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array:23 [ "pii" => "S1130147394711167" "issn" => "11301473" "doi" => "10.1016/S1130-1473(94)71116-7" "estado" => "S300" "fechaPublicacion" => "1994-01-01" "aid" => "71116" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1994" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1994;5:10-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1628 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 851 "PDF" => 758 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147394711179" "issn" => "11301473" "doi" => "10.1016/S1130-1473(94)71117-9" "estado" => "S300" "fechaPublicacion" => "1994-01-01" "aid" => "71117" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1994;5:16-23" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3659 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 853 "PDF" => 2790 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Aneurismas del complejo arteria vertebral-arteria cerebelosa posteroinferior" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "16" "paginaFinal" => "23" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P.A. Gómez, R.D. Lobato, R. Alday, J.J. Rivas, A. Cabrera, J. Domínguez, H. Sandoval, J. Ayerbe, A. Benítez, S. Castro" "autores" => array:10 [ 0 => array:2 [ "nombre" => "P.A." "apellidos" => "Gómez" ] 1 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Alday" ] 3 => array:2 [ "nombre" => "J.J." "apellidos" => "Rivas" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Cabrera" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Domínguez" ] 6 => array:2 [ "nombre" => "H." "apellidos" => "Sandoval" ] 7 => array:2 [ "nombre" => "J." "apellidos" => "Ayerbe" ] 8 => array:2 [ "nombre" => "A." "apellidos" => "Benítez" ] 9 => array:2 [ "nombre" => "S." "apellidos" => "Castro" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147394711179?idApp=UINPBA00004B" "url" => "/11301473/0000000500000001/v1_201305151432/S1130147394711179/v1_201305151432/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147394711155" "issn" => "11301473" "doi" => "10.1016/S1130-1473(94)71115-5" "estado" => "S300" "fechaPublicacion" => "1994-01-01" "aid" => "71115" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1994;5:4-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3990 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 1418 "PDF" => 2553 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Quistes dermoides de la fontanela anterior" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "8" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.A. Alvarez Garijo, P. Riesgo, C. Botella, M. Vila Mengual, J.A. Santamaría" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Alvarez Garijo" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Riesgo" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Botella" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Vila Mengual" ] 4 => array:2 [ "nombre" => "J.A." "apellidos" => "Santamaría" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147394711155?idApp=UINPBA00004B" "url" => "/11301473/0000000500000001/v1_201305151432/S1130147394711155/v1_201305151432/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Influencia de la actinomicina D sobre el flujo sanguíneo cerebral en un modelo de isquemia experimental" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "10" "paginaFinal" => "15" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "G. Posadas Narro, J. de Raro del Moral, J. Vaquero Crespo, C. San Juan Robles, G. Bravo Zabalgoitia, J. Ortiz Berrocal" "autores" => array:6 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Posadas Narro" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "de Raro del Moral" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero Crespo" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "San Juan Robles" ] 4 => array:2 [ "nombre" => "G." "apellidos" => "Bravo Zabalgoitia" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Ortiz Berrocal" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neurocirugía y Medina Nuclear. Clínica Puerta de Hierro. Universidad Autónoma de Madrid-España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162591" "palabras" => array:3 [ 0 => "Isquemia" 1 => "Actinomicina D" 2 => "Flujo sanguíneo cerebral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162590" "palabras" => array:3 [ 0 => "Ischemia" 1 => "Actinomycin D" 2 => "Cerebral blood flow" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existen estudios experimentales sobre el mejoramiento del vasoespasmo que sigue a la hemorragia subaracnoidea por la Actinomicina D, pero no existe ningún estudio acerca de su efecto en la isquemia cerebral.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado el presente estudio experimental en 18 ratas; produciéndoles isquemia cerebral parcial (mediante ligadura permanente de la arteria carótida común derecha, y clipaje transitorio de la carótida común izquierda), que fueron tratadas con Actinomicina D (vía intraperitoneal) por 5 días. Se administró dicha sustancia a las 6 y 12 horas postisquemia, en los grupos A (6 ratas) y B (6 ratas) respectivamente. El grupo C (control) constituído también por 6 ratas, no recibió tratamiento alguno. El análisis estadístico antes y después del tratamiento se realizó observando las modificaciones del flujo sanguíneo cerebral utilizando HMPAO marcado con Tc-99m (marcador radioactivo).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se encontró ausencia de modificación del flujo sanguíneo cerebral, y por lo tanto ausencia de mejoría de la isquemia cerebral.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se concluye que la Actinomicina D no modifica el flujo sanguíneo ni mejora la isquemia cerebral experimental en ratas.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Though there are some studies reporting a favourable effect of Actinomycin D posthemorrhagic cerebral vasospasm, the effect of this drug on brain ischemia has not been analyzed.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We have performed an experimental study in 18 rats. Ischemia was produced by permanent and transitory ligature of the right and left common carotid artery respectively.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The animals were divided into three groups. Actinomycin was injected intraperitoneally 6 and 12 hours after ischemia in groups A and B. Animals in group C did not receive any treatment.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Cerebral blood flow (CBF) was measured using HMPAO labeled with Tc 99m.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There was no modification of CBF. The conclusion is that Actinomycin D does not improve cerebral ischemia in this experimental model.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Posadas Narro, G.; Haro del Moral, J. de; Vaquero Crespo, J.; San Juan Robles, C.; Bravo Zabalgoitia, G. y Ortiz Berrocal, J.: Influencia de la actinomicina D sobre el flujo sanguíneo cerebral en un modelo de isquemia experimental. Neurocirugía 1994; 5: 10–15.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:47 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Strong attenuations of ischemic and postischemic brain edema in rats by a novel free radical scavenger" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. 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