array:23 [
  "pii" => "S1130147306703189"
  "issn" => "11301473"
  "doi" => "10.1016/S1130-1473(06)70318-9"
  "estado" => "S300"
  "fechaPublicacion" => "2006-01-01"
  "aid" => "70318"
  "copyright" => "Sociedad Española de Neurocirugía"
  "copyrightAnyo" => "2006"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Neurocirugia. 2006;17:538-41"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1814
    "formatos" => array:3 [
      "EPUB" => 17
      "HTML" => 1036
      "PDF" => 761
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1130147306703190"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(06)70319-0"
    "estado" => "S300"
    "fechaPublicacion" => "2006-01-01"
    "aid" => "70319"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 2006;17:542-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1513
      "formatos" => array:3 [
        "EPUB" => 18
        "HTML" => 940
        "PDF" => 555
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Primary spinal cord oligodendroglioma. Case illustration"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "542"
          "paginaFinal" => "543"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Oligodendroglioma primario de la médula espinal. Caso clínico"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "E. Yucel, Ö. Ekinci"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "E."
              "apellidos" => "Yucel"
            ]
            1 => array:2 [
              "nombre" => "Ö."
              "apellidos" => "Ekinci"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "D. Gürkanlar, H. Koçak, A. Aciduman"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "D."
              "apellidos" => "Gürkanlar"
            ]
            1 => array:2 [
              "nombre" => "H."
              "apellidos" => "Koçak"
            ]
            2 => array:2 [
              "nombre" => "A."
              "apellidos" => "Aciduman"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703190?idApp=UINPBA00004B"
    "url" => "/11301473/0000001700000006/v1_201305151259/S1130147306703190/v1_201305151259/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1130147306703177"
    "issn" => "11301473"
    "doi" => "10.1016/S1130-1473(06)70317-7"
    "estado" => "S300"
    "fechaPublicacion" => "2006-01-01"
    "aid" => "70317"
    "copyright" => "Sociedad Española de Neurocirugía"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Neurocirugia. 2006;17:532-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1578
      "formatos" => array:3 [
        "EPUB" => 14
        "HTML" => 934
        "PDF" => 630
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Degeneración tumoral en meningocele no intervenido. Descripción de dos casos"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "532"
          "paginaFinal" => "537"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Tumoral degeneration occurring over a non-healing meningocele. Report of two cases"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:2 [
        0 => array:2 [
          "autoresLista" => "D. Rivero-Celada, L.I. Carcavilla-Loncán, J.M. Cantero-Antón, J. Eiras-Ajuria"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "D."
              "apellidos" => "Rivero-Celada"
            ]
            1 => array:2 [
              "nombre" => "L.I."
              "apellidos" => "Carcavilla-Loncán"
            ]
            2 => array:2 [
              "nombre" => "J.M."
              "apellidos" => "Cantero-Antón"
            ]
            3 => array:2 [
              "nombre" => "J."
              "apellidos" => "Eiras-Ajuria"
            ]
          ]
        ]
        1 => array:2 [
          "autoresLista" => "M.A. Marín-Cárdenas, J. Alfaro-Torres, F. Duato- Jané"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M.A."
              "apellidos" => "Marín-Cárdenas"
            ]
            1 => array:2 [
              "nombre" => "J."
              "apellidos" => "Alfaro-Torres"
            ]
            2 => array:2 [
              "nombre" => "F."
              "apellidos" => "Duato- Jané"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703177?idApp=UINPBA00004B"
    "url" => "/11301473/0000001700000006/v1_201305151259/S1130147306703177/v1_201305151259/es/main.assets"
  ]
  "es" => array:15 [
    "idiomaDefecto" => true
    "titulo" => "Macroadenoma de hipófisis descubierto incidentalmente. Indicaciones del tratamiento quirúrgico a propósito de dos casos"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "538"
        "paginaFinal" => "541"
      ]
    ]
    "autores" => array:2 [
      0 => array:4 [
        "autoresLista" => "C. Maciá-Bobes, G. Castaño-Fernández, P. Botas-Cervero"
        "autores" => array:3 [
          0 => array:3 [
            "nombre" => "C."
            "apellidos" => "Maciá-Bobes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "G&#46;"
            "apellidos" => "Casta&#241;o-Fern&#225;ndez"
          ]
          2 => array:2 [
            "nombre" => "P&#46;"
            "apellidos" => "Botas-Cervero"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Unidad de Endocrinolog&#237;a&#46; Hospital San Agust&#237;n&#46; Avil&#233;s&#46; Asturias"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Correspondencia postal&#58; C&#47; Pablo Laloux 13&#44; 6&#176; A-Sur&#46; 33405 Salinas&#46; Castrill&#243;n&#46; Asturias&#46;"
          ]
        ]
      ]
      1 => array:3 [
        "autoresLista" => "A&#46; Ronz&#243;n-Fern&#225;ndez"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Ronz&#243;n-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Unidad de Medicina de Familia&#46; Hospital San Agust&#237;n&#46; Avil&#233;s&#46; Asturias"
            "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
            "identificador" => "aff0010"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Incidentally discovered pituitary macroadenoma&#46; Neurosurgical treatment indications illutrated by two cases"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2005-01-04"
    "fechaAceptado" => "2005-04-10"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec159449"
          "palabras" => array:3 [
            0 => "Incidentalomas hipofisarios"
            1 => "Macroadenomas hipofisarios"
            2 => "Tratamiento neuroquir&#250;rgico"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec159448"
          "palabras" => array:3 [
            0 => "Pituitary incidentalomas"
            1 => "Pituitary macroadenomas"
            2 => "Neurosurgical treatment"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los macroadenomas hipofisarios &#40;de di&#225;metro superior a 10<span class="elsevierStyleHsp" style=""></span>mm&#41; son poco frecuentes como hallazgos casuales&#44; y su manejo diagn&#243;stico y terap&#233;utico no est&#225; bien definido&#46; Los criterios m&#225;s habituales para el tratamiento neuroquir&#250;rgico son la afectaci&#243;n del campo visual&#44; la hipersecreci&#243;n de hormonas distintas a la prolactina&#44; la constataci&#243;n de crecimiento&#44; o la apoplej&#237;a no silente&#46; Presentamos dos casos en los que la indicaci&#243;n de cirug&#237;a se estableci&#243; en funci&#243;n de la edad -joven- de la paciente &#40;caso n&#250;mero uno&#41; y de la afectaci&#243;n del eje gonadal en un var&#243;n no subsidiario de tratamiento androg&#233;nico &#40;caso n&#250;mero dos&#41;&#46; Se discute el beneficio de incluir tales indicaciones quir&#250;rgicas en el protocolo de evaluaci&#243;n de estas lesiones&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Summary"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Pituitary macroadenomas &#40;more than 10<span class="elsevierStyleHsp" style=""></span>mm in diameter&#41; are infrequent as casual findings and optimal management strategy for these tumours has not been established&#46; Neurosurgical approach must be always considered in patients with visual field defects or with hormone-secreting adenomas &#40;but prolactinoma&#41;&#44; and in those with evidence of lesion&#39;s growth or if clinical pituitary apoplexy occurs&#46; We present two cases in which surgical indication was based on patient&#39;s young age &#40;case number one&#41;&#44; and on hypogonadal status&#44; in a male patient not suitable of androgen substitution &#40;case number two&#41;&#46; We also discuss the benefits of including such unusual indications for neurosurgical treatment into the incidentally discovered pituitary macroadenomas evaluation strategy&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Maci&#225;-Bobes&#44; C&#46;&#59; Ronz&#243;n-Fern&#225;ndez&#44; A&#46;&#59; Casta&#241;o-Fern&#225;ndez&#44; G&#46;&#59; Botas-Cervero&#44; P&#46;&#58; Macroadenoma de hip&#243;fisis descubierto incidentalmente&#46; Indicaciones del tratamiento quir&#250;rgico a prop&#243;sito de dos casos&#46; Neurocirug&#237;a 2006&#59; 17&#58; 538&#8211;541&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:25 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Apoplej&#237;a hipofisaria&#58; 3 casos con buena evoluci&#243;n sin tratamiento quir&#250;rgico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Aguirre S&#225;nchez-Covisa"
