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Irdesel, S.B. Aydiner" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Irdesel" ] 1 => array:2 [ "nombre" => "S.B." "apellidos" => "Aydiner" ] ] ] 1 => array:2 [ "autoresLista" => "S. Akgoz" "autores" => array:1 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Akgoz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147307703032?idApp=UINPBA00004B" "url" => "/11301473/0000001800000001/v1_201305151301/S1130147307703032/v1_201305151301/en/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Perspectivas en el tratamiento del vasospasmo cerebral inducido por hemorragia subaracnoidea" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "16" "paginaFinal" => "27" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Fandino, A.R. Fathi, T. Graupner, S. Jacob, H. Landolt" "autores" => array:5 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Fandino" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A.R." "apellidos" => "Fathi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "T." "apellidos" => "Graupner" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "S." 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Suiza" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: M.D. Department of Neurosurgery University Hospital Bern. 3010 Bern. Switzerland." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-01-20" "fechaAceptado" => "2006-05-16" "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec159501" "palabras" => array:6 [ 0 => "Hemorragia subaracnoidea" 1 => "Vasospasmo cerebral" 2 => "Angioplastia" 3 => "Donadores de óxido nítrico" 4 => "Estatinas" 5 => "Antagonistas de los receptores de la endotelina" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec159500" "palabras" => array:23 [ 0 => "ACT" 1 => "ACV" 2 => "ARM" 3 => "CBF" 4 => "CD11 a/CD18" 5 => "CD11 b/CD18" 6 => "DIND" 7 => "EDRF" 8 => "ET" 9 => "ET<span class="elsevierStyleInf">A</span>" 10 => "ET<span class="elsevierStyleInf">B</span>" 11 => "HSA" 12 => "ICAM-1" 13 => "LCR" 14 => "NA" 15 => "NO" 16 => "NOS" 17 => "PPV" 18 => "TCD" 19 => "t-PA" 20 => "UK" 21 => "VC" 22 => "VCAM-1" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec159502" "palabras" => array:6 [ 0 => "Subarachnoid hemorrhage" 1 => "Cerebral vasospasm" 2 => "Angioplasty" 3 => "NO donors" 4 => "Statins" 5 => "Endothelin receptors antagonists" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El vasospasmo cerebral sigue siendo la causa más importante de invalidez y muerte posterior a la ruptura de aneurismas saculares intracerebrales. Las estrategias terapéuticas en el vasospasmo inducido por la hemorragia subaracnoidea pueden ser agrupadas en cuatro categorías a saber: 1) terapias de prevención; 2) terapias de reversión; 3) terapias para el aumento de la perfusión cerebral; y 4) terapias de neuroprotección y rescate. Estudios experimentales recientes han permitido la realización de estudios clínicos fase II que sugieren resultados positivos con medicamentos que incluyen estatinas (simvastatina y pravastatina) y antagonistas de receptores tipo A de la endotelina-1 (clasozentan). De igual manera, evidencias experimentales y clínicas han mostrado las ventajas del drenaje de líquido cefalorraquídeo, administración intratecal de donadores de óxido nítrico, y los efectos desinhibidores de la Ca2+ Protein Kinasa C (Fasudil) y catecolaminas sobre la vascularización cerebral. Este artículo resume el estado de investigación actual de posibles agentes y estrategias terapéuticas relevantes en el tratamiento del vasospasmo cerebral.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cerebral vasospasm is still the most important cause of death and disability after rupture of intracranial aneurysms. The therapeutic strategies in the treatment of subarachnoid hemorrhage induced vasospasm include four groups: 1) prevention of vasospasm; 2) reversion of vasospasm; 3) improvement of cerebral perfusion; and 4) neuroprotection and rescue therapies. Recent experimental studies allowed the design of phase II clinical studies which demonstrated positive results with medications and compounds such as statins (simvastatin and pravastatin) and endothelin-1 receptor antagonists (clasozentan). Moreover, experimental and clinical evidences showed the advantages of early cerebrospinal fluid drainage, intrathecal administration of NO-donors, effects of Ca2+ protein kinase inhibitor (Fasudil) and catecholamines on the cerebral vessels. This review article summarizes the stage of investigation of these medications and therapeutic strategies which will be relevant in the treatment of cerebral vasospasm.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">.. I would caution that vasospasm is still around, it is still alive and living in every neurosurgical unit. Hence my plea that our scientists not falter or lose interest for a final understanding and solution”</span></p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">C.G. Drake, 1990<span class="elsevierStyleSup">9</span></p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Fandino, J.; Fathi, A.R.; Graupner, T.; Jakob, S.; Landolt,H.: Perspectivas en el tratamiento del vasospasmo cerebral inducido por hemorragia subaracnoidea. Neurocirugía 2007; 18: 16–27.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:94 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noninvasive transcranial doppler ultrasound recording of flow velocity in basal cerebral arteries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Aaslid" 1 => "T.M. Markwalder" 2 => "H. Nornes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1982.57.6.0769" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1982" "volumen" => "57" "paginaInicial" => "769" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7143059" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of a nitric oxide donor on and correlation of changes in cyclic nucleotide levels with experimental vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Aihara" 1 => "B.S. Jahromi" 2 => "R. Yassari" 3 => "T. Sayama" 4 => "R.L. Macdonald" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neurosurgery." "fecha" => "2003" "volumen" => "52" "paginaInicial" => "666" "paginaFinal" => "667" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ruptured