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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las dificultades inherentes al diagn&#243;stico&#44; tratamiento y evoluci&#243;n cl&#237;nica de oligodendrogliomas representan un complejo problema reflejado en la ausencia de factores predictivos reproductibles&#44; con capacidad de identificaci&#243;n de las formas agresivas&#46; La utilizaci&#243;n de nuevas metodolog&#237;as de an&#225;lisis biol&#243;gico permite la exploraci&#243;n de caracter&#237;sticas tumorales hasta ahora dif&#237;cilmente abordables&#44; de tal forma que un detallado conocimiento de los acontecimientos moleculares responsables del desarrollo tumoral de oligodendrogliomas &#40;del proceso neopl&#225;sico en general&#41; es un prerrequisito para el establecimiento de nuevos m&#233;todos terap&#233;uticos&#44; encaminados a mejorar el pron&#243;stico y&#44; en &#250;ltima instancia&#44; la curaci&#243;n de los enfermos&#46; En este art&#237;culo revisamos los datos actuales acerca de los mecanismos moleculares implicados en la patog&#233;nesis de oligodendrogliomas&#44; que suponen la acumulaci&#243;n secuencial de diversas alteraciones gen&#233;ticas que producen activaci&#243;n de oncogenes o inactivaci&#243;n de genes oncosupresores o genes reparadores de ADN&#44; as&#237; como la alteraci&#243;n de las v&#237;as de muerte celular programada&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Accurate and reproducible identification of the aggressive subset of oligodendrogliomas is difficult&#44; and this determination of new biological characteristics of these tumors may prove helpful in predicting postoperative survivals&#46; Detailed knowledge of the molecular events participating in brain tumor growth may be an important aspect for the development of new therapeutic strategies to improve prognosis&#46; This article reviews the data available on the molecular mechanisms involved in the pathogenesis of oligodendrogliomas&#44; that imply a sequential accumulation of anomalies leading to oncogene activation and inactivation of genes involved in reparation of DNA replication errors or tumor suppressor genes&#46; These anomaliesgenerate growth factor loops&#44; inactivation of sorne regulatory genes involved in control of cell cycle or alteration of apoptotic pathways&#46;</p>"
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Vol. 10. Núm. 5.
Páginas 381-386 (enero 1998)
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Vol. 10. Núm. 5.
Páginas 381-386 (enero 1998)
III. Oligodendrogliomas: Biología molecular
III. Oligodendrogliomas: Molecular biology
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M.J. Bello, J.A. Rey
Instituto de Investigaciones Biomédicas (CSIC). Madrid
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Resumen

Las dificultades inherentes al diagnóstico, tratamiento y evolución clínica de oligodendrogliomas representan un complejo problema reflejado en la ausencia de factores predictivos reproductibles, con capacidad de identificación de las formas agresivas. La utilización de nuevas metodologías de análisis biológico permite la exploración de características tumorales hasta ahora difícilmente abordables, de tal forma que un detallado conocimiento de los acontecimientos moleculares responsables del desarrollo tumoral de oligodendrogliomas (del proceso neoplásico en general) es un prerrequisito para el establecimiento de nuevos métodos terapéuticos, encaminados a mejorar el pronóstico y, en última instancia, la curación de los enfermos. En este artículo revisamos los datos actuales acerca de los mecanismos moleculares implicados en la patogénesis de oligodendrogliomas, que suponen la acumulación secuencial de diversas alteraciones genéticas que producen activación de oncogenes o inactivación de genes oncosupresores o genes reparadores de ADN, así como la alteración de las vías de muerte celular programada.

Palabras clave:
Oligodendroglioma
Biología molecular
Summary

Accurate and reproducible identification of the aggressive subset of oligodendrogliomas is difficult, and this determination of new biological characteristics of these tumors may prove helpful in predicting postoperative survivals. Detailed knowledge of the molecular events participating in brain tumor growth may be an important aspect for the development of new therapeutic strategies to improve prognosis. This article reviews the data available on the molecular mechanisms involved in the pathogenesis of oligodendrogliomas, that imply a sequential accumulation of anomalies leading to oncogene activation and inactivation of genes involved in reparation of DNA replication errors or tumor suppressor genes. These anomaliesgenerate growth factor loops, inactivation of sorne regulatory genes involved in control of cell cycle or alteration of apoptotic pathways.

Key words:
Oligodendroglioma
Molecular biology

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