III. Oligodendrogliomas: Biología molecular
III. Oligodendrogliomas: Molecular biology
M.J. Bello, J.A. Rey
Instituto de Investigaciones Biomédicas (CSIC). Madrid
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Microscopía Electrónica de los oligodendrogliomas" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "378" "paginaFinal" => "380" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "II. Ultrastructural study of oligodendrogliomas" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. de Oya, S. Coca" "autores" => array:2 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "de Oya" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147399707827?idApp=UINPBA00004B" "url" => "/11301473/0000001000000005/v1_201305151016/S1130147399707827/v1_201305151016/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "III. Oligodendrogliomas: Biología molecular" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "381" "paginaFinal" => "386" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M.J. Bello, J.A. Rey" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M.J." "apellidos" => "Bello" ] 1 => array:2 [ "nombre" => "J.A." "apellidos" => "Rey" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Instituto de Investigaciones Biomédicas (CSIC). Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "III. Oligodendrogliomas: Molecular biology" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156789" "palabras" => array:2 [ 0 => "Oligodendroglioma" 1 => "Biología molecular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156788" "palabras" => array:2 [ 0 => "Oligodendroglioma" 1 => "Molecular biology" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las dificultades inherentes al diagnóstico, tratamiento y evolución clínica de oligodendrogliomas representan un complejo problema reflejado en la ausencia de factores predictivos reproductibles, con capacidad de identificación de las formas agresivas. La utilización de nuevas metodologías de análisis biológico permite la exploración de características tumorales hasta ahora difícilmente abordables, de tal forma que un detallado conocimiento de los acontecimientos moleculares responsables del desarrollo tumoral de oligodendrogliomas (del proceso neoplásico en general) es un prerrequisito para el establecimiento de nuevos métodos terapéuticos, encaminados a mejorar el pronóstico y, en última instancia, la curación de los enfermos. En este artículo revisamos los datos actuales acerca de los mecanismos moleculares implicados en la patogénesis de oligodendrogliomas, que suponen la acumulación secuencial de diversas alteraciones genéticas que producen activación de oncogenes o inactivación de genes oncosupresores o genes reparadores de ADN, así como la alteración de las vías de muerte celular programada.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Accurate and reproducible identification of the aggressive subset of oligodendrogliomas is difficult, and this determination of new biological characteristics of these tumors may prove helpful in predicting postoperative survivals. Detailed knowledge of the molecular events participating in brain tumor growth may be an important aspect for the development of new therapeutic strategies to improve prognosis. This article reviews the data available on the molecular mechanisms involved in the pathogenesis of oligodendrogliomas, that imply a sequential accumulation of anomalies leading to oncogene activation and inactivation of genes involved in reparation of DNA replication errors or tumor suppressor genes. These anomaliesgenerate growth factor loops, inactivation of sorne regulatory genes involved in control of cell cycle or alteration of apoptotic pathways.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Bello, M.J.; Rey, J.A.: Oligodendrogliomas: Estado actual. III. Oligodendrogliomas: biología molecular. Neurocirugía 1999; 10: 381–386.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular analysis of genomic abnormalities in human gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Bello" 1 => "J.M. de Campos" 2 => "M.E. Kusak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "1994" "volumen" => "73" "paginaInicial" => "122" "paginaFinal" => "129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8174086" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular and cytogenetic analysis of chromosomes 9 deletions in 75 malignant gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Bello" 1 => "J.M. de Campos" 2 => "J. Vaquero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chrom Cancer" "fecha" => "1994" "volumen" => "9" "paginaInicial" => "33" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7507698" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allelic status of chromosome 1 in neoplasms of the nervous system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Bello" 1 => "P.E. Leone" 2 => "P. Nebreda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "1995" "volumen" => "83" "paginaInicial" => "160" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7553588" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular abnormalities of chromosome 19 in malignant gliomas: Preferential involvement of the 19ql3.2-q 13.4 region" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Bello" 1 => "P.E. Leone" 2 => "P. Nebreda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int. J. Oncocl." "fecha" => "1995" "volumen" => "6" "paginaInicial" => "655" "paginaFinal" => "658" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Bello" 1 => "P.E. Leone" 2 => "J. Vaquero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int. J. Cancer." "fecha" => "1995" "volumen" => "64" "paginaInicial" => "207" "paginaFinal" => "210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7622310" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.J. Bello" 1 => "J. Vaquero" 