intracranial aneurysms- the role of arterial spasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.J. Allcock" 1 => "C.G. Drake" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1965.22.1.0021" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1965" "volumen" => "22" "paginaInicial" => "21" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14286333" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does intracisternal thrombolysis prevent vasospasm after aneurysmal subarachnoid hemorrhage? A meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Amin-Hanjani" 1 => "C.S. Ogilvy" 2 => "F.G.N. Barker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "2004" "volumen" => "54" "paginaInicial" => "326" "paginaFinal" => "334" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14744278" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fenestration of the lamina terminalis as a valuable adjunct in aneurysm surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Andaluz" 1 => "M. Zuccarello" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "2004" "volumen" => "55" "paginaInicial" => "1050" "paginaFinal" => "1059" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15509311" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early pattern of cerebral circulatory disturbances following subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "U. Bergvall" 1 => "L. Steiner" 2 => "D.M.C. Forster" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neuroradiology." "fecha" => "1979" "volumen" => "5" "paginaInicial" => "24" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4687974" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of cerebral vasospasm by humanized anti cd11/cd18 monoclonal antibody administrated after experimental subarachnoid hemorrhage in nonhuman primates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "R.E. Clatterbuck" 1 => "P. Gailloud" 2 => "L. Ogata" 3 => "A. Gebremariam" 4 => "G.N. Dietsch" 5 => "K.J. Murphy" 6 => "R.J. Tamargo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2003.99.2.0376" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2003" "volumen" => "99" "paginaInicial" => "376" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12924713" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Clousten" 1 => "Y. Numagushi" 2 => "G.H. Zoarski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AJNR." "fecha" => "1995" "volumen" => "16" "paginaInicial" => "27" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7900600" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concluding remaks" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.G. Drake" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "editores" => "K.SanoK.TakakuraN.F.Kassell" "paginaInicial" => "527" "paginaFinal" => "531" "serieTitulo" => "International confererence on cerebral vasospasm in" "serieFecha" => "1990" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral vasospasm after subarachnoid hemorrhage: Putative role of inflamation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "A.S. Dumont" 1 => "R.J. Dumont" 2 => "M.M. Chow" 3 => "C.L. Lin" 4 => "T. Calisaneller" 5 => "K.F. Ley" 6 => "N.F. Kassell" 7 => "K.S. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neursurgery." "fecha" => "2003" "volumen" => "53" "paginaInicial" => "123" "paginaFinal" => "135" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arteriographic demonstration of spasm of the intracranial arteries with special reference to saccular arterial aneurysms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Ecker" 1 => "P.A. Riemenschneider" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1951.8.6.0660" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1951" "volumen" => "8" "paginaInicial" => "660" "paginaFinal" => "667" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14889314" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New developments in the understanding of cerebral vasoregulation and vasospasm: The endothelin-nitric oxide network" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Ehrenreich" 1 => "L. Schilling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cleve Clin J Med." "fecha" => "1995" "volumen" => "62" "paginaInicial" => "105" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7736628" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Balloon angioplasty for the treatment of vasospasm: Result of first 50 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.M. Eskridge" 1 => "W. Mc Auliffe" 2 => "J.K. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1998" "volumen" => "42" "paginaInicial" => "510" "paginaFinal" => "517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9526985" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endovascular treatment of vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Eskridge" 1 => "D.W. Newell" 2 => "H.R. Winn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurg Clin N Am." "fecha" => "1994" "volumen" => "5" "paginaInicial" => "437" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8086797" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improvement of cerebral oxygenation patterns and metabolic validation of superselective intraarterial infusion of papaverine for the treatment of cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Fandiño" 1 => "Y. Kaku" 2 => "B. Schuknecht" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1998.89.1.0093" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1998" "volumen" => "89" "paginaInicial" => "93" "paginaFinal" => "100" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9647178" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelin B receptor null mutation prevents subarachnoid hemorrhage induced cerebral vasospasm in the rat in vivo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Fandiño" 1 => "R.M. Rapoport" 2 => "C.E. Geriepy" 3 => "M. Yanagisawa" 4 => "M. Zuccarello" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Cerebral vasospasm." "serieFecha" => "2003" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical, angiographic, and sonographic findings after structured treatment