array:23 [
  "pii" => "S1130147392708811"
  "issn" => "11301473"
  "doi" => "10.1016/S1130-1473(92)70881-1"
  "estado" => "S300"
  "fechaPublicacion" => "1992-01-01"
  "aid" => "70881"
  "copyright" => "Sociedad Española de Neurocirugía"
  "copyrightAnyo" => "1992"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Neurocirugia. 1992;3:206-11"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2000
    "formatos" => array:3 [
      "EPUB" => 14
      "HTML" => 838
      "PDF" => 1148
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1130147392708823"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(92)70882-3"
    "estado" => "S300"
    "fechaPublicacion" => "1992-01-01"
    "aid" => "70882"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1992;3:212-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1546
      "formatos" => array:3 [
        "EPUB" => 16
        "HTML" => 779
        "PDF" => 751
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Empiemas subdllrales intracraneales"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "212"
          "paginaFinal" => "216"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A. Isla, F. Alvarez, V. Pepín, M. García-Blázquez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A."
              "apellidos" => "Isla"
            ]
            1 => array:2 [
              "nombre" => "F."
              "apellidos" => "Alvarez"
            ]
            2 => array:2 [
              "nombre" => "V."
              "apellidos" => "Pepín"
            ]
            3 => array:2 [
              "nombre" => "M."
              "apellidos" => "García-Blázquez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392708823?idApp=UINPBA00004B"
    "url" => "/11301473/0000000300000003/v1_201305151419/S1130147392708823/v1_201305151419/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S113014739270880X"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(92)70880-X"
    "estado" => "S300"
    "fechaPublicacion" => "1992-01-01"
    "aid" => "70880"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1992;3:197-205"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2480
      "formatos" => array:3 [
        "EPUB" => 18
        "HTML" => 1034
        "PDF" => 1428
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Hemorragia subaracnoidea idiopática. Estudio clínico de una serie de 258 casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "197"
          "paginaFinal" => "205"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P.A. Gómez, J.J. Rivas, R.D. Lobato, A. Cabrera, R. Alday, S. Castro, J.M. Ortega, H. Sandoval, E. Lamas"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "P.A."
              "apellidos" => "Gómez"
            ]
            1 => array:2 [
              "nombre" => "J.J."
              "apellidos" => "Rivas"
            ]
            2 => array:2 [
              "nombre" => "R.D."
              "apellidos" => "Lobato"
            ]
            3 => array:2 [
              "nombre" => "A."
              "apellidos" => "Cabrera"
            ]
            4 => array:2 [
              "nombre" => "R."
              "apellidos" => "Alday"
            ]
            5 => array:2 [
              "nombre" => "S."
              "apellidos" => "Castro"
            ]
            6 => array:2 [
              "nombre" => "J.M."
              "apellidos" => "Ortega"
            ]
            7 => array:2 [
              "nombre" => "H."
              "apellidos" => "Sandoval"
            ]
            8 => array:2 [
              "nombre" => "E."
              "apellidos" => "Lamas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739270880X?idApp=UINPBA00004B"
    "url" => "/11301473/0000000300000003/v1_201305151419/S113014739270880X/v1_201305151419/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Tumores cerebrales experimentales inducidos por etil-nitrosourea en la rata Wistar"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "206"
        "paginaFinal" => "211"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "J. Vaquero, A. Arias, M. Zurita, S. Coca, S. Oya, C. Morales"
        "autores" => array:6 [
          0 => array:2 [
            "nombre" => "J."
            "apellidos" => "Vaquero"
          ]
          1 => array:2 [
            "nombre" => "A."
            "apellidos" => "Arias"
          ]
          2 => array:2 [
            "nombre" => "M."
            "apellidos" => "Zurita"
          ]
          3 => array:2 [
            "nombre" => "S."
            "apellidos" => "Coca"
          ]
          4 => array:2 [
            "nombre" => "S."
            "apellidos" => "Oya"
          ]
          5 => array:2 [
            "nombre" => "C."