                            1 => "A&#46; Hern&#225;ndez Gonz&#225;lez"
                            2 => "R&#46; Chamorro Prado"
                            3 => "M&#46;C&#46; Sanabria P&#233;rez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Endocrinol Nutr"
                        "fecha" => "1998"
                        "volumen" => "45"
                        "paginaInicial" => "64"
                        "paginaFinal" => "67"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary incidentalomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;C&#46; Aron"
                            1 => "T&#46;A&#46; Howlett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "2000"
                        "volumen" => "29"
                        "paginaInicial" => "205"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10732272"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Medical management of thyrotropin-secreting pituitary adenomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "P&#46; Beck-Peccoz"
                            1 => "L&#46; Persani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pituitary"
                        "fecha" => "2002"
                        "volumen" => "5"
                        "paginaInicial" => "83"
                        "paginaFinal" => "88"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12675505"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acromegaly"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Ben-Shlomo"
                            1 => "S&#46; Melmed"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "2001"
                        "volumen" => "30"
                        "paginaInicial" => "565"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11571931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dopamine agonists and pituitary tumor shrinkage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;S&#46; Bevan"
                            1 => "J&#46; Webster"
                            2 => "C&#46;W&#46; Burke"
                            3 => "M&#46;F&#46; Scanlon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/edrv-13-2-220"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "1992"
                        "volumen" => "13"
                        "paginaInicial" => "220"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1352243"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asymptomatic primary hyperparathyroidism"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;P&#46; Bilezikian"
                            1 => "S&#46;J&#46; Silverberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMcp032200"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "350"
                        "paginaInicial" => "1746"
                        "paginaFinal" => "1751"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15103001"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The natural history of the pituitary incidentaloma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;E&#46; Donovan"
                            1 => "B&#46; Corenblum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1995"
                        "volumen" => "155"
                        "paginaInicial" => "181"
                        "paginaFinal" => "183"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7811127"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidentally discovered pituitary lesions&#58; high frequency of macroadenomas and hormone- secreting adenomas - results of a prospective study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Feldkamp"
                            1 => "R&#46; Santen"
                            2 => "E&#46; Harms"
                            3 => "A&#46; Aulich"
                            4 => "U&#46; Modder"
                            5 => "W&#46;A&#46; Scherbaum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Endocrinol &#40;Oxf&#41;"
                        "fecha" => "1999"
                        "volumen" => "51"
                        "paginaInicial" => "109"
                        "paginaFinal" => "113"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The surgical treatment of pituitary adenomas in the eight decade"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Fraioli"
                            1 => "F&#46;S&#46; Pastore"
                            2 => "S&#46; Signoretti"
                            3 => "G&#46;M&#46; De Caro"
                            4 => "R&#46; Giuffre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Neurol"
                        "fecha" => "1999"
                        "volumen" => "51"
                        "paginaInicial" => "261"
                        "paginaFinal" => "266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10086489"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Criteria for early detection of temporal hemianopsia in asymptomatic pituitary tumor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Fujimoto"
                            1 => "N&#46; Saeki"
                            2 => "O&#46; Miyauchi"
                            3 => "E&#46; Adachi-Usami"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.eye.6700165"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eye"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "paginaInicial" => "731"
                        "paginaFinal" => "738"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12439668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis&#44; treatment&#44; and outcome of pituitary tumors and other abnormal intrasellar masses&#46; Retrospective analysis of 353 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Gsponer"
                            1 => "N&#46; De Tribolet"
                            2 => "J&#46;P&#46; Deruaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Medicine &#40;Baltimore&#41;"
                        "fecha" => "1999"
                        "volumen" => "78"
                        "paginaInicial" => "236"
                        "paginaFinal" => "269"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of pituitary incidentalomas&#46; A survey of British and American endocrinologists"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;A&#46; Howlett"
                            1 => "J&#46; Como"
                            2 => "D&#46;C&#46; Aron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "2000"
                        "volumen" => "29"
                        "paginaInicial" => "223"
                        "paginaFinal" => "230"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10732273"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of incidental pituitary macroadenomas&#58; a cost-effectiveness analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;T&#46; King"
                            1 => "A&#46; Justice"
                            2 => "D&#46;C&#46; Aron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.82.11.4383"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1997"
