Compartir
array:23 [ "pii" => "S1130147305704012" "issn" => "11301473" "doi" => "10.1016/S1130-1473(05)70401-2" "estado" => "S300" "fechaPublicacion" => "2005-01-01" "aid" => "70401" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "2005" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 2005;16:345-58" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1722 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 905 "PDF" => 799 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147305704024" "issn" => "11301473" "doi" => "10.1016/S1130-1473(05)70402-4" "estado" => "S300" "fechaPublicacion" => "2005-01-01" "aid" => "70402" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 2005;16:359-63" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1592 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 895 "PDF" => 680 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Metástasis intramedular como primera manifestación de un carcinoma renal" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "359" "paginaFinal" => "363" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Intramedullary spinal cord metastasis as the first manifestation of a renal carcinoma" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Gómez de la Riva, A. Isla, C. Pérez-López, M. Budke, M. Gutiérrez, R. Frutos" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Gómez de la Riva" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Isla" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Pérez-López" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Budke" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Gutiérrez" ] 5 => array:2 [ "nombre" => "R." "apellidos" => "Frutos" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147305704024?idApp=UINPBA00004B" "url" => "/11301473/0000001600000004/v1_201305151241/S1130147305704024/v1_201305151241/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147305704000" "issn" => "11301473" "doi" => "10.1016/S1130-1473(05)70400-0" "estado" => "S300" "fechaPublicacion" => "2005-01-01" "aid" => "70400" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Neurocirugia. 2005;16:344" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1487 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 914 "PDF" => 556 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Comentario al trabajo: <span class="elsevierStyleItalic">Aneurismas del sector distal de la arteria cerebral anterior (arteria pericallosa)</span> de Martínez y cols" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "344" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Vilalta" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vilalta" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147305704000?idApp=UINPBA00004B" "url" => "/11301473/0000001600000004/v1_201305151241/S1130147305704000/v1_201305151241/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Inmunoterapia en astrocitomas de alto grado: principios y estado actual" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "345" "paginaFinal" => "358" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Pinilla-Arias, O. Mateo-Sierra, F.A. Gutiérrez, C. Fernández-Carballal, R. Carrillo" "autores" => array:5 [ 0 => array:3 [ "nombre" => "D." "apellidos" => "Pinilla-Arias" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Mateo-Sierra" ] 2 => array:2 [ "nombre" => "F.A." "apellidos" => "Gutiérrez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Fernández-Carballal" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Carrillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital General Universitario Gregorio Marañón. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Servicio de Neuro-cirugía. Hospital General Universitario Gregorio Marañón. C/Dr. Esquerdo 46. 28007 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Immunotherapy in high grade astrocytomas: principles and current state" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-09-29" "fechaAceptado" => "2004-11-19" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158985" "palabras" => array:4 [ 0 => "Inmunoterapia" 1 => "Tratamiento de gliomas" 2 => "Citoquina" 3 => "Linfocitos" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec158983" "palabras" => array:19 [ 0 => "ADCC" 1 => "APC" 2 => "ASL" 3 => "BCG" 4 => "BHE" 5 => "CMH" 6 => "EFGr" 7 => "GM-CSF" 8 => "HLA" 9 => "IFN" 10 => "IGF" 11 => "IL" 12 => "LAK" 13 => "MAK" 14 => "NK" 15 => "TGF" 16 => "Th" 17 => "TIL" 18 => "TNF" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec158984" "palabras" => array:3 [ 0 => "Immunotherapy" 1 => "Glioma treatment" 2 => "Interleukin Lymphocytes" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Desde hace tiempo se conoce que la presencia de un tumor origina en el organismo una reacción del sistema inmune enfocada a eliminar la amenaza que el desarrollo tumoral implica. Sin embargo, se van averiguando diferentes mecanismos por los cuales los tumores provocan un estado de inmunosupresión que dificulta el desa-rrollo de una reacción inmunitaria eficaz. La utilización del sistema inmune como arma frente a los astrocitomas de alto grado constituye una de las principales estrategias de investigación desde los primeros ensayos de Bloom en 1960, siendo hoy en día una práctica habitual en la terapia antineoplásica de múltiples disciplinas médicas.