Significación pronóstica de la determinación del anticuerpo monoclonal Ki 67 en tumores cerebrales
F.G. Salazar, C. Lacruz, R. Carrillo
Servicios de Neurocirugía y de Anatomía Patológica. Hospital «Gregario Marañón». Madrid
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Martínez, J. Vaquero" "autores" => array:2 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Martínez" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147391711767?idApp=UINPBA00004B" "url" => "/11301473/0000000200000002/v1_201305151324/S1130147391711767/v1_201305151324/en/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Significación pronóstica de la determinación del anticuerpo monoclonal Ki 67 en tumores cerebrales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "107" "paginaFinal" => "110" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "F.G. Salazar, C. Lacruz, R. Carrillo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "F.G." "apellidos" => "Salazar" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Lacruz" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Carrillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neurocirugía y de Anatomía Patológica. Hospital «Gregario Marañón». Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec160301" "palabras" => array:3 [ 0 => "Ki 67" 1 => "Actividad proliferativa" 2 => "Tumor cerebral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec160300" "palabras" => array:4 [ 0 => "Ki-67" 1 => "Proliferating cells" 2 => "Proliferating activity" 3 => "Brain tumors" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Uno de los principales fines de los estudios patológicos sobre un tumor extirpado es el de estimar el potencial proliferativo del tejido residual. Esto es muy importante para establecer un pronóstico del paciente y una eventual terapia postquirúrgica. La determinación del índice de Ki 67 ofrece un dato de máxima fiabilidad a la hora de cuantificar el potencial proliferativo de la neoplasia.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio consiste en correlacionar el seguimiento de 20 pacientes intervenidos por tumores cerebrales de diversas estirpes y el índice de Ki 67 obtenido al valorar citológicamente las muestras obtenidas.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La evolución que han seguido las neoformaciones objeto de nuestro estudio se han correlacionado con los diferentes índices de Ki 67 obtenidos. De esta forma aquellos tumores con Ki 67 más alto han demostrado más tendencia a recidivar.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The pathological examination of a brain tumor is important in order to determine the prognosis and the postoperative treatment. Ki-67 is a monoclonal antibody directed against a nuclear antigen present only in the proliferating cells. The Ki-67 positive cells percentage offers a good index of the proliferating capabilities of a tumor.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The specimens of 20 patients that were operated on from an intracranial tumor were analyzed and their Ki-67 index obtained in a cytologic smear. The follow-up correlated well with the Ki-67 index.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Salazar R. G.; Lacruz C.; Carrillo R.: Significación pronóstica de la determinación del anticuerpo monoclonal Ki 67 en tumores cerebrales. Neurocirugía, 1991; 2: 107–110.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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