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array:22 [ "pii" => "S113014739071192X" "issn" => "11301473" "doi" => "10.1016/S1130-1473(90)71192-X" "estado" => "S300" "fechaPublicacion" => "1990-01-01" "aid" => "71192" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1990" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1990;1:197" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1763 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 897 "PDF" => 856 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147390711931" "issn" => "11301473" "doi" => "10.1016/S1130-1473(90)71193-1" "estado" => "S300" "fechaPublicacion" => "1990-01-01" "aid" => "71193" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1990;1:203-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1809 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 784 "PDF" => 1014 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Estimulación eléctrica intraoperatoria en Neurocirugía funcional" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "203" "paginaFinal" => "207" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R.D. Lobato, J.J. Rivas, H. Sánchez Albisua, R. Sarabia" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Rivas" ] 2 => array:2 [ "nombre" => "H." "apellidos" => "Sánchez Albisua" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Sarabia" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147390711931?idApp=UINPBA00004B" "url" => "/11301473/0000000100000004/v1_201305150958/S1130147390711931/v1_201305150958/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Nuevas perspectivas en el tratamiento biológico de los gliomas" "tieneTextoCompleto" => 0 "paginas" => array:2 [ 0 => array:1 [ "paginaInicial" => "197" ] 1 => array:2 [ "paginaInicial" => "200" "paginaFinal" => "201" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Vaquero, R. Martínez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Martínez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Clínica Puerta de Hierro. Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156546" "palabras" => array:8 [ 0 => "Tumores cerebrales" 1 => "Inmunoterapia" 2 => "Linfocitos" 3 => "Interferon" 4 => "Células LAK" 5 => "Células NK" 6 => "Glioblastoma" 7 => "Gliomas malignos" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156545" "palabras" => array:8 [ 0 => "Brain tumors" 1 => "Immunotherapy" 2 => "Lymphocytes" 3 => "Interferon" 4 => "LAK-cells" 5 => "NK-cells" 6 => "Glioblastoma" 7 => "Malignant gliomas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En los últimos años, el descubrimiento de nuevos sistemas linfocitotóxicos, con capacidad de lisar <span class="elsevierStyleItalic">in vivo</span> células tumorales, abre nuevas perspectivas en el tratamiento de diversas neoplasias.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las peculiares características inmunológicas del Sistema Nervioso y de los tumores que en él se desarrollan, hace que los gliomas malignos sean un atractivo campo para ensayar la posible aplicación clínica de las técnicas de inmunoterapia.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Aunque en el momento actual, la experiencia en este terreno es muy limitada y los resultados poco significativos, es indudable que el tratamiento biológico de los gliomas ofrece interesantes perspectivas de investigación y su eficacia real, en combinación con otras modalidades terapéuticas bien establecidas, merece ser estudiada.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Recently, new lymphocytotoxic systems for lysing tumoral cells have led to consider modalities in the treatment of different neoplasms.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The peculiar immunological features of the Nervous System and its tumors, made the malignant gliomas a very atractive field for assaying immunotherapeutical procedures.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Although the very limited experience with these trials, and their poor significant results obtained at present, the biological treatment of brain tumors has to be considered.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Vaquero, J.; Martínez, R.: Nuevas perspectivas en el tratamiento biológico de los gliomas. Neurocirugía 1990; 1: 197–201.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunological aspects of intrinsic glial tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.L.J. Apuzzo" 1 => "M.S. Mitchell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Neurosurg." "fecha" => "1981" "volumen" => "51" "paginaInicial" => "1" "paginaFinal" => "18" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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