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio es describir las características de las reacciones inmunológicas del sistema nervioso central, los mecanismos utilizados por los tumores astrocitarios para despistar las defensas del organismo y las diferentes líneas de investigación llevadas a cabo hasta la fecha, mostrando sus bases fisiopatológicas y los resultados obtenidos, basándonos en una extensa revisión bibliográfica.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">It is generally accepted that tumour development promotes a systemic response leading to protect the host against cancer. However, tumours may as well elicit a partial immunodeficiency to avoid the development of a complete and active immune response. Since Bloom's first studies on immunotherapy to treat high grade gliomas in 1960, many attempts have been made from different medical specialties to use the immune system as a weapon against a great diversity of cancers.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Main objective of this study is to outline the basic features of the immune response inside the Central Nervous System, the strategies employed by astrocytic tumours to evade body defences, and to provide an extended literature review on research on immunotherapy, especially concerning its patho-physiology and the clinical results achieved till date.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pinilla-Arias, D.; Mateo Sierra, O.; Gutiérrez, F.A.; Fernández-Carballal, C.; Carrillo, R.: Inmunoterapia en astrocitomas de alto grado: principios y estado actual. Neurocirugía 2005; 16: 345–358.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:115 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neuroimmunol" "fecha" => "1997" "volumen" => "78" "paginaInicial" => "34" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intratumoral LAK cell and interleukin-2 therapy of human gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.70.2.0175" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1989" "volumen" => "70" "paginaInicial" => "175" "paginaFinal" => "182" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eradication of rat malignant gliomas by retroviral in vitro delivery of the interleukin 4 gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1999" "volumen" => "59" "paginaInicial" => "645" "paginaFinal" => "652" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene therapy of experimental brain tumors using neural progenitor cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/74710" "Revista" => array:6 [ "tituloSerie" => "Nat. Med." "fecha" => "2000" "volumen" => "6" "paginaInicial" => "447" "paginaFinal" => "450" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase I studies of treatment of malignant gliomas and neoplastic meningitis with <span class="elsevierStyleSup">131</span>I-radiolabeled monoclonal antibodies antitenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F(ab’)2: A preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol." "fecha" => "1995" "volumen" => "24" "paginaInicial" => "109" "paginaFinal" => "122" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: Phase I trial results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1998.16.6.2202" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol." "fecha" => "1998" "volumen" => "16" "paginaInicial" => "2202" "paginaFinal" => "2212" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glioblastoma multiforme: A controlled trial to assess the value of specific active immunotherapy in patients treated by radical surgery and radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1973" "volumen" => "27" "paginaInicial" => "253" "paginaFinal" => "267" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autologous glioma transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1960" "volumen" => "2" "paginaInicial" => "77" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunosuppression and Transforming Growth Factor-beta in glioblastoma: preferential production of transforming growth factor-beta 2" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1989" "volumen" => "143" "paginaInicial" => "3222" "paginaFinal" => "3229" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Junctions between intimately apposed cell membranes in the vertebrate brain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cell Biol" "fecha" => "1969" "volumen" => "40" "paginaInicial" => "648" "paginaFinal" => "677" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Depressed cell-mediated immunity in patients with primary intracranial tumors: characterization of a humoral immunosuppressive factor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1972" "volumen" => "136" "paginaInicial" => "1631" "paginaFinal" => "1647" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of lymphocyte invasion and survival of brain tumor patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410040305" "Revista" => array:7 [ "tituloSerie" => "Ann Neurol" "fecha" => "1978" "volumen" => "4" "paginaInicial" => "219" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ …2] ] "itemHostRev" => array:3 [ "pii" => "S0735109711001768" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunobiology of primary intracranial tumors, part 5: correlation of a lymphocyte