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          "autoresLista" => "J.L. Gil Salú"
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    "titulo" => "IV. Angiogénesis en oligodendrogliomas"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En la presente revisi&#243;n se muestra la experiencia de los autores en el estudio de los patrones de angiog&#233;nesis en oligodendrogliomas&#46; Marcando inmunohistoqu&#237;micamente el endotelio vascular &#40;CD-34&#41; se aprecia que los oligodendrogliomas malignos muestran un t&#237;pico patr&#243;n glomeruloide de los capilares intratumorales&#44; que contrasta con el aspecto lineal de los capilares correspondientes a los oligodendrogliomas de bajo grado&#46; Cuando se realizan estudios cuantitativos se observa que&#44; al contrario de observaciones descritas en astrocitomas&#44; en oligodendrogliomas de bajo grado &#40;al menos cuado se cumplen las condiciones de haber presentado un &#237;ndice de Ki-67 inferior a 1&#37; Y haber sido tratados con cirug&#237;a y radioterapia&#41; el simple an&#225;lisis de la densidad vascular no parece constituir un factor pron&#243;stico significativo&#46; Sin embargo&#44; s&#237; se obtiene significaci&#243;n pron&#243;stica cuando se analiza morfom&#233;tricamente el &#225;rea endotelial en relaci&#243;n al n&#250;mero de c&#233;lulas&#46; Pacientes con tumores que presentaron un &#237;ndice de superficie vascular &#40;ISV&#41; superior a 15<span class="elsevierStyleHsp" style=""></span>&#956;m<span class="elsevierStyleSup">2</span> tuvieron una supervivencia a 5 y 10 a&#241;os del 50 y 0&#37; respectivamente&#44; frente a una supervivencia del 100 y 71&#37; para pacientes cuyos tumores mostraron un ISV inferior a 15<span class="elsevierStyleHsp" style=""></span>&#956;m<span class="elsevierStyleSup">2</span>&#46;</p>"
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        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The authors show the different patterns of angiogenesis in oligodendrogliomas after inmunohistochemical demonstration of the endothelial marker CD-34&#46; High-grade oligodendrogliomas show a glomeruloid morphology of intratumor vessels&#46; Nevertheless low-grade oligodendrogliomas show a lineal pattern of intratumor vessels&#46; Furthermore&#44; in contrast with previous observations in astrocytomas&#44; the present study suggests that tumor angiogenesis&#44; expressed as number of microvessels in tumor specimens&#44; has no influence on behavior of low-grade oligodendrogliomas&#46; In low-grade oligodendrogliomas treated by surgery and radiotherapy&#44; and showing a Ki-67 index lesser to 1&#37;&#44; a tumor vascular surface index &#40;VSI&#41; was determined as the CD-34 immunostained endothelial surface in &#956;m<span class="elsevierStyleSup">2</span> per 1000 tumor cells&#46; Patients with a VSI of less than 15 showed a survival at 5 and 10 years of 100&#37; and 71&#37;&#44; respectively&#44; versus a survival of 50&#37; and 0&#37; for patients presenting a VSI greater than 15 &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">These observations suggest the usefulness of the VSI as a long-term prognostic factor in low-grade oligodendroglioma&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara">Vaquero&#44; J&#46;&#59; Zurita&#44; M&#46;&#59; Coca&#44; S&#46;&#58; Oligodendrogliomas&#58; Estado actual&#46; IV&#46; Angiog&#233;nesis en oligodendrogliomas&#46; Neurocirug&#237;a 1999&#59; 10&#58; 388&#8211;392&#46;</p>"
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                    0 => array:2 [
                      "titulo" => "Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma"
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                            3 => "X&#46;Y&#46; Yang"
                            4 => "J&#46;P&#46; Rock"
                            5 => "M&#46;L&#46; Rosenblum"
                          ]
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                    0 => array:2 [
                      "doi" => "10.3171/jns.1998.88.3.0513"
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                        "tituloSerie" => "J&#46; Neurosurg&#46;"
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                        "volumen" => "88"
                        "paginaInicial" => "513"
                        "paginaFinal" => "520"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9488306"
                            "web" => "Medline"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Pathol&#46; Bacteriol&#46;"
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                        "volumen" => "32"
                        "paginaInicial" => "735"
                        "paginaFinal" => "751"
                      ]
                    ]
                  ]
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              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Classificatiou of the Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis"
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                    0 => array:1 [
                      "Libro" => array:3 [
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                        "editorial" => "JB Lippincott"
                        "editorialLocalizacion" => "Philadelphia"
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                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Surgical aspects and general management of oligodendrogliomas"
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                        "paginaInicial" => "397"
                        "paginaFinal" => "412"
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                        "serieTitulo" => "Benign Cerebral Glioma"
                        "serieFecha" => "1995"
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                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Clinicopathologic correlations in the oligodendroglioma"
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                            2 => "E&#46;B&#46; Cox"
                            3 => "R&#46;E&#46; Mc Lendon"
                            4 => "S&#46;C&#46; Schold Jr&#46;"
                            5 => "D&#46;E&#46; Bullard"
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                    ]
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                    0 => array:1 [
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                        "tituloSerie" => "Cancer"
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                        "paginaInicial" => "1&#46;345"
                        "paginaFinal" => "1&#46;352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3567872"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Surgical Pathology of the Nervous System and its Coverings"
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                            0 => "P&#46;C&#46; Burger"
                            1 => "F&#46;S&#46; Vogel"
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                        "edicion" => "ed 2&#46;"
                        "fecha" => "1982"
                        "editorial" => "John Wiley &#38; Sons"
                        "editorialLocalizacion" => "New York"
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                    0 => array:2 [
                      "titulo" => "The prognostic significance of Ki-67 labeling indices for oligodendrogliomas"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;W&#46; Coons"
                            1 => "P&#46;C&#46; Johnson"
                            2 => "D&#46;K&#46; Pearl"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1997"
                        "volumen" => "41"
                        "paginaInicial" => "878"
                        "paginaFinal" => "885"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9316050"
                            "web" => "Medline"
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                ]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracranial Tumours&#46; Notes Upon a Series of Two Thousand Verified Cases with Surgical-Mortality Percentages Pertaining Thereto"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                    ]
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                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1932"
                        "editorial" => "Charles C Thomas"
                        "editorialLocalizacion" => "Springfield&#44; III"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Grading of astrocytomas&#46; A simple and reproducible method"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Daumas-Duport"
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                            2 => "J&#46; O&#8217;Fallon"
                            3 => "P&#46; Kelly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1988"
                        "volumen" => "62"
                        "paginaInicial" => "2&#46;152"
                        "paginaFinal" => "2&#46;156"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3263896"
                            "web" => "Medline"