            "apellidos" => "Morales"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro y Departamento de Biología Celular, Universidad Complutense, Madrid"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec162261"
          "palabras" => array:6 [
            0 => "Tumores cerebrales experimentales"
            1 => "ENU"
            2 => "Tumores neuroectodérrnicos primitivos"
            3 => "Sinaptofisina"
            4 => "Schwanomas"
            5 => "Oligodendrogliomas"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec162262"
          "palabras" => array:6 [
            0 => "Experimental brain tumors"
            1 => "ENU"
            2 => "Primitive neuroectoderrnal tumors"
            3 => "Synaptophysin"
            4 => "Schwannoma"
            5 => "Oligodendroglioma"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se muestra la experiencia obtenida en la inducci&#243;n de tumores experimentales del Sistema Nervioso en la rata Wistar&#44; tras la exposici&#243;n a etil-nitrosourea &#40;ENU&#41; durante el per&#237;odo fetal&#46; En las condiciones experimentales utilizadas &#40;inyecci&#243;n IP de 50<span class="elsevierStyleHsp" style=""></span>mg&#47;kg de ENU en el d&#237;a 17 de gestaci&#243;n&#41;&#44; se obtuvieron schwanomas&#44; generalmente del trig&#233;mino y&#47;o ganglio de Gasser&#44; con una latencia que oscil&#243; entre 4 y 7 meses&#44; y tumores intracerebrales con aspecto morfol&#243;gico de oligodendrogliomas&#44; tras una latencia que oscil&#243; entre 7 y 10 meses tras la exposici&#243;n al carcin&#243;geno&#46; El estudio inmunohistoqu&#237;mico de ambos tipos de tumores mostr&#243; una clara positividad a la sinaptofisina&#44; y en menor grado a la vimentina&#44; lo que sugiere que&#44; independientemente de su aspecto histol&#243;gico&#44; las neoplasias experimentales inducidas por ENU deben ser consideradas como tumores neuroectod&#233;rmicos primitivos&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The experience with experimental brain tumors&#44; induced in the Wistar rat after transplacental administration &#40;50<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#44; 17 day of gestafion&#41; of ethyl-nitrosourea &#40;ENU&#41; is presented&#46; Malignant schwannomas&#44; arising from the trigeminal nerves or Gasserian ganglia&#44; were found after a latency between 4&#8211;7 months&#46; Oligodendroglioma-like tumors appeared between 7&#8211;10 months after ENU administration&#46; Imunohistochemical study of the ENU-induced tumors showed that most of them expressed strong positivity to synaptophysin and&#44; to a lesser degree&#44; to vimentin&#44; suggesting their interpretation as primitive neuroectodermal tumors&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Vaquero&#44; J&#46;&#59; Arias&#44; A&#46;&#59; Zurita&#44; M&#46;&#59; Coca&#44; S&#46;&#59; Oya&#44; S&#46;&#59; Morales&#44; c&#46;&#58; Tumores cerebrales experimentales inducidos por etil-nitrosurea en la rata Wistar&#46; Neurocirug&#237;a 1992&#59; 3&#58; 206&#8211;211&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short and long-tenn effects of methyl-and ethylnitrosourea &#40;MNU &#38; ENU&#41; on the developing nervous system of the rat&#46; II&#46; Short-tenn&#58; concluding remarks on chernical neuro-oncog&#233;nesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Bosch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurol&#46; Scand&#46;"
                        "fecha" => "1977"
                        "volumen" => "55"
                        "paginaInicial" => "106"
                        "paginaFinal" => "122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/842282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental model of tumors associated with neurofibromatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Cardesa"
                            1 => "T&#46; Ribalta"
                            2 => "B&#46; Von Schilllng"
                            3 => "A&#46; Palacin"
                            4 => "U&#46; Mohr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "1737"
                        "paginaFinal" => "1749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2539245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The immunocytochemical localization of GFA protein in experimental murine CNS tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46;K&#46; Conley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1979"
                        "volumen" => "45"
                        "paginaInicial" => "9"
                        "paginaFinal" => "16"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Teratogenic and carcinogenic effects in the offspring after a single injection of ethylnitrosourea to pregnant rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Druckrey"
                            1 => "S&#46; Ivankovic"
                            2 => "R&#46; Preussmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1966"
                        "volumen" => "210"
                        "paginaInicial" => "1378"
                        "paginaFinal" => "1379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6007120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumors of the nervous system induced by ethylnitrosourea adrninistered either intracerebrally or subcutaneously to newbom rats&#46; Morphological and biochernical characteristics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Grossi-Paoletti"
                            1 => "P&#46; Paoletti"
                            2 => "S&#46; Pezzotta"
                            3 => "D&#46; Schiffer"
                            4 => "A&#46; Fabiani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1972.37.5.0580"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1972"
                        "volumen" => "37"