index and clinical status" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1981.54.3.0331" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1981" "volumen" => "54" "paginaInicial" => "331" "paginaFinal" => "337" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antitumor and antimetastatic activity of interleukin 12 against murine tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1993" "volumen" => "178" "paginaInicial" => "1223" "paginaFinal" => "1230" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II evaluation of recombinant interferon alpha and BCNU in recurrent glioma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1995.82.3.0430" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1995" "volumen" => "82" "paginaInicial" => "430" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of the proinflammatory effects of Fas ligand (CD95L)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1998" "volumen" => "282" "paginaInicial" => "1714" "paginaFinal" => "1717" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2000.18.22.3862" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "3862" "paginaFinal" => "3872" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0167-5699(92)90027-5" "Revista" => array:6 [ "tituloSerie" => "Immunol. Today." "fecha" => "1992" "volumen" => "13" "paginaInicial" => "507" "paginaFinal" => "512" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A surgical history of Maida Vale Hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Biology of brain tumor" "serieFecha" => "1986" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunology of brain tumors and implications for immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Brain tumors" "paginaInicial" => "135" "paginaFinal" => "150" "edicion" => "2<span class="elsevierStyleSup">nd</span>" "serieFecha" => "2003" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interferon α-2a and external beam radiotherapy in the initial management of patients with glioma: a pilot study of the national biotherapy study group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Biother" "fecha" => "1995" "volumen" => "10" "paginaInicial" => "265" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The neurosurgeon as local oncologist: cellular and molecular neurosurgery in malignant glioma therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2003" "volumen" => "52" "paginaInicial" => "1411" "paginaFinal" => "1424" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A Phase I study of an anti-epidermal growth factor receptor monoclonal antibody for the treatment of malignant gliomas" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1996" "volumen" => "39" "paginaInicial" => "478" "paginaFinal" => "483" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "1996" "volumen" => "93" "paginaInicial" => "2909" "paginaFinal" => "2914" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New directions in natural killer cell-based immunotherapy of human cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1517/14712598.3.2.237" "Revista" => array:6 [ "tituloSerie" => "Expert Opin Biol Ther" "fecha" => "2003" "volumen" => "3" "paginaInicial" => "237" "paginaFinal" => "250" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomised, controlled study of intratumoral recombinant γ-interferon treatment in newly diagnosed glioblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "1994" "volumen" => "70" "paginaInicial" => "138" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination immunotherapy with rituximab and interleukin 2 in patients with relapsed or refractory follicular non-Hodgkin's lymphoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true …1 ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Haematol" "fecha" => "2002" "volumen" => "117" "paginaInicial" => "828" "paginaFinal" => "834" "link" => array:1 [ …1] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracerebral versus subcutaneous immunization with allogenic fibroblasts genetically engineered to secrete interleukin-2 in the treatment of central nervous system glioma and melanoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1997" "volumen" => "41" "paginaInicial" => "898" "paginaFinal" => "906" "link" => array:1 [ …1] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment with allogeneic interleukin-2 secreting fibroblasts protects against the development of malignant brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "2003" "volumen" => "64" "paginaInicial" => "139" "paginaFinal" => "146" "link" => array:1 [ …1] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signalling in T cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nm1001-1118" "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "1118" "paginaFinal" => "1122" "link" => array:1 [ …1] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microglia are the major cell type expressing MHC class II in human white matter" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J. Neurol. Sci." "fecha" => "1987" "volumen" => "80" "paginaInicial" => "25" "paginaFinal" => "37" "link" => array:1 [ …1] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved long term survival after intracavitary interleukin-2 and lymphokine-activated killer cells for adults with recurrent malignant glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1995" "volumen" => "76" "paginaInicial" => "840" "paginaFinal" => "852" "link" => array:1 [ …1] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2002" "volumen" => "98" "paginaInicial" => "352" "paginaFinal" => "356" "link" => array:1 [ …1] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination for experimental gliomas using GM-CSF-transduced glioma cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Gene Ther" "fecha" => "1997" "volumen" => "4" "paginaInicial" => "345" "paginaFinal" => "352" "link" => array:1 [ …1] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Leukocyte traffic in the Central Nervous System: the participants and their roles" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semin Inmunol" "fecha" => "1999" "volumen" => "11" "paginaInicial" => "125" "paginaFinal" => "137" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autologous tumor cell vaccination combined with adoptive cellular immunotherapy in patients with grade III/IV astrocytoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "1996" "volumen" => "27" "paginaInicial" => "179" "paginaFinal" => "189" "link" => array:1 [ …1] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "1996" "volumen" => "2" "paginaInicial" => "52" "paginaFinal" => "58" "link" => array:1 [ …1] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent pathway of tumor cell-mediated immunosuppression" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1992" "volumen" => "148" "paginaInicial" => "277" "paginaFinal" => "284" "link" => array:1 [ …1] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunomodulatory effects of transforming growth factor-beta on lymphocytes. Induction of CD8 expression in the CTLL-2 cell line and in normal thymocytes" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1992" "volumen" => "148" "paginaInicial" => "3847" "paginaFinal" => "3856" "link" => array:1 [ …1] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salvage immunotherapy of malignant glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1987" "volumen" => "122" "paginaInicial" => "1483" "paginaFinal" => "1486" "link" => array:1 [ …1] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modulation of proliferation and antigen expression of a cloned human glioblastoma by interleukin-4 alone and in combination with tumor necrosis factor-alpha and/or interferon-gamma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1993" "volumen" => "33" "paginaInicial" => "489" "paginaFinal" => "494" "link" => array:1 [ …1] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapy of recurrent high grade gliomas with surgery, and autologous mitogen activated IL-2 stimulated killer (MAK) lymphocytes. I. Enhancement of MAK lytic activity and cytokine production by PHA and clinical use of PHA" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "1993" "volumen" => "15" "paginaInicial" => "141" "paginaFinal" => "155" "link" => array:1 [ …1] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth factor-mediated angiogenesis in the malignant progression of glial tumors: a review" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surg Neurol" "fecha" => "1998" "volumen" => "49" "paginaInicial" => "189" "paginaFinal" => "195" "link" => array:1 [ …1] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intratumor application of human leukocyte interferon-α in patients with malignant brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Oncol" "fecha" => "1989" "volumen" => "12" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ …1] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Addition of IFN-alpha to treatment of malignant brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Oncol" "fecha" => "1994" "volumen" => "33" "paginaInicial" => "651" "paginaFinal" => "654" "link" => array:1 [ …1] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Local immunotherapy of glioma patients with a combination of 2 bispecific antibody fragments and resting autologous lymphocytes: evidence for in situ T-cell activation and therapeutic efficacy" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2001" "volumen" => "91" "paginaInicial" => "225" "paginaFinal" => "230" "link" => array:1 [ …1] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1986" "volumen" => "137" "paginaInicial" => "3855" "paginaFinal" => "3860" "link" => array:1 [ …1] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1986" "volumen" => "163" "paginaInicial" => "1037" "paginaFinal" => "1050" "link" => array:1 [ …1] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2001" "volumen" => "97" "paginaInicial" => "3132" "paginaFinal" => "3137" "link" => array:1 [ …1] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of recurrent glioma with intracavitary alloreactive cytotoxic T lymphocytes and interleukin-2" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Immunol Immunother" "fecha" => "1997" "volumen" => "45" "paginaInicial" => "77" "paginaFinal" => "87" "link" => array:1 [ …1] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human Leucemic T-Cell line, TALL-104, is cytotoxic to human malignant brain tumors and traffics through brain tissue: implications for local adoptive immunotherapy" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "2000" "volumen" => "60" "paginaInicial" => "5731" "paginaFinal" => "5739" "link" => array:1 [ …1] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EGFRvIII as a promising target for antibody-based brain tumor therapy" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain Tumor Pathol" "fecha" => "2000" "volumen" => "17" "paginaInicial" => "71" "paginaFinal" => "78" "link" => array:1 [ …1] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Cancer" "fecha" => "2000" "volumen" => "15" "paginaInicial" => "962" "paginaFinal" => "969" "link" => array:1 [ …1] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of PGE2- and cAMP-modulating agents on human glioblastoma cell killing by interleukin-2-activated lymphocytes" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1990.72.4.0619" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1990" "volumen" => "72" "paginaInicial" => "619" "paginaFinal" => "625" "link" => array:1 [ …1] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modulation by interferon alpha of the decreased natural killer activity in patients with glioblastoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir (Wien)" "fecha" => "1991" "volumen" => "109" "paginaInicial" => "109" "paginaFinal" => "113" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors”" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "1997" "volumen" => "3" "paginaInicial" => "1362" "paginaFinal" => "1368" "link" => array:1 [ …1] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1999.90.6.1115" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1999" "volumen" => "90" "paginaInicial" => "1115" "paginaFinal" => "1124" "link" => array:1 [ …1] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor immunity within the Central Nervous System stimulated by recombinant Listeria monocytogenes vaccination" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "2002" "volumen" => "62" "paginaInicial" => "2287" "paginaFinal" => "2293" "link" => array:1 [ …1] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2001: Things to come" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2001" "volumen" => "49" "paginaInicial" => "765" "paginaFinal" => "778" "link" => array:1 [ …1] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cell-mediated immunotherapy: a new approach to the treatment of malignant glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Control" "fecha" => "2003" "volumen" => "10" "paginaInicial" => "138" "paginaFinal" => "147" "link" => array:1 [ …1] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunobiology of primary intracranial tumors, part 1: studies of the cellular and humoral general immune competence of brain-tumor patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1977.46.4.0467" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1977" "volumen" => "46" "paginaInicial" => "467" "paginaFinal" => "476" "link" => array:1 [ …1] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intratumoral and Intraventricular Human Lymphoblastoid Alpha Interferon (HLBI) for treatment of Glioblastoma Multiforme" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir (Wien)" "fecha" => "1989" "volumen" => "100" "paginaInicial" => "46" "paginaFinal" => "49" ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparison of leukocyte responses to heat-killed bacillus Calmette-Guerin in different CNS compartments" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuropathol. Appl. Neurobiol." "fecha" => "1996" "volumen" => "22" "paginaInicial" => "44" "paginaFinal" => "53" "link" => array:1 [ …1] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammation in the CNS: balance between immunological privilege and immune responses" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Prog Neurobiol" "fecha" => "1998" "volumen" => "56" "paginaInicial" => "19" "paginaFinal" => "35" "link" => array:1 [ …1] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunity to homologous grafted skin: the fate of skin homografts transplanted to the brain, to subcutaneous tissue, to the anterior chamber of the eye" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Exp Pathol" "fecha" => "1948" "volumen" => "29" "paginaInicial" => "58" "paginaFinal" => "69" "link" => array:1 [ …1] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adoptive immunotherapy for recurrent glioblastoma multiforme using lymphokine activated killer cells and recombinant interleukin-2" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1988" "volumen" => "62" "paginaInicial" => "665" "paginaFinal" => "671" "link" => array:1 [ …1] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intralesional infusion of lymphokine activated killer (LAK) cells and recombinant interleukin-2 (rIL2) for the treatment of patients with malignant brain tumor" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "1988" "volumen" => "23" "paginaInicial" => "725" "paginaFinal" => "732" "link" => array:1 [ …1] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "1990" "volumen" => "8" "paginaInicial" => "173" "paginaFinal" => "188" "link" => array:1 [ …1] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of recurrent malignant glioma by repeated intracerebral injections of human recombinant interleukin-2 alone or in combination with systemic interferon-α. Results of a phase I clinical