                          ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Oligodendrogliomas&#46; Part 1&#58; Patterns of growth&#44; histological diagnosis&#44; clinical and imaging correlations&#58; a study of 153 cases"
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                            2 => "M&#46;L&#46; Tucker"
                            3 => "F&#46; Beuvon"
                            4 => "P&#46; Cervera"
                            5 => "J&#46;P&#46; Chodkiewicz"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurooncol&#46;"
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                        "paginaInicial" => "37"
                        "paginaFinal" => "59"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9210052"
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                      "titulo" => "Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis"
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                          "autores" => array:4 [
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                            3 => "O&#46; Broendstrup"
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                        "tituloSerie" => "Cancer"
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                        "paginaFinal" => "1&#46;813"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8625086"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nonparametric estimation for incomplete observations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;L&#46; Kaplan"
                            1 => "P&#46; Meier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J&#46; Am&#46; Stat&#46; Assoc&#46;"
                        "fecha" => "1958"
                        "volumen" => "53"
                        "paginaInicial" => "457"
                        "paginaFinal" => "481"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;M&#46; Kros"
                            1 => "W&#46;C&#46; Hop"
                            2 => "J&#46;J&#46; Godschakl"
                            3 => "K&#46;K&#46; Krishnadath"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1996"
                        "volumen" => "78"
                        "paginaInicial" => "1&#46;107"
                        "paginaFinal" => "1&#46;113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8952566"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statistical analysis of clinico pathological features&#44; radiotherapy&#44; and survival in 170 cases of oligodendroglioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "K&#46;F&#46; Lindegaard"
                            1 => "S&#46;J&#46; Mork"
                            2 => "G&#46;E&#46; Eide"
                            3 => "T&#46;B&#46; Halvorsen"
                            4 => "R&#46; Hatlevoli"
                            5 => "T&#46; Solgaard"
                            6 => "O&#46; Dahl"
                            7 => "J&#46; Ganz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1987.67.2.0224"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1987"
                        "volumen" => "67"
                        "paginaInicial" => "224"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3598683"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oligodendroglioma&#46; Histologic evaluation and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;J&#46; Mork"
                            1 => "T&#46;B&#46; Halvorsen"
                            2 => "K&#46;F&#46; Lindegaard"
                            3 => "G&#46;E&#46; Eide"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neuropathol&#46; Exp&#46; Neurol&#46;"
                        "fecha" => "1986"
                        "volumen" => "45"
                        "paginaInicial" => "65"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3941327"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oligodendroglioma&#58; incidence and biological behavior in a defined population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "S&#46;J&#46; Mork"
                            1 => "K&#46;F&#46; Lindegaard"
                            2 => "T&#46;B&#46; Halvorsen"
                            3 => "E&#46;H&#46; Lehmann"
                            4 => "T&#46; Solgaard"
                            5 => "R&#46; Hatlevoli"
                            6 => "S&#46; Harvei"
                            7 => "J&#46; Ganz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1985.63.6.0881"
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1985"
                        "volumen" => "63"
                        "paginaInicial" => "881"
                        "paginaFinal" => "889"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4056902"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of radiation therapy in the treatment of cerebral oligodendroglioma&#58; an analysis of 57 cases and a literature review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;P&#46; Reedy"
                            1 => "J&#46;W&#46; Bay"
                            2 => "J&#46;F&#46; Hahn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1983"
                        "volumen" => "13"
                        "paginaInicial" => "499"
                        "paginaFinal" => "503"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6646376"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathology of Tumours of the Nervous System"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Russell"
                            1 => "L&#46;J&#46; Rubinstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "ed 4"
                        "fecha" => "1977"
                        "editorial" => "Edward Amold"
                        "editorialLocalizacion" => "London"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The natural history of low-grade gliomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Salcman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "paginaInicial" => "213"
                        "paginaFinal" => "229"
                        "serieVolumen" => "Vol&#46; II"
                        "serieTitulo" => "Benign Cerebral Glioma"
                        "serieFecha" => "1995"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oligodendrogliomas&#58; the Mayo Cl&#237;nic experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;G&#46; Shaw"
                            1 => "B&#46;W&#46; Seheithauer"
                            2 => "J&#46;R&#46; O&#8217;Fallon"
                            3 => "H&#46;D&#46; Tazelaar"
                            4 => "D&#46;H&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurosurg"
                        "fecha" => "1992"
                        "volumen" => "76"
                        "paginaInicial" => "428"
                        "paginaFinal" => "434"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oligodendrogliomas&#58; CT-patterns with emphasis on features indicating malignaney"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Vonofakos"
                            1 => "H&#46; Mareu"
                            2 => "H&#46; Haeker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J&#46; Computo Assist&#46; Tomogr&#46;"
                        "fecha" => "1979"
                        "volumen" => "3"
                        "paginaInicial" => "783"
                        "paginaFinal" => "788"
                        "itemHostRev" => array:3 [
                          "pii" => "S0735109704008708"
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                          "issn" => "07351097"
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                  ]
                ]
              ]
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            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of oligodendrogliomas with or without postoperative irradiation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;E&#46; Wallner"
                            1 => "M&#46; Gonzales"
                            2 => "G&#46;E&#46; Sheliny"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1988.68.5.0684"
                      "Revista" => array:7 [
                        "tituloSerie" => "J&#46; Neurosurg&#46;"
                        "fecha" => "1988"
                        "volumen" => "68"
                        "paginaInicial" => "684"
                        "paginaFinal" => "688"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3357029"
                            "web" => "Medline"
                          ]
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                          "pii" => "S120197120700152X"
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Vol. 10. Núm. 5.
Páginas 388-392 (enero 1998)
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Vol. 10. Núm. 5.
Páginas 388-392 (enero 1998)
IV. Angiogénesis en oligodendrogliomas
IV. Angiogenesis in oligodendrogliomas
Visitas
1351
J. Vaquero, M. Zurita, S. Coca
Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina, Laboratorio Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro, Madrid
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Resumen