                        "paginaInicial" => "580"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5076376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental brain tumours induced in rats by nitrosourea derivatives&#46; Part 2&#46; Morphological aspects of nitrosoethylurea tumours obtained by transplacental induction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Grossi-Paoletti"
                            1 => "P&#46; Paoletti"
                            2 => "D&#46; Schiffer"
                            3 => "A&#46; Fabiani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Sci&#46;"
                        "fecha" => "1970"
                        "volumen" => "11"
                        "paginaInicial" => "573"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4321468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Central neurocytoma&#46; An electron rnicroscopic study of two cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Hassoun"
                            1 => "D&#46; Gambarelll"
                            2 => "F&#46; Grisoll"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1982"
                        "volumen" => "56"
                        "paginaInicial" => "151"
                        "paginaFinal" => "156"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinogenesis in the progeny after exposure of pregnant animals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ivankovic"
                            1 => "H&#46; Druckrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Food Cosmet&#46; Toxicol&#46;"
                        "fecha" => "1968"
                        "volumen" => "6"
                        "paginaInicial" => "584"
                        "paginaFinal" => "585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5732318"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transplacental induction of malignant tumors of the nervous system&#46; I&#46; ENU in BD IX rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ivankovic"
                            1 => "H&#46; Druckrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Z&#46; Krebsforch"
                        "fecha" => "1968"
                        "volumen" => "71"
                        "paginaInicial" => "320"
                        "paginaFinal" => "360"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46; J&#228;nisch"
                            1 => "D&#46; Schreiber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Experimental Tumors of the Central Nervous System"
                        "serieFecha" => "1977"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumours of the nervous system induced in rats by the neonatal adrninistration of N-ethyl-N-nitrosourea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;L&#46; Jones"
                            1 => "C&#46;E&#46; Searle"
                            2 => "W&#46;T&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.1711090206"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Path&#46;"
                        "fecha" => "1973"
                        "volumen" => "109"
                        "paginaInicial" => "123"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4720907"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chernical Carcinogenesis in the Nervous System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Klelhues"
                            1 => "P&#46;L&#46; Lantos"
                            2 => "P&#46;N&#46; Magee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int&#46; Rev&#46; Exp&#46; Pathol&#46;"
                        "fecha" => "1976"
                        "volumen" => "15"
                        "paginaInicial" => "153"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/176123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of N-nitrosourea-induced tumors of the nervous system&#59; their prospective value for studies of neurocarcinogenesis and brain tumor therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Koestner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol&#46; Pathol&#46;"
                        "fecha" => "1990"
                        "volumen" => "18"
                        "paginaInicial" => "186"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2195638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chernical induction of tumours in the nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;L&#46; Lantos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Brain Tumours&#46; Scientific basis&#44; clinical investigation and current therapy"
                        "paginaInicial" => "85"
                        "paginaFinal" => "108"
                        "serieFecha" => "1980"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrastructural findings in so-called ependymal rat tumors induced by transplacental administration of ethylnitrosourea &#40;ENU&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;I&#46; Mandybur"
                            1 => "M&#46;M&#46; Alvira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1982"
                        "volumen" => "57"
                        "paginaInicial" => "51"
                        "paginaFinal" => "58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glial fibrillary acidic protein &#40;GFAP&#41; in rat brain tumors transplacentally induced by ethylnitrosourea &#40;ENU&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Mauro"
                            1 => "M&#46;T&#46; Giordana"
                            2 => "A&#46; Mighell"
                            3 => "D&#46; Schiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Sci&#46;"
                        "fecha" => "1983"
                        "volumen" => "61"
                        "paginaInicial" => "349"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6361219"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochemical investigations in experimentally induced tumors of the nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;D&#46; Mennel"