                        "volumen" => "82"
                        "paginaInicial" => "3625"
                        "paginaFinal" => "3632"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9360517"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46;R&#46; Laws Jr&#46;"
                            1 => "K&#46; Thapar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "1999"
                        "volumen" => "28"
                        "paginaInicial" => "119"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10207687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Curaci&#243;n espont&#225;nea de una acromegalia despu&#233;s de una apoplej&#237;a hipofisaria&#59; presentaci&#243;n de dos casos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Marazuela"
                            1 => "Y&#46; Lucas"
                            2 => "J&#46; Estrada"
                            3 => "B&#46; Barcel&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "1993"
                        "volumen" => "100"
                        "paginaInicial" => "556"
                        "paginaFinal" => "557"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sustituci&#243;n con testosterona en pacientes con hipogonadismo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46;J&#46; Mart&#237;nez Portillo"
                            1 => "A&#46; Cueva Mart&#237;nez"
                            2 => "P&#46; Mart&#237;n Braun"
                            3 => "M&#46;I&#46; Fern&#225;ndez Arancibia"
                            4 => "K&#46;P&#46; Junemann"
                            5 => "P&#46; Alken"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Esp Urol"
                        "fecha" => "2002"
                        "volumen" => "55"
                        "paginaInicial" => "827"
                        "paginaFinal" => "838"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12380312"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pituitary incidentalomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;E&#46; Molitch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "1997"
                        "volumen" => "26"
                        "paginaInicial" => "725"
                        "paginaFinal" => "740"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9429857"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aron&#44; D&#46; C&#46; Incidental pituitary macroadenoma&#58; a population- based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;M&#46; Nammour"
                            1 => "J&#46; Ybarra"
                            2 => "M&#46;H&#46; Naheedy"
                            3 => "J&#46;H&#46; Romeo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med Sci"
                        "fecha" => "1997"
                        "volumen" => "314"
                        "paginaInicial" => "287"
                        "paginaFinal" => "291"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9365329"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic strategy for incidentally found pituitary tumors &#40;&#8220;pituitary incidentalomas&#8221;&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46; Nishizawa"
                            1 => "S&#46; Ohta"
                            2 => "T&#46; Yokoyama"
                            3 => "K&#46; Uemura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1998"
                        "volumen" => "46"
                        "paginaInicial" => "1344"
                        "paginaFinal" => "1350"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10834640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical versus subclinical pituitary apoplexy&#58; presentation&#44; surgical management&#44; and outcome in 21 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;T&#46; Onesti"
                            1 => "T&#46; Wisnieewski"
                            2 => "K&#46;D&#46; Post"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1990"
                        "volumen" => "26"
                        "paginaInicial" => "980"
                        "paginaFinal" => "986"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2362675"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A survey of pituitary incidentaloma in Japan"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Sanno"
                            1 => "K&#46; Oyama"
                            2 => "S&#46; Tahara"
                            3 => "A&#46; Teramoto"
                            4 => "Y&#46; Kato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Endocrinol"
                        "fecha" => "2003"
                        "volumen" => "149"
                        "paginaInicial" => "123"
                        "paginaFinal" => "127"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12887289"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidental pituitary lesions in 1000 unelected autopsy specimens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Teramoto"
                            1 => "K&#46; Hirakawa"
                            2 => "N&#46; Sanno"
                            3 => "Y&#46; Osamura"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Neuroradiology"
                        "fecha" => "1994"
                        "volumen" => "193"
                        "paginaInicial" => "161"
                        "paginaFinal" => "164"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Incidentaloma hipofisario&#58; evaluaci&#243;n y abordaje terap&#233;utico en la actualidad"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Torres"
                            1 => "J&#46;J&#46; Acebes"
                            2 => "J&#46; Soler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Endocrinol Nutr"
                        "fecha" => "2003"
                        "volumen" => "50"
                        "paginaInicial" => "153"
                        "paginaFinal" => "155"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;M&#46; Webb"
                            1 => "M&#46; Rigla"
                            2 => "A&#46; Wagner"
                            3 => "B&#46; Oliver"
                            4 => "F&#46; Bartumeus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.84.10.6019"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1999"
                        "volumen" => "84"
                        "paginaInicial" => "3696"
                        "paginaFinal" => "3700"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10523016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Empty sella following spontaneous resolution of a pituitary macroadenoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;E&#46; Weiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Horro Res"
                        "fecha" => "2003"
                        "volumen" => "60"
                        "paginaInicial" => "49"
                        "paginaFinal" => "52"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/11301473/0000001700000006/v1_201305151259/S1130147306703189/v1_201305151259/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001700000006/v1_201305151259/S1130147306703189/v1_201305151259/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703189?idApp=UINPBA00004B"
]
Compartir
Información de la revista
Vol. 17. Núm. 6.
Páginas 538-541 (enero 2005)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 17. Núm. 6.
Páginas 538-541 (enero 2005)
Macroadenoma de hipófisis descubierto incidentalmente. Indicaciones del tratamiento quirúrgico a propósito de dos casos
Incidentally discovered pituitary macroadenoma. Neurosurgical treatment indications illutrated by two cases
Visitas
1804
C. Maciá-Bobes
, G. Castaño-Fernández, P. Botas-Cervero
Unidad de Endocrinología. Hospital San Agustín. Avilés. Asturias
A. Ronzón-Fernández*
* Unidad de Medicina de Familia. Hospital San Agustín. Avilés. Asturias
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen

Los macroadenomas hipofisarios (de diámetro superior a 10mm) son poco frecuentes como hallazgos casuales, y su manejo diagnóstico y terapéutico no está bien definido. Los criterios más habituales para el tratamiento neuroquirúrgico son la afectación del campo visual, la hipersecreción de hormonas distintas a la prolactina, la constatación de crecimiento, o la apoplejía no silente. Presentamos dos casos en los que la indicación de cirugía se estableció en función de la edad -joven- de la paciente (caso número uno) y de la afectación del eje gonadal en un varón no subsidiario de tratamiento androgénico (caso número dos). Se discute el beneficio de incluir tales indicaciones quirúrgicas en el protocolo de evaluación de estas lesiones.

Palabras clave:
Incidentalomas hipofisarios
Macroadenomas hipofisarios
Tratamiento neuroquirúrgico
Summary

Pituitary macroadenomas (more than 10mm in diameter) are infrequent as casual findings and optimal management strategy for these tumours has not been established. Neurosurgical approach must be always considered in patients with visual field defects or with hormone-secreting adenomas (but prolactinoma), and in those with evidence of lesion's growth or if clinical pituitary apoplexy occurs. We present two cases in which surgical indication was based on patient's young age (case number one), and on hypogonadal status, in a male patient not suitable of androgen substitution (case number two). We also discuss the benefits of including such unusual indications for neurosurgical treatment into the incidentally discovered pituitary macroadenomas evaluation strategy.