2 => "J.M. de Campos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int. J. Cancer." "fecha" => "1994" "volumen" => "57" "paginaInicial" => "172" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8157354" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene amplification in human gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.P. Collins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/glia.440150309" "Revista" => array:6 [ "tituloSerie" => "Glia" "fecha" => "1995" "volumen" => "15" "paginaInicial" => "289" "paginaFinal" => "296" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8586464" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Chou" 1 => "Y. Miyashita" 2 => "R.W. Mohrenweiser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet. Cytogenet." "fecha" => "1996" "volumen" => "88" "paginaInicial" => "136" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8640722" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PTEN mutations in gliomas and glioneural tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.-M. Duerr" 1 => "B. Rollbrocker" 2 => "Y. Rayashi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1201876" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1998" "volumen" => "16" "paginaInicial" => "2.259" "paginaFinal" => "2.264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9692555" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Bloom's syndrome gene product is homologous to RecQ helicases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.A. Ellis" 1 => "J. Groden" 2 => "T.Z. Ye" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1995" "volumen" => "83" "paginaInicial" => "655" "paginaFinal" => "666" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7585968" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Fujimoto" 1 => "D.W. Fults" 2 => "G.A. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genomics" "fecha" => "1989" "volumen" => "4" "paginaInicial" => "210" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2544511" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demonstration of p53 protein and TP 53 gene mutations in oligodendrogliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Ragel" 1 => "G. Laking" 2 => "R. Laas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Europ. J. Cancer." "fecha" => "1996" "volumen" => "32A" "paginaInicial" => "2.242" "paginaFinal" => "2.248" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clonal genomic alterations in glioma malignancy stages" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.D. James" 1 => "E. Carlbom" 2 => "lP. Dumanski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1988" "volumen" => "48" "paginaInicial" => "5.546" "paginaFinal" => "5.551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3263899" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p73 is a human p53-related protein that can induce apoptosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.A. Jost" 1 => "M.C. Marin" 2 => "W.G. Kaelin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/38298" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1997" "volumen" => "389" "paginaInicial" => "191" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9296498" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglial and oligoastrocytoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.A. Kraus" 1 => "J. Koopmann" 2 => "P. Kasel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neuropathol. Exp. Neurol." "fecha" => "1995" "volumen" => "54" "paginaInicial" => "91" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7815084" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathways 1eading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.F. Lang" 1 => "D.C. Miller" 2 => "M. Koslow" 3 => "E.W. Newcomb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurosurgery" "fecha" => "1994" "volumen" => "81" "paginaInicial" => "427" "paginaFinal" => "436" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic aberrations in human brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.P. Leon" 1 => "J. Zhu" 2 => "P.McL. Black" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1994" "volumen" => "34" "paginaInicial" => "708" "paginaFinal" => "722" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8008171" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PTEN, a putative protein tyrosine phosphatse gene mutated in human brain, breast, and prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Li" 1 => "C. Yen" 2 => "D. Liaw" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1997" "volumen" => "275" "paginaInicial" => "1943" "paginaFinal" => "1947" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9072974" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y-J. Li" 1 => "K. Hoang-Xuan" 2 => "J.-Y. Delattre" 3 => "M. Poisson" 4 => "G. Thomas" 5 => "R. Hamelin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1995" "volumen" => "11" "paginaInicial" => "597" "paginaFinal" => "600" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7630644" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New deletion in low-grade oligodendroglioma at the glioblastoma suppressor locus on chromosome 10q25-26" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Maier" 1 => "D. Comparone" 2 => "E. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1201209" "Revista" => array:7 [ "tituloSerie" => "Oncogene" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "997" "paginaFinal" => "1001" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9285695" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S120197120700207X" "estado" => "S300" "issn" => "12019712" ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular genetic evidence for subtypes of oligoastrocytomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Maintz" 1 => "K. Fiedler" 2 => "J. Koopmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neupathol. Exp. Neurol." "fecha" => "1997" "volumen" => "56" "paginaInicial" => "1.098" "paginaFinal" => "1.104" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delimitation of a critical tumour suppressor region at distal 1p in neuroblastoma tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Martinsson" 1 => "R.M. Sjoberg" 2 => "K. Hallstensson" 3 => "M. Nording" 4 => "F. Hedborg" 5 => "P. Kogner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eurp. J. Cancer." "fecha" => "1997" "volumen" => "33" "paginaInicial" => "1.997" "paginaFinal" => "2.001" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Mohapatra" 1 => "A.W. Bollen" 2 => "D.R. Klm" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chrom Cancer" "fecha" => "1998" "volumen" => "21" "paginaInicial" => "195" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9523194" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Refined mapping of three DNA repair genes, ERCC1, ERCC2, and XRCC1, on human chromosome 19" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H.W. Mohrenweiser" 1 => "A.V. Carrima" 2 => "A. Fertitta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cytogenet Cell Genet" "fecha" => "1989" "volumen" => "52" "paginaInicial" => "11" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2558854" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Mollenhauer" 1 => "S. Wiemann" 2 => "W. Scheurlen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng0997-32" "Revista" => array:6 [ "tituloSerie" => "Nature Genet" "fecha" => "1997" "volumen" => "17" "paginaInicial" => "32" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9288095" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "cDNA cloning and mapping of the human creatine kinase M gene to 19q13" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "lM. Nigro" 1 => "C.W. Schweinfest" 2 => "A. Rajkovic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am. J. Hum. Genet." "fecha" => "1987" "volumen" => "40" "paginaInicial" => "115" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3031982" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "p53 mutations in nonastrocytic human brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Ohgaki" 1 => "R.H. Eibl" 2 => "O.D. Wiestler" 3 => "M.G. Yasargil" 4 => "E.W. Newcombr" 5 => "P. Kleihues" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer res" "fecha" => "1991" "volumen" => "51" "paginaInicial" => "6.202" "paginaFinal" => "6.205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1742745" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of the human homologue of RAD54: A gene located on chromosome 1p332 at a region of high loss of heterozygosity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Rasio" 1 => "Y. Murakumo" 2 => "D. Robbins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1997" "volumen" => "57" "paginaInicial" => "2.378" "paginaFinal" => "2.383" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9407975" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Reifenberger" 1 => "G.U. Ring" 2 => "U. Gies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neuropathol. Exp. neurol." "fecha" => "1996" "volumen" => "55" "paginaInicial" => "822" "paginaFinal" => "831" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8965097" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Reifenberger" 1 => "G. Reifenberger" 2 => "L. Liu" 3 => "C.D. James" 4 => "W. Wechsler" 5 => "V.P. Collins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am. J. Pathol." "fecha" => "1994" "volumen" => "145" "paginaInicial" => "1.175" "paginaFinal" => "1.190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7992854" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of chromosomal changes by interphase cytogenetics in biopsies of recurrent astrocytomas and oligodendrogliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.M. Rosso" 1 => "R. Van Dekken" 2 => "K.K. Krishnadath" 3 => "J.C. Alers" 4 => "J.M. Kros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neupathol. Exp. Neurol." "fecha" => "1997" "volumen" => "56" "paginaInicial" => "1.125" "paginaFinal" => "1.131" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The putative glioma tumor suppressor gene on chromosome 19q maps between APOC2 and HRC" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.-P. Rubio" 1 => "K.M. Correa" 2 => "U. Keisuke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1994" "volumen" => "54" "paginaInicial" => "4.760" "paginaFinal" => "4.763" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7987856" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infrequent alterations ofthe p15, p16, CDK4 and cyclin Digenes in non-astrocytic human brain tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Sato" 1 => "B. Schauble" 2 => "P. Kleihues" 3 => "H. Ohgaki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1097-0215(19960503)66:3<305::AID-IJC6>3.0.CO;2-2" "Revista" => array:6 [ "tituloSerie" => "Int. J. Cancer." "fecha" => "1996" "volumen" => "66" "paginaInicial" => "305" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8621248" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23. 3 that is mutated in multiple advanced cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.A. Steck" 1 => "M.A. Perhouse" 2 => "S.A. Jasser" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng0497-356" "Revista" => array:6 [ "tituloSerie" => "Nature Genet" "fecha" => "1997" "volumen" => "15" "paginaInicial" => "356" "paginaFinal" => "362" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9090379" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple sequential molecular abnorrnalities in the evolution of human gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.J. Venter" 1 => "D.G.T. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br. J. Cancer." "fecha" => "1991" "volumen" => "63" "paginaInicial" => "753" "paginaFinal" => "757" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1674878" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subsets of glioblastoma multiforme defined by’molecular genetic analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Von Deimling" 1 => "K. Von Ammon" 2 => "D. Schoenfeld" 3 => "O.D. Wiestler" 4 => "B.R. Seizinger" 5 => "D.N. Louis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain. Pathol." "fecha" => "1993" "volumen" => "3" "paginaInicial" => "19" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8269081" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for a tumor suppressor gene on chromosome 19q associated with human astrocytomas, oligodendrogliomas, and mixed gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Von Deimling" 1 => "D.N. Louis" 2 => "K. Von Ammon" 3 => "I. Petersen" 4 => "O.D. Wiestler" 5 => "B.R. Seizinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1992" "volumen" => "52" "paginaInicial" => "4.277" "paginaFinal" => "4.279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1458492" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne?s syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Weeda" 1 => "R.C. Van Ham" 2 => "W. Vermeuden" 3 => "D. Bootsma" 4 => "A.J. Van Der Eb" 5 => "J.H. Hoeijmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1990" "volumen" => "62" "paginaInicial" => "777" "paginaFinal" => "791" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2167179" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aggressive oligodendroglioma predicted by chromosome 10 restriction fragment length poymorphism analysis. Case study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.K. Wu" 1 => "R.D. Folkerth" 2 => "Z. Ye" 3 => "B.T. Darras" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neuro-Oncol." "fecha" => "1992" "volumen" => "15" "paginaInicial" => "29" "paginaFinal" => "35" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W.R. Yong" 1 => "K. Ueki" 2 => "D. Chou" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genomics" "fecha" => "1995" "volumen" => "29" "paginaInicial" => "533" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8666404" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positional cloning of the Werner’ s syndrome gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.E. Yu" 1 => "J. Oshima" 2 => "Y.H. Fuy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1996" "volumen" => "272" "paginaInicial" => "258" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8602509" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of meningiomas by methylation –and transcription– based clonality assays" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.J. Zhu" 1 => "M.P. Frosh" 2 => "L. Busque" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1995" "volumen" => "55" "paginaInicial" => "3.865" "paginaFinal" => "3.872" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8521420" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Screening for loss of heterozygosity and microsatellite instability in oligodendrogliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.J. Zhu" 1 => "T. Santarius" 2 => "X. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chrom. Cancer." "fecha" => "1998" "volumen" => "21" "paginaInicial" => "207" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9523195" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001000000005/v1_201305151016/S1130147399707839/v1_201305151016/es/main.assets" "Apartado" => array:4 [ "identificador" => "9410" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Oligodendrogliomas: Estado actual" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001000000005/v1_201305151016/S1130147399707839/v1_201305151016/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147399707839?idApp=UINPBA00004B" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 15 | 8 | 23 |
| 2018 Enero | 23 | 8 | 31 |
| 2017 Diciembre | 19 | 7 | 26 |
| 2017 Noviembre | 57 | 41 | 98 |
| 2017 Octubre | 17 | 7 | 24 |
| 2017 Septiembre | 17 | 11 | 28 |
| 2017 Agosto | 15 | 9 | 24 |
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| 2017 Junio | 26 | 11 | 37 |
| 2017 Mayo | 12 | 8 | 20 |
| 2017 Abril | 14 | 14 | 28 |
| 2017 Marzo | 13 | 9 | 22 |
| 2017 Febrero | 6 | 5 | 11 |
| 2017 Enero | 10 | 4 | 14 |
| 2016 Diciembre | 39 | 10 | 49 |
| 2016 Noviembre | 26 | 17 | 43 |
| 2016 Octubre | 42 | 6 | 48 |
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| 2016 Agosto | 61 | 12 | 73 |
| 2016 Julio | 33 | 10 | 43 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Agosto | 1 | 0 | 1 |
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| 2015 Junio | 12 | 16 | 28 |
| 2015 Mayo | 18 | 18 | 36 |
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| 2015 Marzo | 20 | 11 | 31 |
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| 2014 Diciembre | 14 | 17 | 31 |
| 2014 Noviembre | 12 | 16 | 28 |
| 2014 Octubre | 16 | 19 | 35 |
| 2014 Septiembre | 11 | 18 | 29 |
| 2014 Agosto | 17 | 22 | 39 |
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| 2014 Abril | 13 | 14 | 27 |
| 2014 Marzo | 11 | 17 | 28 |
| 2014 Febrero | 12 | 20 | 32 |
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| 2013 Diciembre | 17 | 19 | 36 |
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| 2013 Octubre | 18 | 17 | 35 |
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| 2013 Julio | 14 | 17 | 31 |
| 2013 Junio | 13 | 20 | 33 |
| 2013 Mayo | 15 | 24 | 39 |
| 2013 Abril | 10 | 22 | 32 |
| 2013 Marzo | 14 | 18 | 32 |
| 2013 Febrero | 8 | 5 | 13 |
| 2013 Enero | 15 | 6 | 21 |
| 2012 Diciembre | 9 | 12 | 21 |
| 2012 Noviembre | 2 | 13 | 15 |
| 2012 Octubre | 0 | 3 | 3 |
| 2012 Septiembre | 0 | 3 | 3 |
| 2012 Enero | 8 | 0 | 8 |
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