                            1 => "T&#46; Dreyhaupt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp&#46; Pathol&#46;"
                        "fecha" => "1990"
                        "volumen" => "40"
                        "paginaInicial" => "45"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2126242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biological markers of glial and primitive tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;M&#46; Molenaar"
                            1 => "J&#46;Q&#46; Trojanowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "M&#46;Salcman"
                        "paginaInicial" => "185"
                        "paginaFinal" => "210"
                        "serieVolumen" => "4"
                        "serieTitulo" => "Neurobiology of Brain Tumors&#46; Concepts in Neurosurgery"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochernical characterization of rat central and peripheral nerve tumors induced by ethylnitrosourea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;R&#46; Raju"
                            1 => "M&#46;J&#46; Yaeger"
                            2 => "D&#46;L&#46; Okazaki"
                            3 => "K&#46; Lovell"
                            4 => "A&#46; Koestner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol&#46; Pathol&#46;"
                        "fecha" => "1990"
                        "volumen" => "18"
                        "paginaInicial" => "18"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1694597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of vimentin and glial fibriilary acidic protein in ethylnitrosourea-induced rat gliomas and glioma celllines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Reifenberger"
                            1 => "T&#46; Bilzer"
                            2 => "R&#46;J&#46; Seiti"
                            3 => "W&#46; Wechsler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1989"
                        "volumen" => "78"
                        "paginaInicial" => "270"
                        "paginaFinal" => "282"
                        "itemHostRev" => array:3 [
                          "pii" => "S1529943007009096"
                          "estado" => "S300"
                          "issn" => "15299430"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pattemsof tumor growth"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Schiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "M&#46;Salcman"
                        "paginaInicial" => "185"
                        "paginaFinal" => "210"
                        "serieVolumen" => "4"
                        "serieTitulo" => "Neurobiology of Brain Tumors&#46; Concepts in Neurosurgery"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral tumors induced by transplacental ENU&#58; Study of the different tumoral stages&#44; particularly of early proliferations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Schiffer"
                            1 => "M&#46;T&#46; Giordana"
                            2 => "S&#46; Pezzotta"
                            3 => "C&#46; Lechner"
                            4 => "P&#46; Paoletti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1978"
                        "volumen" => "41"
                        "paginaInicial" => "27"
                        "paginaFinal" => "31"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Vaquero&#44; J&#46;&#44; Coca&#44; S&#46;&#44; Del Pozo&#44; J&#46;M&#46;&#44; Martinez&#44; R&#46;&#44; Arias&#44; A&#46;&#58; Clinicopathological experience with intraventricular neurocytomas&#46; J&#46; Neurosurg Sci&#46; 1992&#59; In press&#46;"
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification and localization of synaptophysin&#44; integral membrane glycoprotein of Mr 38&#44;000 characteristic of presynaptic vesicles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Wiedenmann"
                            1 => "W&#46;W&#46; Franke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1985"
                        "volumen" => "41"
                        "paginaInicial" => "1017"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3924408"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Irnmunohistochemical studies on cellular character of microtumors induced by ethylnitrosourea in the rat brain utilizing anti-Leu 7 and antiglial fibrillaty acidic protein antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Yoshino"
                            1 => "M&#46; Motoi"
                            2 => "K&#46; Ogawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropath&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1985"
                        "volumen" => "66"
                        "paginaInicial" => "167"
                        "paginaFinal" => "169"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/11301473/0000000300000003/v1_201305151419/S1130147392708811/v1_201305151419/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000300000003/v1_201305151419/S1130147392708811/v1_201305151419/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392708811?idApp=UINPBA00004B"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Tumores cerebrales experimentales inducidos por etil-nitrosourea en la rata Wistar
J. Vaquero, A. Arias, M. Zurita, S. Coca, S. Oya, C. Morales
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro y Departamento de Biología Celular, Universidad Complutense, Madrid
Leído
1989
Veces
se ha leído el artículo
1149
Total PDF
840
Total HTML
Compartir estadísticas
 array:23 [
  "pii" => "S1130147392708811"
  "issn" => "11301473"
  "doi" => "10.1016/S1130-1473(92)70881-1"
  "estado" => "S300"
  "fechaPublicacion" => "1992-01-01"
  "aid" => "70881"