of cerebral vasospasm and their relation to final outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Fandiño" 1 => "B. Schuknecht" 2 => "C. Yüksel" 3 => "H.G. Wieser" 4 => "A. Valavanis" 5 => "Y. Yonekawa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir." "fecha" => "1999" "volumen" => "141" "paginaInicial" => "677" "paginaFinal" => "690" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10481778" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Barbiturate coma for intractable cerebral vasospasm after aneurysmal subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Fandiño" 1 => "H.G. Wieser" 2 => "S. Krayer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Neurosurg." "fecha" => "1998" "volumen" => "88" "paginaInicial" => "192A" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nitric oxide and the cerbral circulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Faraci" 1 => "J.E. Brian" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "1994" "volumen" => "25" "paginaInicial" => "692" "paginaFinal" => "703" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7510430" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory citokines in subarachnoid hemorrhege: Association with abnormal blood flow velocities in the basal cerebral arteries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "K. Fassbender" 1 => "B. Hodapp" 2 => "S. Rossol" 3 => "T. Bertsch" 4 => "J. Schmeck" 5 => "S. Schutt" 6 => "M. Fritzinger" 7 => "P. Horn" 8 => "P. Vajkoczy" 9 => "S. Kreisel" 10 => "J. Brunner" 11 => "P. Schmiedek" 12 => "M. Hennerici" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry." "fecha" => "2001" "volumen" => "70" "paginaInicial" => "534" "paginaFinal" => "537" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254783" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Norepinephrine induces dilatation in the rabbit basilar artery after subarachnoid hemorrhage in vivo Schweiz" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.R. Fathi" 1 => "T. Graupner" 2 => "T. Hidalgo" 3 => "J. Rohrer" 4 => "G. Schroth" 5 => "J. Fandiño" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Arch Neurol Psych" "fecha" => "2005" "volumen" => "156" "paginaInicial" => "382" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral blood flow measurements after spontaneous subarachnoidhemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.G. Ferguson" 1 => "Harper" 2 => "W. Fitch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Neurol." "fecha" => "1972" "volumen" => "8" "paginaInicial" => "15" "paginaFinal" => "22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4559481" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of intratechal thrombolytic therapy in a primate model of cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.M. Findlay" 1 => "B.K.A. Weir" 2 => "P. Gordon" 3 => "M. Grace" 4 => "R. Baugham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1989" "volumen" => "24" "paginaInicial" => "491" "paginaFinal" => "498" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2496328" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.M. Fisher" 1 => "J.P. Kistler" 2 => "J.M. Davis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1980" "volumen" => "6" "paginaInicial" => "1" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7354892" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelin and aneurysmal subarachnoid haemorrhage: A study of subarachnoid cisternal cerebrospinal fluid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "P. Gaetani" 1 => "Rodríguez" 2 => "R. Baena" 3 => "G. Grignani" 4 => "G. Spanu" 5 => "L. Pacchiarini" 6 => "P. Paoletti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry." "fecha" => "1994" "paginaInicial" => "66" "paginaFinal" => "72" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term hypothermia in patients with severe brain edema after poor-grade subarachnoid hemorrhage: Feasibility and intensive care complications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Gasser" …4 ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Neusurg Anesthesiol." "fecha" => "2003" "volumen" => "15" "paginaInicial" => "240" "paginaFinal" => "248" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regional cerbral blood flow in patients with subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir (Wien)." "fecha" => "1979" "volumen" => "47" "paginaInicial" => "245" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The prognostic value of noninvasive cbf measurement in subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "1984" "volumen" => "15" "paginaInicial" => "301" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vasospasm after subarachnoid hemorrhage: Diagnosis with mr angiography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AJNR." "fecha" => "2000" "volumen" => "21" "paginaInicial" => "1571" "paginaFinal" => "1572" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of intrathecal nitroglycerin on subarachnoid hemorrhage-induced cerebral vasospasm in the rabbit in vivo Schweiz" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Arch Neurol Psych." "fecha" => "2005" "volumen" => "156" "paginaInicial" => "383" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: A sooperative study in north america" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1997.86.3.0467" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1997" "volumen" => "86" "paginaInicial" => "467" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regional cerebral blood flow studies in subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1972.37.1.0036" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1972" "volumen" => "37" "paginaInicial" => "36" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral vasospasm after subarachnoid hemorrhage: An update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ana.410140602" "Revista" => array:6 [ "tituloSerie" => "Ann Neurol." "fecha" => "1983" "volumen" => "14" "paginaInicial" => "599" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transluminal angioplasty for the treatment of intracranial arterial vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.71.5.0648" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1989" "volumen" => "71" "paginaInicial" => "648" "paginaFinal" => "653" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of normal saline bolus on cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2005.103.1.0025" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2005" "volumen" => "103" "paginaInicial" => "25" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Plasma endothelin concentrations after aneurysmal subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2000.92.3.0390" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2000" "volumen" => "92" "paginaInicial" => "390" "paginaFinal" => "400" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Supraselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.77.6.0842" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1992" "volumen" => "77" "paginaInicial" => "842" "paginaFinal" => "848" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of cerebral vasospasm with intra-arterial papaverine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.77.6.0848" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1992" "volumen" => "77" "paginaInicial" => "848" "paginaFinal" => "853" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1982" "volumen" => "11" "paginaInicial" => "337" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The international cooperative study on the timing of aneurysm surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1990.73.1.0018" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1990" "volumen" => "73" "paginaInicial" => "18" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction in serum cholesterol with pravastatin improves endotheliumdependent coronary vasomotion in patients with hypercholesterolemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation." "fecha" => "1994" "volumen" => "89" "paginaInicial" => "2519" "paginaFinal" => "2524" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhance responses of the basilar artery mto activation of endothelinb receptors in stroke-prone spontaneously hypertensive rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hypertension." "fecha" => "1995" "volumen" => "25" "paginaInicial" => "490" "paginaFinal" => "494" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Marked reduction of cerebral vasopasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2004.100.2.0215" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2004" "volumen" => "100" "paginaInicial" => "215" "paginaFinal" => "224" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microsurgical fenestration of the lamina terminalis reduces the incidence of shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "2002" "volumen" => "51" "paginaInicial" => "1403" "paginaFinal" => "1412" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of early and late intravenous norepinephrine infusion on cerebral perfusion, microcirculation, braintissue oxygenation, and edema formation in brain-injured rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ …8] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.CCM.0000080482.06856.62" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med." "fecha" => "2003" "volumen" => "31" "paginaInicial" => "2211" "paginaFinal" => "2221" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Upregulation of endothelial nitric oxide synthesa by hnigcoa reductase inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am Heart J." "fecha" => "1998" "volumen" => "97" "paginaInicial" => "1129" "paginaFinal" => "1135" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: Blunted response in esetial hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation." "fecha" => "1990" "volumen" => "81" "paginaInicial" => "1762" "paginaFinal" => "1767" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical course of spontaneous subarachnoid hemorrhage: A population-based study in king county, washington" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurology." "fecha" => "1993" "volumen" => "43" "paginaInicial" => "712" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: Results of a pilot clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ …11] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.STR.0000177879.11607.10" "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "2005" "volumen" => "36" "paginaInicial" => "2024" "paginaFinal" => "2026" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiology and molecular genetics of vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochirur." "fecha" => "2001" "volumen" => "77" "numero" => "Suppl" "paginaInicial" => "7" "paginaFinal" => "11" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ …8] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "2002" "volumen" => "51" "paginaInicial" => "761" "paginaFinal" => "768" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracranial pressure changes induced during papaverine infusion for treatment of vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1995.83.3.0430" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1995" "volumen" => "83" "paginaInicial" => "430" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ …8] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "2002" "volumen" => "33" "paginaInicial" => "2950" "paginaFinal" => "2956" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence of cerebral vasospasm after endovascular treatment of acutely ruptured aneurysms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ …9] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1997.87.6.0830" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1997" "volumen" => "87" "paginaInicial" => "830" "paginaFinal" => "835" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angioplasty for the treatment of symptomatic vasospasm following subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1989.71.5.0654" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1989" "volumen" => "71" "paginaInicial" => "654" "paginaFinal" => "660" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sustained increased cerebral blood flow with prophylactic hypertensive, hypervolemic hemodilution (“Triple-h