowing closed head injury: vasospasm or vasoparalysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.R. Gomez" 1 => "R.J. Backer" 2 => "R.D. Bucholz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surg. Neurol" "fecha" => "1991" "volumen" => "35" "paginaInicial" => "30" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1983879" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischaemic brain damage in fatal head injuries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.I. Graham" 1 => "J.H. Adams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1971" "volumen" => "1" "paginaInicial" => "265" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2868269" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischaemic brain damage in fatal head non-missile head injuries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.I. Graham" 1 => "J.H. Adams" 2 => "D. Doyle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurol. Sci." "fecha" => "1978" "volumen" => "39" "paginaInicial" => "213" "paginaFinal" => "234" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/739268" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology of brain damage in head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.I. Graham" 1 => "J.H. Adams" 2 => "T.A. Gennarelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Head lnjury" "paginaInicial" => "72" "paginaFinal" => "88" "edicion" => "2nd. Ed." "serieFecha" => "1987" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischaemic brain damage is still common in fatal non-missile head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "D.I. Graham" 1 => "D.I. Ford" 2 => "J.H. Adams" 3 => "D. Doyle" 4 => "G.M. Teasdale" 5 => "A.E. Lawrence" 6 => "D.R. McLellan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neurol Neurosurg and Psychiatry" "fecha" => "1989" "volumen" => "52" "paginaInicial" => "346" "paginaFinal" => "350" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain damage in non-missile head injury secondary to high intracranial pressure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.I. Graham" 1 => "A.E. Lawrence" 2 => "J.H. Adams" 3 => "D. Doyle" 4 => "D.R. McLellan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuropathol. Appl. Neurobiol." "fecha" => "1987" "volumen" => "13" "paginaInicial" => "209" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3614546" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of outcome after severe brain damage. A practical scale" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Jennett" 1 => "M. Bond" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1975" "volumen" => "1" "paginaInicial" => "480" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2893908" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome from severe head injury related to the type of intracranial lesion. A computerized tomography study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "R.D. Lobato" 1 => "F. Cordobés" 2 => "J.J. Rivas" 3 => "M. De la Fuente" 4 => "A. Montero" 5 => "A. Barcena" 6 => "C. Pérez" 7 => "A. Cabrera" 8 => "E. Lamas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1983.59.5.0762" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1983" "volumen" => "59" "paginaInicial" => "762" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6619928" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood volume responsivity to ICP changes in head injured patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Marmarou" 1 => "A. Wachi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure VII" "paginaInicial" => "688" "paginaFinal" => "690" "serieFecha" => "1989" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part I: pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier, and neurological function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.F. Marshall" 1 => "F. Durity" 2 => "R. Lounsbury" 3 => "D.I. Graham" 4 => "F. Welsh" 5 => "T.W. Langfitt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1975.43.3.0308" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1975" "volumen" => "43" "paginaInicial" => "308" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1151466" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 2: brain morphology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.F. Marshall" 1 => "D.I. Graham" 2 => "F. Durity" 3 => "R. Lounsbury" 4 => "F. Welsh" 5 => "T.W. Langfitt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1975.43.3.0318" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1975" "volumen" => "43" "paginaInicial" => "318" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1151467" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 3: brain energy metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.F. Marshall" 1 => "F. Welsh" 2 => "F. Durity" 3 => "R. Lounsbury" 4 => "D.I. Graham" 5 => "T.W. Langfitt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1975.43.3.0323" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1975" "volumen" => "43" "paginaInicial" => "323" "paginaFinal" => "328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1151468" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology of human head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.D. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Textbook of head injury" "paginaInicial" => "507" "paginaFinal" => "524" "serieFecha" => "1989" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safe placement of central venous cartheter into internal jugular vein" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.W. Mostert" 1 => "G.M. Kenny" 2 => "G.P. Murphy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1970" "volumen" => "103" "paginaInicial" => "431" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5094546" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow and metabolism in severely head-injury children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.P. Muizelaar" 1 => "J.D. Ward" 2 => "A. Marmarou" 3 => "P.G. Newlon" 4 => "A. Wachi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.71.1.0072" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1989" "volumen" => "71" "paginaInicial" => "72" "paginaFinal" => "76" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2738644" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Methoden der enzymatischen analyse" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Noll" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "3rd Ed." "fecha" => "1974" "editorial" => "Verlag Chemie" "editorialLocalizacion" => "Weinheim" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Poca M. A, Sahuquillo J, Robles A, Baquena M, Triginer C, Rubio E. Monitorización de la hemodinámica cerebral a partir de las diferencias arterio-yugulares de oxígeno en los traumatismos craneoencefálicos graves. Parte I. Indicaciones y métodos. En preparación, 1991." ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Rehncrona" 1 => "I. Rosen" 2 => "B.K. Siesiö" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Journal of Cerebal Blood Flow and Metabolism" "fecha" => "1991" "volumen" => "1" "paginaInicial" => "297" "paginaFinal" => "311" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The predictive value of cerebral anaerobic metabolism with cerebral infarction after head injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.S. Robertson" 1 => "R.G. Grossman" 2 => "J.C. Goodman" 3 => "R.K. Narayan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1987.67.3.0361" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1987" "volumen" => "67" "paginaInicial" => "361" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3612268" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral arteriovenous oxygen difference as an estimate of cerebral blood flow in comatose patiens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C.S. Robertson" 1 => "R.K. Narayan" 2 => "Z.L. Gokaslan" 3 => "R. Pahwa" 4 => "R.G. Gossman" 5 => "P. Caram" 6 => "E. Allen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.70.2.0222" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1989" "volumen" => "70" "paginaInicial" => "222" "paginaFinal" => "230" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2913221" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Sahuquillo J. Coma postraumático por lesiones encefálicas difusas. Tesis Doctoral. Barcelona: Universidad Autónoma de Barcelona, 1985." ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactividad vascular al CO2 en la fase aguda de los traumatismos craneoencefálicos severos. Estudio preliminar de 20 casos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J. Sahuquillo" 1 => "C. Castaño" 2 => "J. Vilalta" 3 => "M. Baguena" 4 => "R. Monforte" 5 => "E. Rubio" 6 => "A. Bermejo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neurocirugía" "fecha" => "1990" "volumen" => "1" "paginaInicial" => "261" "paginaFinal" => "268" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse axonal injury after severe head trauma. A clinico-pathological study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Sahuquillo" 1 => "J. Vilalta" 2 => "J. Lamarca" 3 => "E. Rubio" 4 => "M. Rodriguez-Pazos" 5 => "J.A. Salva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochirurgica (Wien)" "fecha" => "1989" "volumen" => "101" "paginaInicial" => "149" "paginaFinal" => "158" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Computed tomography of shearing injuries of the cerebral white matter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.A. Zimmerman" 1 => "L.T. Bilaniuk" 2 => "T. Genneralli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/127.2.393" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "1978" "volumen" => "127" "paginaInicial" => "393" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/644064" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000000200000004/v1_201305151330/S1130147391709111/v1_201305151330/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000200000004/v1_201305151330/S1130147391709111/v1_201305151330/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147391709111?idApp=UINPBA00004B" ]
año/Mes | Html | Total | |
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2023 Marzo | 1 | 2 | 3 |
2018 Marzo | 0 | 1 | 1 |
2018 Febrero | 8 | 2 | 10 |
2018 Enero | 13 | 10 | 23 |
2017 Diciembre | 9 | 12 | 21 |
2017 Noviembre | 27 | 37 | 64 |
2017 Octubre | 5 | 13 | 18 |
2017 Septiembre | 17 | 13 | 30 |
2017 Agosto | 20 | 10 | 30 |
2017 Julio | 13 | 7 | 20 |
2017 Junio | 15 | 10 | 25 |
2017 Mayo | 20 | 12 | 32 |
2017 Abril | 11 | 11 | 22 |
2017 Marzo | 8 | 5 | 13 |
2017 Febrero | 4 | 1 | 5 |
2017 Enero | 10 | 6 | 16 |
2016 Diciembre | 21 | 10 | 31 |
2016 Noviembre | 18 | 10 | 28 |
2016 Octubre | 25 | 18 | 43 |
2016 Septiembre | 41 | 23 | 64 |
2016 Agosto | 34 | 20 | 54 |
2016 Julio | 37 | 21 | 58 |
2015 Diciembre | 2 | 0 | 2 |
2015 Agosto | 6 | 0 | 6 |
2015 Julio | 2 | 0 | 2 |
2015 Junio | 14 | 12 | 26 |
2015 Mayo | 27 | 26 | 53 |
2015 Abril | 11 | 15 | 26 |
2015 Marzo | 15 | 16 | 31 |
2015 Febrero | 12 | 23 | 35 |
2015 Enero | 15 | 17 | 32 |
2014 Diciembre | 11 | 17 | 28 |
2014 Noviembre | 11 | 18 | 29 |
2014 Octubre | 16 | 26 | 42 |
2014 Septiembre | 15 | 22 | 37 |
2014 Agosto | 15 | 21 | 36 |
2014 Julio | 14 | 25 | 39 |
2014 Junio | 16 | 29 | 45 |
2014 Mayo | 20 | 23 | 43 |
2014 Abril | 11 | 15 | 26 |
2014 Marzo | 9 | 22 | 31 |
2014 Febrero | 17 | 18 | 35 |
2014 Enero | 10 | 12 | 22 |
2013 Diciembre | 14 | 11 | 25 |
2013 Noviembre | 11 | 12 | 23 |
2013 Octubre | 14 | 12 | 26 |
2013 Septiembre | 15 | 18 | 33 |
2013 Agosto | 16 | 28 | 44 |
2013 Julio | 16 | 45 | 61 |
2013 Junio | 9 | 27 | 36 |
2013 Mayo | 7 | 17 | 24 |
2013 Abril | 8 | 15 | 23 |
2013 Marzo | 9 | 22 | 31 |
2013 Febrero | 8 | 11 | 19 |
2013 Enero | 11 | 8 | 19 |
2012 Diciembre | 6 | 12 | 18 |
2012 Noviembre | 1 | 12 | 13 |
2012 Octubre | 0 | 3 | 3 |
2012 Septiembre | 0 | 2 | 2 |