  "copyright" => "Sociedad Espa&#241;ola de Neurocirug&#237;a"
  "copyrightAnyo" => "1992"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Neurocirugia. 1992;3:206-11"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2000
    "formatos" => array:3 [
      "EPUB" => 14
      "HTML" => 838
      "PDF" => 1148
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1130147392708823"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(92)70882-3"
    "estado" => "S300"
    "fechaPublicacion" => "1992-01-01"
    "aid" => "70882"
    "copyright" => "Sociedad Espa&#241;ola de Neurocirug&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1992;3:212-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1546
      "formatos" => array:3 [
        "EPUB" => 16
        "HTML" => 779
        "PDF" => 751
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Empiemas subdllrales intracraneales"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "212"
          "paginaFinal" => "216"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Isla, F&#46; Alvarez, V&#46; Pep&#237;n, M&#46; Garc&#237;a-Bl&#225;zquez"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Isla"
            ]
            1 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Alvarez"
            ]
            2 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Pep&#237;n"
            ]
            3 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Garc&#237;a-Bl&#225;zquez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392708823?idApp=UINPBA00004B"
    "url" => "/11301473/0000000300000003/v1_201305151419/S1130147392708823/v1_201305151419/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S113014739270880X"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(92)70880-X"
    "estado" => "S300"
    "fechaPublicacion" => "1992-01-01"
    "aid" => "70880"
    "copyright" => "Sociedad Espa&#241;ola de Neurocirug&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 1992;3:197-205"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2480
      "formatos" => array:3 [
        "EPUB" => 18
        "HTML" => 1034
        "PDF" => 1428
      ]
    ]
    "es" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Hemorragia subaracnoidea idiop&#225;tica&#46; Estudio cl&#237;nico de una serie de 258 casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "197"
          "paginaFinal" => "205"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46;A&#46; G&#243;mez, J&#46;J&#46; Rivas, R&#46;D&#46; Lobato, A&#46; Cabrera, R&#46; Alday, S&#46; Castro, J&#46;M&#46; Ortega, H&#46; Sandoval, E&#46; Lamas"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "P&#46;A&#46;"
              "apellidos" => "G&#243;mez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;J&#46;"
              "apellidos" => "Rivas"
            ]
            2 => array:2 [
              "nombre" => "R&#46;D&#46;"
              "apellidos" => "Lobato"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Cabrera"
            ]
            4 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Alday"
            ]
            5 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Castro"
            ]
            6 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Ortega"
            ]
            7 => array:2 [
              "nombre" => "H&#46;"
              "apellidos" => "Sandoval"
            ]
            8 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Lamas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739270880X?idApp=UINPBA00004B"
    "url" => "/11301473/0000000300000003/v1_201305151419/S113014739270880X/v1_201305151419/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Tumores cerebrales experimentales inducidos por etil-nitrosourea en la rata Wistar"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "206"
        "paginaFinal" => "211"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "J&#46; Vaquero, A&#46; Arias, M&#46; Zurita, S&#46; Coca, S&#46; Oya, C&#46; Morales"
        "autores" => array:6 [
          0 => array:2 [
            "nombre" => "J&#46;"
            "apellidos" => "Vaquero"
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Arias"
          ]
          2 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Zurita"
          ]
          3 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Coca"
          ]
          4 => array:2 [
            "nombre" => "S&#46;"
            "apellidos" => "Oya"
          ]
          5 => array:2 [
            "nombre" => "C&#46;"
            "apellidos" => "Morales"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Laboratorio de Neuro-oncolog&#237;a experimental&#44; Servicio de Neurocirug&#237;a&#44; Cl&#237;nica Puerta de Hierro y Departamento de Biolog&#237;a Celular&#44; Universidad Complutense&#44; Madrid"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec162261"
          "palabras" => array:6 [
            0 => "Tumores cerebrales experimentales"
            1 => "ENU"
            2 => "Tumores neuroectod&#233;rrnicos primitivos"
            3 => "Sinaptofisina"
            4 => "Schwanomas"
            5 => "Oligodendrogliomas"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec162262"
          "palabras" => array:6 [
            0 => "Experimental brain tumors"
            1 => "ENU"
            2 => "Primitive neuroectoderrnal tumors"
            3 => "Synaptophysin"
            4 => "Schwannoma"
