Probable enfermedad de Whipple limitada al SNC. Caso clínico
Probable Whipple's disease confined to the CNS. Case report
A. Aparicio, J.L. Maestro, M. García-Bach, J. Borrás, F. Vila
Servicio de Neurocirugía. Hospital de Mutua de Terrassa. Terrassa (Barcelona)
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"apellidos" => "Maestro" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "García-Bach" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Borrás" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Vila" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital de Mutua de Terrassa. Terrassa (Barcelona)" ] ] ] 1 => array:3 [ "autoresLista" => "A. Salas, C. Sánchez, G. González, J. Casalots" "autores" => array:4 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Salas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "G." "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Casalots" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital de Mutua de Terrassa. Terrassa (Barcelona)" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna. Hospital de Mutua de Terrassa. Terrassa (Barcelona)" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Probable Whipple's disease confined to the CNS. Case report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156828" "palabras" => array:5 [ 0 => "Enfermedad de Whipple" 1 => "Trimetoprim-Sulfometoxazol (TMP-SMX)" 2 => "Biopsia esterotáxica" 3 => "Macrófagos PAS positivo" 4 => "Tropheryma whippelii" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156829" "palabras" => array:6 [ 0 => "Whipple Disease" 1 => "Trimethoprim-Sulfamethoxazole" 2 => "(TMP-SMX)" 3 => "Stereotactic biopsy" 4 => "PAS positive macrophages" 5 => "Tropheryma whippelii" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Whipple, es una enfermedad sistémica cuyas principales manifestaciones se localizan en el intestino delgado y articulaciones; la afectación primaria del SNC es infrecuente y de difícil diagnóstico cuando no se acompaña de artritis o sintomatología abdominal, más aún, si consideramos a las imágenes TAC y RM como inespecíficas. Presentamos un caso clínico de esta enfermedad, diagnosticado mediante biopsia estereotáxica y tratado a lo largo de 24 meses con Trimetoprim-Sulfametoxazol (TMP-SMX), con importante remisión de la sintomatología y desaparición de la lesión expansiva intracerebral.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The main symptomathology of systemic Wipple's disease is related with the small bowel and joints. Primary CNS involvement is very unusual and it is difficult to diagnose when arthritis ana abdominal symptons are not presento CT and MR images are not considered especific. We present a single case of Whipple's disease diagnosed by stereotactic biopsy and treated with Trimethoprim-Sulfamethoxazole (TMP-SMX) during a twenty-four months period. The patient showed significant remission of symptoms with dissaperance of the expansive cerebrallesion.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Aparicio, A.; Salas, A.; Maestro, J.L.; García-Bach, M.; Borrás, J.; Vila, F.; Sánchez, c.; González, G.; Casalots, J.: Probable enfermedad de Whipple limitada al SNC. Caso clínico. Neurocirugía 1999; 10: 461–465.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal mesenteric lymphatics tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.H. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 0 | 2 | 2 |
| 2020 Enero | 1 | 2 | 3 |
| 2018 Febrero | 15 | 3 | 18 |
| 2018 Enero | 12 | 24 | 36 |
| 2017 Diciembre | 10 | 17 | 27 |
| 2017 Noviembre | 39 | 18 | 57 |
| 2017 Octubre | 11 | 23 | 34 |
| 2017 Septiembre | 17 | 20 | 37 |
| 2017 Agosto | 10 | 26 | 36 |
| 2017 Julio | 9 | 16 | 25 |
| 2017 Junio | 20 | 24 | 44 |
| 2017 Mayo | 16 | 24 | 40 |
| 2017 Abril | 18 | 16 | 34 |
| 2017 Marzo | 8 | 31 | 39 |
| 2017 Febrero | 2 | 20 | 22 |
| 2017 Enero | 6 | 18 | 24 |
| 2016 Diciembre | 21 | 25 | 46 |
| 2016 Noviembre | 12 | 14 | 26 |
| 2016 Octubre | 21 | 37 | 58 |
| 2016 Septiembre | 48 | 40 | 88 |
| 2016 Agosto | 59 | 36 | 95 |
| 2016 Julio | 35 | 23 | 58 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Noviembre | 1 | 0 | 1 |
| 2015 Julio | 2 | 6 | 8 |
| 2015 Junio | 16 | 10 | 26 |
| 2015 Mayo | 23 | 27 | 50 |
| 2015 Abril | 16 | 20 | 36 |
| 2015 Marzo | 20 | 33 | 53 |
| 2015 Febrero | 13 | 28 | 41 |
| 2015 Enero | 15 | 23 | 38 |
| 2014 Diciembre | 12 | 28 | 40 |
| 2014 Noviembre | 18 | 38 | 56 |
| 2014 Octubre | 34 | 37 | 71 |
| 2014 Septiembre | 23 | 40 | 63 |
| 2014 Agosto | 32 | 31 | 63 |
| 2014 Julio | 18 | 23 | 41 |
| 2014 Junio | 23 | 26 | 49 |
| 2014 Mayo | 21 | 40 | 61 |
| 2014 Abril | 24 | 37 | 61 |
| 2014 Marzo | 13 | 40 | 53 |
| 2014 Febrero | 16 | 33 | 49 |
| 2014 Enero | 18 | 29 | 47 |
| 2013 Diciembre | 8 | 23 | 31 |
| 2013 Noviembre | 11 | 33 | 44 |
| 2013 Octubre | 20 | 27 | 47 |
| 2013 Septiembre | 18 | 22 | 40 |
| 2013 Agosto | 30 | 43 | 73 |
| 2013 Julio | 25 | 24 | 49 |
| 2013 Junio | 28 | 25 | 53 |
| 2013 Mayo | 14 | 29 | 43 |
| 2013 Abril | 11 | 16 | 27 |
| 2013 Marzo | 14 | 16 | 30 |
| 2013 Febrero | 13 | 13 | 26 |
| 2013 Enero | 15 | 14 | 29 |
| 2012 Diciembre | 15 | 21 | 36 |
| 2012 Noviembre | 1 | 8 | 9 |
| 2012 Octubre | 0 | 6 | 6 |
| 2012 Septiembre | 0 | 3 | 3 |
| 2012 Enero | 8 | 0 | 8 |
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