Key words:
Pituitary incidentalomas
Pituitary macroadenomas
Neurosurgical treatment

Artículo

Opciones para acceder a los textos completos de la publicación Neurocirugía
Socio
Socio de la Sociedad Española de Neurocirugía

Si es la primera vez que accede a la web puede obtener sus claves de acceso poniéndose en contacto con Elsevier España en suscripciones@elsevier.com o a través de su teléfono de Atención al Cliente 902 88 87 40 si llama desde territorio español o del +34 932 418 800 (de 9 a 18h., GMT + 1) si lo hace desde el extranjero.

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".

Suscriptor
Suscriptor de la revista

Si ya tiene sus datos de acceso, clique aquí.

Si olvidó su clave de acceso puede recuperarla clicando aquí y seleccionando la opción "He olvidado mi contraseña".
Suscribirse
Suscribirse a:

Neurocirugía

Comprar
Comprar acceso al artículo

Comprando el artículo el PDF del mismo podrá ser descargado

Precio 19,34 €

Comprar ahora
Contactar
Teléfono para suscripciones e incidencias
De lunes a viernes de 9h a 18h (GMT+1) excepto los meses de julio y agosto que será de 9 a 15h
Llamadas desde España
932 415 960
Llamadas desde fuera de España
+34 932 415 960
Email
Idiomas
Neurocirugía
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?