            5 => "Oligodendroglioma"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se muestra la experiencia obtenida en la inducci&#243;n de tumores experimentales del Sistema Nervioso en la rata Wistar&#44; tras la exposici&#243;n a etil-nitrosourea &#40;ENU&#41; durante el per&#237;odo fetal&#46; En las condiciones experimentales utilizadas &#40;inyecci&#243;n IP de 50<span class="elsevierStyleHsp" style=""></span>mg&#47;kg de ENU en el d&#237;a 17 de gestaci&#243;n&#41;&#44; se obtuvieron schwanomas&#44; generalmente del trig&#233;mino y&#47;o ganglio de Gasser&#44; con una latencia que oscil&#243; entre 4 y 7 meses&#44; y tumores intracerebrales con aspecto morfol&#243;gico de oligodendrogliomas&#44; tras una latencia que oscil&#243; entre 7 y 10 meses tras la exposici&#243;n al carcin&#243;geno&#46; El estudio inmunohistoqu&#237;mico de ambos tipos de tumores mostr&#243; una clara positividad a la sinaptofisina&#44; y en menor grado a la vimentina&#44; lo que sugiere que&#44; independientemente de su aspecto histol&#243;gico&#44; las neoplasias experimentales inducidas por ENU deben ser consideradas como tumores neuroectod&#233;rmicos primitivos&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The experience with experimental brain tumors&#44; induced in the Wistar rat after transplacental administration &#40;50<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#44; 17 day of gestafion&#41; of ethyl-nitrosourea &#40;ENU&#41; is presented&#46; Malignant schwannomas&#44; arising from the trigeminal nerves or Gasserian ganglia&#44; were found after a latency between 4&#8211;7 months&#46; Oligodendroglioma-like tumors appeared between 7&#8211;10 months after ENU administration&#46; Imunohistochemical study of the ENU-induced tumors showed that most of them expressed strong positivity to synaptophysin and&#44; to a lesser degree&#44; to vimentin&#44; suggesting their interpretation as primitive neuroectodermal tumors&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Vaquero&#44; J&#46;&#59; Arias&#44; A&#46;&#59; Zurita&#44; M&#46;&#59; Coca&#44; S&#46;&#59; Oya&#44; S&#46;&#59; Morales&#44; c&#46;&#58; Tumores cerebrales experimentales inducidos por etil-nitrosurea en la rata Wistar&#46; Neurocirug&#237;a 1992&#59; 3&#58; 206&#8211;211&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Short and long-tenn effects of methyl-and ethylnitrosourea &#40;MNU &#38; ENU&#41; on the developing nervous system of the rat&#46; II&#46; Short-tenn&#58; concluding remarks on chernical neuro-oncog&#233;nesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;A&#46; Bosch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neurol&#46; Scand&#46;"
                        "fecha" => "1977"
                        "volumen" => "55"
                        "paginaInicial" => "106"
                        "paginaFinal" => "122"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/842282"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental model of tumors associated with neurofibromatosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Cardesa"
                            1 => "T&#46; Ribalta"
                            2 => "B&#46; Von Schilllng"
                            3 => "A&#46; Palacin"
                            4 => "U&#46; Mohr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1989"
                        "volumen" => "63"
                        "paginaInicial" => "1737"
                        "paginaFinal" => "1749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2539245"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The immunocytochemical localization of GFA protein in experimental murine CNS tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46;K&#46; Conley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1979"
                        "volumen" => "45"
                        "paginaInicial" => "9"
                        "paginaFinal" => "16"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Teratogenic and carcinogenic effects in the offspring after a single injection of ethylnitrosourea to pregnant rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Druckrey"
                            1 => "S&#46; Ivankovic"
                            2 => "R&#46; Preussmann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1966"
                        "volumen" => "210"
                        "paginaInicial" => "1378"
                        "paginaFinal" => "1379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6007120"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumors of the nervous system induced by ethylnitrosourea adrninistered either intracerebrally or subcutaneously to newbom rats&#46; Morphological and biochernical characteristics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Grossi-Paoletti"
                            1 => "P&#46; Paoletti"
                            2 => "S&#46; Pezzotta"
                            3 => "D&#46; Schiffer"
                            4 => "A&#46; Fabiani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1972.37.5.0580"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1972"
                        "volumen" => "37"
                        "paginaInicial" => "580"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5076376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental brain tumours induced in rats by nitrosourea derivatives&#46; Part 2&#46; Morphological aspects of nitrosoethylurea tumours obtained by transplacental induction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Grossi-Paoletti"
                            1 => "P&#46; Paoletti"
                            2 => "D&#46; Schiffer"
                            3 => "A&#46; Fabiani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Sci&#46;"
                        "fecha" => "1970"
                        "volumen" => "11"
                        "paginaInicial" => "573"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4321468"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Central neurocytoma&#46; An electron rnicroscopic study of two cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Hassoun"
                            1 => "D&#46; Gambarelll"
                            2 => "F&#46; Grisoll"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1982"
                        "volumen" => "56"
