A very large proportion of human brain tumours show DNA alterations at the EGF-R gene
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Nuestra experiencia en 50 pacientes" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "12" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. San Emeterio Samperio, J. Ailagas de las Heras, J.M. Coca Martín, J.I. Díaz de Tuesta" "autores" => array:4 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "San Emeterio Samperio" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Ailagas de las Heras" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Coca Martín" ] 3 => array:2 [ "nombre" => "J.I." "apellidos" => "Díaz de Tuesta" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392709014?idApp=UINPBA00004B" "url" => "/11301473/0000000300000001/v1_201305151416/S1130147392709014/v1_201305151416/es/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "A very large proportion of human brain tumours show DNA alterations at the EGF-R gene" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "13" "paginaFinal" => "19" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "A. Del Arco, J. García, M. Izquierdo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Del Arco" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "García" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Izquierdo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Bioquímica, Biología Molecular. Universidad Autónoma de Madrid" ] ] ] 1 => array:3 [ "autoresLista" => "J.M. Izquierdo, M.G. Blázquez" "autores" => array:2 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "Izquierdo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "M.G." "apellidos" => "Blázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neurocirugía. Hospital Valdecilla (Santander)" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicio de Neurocirugía. Hospital La Paz (Madrid)" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162135" "palabras" => array:4 [ 0 => "Brain tumors" 1 => "Epidermal Grow Factor" 2 => "EGF-R gene" 3 => "DNA alterations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162136" "palabras" => array:4 [ 0 => "Tumores cerebrales" 1 => "Factor de crecimiento epidérmico" 2 => "Gen receptor del EGF" 3 => "Alteraciones del DNA" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">DNA alterations occurs frequently in sorne types of neoplasia such as retinoblastoma, and lung, breast and colorectal carcinoma, We have found that loses of restriction fragments at the epidermal growth factor receptor gene (EGEF-R) are present in as much as 82% of human brain tumours. Amplifications of fragments are present at a much lower proportion reaching only 10% of the samples examined. Two fragments of 9<span class="elsevierStyleHsp" style=""></span>kb and 3.6<span class="elsevierStyleHsp" style=""></span>kb are preferentially lost during tumorigenesis and the latter only is not present in 79% of the cases in which normal and tumoral samples from the same individual were compared. In all but one sample examined in which alterations are present, the 3.6<span class="elsevierStyleHsp" style=""></span>kb fragment was heterozygotic in normal tissues and was not present in the tumour. Normal tissue surrounding the tumour was analyzed in a few examples and already showed a certain degree of alteration but normally not as much as the tumour itself. This will suggest that an accumulation ofseveral DNA aberrations might be responsible for determining the tumour biological propertieso Restriction fragment length polymorphism (RFLP), irrelevant to tumorigenesis, was found in about 22% of the cases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Alteraciones en las cadenas de DNA han sido detectadas en algunos tipos tumorales, como retinoblastomas y carcinomas de pulmón, mama y colon. Por nuestra parte, hemos observado que en el 82% de los tumores cerebrales examinados existen pérdidas de fragmentos de DNA en el gen del receptor del factor de crecimiento epidérmico, así como amplificación de otros fragmentos en el 10% de los tumores. Los fragmentos que más frecuentemente faltan son dos, uno de 9<span class="elsevierStyleHsp" style=""></span>kb (kilobase) y otro de 3,6. Este último no se encontró en el 79% de los casos en los que existía en el tejido normal del mismo paciente. En todos los casos excepto en uno, este fragmento era heterozigoto en el tejido normal y faltaba en el tumoral. El tejido aparentemente normal que rodea al tumor fue analizado en algunos casos, observándose en él algunas anomalías, aunque no tantas como en el propio tumor. Esto sugiere que probablemente sean necesarias varias alteraciones del DNA para que aparezcan las propiedades tumorales. Polimorfismo en la longitud de los fragmentos de restricción fue observado en el 22% de los casos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| 2017 Marzo | 15 | 24 | 39 |
| 2017 Febrero | 2 | 3 | 5 |
| 2017 Enero | 10 | 6 | 16 |
| 2016 Diciembre | 36 | 13 | 49 |
| 2016 Noviembre | 33 | 13 | 46 |
| 2016 Octubre | 50 | 12 | 62 |
| 2016 Septiembre | 24 | 3 | 27 |
| 2016 Agosto | 0 | 4 | 4 |
| 2016 Julio | 0 | 12 | 12 |
| 2015 Diciembre | 3 | 0 | 3 |
| 2015 Julio | 0 | 7 | 7 |
| 2015 Junio | 21 | 6 | 27 |
| 2015 Mayo | 21 | 14 | 35 |
| 2015 Abril | 25 | 15 | 40 |
| 2015 Marzo | 28 | 24 | 52 |
| 2015 Febrero | 20 | 12 | 32 |
| 2015 Enero | 19 | 11 | 30 |
| 2014 Diciembre | 18 | 14 | 32 |
| 2014 Noviembre | 20 | 9 | 29 |
| 2014 Octubre | 28 | 14 | 42 |
| 2014 Septiembre | 23 | 16 | 39 |
| 2014 Agosto | 21 | 13 | 34 |
| 2014 Julio | 17 | 14 | 31 |
| 2014 Junio | 28 | 23 | 51 |
| 2014 Mayo | 27 | 14 | 41 |
| 2014 Abril | 17 | 13 | 30 |
| 2014 Marzo | 11 | 13 | 24 |
| 2014 Febrero | 22 | 18 | 40 |
| 2014 Enero | 20 | 12 | 32 |
| 2013 Diciembre | 9 | 8 | 17 |
| 2013 Noviembre | 24 | 6 | 30 |
| 2013 Octubre | 34 | 10 | 44 |
| 2013 Septiembre | 23 | 9 | 32 |
| 2013 Agosto | 25 | 26 | 51 |
| 2013 Julio | 15 | 8 | 23 |
| 2013 Junio | 18 | 10 | 28 |
| 2013 Mayo | 13 | 17 | 30 |
| 2013 Abril | 15 | 6 | 21 |
| 2013 Marzo | 15 | 5 | 20 |
| 2013 Febrero | 11 | 5 | 16 |
| 2013 Enero | 18 | 6 | 24 |
| 2012 Diciembre | 16 | 14 | 30 |
| 2012 Noviembre | 0 | 4 | 4 |
| 2012 Septiembre | 0 | 2 | 2 |
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