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array:23 [ "pii" => "S1130147397710273" "issn" => "11301473" "doi" => "10.1016/S1130-1473(97)71027-3" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "71027" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1997" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1997;8:171-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1576 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 1020 "PDF" => 537 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147397710285" "issn" => "11301473" "doi" => "10.1016/S1130-1473(97)71028-5" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "71028" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1997;8:178-82" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1663 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 922 "PDF" => 724 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "178" "paginaFinal" => "182" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effects of tetracycline derivates as inhibitors of tumor angiogenesis (C.N.S.). Experimental study on an undifferentiated neuroectodermal tumor" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Vaquero, M. Zurita, S. Coca, S. Oya" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Zurita" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Oya" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397710285?idApp=UINPBA00004B" "url" => "/11301473/0000000800000003/v1_201305151502/S1130147397710285/v1_201305151502/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147397710261" "issn" => "11301473" "doi" => "10.1016/S1130-1473(97)71026-1" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "71026" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1997;8:163-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2920 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 1230 "PDF" => 1674 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Anatomía quirúrgica de la porción cisternal del IV par craneal" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "163" "paginaFinal" => "170" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Surgical anatomy of the cisternal segment of the trochlear nerve" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Urculo Bareño" "autores" => array:1 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Urculo Bareño" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397710261?idApp=UINPBA00004B" "url" => "/11301473/0000000800000003/v1_201305151502/S1130147397710261/v1_201305151502/es/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "titulo" => "Grading and therapy monitoring of astrocytomas with 1H spectroscopy" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "171" "paginaFinal" => "177" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "W. Bini" "autores" => array:1 [ 0 => array:2 [ "nombre" => "W." "apellidos" => "Bini" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Dept. of Neurosurgery, Neurozentrum MR Hochfeld, University of Freiburg, Freiburg-Germany" ] ] ] 1 => array:3 [ "autoresLista" => "O. Speck, Th. Thiel, J. Hennig" "autores" => array:3 [ 0 => array:3 [ "nombre" => "O." "apellidos" => "Speck" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Th." "apellidos" => "Thiel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J." "apellidos" => "Hennig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Dept. of Radiology, MR Hochfeld, University of Freiburg, Freiburg-Germany" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Grado de diferenciación y control terapéutico de astrocitomas mediante lH espectroscopía" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163156" "palabras" => array:4 [ 0 => "Non-invasive tissue characterization" 1 => "MR spectroscopy" 2 => "Astrocytomas" 3 => "Therapy monitoring" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163157" "palabras" => array:1 [ 0 => "Caracterización tisular no-invasiva. Espectroscopia magnética nuclear. Astrocitomas. Monitoring terapéutico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">As Magnetic Resonance Spectroscopy is one of the most powerful methods to obtain a non-invasive view of brain metabolism we, as others, judge it a promising tool for tumor grading. We investigated 8 patients harbouring astrocytomas (histologically confirmed via stereotactic serial biopsy) of different malignity with single voxel (PRESS) 1 H MRS techniques. The measurements were also repeated after interstitial radiosurgery using 125 Iodine, when this treatment modality was deemed indicated.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Apart from the decrease of NAA (N-acetyl-L-aspartate), the tumor spectra show the presence of lactate (Lac) which however does not correlate to the tumor grade. More interesting for this and confirmed in our initial trial is the fact that choline (Cho) varies from almost normal concentrations in low-grade astrocytomas to a fourfould increase in the high-grade lesions with strong correlation to the tumor malignity. After stereotactic radiosurgical treatment, a decrease of the previously increased choline signal is observed. The reduction of choline seems to be dose related.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Considerando que la espectroscopia magnética nuclear (MRS) es uno de los métodos más eficaces para obtener una imagen no-invasiva del metabolismo cerebral, juzgamos esta técnica muy prometedora para la diferenciación (graduación) tumoral.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Examinamos ocho pacientes con astrocitomas (his tológicamente confirmados por medio de biopsia estereotáctica seriada) de diferente grado de malignidad con técnica single voxel (PRESS) 1 H MRS. Los estudios fueron repetidos después de radiocirugía intersticial usando I125 en aquellos pacientes en los cuales esta modalidad de tratamiento parecía indicada. Aparte de la disminución de NAA (N-acetil-L-aspartato), los espectra de los tumores muestran la presencia de lactato (Lac) lo cual, no obstante, no está en correlación con la graduación histológica de la lesión. Más interesante y confirmado por nuestros estudios iniciales, es el hecho que la cholina (Cho) varía de una concentración casi normal en astrocitomas de bajo grado a un incremento cuadruple en las lesiones de alto grado con una fuerte correlación con el grado de malignidad del tumor. Después de un tratamiento radioquirúrgico se observa una disminución de la señal de cholina que previamente había aumentado. La reducción de cholina parece ser relacionada a la dosis.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pudimos confirmar los valores obtenidos en análisis in vitro y consideramos que una graduación tumoral no-invasiva de astrocitomas es posible por medio de la relación (ratio) entre cholina-creatina. No obstante, será necesario un colectivo de pacientes más grande para verificar nuestros resultados y evaluar la sensitividad de MRS en el monitoring terapéutico a corto y largo plazo.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Bini, W.; Speck, O.; Thiel, Th.; Henning, J.: Grading and therapy monitoring of astrocytomas with 1H spectroscopy. Neurocirugía 1997; 8: 171–177.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolism of Human Gliomas: Assessment with H-1 Spectroscopy and F18 Fluorodeoxyglucose PET" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.R. Alger" 1 => "J.A. Frank" 2 => "A. 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