                        "paginaInicial" => "151"
                        "paginaFinal" => "156"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinogenesis in the progeny after exposure of pregnant animals"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ivankovic"
                            1 => "H&#46; Druckrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Food Cosmet&#46; Toxicol&#46;"
                        "fecha" => "1968"
                        "volumen" => "6"
                        "paginaInicial" => "584"
                        "paginaFinal" => "585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5732318"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transplacental induction of malignant tumors of the nervous system&#46; I&#46; ENU in BD IX rats"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ivankovic"
                            1 => "H&#46; Druckrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Z&#46; Krebsforch"
                        "fecha" => "1968"
                        "volumen" => "71"
                        "paginaInicial" => "320"
                        "paginaFinal" => "360"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46; J&#228;nisch"
                            1 => "D&#46; Schreiber"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Experimental Tumors of the Central Nervous System"
                        "serieFecha" => "1977"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumours of the nervous system induced in rats by the neonatal adrninistration of N-ethyl-N-nitrosourea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46;L&#46; Jones"
                            1 => "C&#46;E&#46; Searle"
                            2 => "W&#46;T&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/path.1711090206"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Path&#46;"
                        "fecha" => "1973"
                        "volumen" => "109"
                        "paginaInicial" => "123"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4720907"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chernical Carcinogenesis in the Nervous System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Klelhues"
                            1 => "P&#46;L&#46; Lantos"
                            2 => "P&#46;N&#46; Magee"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int&#46; Rev&#46; Exp&#46; Pathol&#46;"
                        "fecha" => "1976"
                        "volumen" => "15"
                        "paginaInicial" => "153"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/176123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization of N-nitrosourea-induced tumors of the nervous system&#59; their prospective value for studies of neurocarcinogenesis and brain tumor therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Koestner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol&#46; Pathol&#46;"
                        "fecha" => "1990"
                        "volumen" => "18"
                        "paginaInicial" => "186"
                        "paginaFinal" => "192"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2195638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chernical induction of tumours in the nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;L&#46; Lantos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Brain Tumours&#46; Scientific basis&#44; clinical investigation and current therapy"
                        "paginaInicial" => "85"
                        "paginaFinal" => "108"
                        "serieFecha" => "1980"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ultrastructural findings in so-called ependymal rat tumors induced by transplacental administration of ethylnitrosourea &#40;ENU&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46;I&#46; Mandybur"
                            1 => "M&#46;M&#46; Alvira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1982"
                        "volumen" => "57"
                        "paginaInicial" => "51"
                        "paginaFinal" => "58"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Glial fibrillary acidic protein &#40;GFAP&#41; in rat brain tumors transplacentally induced by ethylnitrosourea &#40;ENU&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Mauro"
                            1 => "M&#46;T&#46; Giordana"
                            2 => "A&#46; Mighell"
                            3 => "D&#46; Schiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurol&#46; Sci&#46;"
                        "fecha" => "1983"
                        "volumen" => "61"
                        "paginaInicial" => "349"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6361219"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochemical investigations in experimentally induced tumors of the nervous system"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;D&#46; Mennel"
                            1 => "T&#46; Dreyhaupt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp&#46; Pathol&#46;"
                        "fecha" => "1990"
                        "volumen" => "40"
                        "paginaInicial" => "45"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2126242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biological markers of glial and primitive tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;M&#46; Molenaar"
                            1 => "J&#46;Q&#46; Trojanowski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "M&#46;Salcman"
                        "paginaInicial" => "185"
                        "paginaFinal" => "210"
                        "serieVolumen" => "4"
                        "serieTitulo" => "Neurobiology of Brain Tumors&#46; Concepts in Neurosurgery"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochernical characterization of rat central and peripheral nerve tumors induced by ethylnitrosourea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;R&#46; Raju"