En la presente revisión se muestra la experiencia de los autores en el estudio de los patrones de angiogénesis en oligodendrogliomas. Marcando inmunohistoquímicamente el endotelio vascular (CD-34) se aprecia que los oligodendrogliomas malignos muestran un típico patrón glomeruloide de los capilares intratumorales, que contrasta con el aspecto lineal de los capilares correspondientes a los oligodendrogliomas de bajo grado. Cuando se realizan estudios cuantitativos se observa que, al contrario de observaciones descritas en astrocitomas, en oligodendrogliomas de bajo grado (al menos cuado se cumplen las condiciones de haber presentado un índice de Ki-67 inferior a 1% Y haber sido tratados con cirugía y radioterapia) el simple análisis de la densidad vascular no parece constituir un factor pronóstico significativo. Sin embargo, sí se obtiene significación pronóstica cuando se analiza morfométricamente el área endotelial en relación al número de células. Pacientes con tumores que presentaron un índice de superficie vascular (ISV) superior a 15μm2 tuvieron una supervivencia a 5 y 10 años del 50 y 0% respectivamente, frente a una supervivencia del 100 y 71% para pacientes cuyos tumores mostraron un ISV inferior a 15μm2.

Palabras clave:
Oligodendroglioma
Factores pronósticos
Angiogénesis
Summary

The authors show the different patterns of angiogenesis in oligodendrogliomas after inmunohistochemical demonstration of the endothelial marker CD-34. High-grade oligodendrogliomas show a glomeruloid morphology of intratumor vessels. Nevertheless low-grade oligodendrogliomas show a lineal pattern of intratumor vessels. Furthermore, in contrast with previous observations in astrocytomas, the present study suggests that tumor angiogenesis, expressed as number of microvessels in tumor specimens, has no influence on behavior of low-grade oligodendrogliomas. In low-grade oligodendrogliomas treated by surgery and radiotherapy, and showing a Ki-67 index lesser to 1%, a tumor vascular surface index (VSI) was determined as the CD-34 immunostained endothelial surface in μm2 per 1000 tumor cells. Patients with a VSI of less than 15 showed a survival at 5 and 10 years of 100% and 71%, respectively, versus a survival of 50% and 0% for patients presenting a VSI greater than 15 (P<0.05).

These observations suggest the usefulness of the VSI as a long-term prognostic factor in low-grade oligodendroglioma.

Key words:
Oligodendroglioma
Prognostic factors
Angiogenesis

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