trial" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "1992" "volumen" => "12" "paginaInicial" => "75" "paginaFinal" => "83" "link" => array:1 [ …1] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of epidermal growth factor receptor-425 monoclonal antibodies radiolabeled with iodine-125 in the adjuvant treatment of patients with high grade gliomas of the brain. Recent Results" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Research" "fecha" => "1996" "volumen" => "141" "paginaInicial" => "183" "paginaFinal" => "192" ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant immunotherapy for solid tumors: from promise to clinical application" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00262-002-0308-0" "Revista" => array:6 [ "tituloSerie" => "Cancer Immunol Immunother" "fecha" => "2002" "volumen" => "51" "paginaInicial" => "583" "paginaFinal" => "595" "link" => array:1 [ …1] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TGF-B independent induction of immunogenicity by decorin gene transfer in human malignant glioma cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Immunol" "fecha" => "1999" "volumen" => "29" "paginaInicial" => "1032" "paginaFinal" => "1040" "link" => array:1 [ …1] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nat Med" "fecha" => "1998" "volumen" => "4" "paginaInicial" => "328" "paginaFinal" => "332" "link" => array:1 [ …1] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib74" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preliminary trial of specific targeting therapy against malignant glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1990" "volumen" => "335" "paginaInicial" => "368" "paginaFinal" => "376" "link" => array:1 [ …1] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib75" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glioma immunology and immunotherapy" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2000" "volumen" => "46" "paginaInicial" => "778" "paginaFinal" => "792" "link" => array:1 [ …1] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib76" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Astrocytoma infiltrating lymphocytes include major T cell clonal expansions confined to the CD8 subset" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int Immunol" "fecha" => "1999" "volumen" => "11" "paginaInicial" => "1337" "paginaFinal" => "1349" "link" => array:1 [ …1] ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib77" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic T cell adoptive immunotherapy of malignant gliomas" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1998.89.1.0042" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "1998" "volumen" => "89" "paginaInicial" => "42" "paginaFinal" => "51" "link" => array:1 [ …1] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib78" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunology and Immunotherapy in Neurosurgical disease" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neurosurgery" "fecha" => "2003" "volumen" => "53" "paginaInicial" => "114" "paginaFinal" => "153" ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib79" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Cancer Research" "fecha" => "2000" "volumen" => "6" "paginaInicial" => "2157" "paginaFinal" => "2165" ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib80" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "1987" "volumen" => "166" "paginaInicial" => "991" "paginaFinal" => "998" "link" => array:1 [ …1] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib81" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II trial of murine <span class="elsevierStyleSup">131</span>I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.2002.20.5.1389" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "1389" "paginaFinal" => "1397" "link" => array:1 [ …1] ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib82" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1994" "volumen" => "54" "paginaInicial" => "2218" "paginaFinal" => "2222" "link" => array:1 [ …1] ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib83" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Local immunotherapy with Interleukin-2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery" "fecha" => "2003" "volumen" => "52" "paginaInicial" => "872" "paginaFinal" => "880" "link" => array:1 [ …1] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib84" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with <span class="elsevierStyleSup">90</span>Y: a phase I study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "1999" "volumen" => "5" "paginaInicial" => "3275s" "paginaFinal" => "3280s" "link" => array:1 [ …1] ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib85" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleSup">131</span>I radioconjugated antibodies for the locoregional radioimmunotherapy of high-grade malignant glioma: phase I and II study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Oncol" "fecha" => "1999" "volumen" => "38" "paginaInicial" => "351" "paginaFinal" => "359" "link" => array:1 [ …1] ] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib86" "etiqueta" => "86." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1986" "volumen" => "233" "paginaInicial" => "1318" "paginaFinal" => "1321" "link" => array:1 [ …1] ] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib87" "etiqueta" => "87." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198704093161501" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1987" "volumen" => "316" "paginaInicial" => "889" "paginaFinal" => "897" "link" => array:1 [ …1] ] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib88" "etiqueta" => "88." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modulation of T-cell function by gliomas" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0167-5699(91)90068-5" "Revista" => array:6 [ "tituloSerie" => "Immunol Today" "fecha" => "1991" "volumen" => "12" "paginaInicial" => "370" "paginaFinal" => "374" "link" => array:1 [ …1] ] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib89" "etiqueta" => "89." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors, including transforming growth factor beta, released in the glioblastoma residual cavity, impair activity of adherent lymphokine-activated killer cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Immunol Immunother" "fecha" => "1993" "volumen" => "36" "paginaInicial" => "409" "paginaFinal" => "416" "link" => array:1 [ …1] ] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib90" "etiqueta" => "90." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of donor natural killers cell alloreactivity in mismatched hematopoietic transplants" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1126/science.1068440" "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "2002" "volumen" => "295" "paginaInicial" => "2097" "paginaFinal" => "3100" "link" => array:1 [ …1] ] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib91" "etiqueta" => "91." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Paracrine Immunotherapy with interleukin-2 and local Chemotherapy is synergistic in the treatment of experimental brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1999" "volumen" => "59" "paginaInicial" => "2107" "paginaFinal" => "2114" "link" => array:1 [ …1] ] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib92" "etiqueta" => "92." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.130166597" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "2000" "volumen" => "97" "paginaInicial" => "7503" "paginaFinal" => "7508" "link" => array:1 [ …1] ] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib93" "etiqueta" => "93." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunological aspects of brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "H.KrayenbühlP.E.MaspesW.H.Sweet" "paginaInicial" => "267" "paginaFinal" => "291" "serieVolumen" => "2" "serieTitulo" => "Progress in neurological surgery" "serieFecha" => "1968" ] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib94" "etiqueta" => "94." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-2 gene therapy in a patient with glioblastoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gene Ther" "fecha" => "1995" "volumen" => "2" "paginaInicial" => "164" "paginaFinal" => "167" "link" => array:1 [ …1] ] ] ] ] ] ] 94 => array:3 [ "identificador" => "bib95" "etiqueta" => "95." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.gt.3300709" "Revista" => array:6 [ "tituloSerie" => "Gene Ther" "fecha" => "1998" "volumen" => "5" "paginaInicial" => "1187" "paginaFinal" => "1194" "link" => array:1 [ …1] ] ] ] ] ] ] 95 => array:3 [ "identificador" => "bib96" "etiqueta" => "96." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1994" "volumen" => "54" "paginaInicial" => "182" "paginaFinal" => "189" "link" => array:1 [ …1] ] ] ] ] ] ] 96 => array:3 [ "identificador" => "bib97" "etiqueta" => "97." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of phase I/II clinical trials in prostate cancer with dendritic cells and PSMA peptides" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Prostate" "fecha" => "1998" "volumen" => "36" "paginaInicial" => "39" "paginaFinal" => "44" "link" => array:1 [ …1] ] ] ] ] ] ] 97 => array:3 [ "identificador" => "bib98" "etiqueta" => "98." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RG-2 glioma growth attenuation and severe brain edema caused by local production of IL-4 and IFN-γ" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1995" "volumen" => "55" "paginaInicial" => "1902" "paginaFinal" => "1910" "link" => array:1 [ …1] ] ] ] ] ] ] 98 => array:3 [ "identificador" => "bib99" "etiqueta" => "99." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in molecular therapies in patients with brain tumors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Control" "fecha" => "2003" "volumen" => "10" "paginaInicial" => "125" "paginaFinal" => "137" "link" => array:1 [ …1] ] ] ] ] ] ] 99 => array:3 [ "identificador" => "bib100" "etiqueta" => "100." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunology and immunotherapy of cerebral tumors. Current status" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Neurol (Paris)" "fecha" => "1973" "volumen" => "128" "paginaInicial" => "23" "paginaFinal" => "38" ] ] ] ] ] ] 100 => array:3 [ "identificador" => "bib101" "etiqueta" => "101." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokines and tumors of the Central Nervous System" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/glia.440150308" "Revista" => array:6 [ "tituloSerie" => "Glia" "fecha" => "1995" "volumen" => "15" "paginaInicial" => "264" "paginaFinal" => "288" "link" => array:1 [ …1] ] ] ] ] ] ] 101 => array:3 [ "identificador" => "bib102" "etiqueta" => "102." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy of Glioblastoma with Intratumoral administration of autologous Lymphocytes and human Lymphoblastoid Interferon. A further clinical Study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir (Wien)" "fecha" => "1991" "volumen" => "109" "paginaInicial" => "42" "paginaFinal" => "45" "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 102 => array:3 [ "identificador" => "bib103" "etiqueta" => "103." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "1997" "volumen" => "158" "paginaInicial" => "4521" "paginaFinal" => "4524" "link" => array:1 [ …1] ] ] ] ] ] ] 103 => array:3 [ "identificador" => "bib104" "etiqueta" => "104." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "T-cells responses in the brain and their relevance for cerebral malignancies" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Brain Res Rev" "fecha" => "2003" "volumen" => "42" "paginaInicial" => "97" "paginaFinal" => "112" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 104 => array:3 [ "identificador" => "bib105" "etiqueta" => "105." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab-induced antibody dependent cellular cytotoxicity (ADCC) in follicular non-Hodgkin's lymphoma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Blood" "fecha" => "2002" "volumen" => "100" "paginaInicial" => "157a" ] ] ] ] ] ] 105 => array:3 [ "identificador" => "bib106" "etiqueta" => "106." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6601268" "Revista" => array:6 [ "tituloSerie" => "Br J Cancer" "fecha" => "2003" "volumen" => "89" "paginaInicial" => "1172" "paginaFinal" => "1179" "link" => array:1 [ …1] ] ] ] ] ] ] 106 => array:3 [ "identificador" => "bib107" "etiqueta" => "107." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2003.99.4.0746" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg" "fecha" => "2003" "volumen" => "99" "paginaInicial" => "746" "paginaFinal" => "753" "link" => array:1 [ …1] ] ] ] ] ] ] 107 => array:3 [ "identificador" => "bib108" "etiqueta" => "108." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cell-based glioma immunotherapy (review)" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Oncol" "fecha" => "2003" "volumen" => "23" "paginaInicial" => "5" "paginaFinal" => "15" "link" => array:1 [ …1] ] ] ] ] ] ] 108 => array:3 [ "identificador" => "bib109" "etiqueta" => "109." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of glioma by engineered IL-4 secreting cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1993" "volumen" => "53" "paginaInicial" => "3125" "paginaFinal" => "3128" "link" => array:1 [ …1] ] ] ] ] ] ] 109 => array:3 [ "identificador" => "bib110" "etiqueta" => "110." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2001" "volumen" => "61" "paginaInicial" => "842" "paginaFinal" => "847" "link" => array:1 [ …1] ] ] ] ] ] ] 110 => array:3 [ "identificador" => "bib111" "etiqueta" => "111." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth inhibitory effect of recombinant α and β interferon on human glioma cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neurooncol" "fecha" => "1987" "volumen" => "5" "paginaInicial" => "320" "paginaFinal" => "330" ] ] ] ] ] ] 111 => array:3 [ "identificador" => "bib112" "etiqueta" => "112." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pilot study of recombinant interferon beta (IFN-β ser) in patients with recurrent glioma" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurooncol" "fecha" => "1990" "volumen" => "9" "paginaInicial" => "29" "paginaFinal" => "34" "link" => array:1 [ …1] ] ] ] ] ] ] 112 => array:3 [ "identificador" => "bib113" "etiqueta" => "113." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy of malignant brain tumors in children and adults: from theoretical principles to clinical application" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Child's Nerv Sys" "fecha" => "1999" "volumen" => "15" "paginaInicial" => "514" "paginaFinal" => "528" ] ] ] ] ] ] 113 => array:3 [ "identificador" => "bib114" "etiqueta" => "114." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Directional and compartimentalised drainage of interstitial fluid and cerebrospinal fluid from the rat brain" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neuropathol" "fecha" => "1992" "volumen" => "83" "paginaInicial" => "233" "paginaFinal" => "239" "link" => array:1 [ …1] ] ] ] ] ] ] 114 => array:3 [ "identificador" => "bib115" "etiqueta" => "115." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transforming growth factor-beta 2 down-regulates HLA-DR antigen expression on human malignant glioma cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/eji.1830181023" "Revista" => array:6 [ "tituloSerie" => "Eur J Immunol" "fecha" => "1988" "volumen" => "18" "paginaInicial" => "1623" "paginaFinal" => "1626" "link" => array:1 [ …1] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001600000004/v1_201305151241/S1130147305704012/v1_201305151241/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001600000004/v1_201305151241/S1130147305704012/v1_201305151241/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147305704012?idApp=UINPBA00004B" ]
