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array:23 [ "pii" => "S1130147306703372" "issn" => "11301473" "doi" => "10.1016/S1130-1473(06)70337-2" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "70337" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "2006" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 2006;17:340-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1619 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 955 "PDF" => 645 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147306703384" "issn" => "11301473" "doi" => "10.1016/S1130-1473(06)70338-4" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "70338" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Neurocirugia. 2006;17:346-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1399 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 825 "PDF" => 555 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Comentario al trabajo <span class="elsevierStyleItalic">Glioblastoma familiar múltiple de aparición metácrona: implicaciones etiopatogénicas y pronósticas</span> de B. Iza y cols" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "346" "paginaFinal" => "347" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Brell" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Brell" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703384?idApp=UINPBA00004B" "url" => "/11301473/0000001700000004/v1_201305151256/S1130147306703384/v1_201305151256/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147306703360" "issn" => "11301473" "doi" => "10.1016/S1130-1473(06)70336-0" "estado" => "S300" "fechaPublicacion" => "2006-01-01" "aid" => "70336" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Neurocirugia. 2006;17:339" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1372 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 795 "PDF" => 560 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Comentario al trabajo: <span class="elsevierStyleItalic">Hernias discales calcificadas en la infancia</span> de Ortega-Martínez y cols" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "339" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.F. Martínez-Lage" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.F." "apellidos" => "Martínez-Lage" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703360?idApp=UINPBA00004B" "url" => "/11301473/0000001700000004/v1_201305151256/S1130147306703360/v1_201305151256/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Glioblastoma familiar múltiple de aparición metácrona: implicaciones etiopatogénicas y pronósticas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "340" "paginaFinal" => "346" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "B. Iza, O. Mateo-Sierra, F. Ruiz-Juretszke, J. Garbizu, R. Carrillo" "autores" => array:5 [ 0 => array:3 [ "nombre" => "B." "apellidos" => "Iza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Mateo-Sierra" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Ruiz-Juretszke" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Garbizu" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Carrillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía, Hospital General Universitario Gregorio Marañón. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Servicio de Neurocirugía. Hospital General Universitario Gregorio Marañón. c/ Doctor Esquerdo 46. 28007 Madrid." ] ] ] 1 => array:3 [ "autoresLista" => "J. Guzmán de Villoria" "autores" => array:1 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Guzmán de Villoria" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Neurorradiología, Hospital General Universitario Gregorio Marañón. Madrid" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Familiar glioblastoma presentig as a true multicentric tumor: etiopathogenic and pronostic features" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-09-06" "fechaAceptado" => "2005-12-02" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec159350" "palabras" => array:4 [ 0 => "Glioma multicéntrico" 1 => "Glioma familiar" 2 => "Glioblastoma metácrono" 3 => "Glioblastoma multiforme" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec159351" "palabras" => array:4 [ 0 => "Multicentric glioma" 1 => "Familiar glioma" 2 => "Metachronous glioblastoma" 3 => "Glioblastoma multiforme" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El Glioblastoma multiforme con agregación familiar es poco frecuente, asociándose la mayor parte de los casos a síndromes genéticos conocidos (como el síndrome de Turcot, el síndrome de Li-Fraumeni, la neurofibromatosis, etc). Sin embargo, existen otros gliomas familiares no asociados a estos cuadros sindrómicos que, aunque menos frecuentes, han mostrado unas características etiológicas y clínicas diferentes a las de los gliomas esporádicos.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Por otra parte, hasta un 10% de los gliomas se consideran verdaderamente multicéntricos, apareciendo de modo síncrono o metácrono. Los glioblastomas de aparición metácrona han mostrado en algunos estudios un mejor pronóstico, habiéndose encontrado trastornos genéticos diferentes en los tumores de un mismo paciente.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los gliomas familiares con presentación metácrona son excepcionales. Estos tumores presentan unas implicaciones terapéuticas especiales por la limitación del tratamiento radioterápico tras el tratamiento inicial. Aunque se han identificado mutaciones variadas en estos pacientes, la identificación precisa de dichos trastornos se basará en el estudio de su sustrato genético específico. Presentamos un caso clínico que combina ambas peculiaridades revisando las características de esta patología.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Familial glioblastoma multiforme is a rather uncommon entity, being in most cases associated to known genetic disorders (as Turcot syndrome, Li-Fraumeni syndrome, neurofibromatosis, etc.). However, familial gliomas have also been described, although less frequently, independently of these genetic syndromes showing some special features regarding its etiology and clinical manifestations.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Less than 10% of gliomas may be considered as true multicentric tumours either synchronous or metachronous in clinical presentation. Metachronous glioblastomas have been associated to better prognosis in some studies, with genetic studies having found clear differences among the tumors within same patients.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Familial glioblastoma with metachronous presentation is an exceptional disorder. These tumors show special therapeutic implications due to the limitations of radiotherapy once the patient has already irradiated. A variety of non-specific mutations have been found in these patients but true characterization of this disorder remains unclear and will be based on further genetic studies. We present a clinical report on a patient harbouring a familial and metachronous glioblastoma. The main aspects of this entity are reviwed.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Iza, B.; Mateo-Sierra, O.; Ruiz-Juretszke, F.; Garbizu, J.; Guzmán de Villoria, J.; Carrillo, R.: Glioblastoma familiar múltiple de aparición metácrona: implicaciones etiopatogénicas y pronósticas. Neurocirugía 2006; 17: 340–347.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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