                            1 => "M&#46;J&#46; Yaeger"
                            2 => "D&#46;L&#46; Okazaki"
                            3 => "K&#46; Lovell"
                            4 => "A&#46; Koestner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol&#46; Pathol&#46;"
                        "fecha" => "1990"
                        "volumen" => "18"
                        "paginaInicial" => "18"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1694597"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of vimentin and glial fibriilary acidic protein in ethylnitrosourea-induced rat gliomas and glioma celllines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46; Reifenberger"
                            1 => "T&#46; Bilzer"
                            2 => "R&#46;J&#46; Seiti"
                            3 => "W&#46; Wechsler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1989"
                        "volumen" => "78"
                        "paginaInicial" => "270"
                        "paginaFinal" => "282"
                        "itemHostRev" => array:3 [
                          "pii" => "S1529943007009096"
                          "estado" => "S300"
                          "issn" => "15299430"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pattemsof tumor growth"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46; Schiffer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:6 [
                        "editores" => "M&#46;Salcman"
                        "paginaInicial" => "185"
                        "paginaFinal" => "210"
                        "serieVolumen" => "4"
                        "serieTitulo" => "Neurobiology of Brain Tumors&#46; Concepts in Neurosurgery"
                        "serieFecha" => "1991"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral tumors induced by transplacental ENU&#58; Study of the different tumoral stages&#44; particularly of early proliferations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Schiffer"
                            1 => "M&#46;T&#46; Giordana"
                            2 => "S&#46; Pezzotta"
                            3 => "C&#46; Lechner"
                            4 => "P&#46; Paoletti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropathol&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1978"
                        "volumen" => "41"
                        "paginaInicial" => "27"
                        "paginaFinal" => "31"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Vaquero&#44; J&#46;&#44; Coca&#44; S&#46;&#44; Del Pozo&#44; J&#46;M&#46;&#44; Martinez&#44; R&#46;&#44; Arias&#44; A&#46;&#58; Clinicopathological experience with intraventricular neurocytomas&#46; J&#46; Neurosurg Sci&#46; 1992&#59; In press&#46;"
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification and localization of synaptophysin&#44; integral membrane glycoprotein of Mr 38&#44;000 characteristic of presynaptic vesicles"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46; Wiedenmann"
                            1 => "W&#46;W&#46; Franke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1985"
                        "volumen" => "41"
                        "paginaInicial" => "1017"
                        "paginaFinal" => "1028"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3924408"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Irnmunohistochemical studies on cellular character of microtumors induced by ethylnitrosourea in the rat brain utilizing anti-Leu 7 and antiglial fibrillaty acidic protein antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46; Yoshino"
                            1 => "M&#46; Motoi"
                            2 => "K&#46; Ogawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neuropath&#46; &#40;Berl&#46;&#41;"
                        "fecha" => "1985"
                        "volumen" => "66"
                        "paginaInicial" => "167"
                        "paginaFinal" => "169"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/11301473/0000000300000003/v1_201305151419/S1130147392708811/v1_201305151419/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000300000003/v1_201305151419/S1130147392708811/v1_201305151419/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392708811?idApp=UINPBA00004B"
]
Información del artículo
ISSN: 11301473
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2023 Marzo 2 1 3
2018 Febrero 8 10 18
2018 Enero 8 6 14
2017 Diciembre 10 15 25
2017 Noviembre 37 21 58
2017 Octubre 7 9 16
2017 Septiembre 13 24 37
2017 Agosto 10 16 26
2017 Julio 10 13 23
2017 Junio 19 21 40
2017 Mayo 13 28 41
2017 Abril 13 11 24
2017 Marzo 13 25 38
2017 Febrero 2 8 10
2017 Enero 9 12 21
2016 Diciembre 29 21 50
2016 Noviembre 22 21 43
2016 Octubre 27 18 45
2016 Septiembre 36 29 65
2016 Agosto 42 19 61
2016 Julio 40 29 69
2015 Diciembre 2 0 2
2015 Julio 0 4 4
2015 Junio 13 9 22
2015 Mayo 20 18 38
2015 Abril 17 14 31
2015 Marzo 19 26 45
2015 Febrero 18 28 46
2015 Enero 17 21 38
2014 Diciembre 10 29 39
2014 Noviembre 12 19 31
2014 Octubre 10 32 42
2014 Septiembre 13 27 40
2014 Agosto 20 29 49
2014 Julio 8 19 27
2014 Junio 16 23 39
2014 Mayo 18 21 39
2014 Abril 12 25 37
2014 Marzo 17 29 46
2014 Febrero 20 35 55
2014 Enero 14 13 27
2013 Diciembre 11 17 28
2013 Noviembre 14 26 40
2013 Octubre 17 22 39
2013 Septiembre 17 30 47
2013 Agosto 14 29 43
2013 Julio 20 37 57
2013 Junio 15 30 45
2013 Mayo 19 24 43
2013 Abril 16 29 45
2013 Marzo 14 38 52
2013 Febrero 12 22 34
2013 Enero 16 12 28
2012 Diciembre 9 25 34
2012 Noviembre 0 23 23
2012 Octubre 0 5 5
2012 Septiembre 0 2 2
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Neurocirugía
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?