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"apellidos" => "García-Blázquez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Neurocirugía y de Oncología Pediátrica. Hospital «La Paz». Madrid. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162541" "palabras" => array:3 [ 0 => "Neuroblastoma" 1 => "Tumor cerebral" 2 => "Metástasis en niños" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162540" "palabras" => array:3 [ 0 => "Neuroblastoma" 1 => "Brain neoplasms" 2 => "Metastases in children" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presentan 8 casos de metástasis intracraneales de neuroblastomas en niños. Una vez diagnosticado el tumor primitivo, el intervalo de tiempo transcurrido hasta la aparición de la manifestación neurológica, por metastasis intracraneales, varió entre 2 meses y 30 meses con una media de 12,3 meses. La TAC se utilizó en todos los casos como medio diagnóstico, observándose metástasis múltiples en 6 casos y únicas en 2 casos. El tratamiento realizado nna vez diagnosticada la afectación intracraneal fue de quimioterapia en 2 casos, quimioterapia y radioterapia en 5 casos y cirugía, quimioterapia y radioterapia en un paciente con una metástasis única localizada en el cerebelo. La supervivencia después de la afectación neurológica fue corta varian· do entre 1 mes y 22 meses con una media de 9 meses. Las metástasis cerebrales por neurobastomas, en niños, se pueden considerar como un signo de mal pronóstico en la evolución de los pacientes.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Eight cases of intracranial metastatic neuroblastoma in children· are reported. The interval between diagnosis of primitive neuroblastoma and the development of neurological symptoms ranged from 2 to 30 months (mean = 12,3 months). Cerebral CT scans were performed in all patients. Multiple intracranial metastases were observed in 6 cases and a single metatases in only 2 cases. Treatment regimes were: chemotherapy in 2 cases, chemotherapy and radiotherapy in 5 cases, and surgery, chemotherapy and radiotherapy in one case with a single metastases, which was located in the cerebellum. Survival after neurological manifestation was short, ranging between 1 and 22 months, (average 9 months). According to our experience cerebral involvement can ben considered a sign of a bad prognosis in the evolution of patients with neuroblastoma.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Isla, A.; Alvarez, F.; González, Mª C.; Pérez-Higueras, A. y García-Blázquez, M.: Metástasis intracraneales de neuroblastoma en el niño. Neurocirugía 1993; 4: 281–284.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A proposed stating for children with neuroblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.E. Evans" 1 => "G.J. D’angio" 2 => "J. 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Metástasis intracraneales de neuroblastoma en el niño
A. Isla, F. Alvarez, M.ªC. González, A. Pérez-Higueras, M. García-Blázquez
Servicios de Neurocirugía y de Oncología Pediátrica. Hospital «La Paz». Madrid. España