therapy”) after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1990" "volumen" => "27" "paginaInicial" => "729" "paginaFinal" => "740" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of vasospasm after subarachnoid hemorrhage by use of multiislice computed tomography angiography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "2002" "volumen" => "51" "paginaInicial" => "939" "paginaFinal" => "942" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Source and cause of endothelin- 1 release into cerebrospinal fluid after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1997.87.2.0287" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1997" "volumen" => "87" "paginaInicial" => "287" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intraarterial administered papaverine for the treatment of symptomatic cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1998" "volumen" => "42" "paginaInicial" => "1256" "paginaFinal" => "1267" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of soluble eselectine, icam-1, vcam-1, and 1-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1998.89.4.0559" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1998" "volumen" => "89" "paginaInicial" => "559" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM195812252592605" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med." "fecha" => "1958" "volumen" => "259" "paginaInicial" => "1259" "paginaFinal" => "1264" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Local delivery of ibuprofen via controled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Neurosurgery" "fecha" => "2005" "volumen" => "57" "numero" => "ONS Suppl 1" "paginaInicial" => "184" "paginaFinal" => "190" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ …7] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Neurosurgery." "fecha" => "2004" "volumen" => "55" "paginaInicial" => "1399" "paginaFinal" => "1400" ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelial expression of icam-1 and vcam-1 after subarachnoid hemorrhage in monkeys treated with locally-delivered ibuprofen (abstract)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ …8] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Congress of Neurological Surgeons, 55th Annual Meeting" "conferencia" => "Boston" "serieFecha" => "2005" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacokinetics of controlled-release polymers in the subarachnoid space after subarachnoid hemorrhage in rabbits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2004.101.1.0099" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2004" "volumen" => "101" "paginaInicial" => "99" "paginaFinal" => "103" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Agonist-induced endothelium- dependent relaxation in rat thoracic aorta may be mediated through cgmp" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cir Res." "fecha" => "1983" "volumen" => "52" "paginaInicial" => "352" "paginaFinal" => "357" ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral lesions due to intracranial aneuryms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Brain." "fecha" => "1949" "volumen" => "72" "paginaInicial" => "150" "paginaFinal" => "185" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ro 61-1790, a new hydrosoluble endothelin antagonist: General pharmacology and effects on experimental cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pharmacol Exp Ther." "fecha" => "1997" "volumen" => "283" "paginaInicial" => "992" "paginaFinal" => "997" ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pharmacol Rev." "fecha" => "1994" "volumen" => "46" "paginaInicial" => "325" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelins and the cerebral circulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cerebrovasc Brain Metab Rev." "fecha" => "1995" "volumen" => "7" "paginaInicial" => "131" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased nitric oxide availability contributes to acute cerebral ischemia after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "2000" "volumen" => "47" "paginaInicial" => "208" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of s-nitrosoglutathione on acute vasoconstriction and glutamate release after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "1999" "volumen" => "30" "paginaInicial" => "1955" "paginaFinal" => "1961" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00004647-200003000-00018" "Revista" => array:6 [ "tituloSerie" => "J Cereb Blood Flow Metab." "fecha" => "2000" "volumen" => "20" "paginaInicial" => "604" "paginaFinal" => "611" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib74" "etiqueta" => "74." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1995.82.1.0055" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1995" "volumen" => "82" "paginaInicial" => "55" "paginaFinal" => "62" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib75" "etiqueta" => "75." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of aneurysmal subarachnoid hemorrhage in a hospital population: A prospective study including early operation, intravenous nimodipine, and transcranial doppler ultrasound" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neurosurgery." "fecha" => "1988" "volumen" => "23" "paginaInicial" => "598" "paginaFinal" => "604" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib76" "etiqueta" => "76." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of fasudil HCL (Ca pro- 16-27 tein kinase inhibitor) on cerebral vasospasm and infarction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "Cerebral vasospasm." "serieFecha" => "2003" ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib77" "etiqueta" => "77." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary structure of icam-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell." "fecha" => "1988" "volumen" => "52" "paginaInicial" => "925" "paginaFinal" => "933" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib78" "etiqueta" => "78." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subarachnoid hemorrhage- factors in prognosis and mamgement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1964.21.9.0769" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1964" "volumen" => "21" "paginaInicial" => "769" "paginaFinal" => "780" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib79" "etiqueta" => "79." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Norepinephrine-induced hyperglycemia does not increase cortical lactate in brain-injured rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00134-002-1431-2" "Revista" => array:6 [ "tituloSerie" => "Intensive Care Med." "fecha" => "2002" "volumen" => "28" "paginaInicial" => "1491" "paginaFinal" => "1497" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib80" "etiqueta" => "80." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelin-1 concentration increases in the cerebrospinal fluid in cerebral vasospasm caused by subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surg Neurol." "fecha" => "2000" "volumen" => "53" "paginaInicial" => "131" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib81" "etiqueta" => "81." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transluminal balloon angioplasty for vasospasm after subarachnoid hemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Cerebral vasospasm" "paginaInicial" => "429" "paginaFinal" => "432" "serieFecha" => "1990" ] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib82" "etiqueta" => "82." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of acute treatment with pravastatin on cerbral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage. A phase ii randomized placebo-controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.STR.0000176743.67564.5d" "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "2005" "volumen" => "36" "paginaInicial" => "1627" "paginaFinal" => "1632" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib83" "etiqueta" => "83." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clazosentan (AXV-034343), a selective endothelin a receptor antagonist, in the prevention of cerebral vasospasm following severe aneurysmal subarachnoid hemorrhage: Results of a randomized, double-blind, placebo-controlled, multicenter phase iia study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2005.103.1.0009" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2005" "volumen" => "103" "paginaInicial" => "9" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib84" "etiqueta" => "84." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebrovascular characterization of clazosentan, the first nonpeptide endothelin receptor antagonist clinically effective fro the treatment of cerbral vasospasm Part is Inhibitory effect on endothelin a receptor-mediated contraction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2005.102.6.1101" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2005" "volumen" => "102" "paginaInicial" => "1101" "paginaFinal" => "1107" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib85" "etiqueta" => "85." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebrovascular characterization of clazosentan, the first nonpeptide endothelin receptor antagonist shown to be clinically effective for the treatment of cerebral vasospasm Part ii: Effect on endothelin b receptormediated relaxation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.2005.102.6.1108" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "2005" "volumen" => "102" "paginaInicial" => "1108" "paginaFinal" => "1114" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib86" "etiqueta" => "86." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cigarette smoking as a cause of aneurysmal subarachnoid hemorrhage and risk for vasospasm: A report of the cooperative aneurysm study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1998.89.3.0405" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1998" "volumen" => "89" "paginaInicial" => "405" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib87" "etiqueta" => "87." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional roles of the rho/rho kinase pathway and protein kinase c in the regulation of cerebrovascular constriction mediated by hemoglobin: Relevance to subarachnoid hemorrhage and vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.RES.0000066663.12256.B2" "Revista" => array:6 [ "tituloSerie" => "Circ Res." "fecha" => "2003" "volumen" => "92" "paginaInicial" => "809" "paginaFinal" => "816" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib88" "etiqueta" => "88." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversal of cerebral vasospasm using an intrathecally administered nitric oxide donor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1998.89.2.0279" "Revista" => array:6 [ "tituloSerie" => "J Neurosurg." "fecha" => "1998" "volumen" => "89" "paginaInicial" => "279" "paginaFinal" => "288" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib89" "etiqueta" => "89." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nitric oxide metabolites in cisternal CSF correlate with cerebral vasospasm in patients with a subarachnoid haemorrhage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00701-003-0004-7" "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir (Wien)." "fecha" => "2003" "volumen" => "145" "paginaInicial" => "257" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib90" "etiqueta" => "90." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A novel potent vasoconstrictor peptide produced by vascular endothelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/332411a0" "Revista" => array:6 [ "tituloSerie" => "Nature." "fecha" => "1988" "volumen" => "332" "paginaInicial" => "411" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib91" "etiqueta" => "91." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Current review of cerebrovascular disease" "paginaInicial" => "220" "paginaFinal" => "232" "serieFecha" => "2001" ] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib92" "etiqueta" => "92." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Balloon catheter technique for the dilatation of constricted cerebral arteries after aneurysmal sah" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Neurochir (Wien)." "fecha" => "1984" "volumen" => "70" "paginaInicial" => "65" "paginaFinal" => "79" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib93" "etiqueta" => "93." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelin b receptor antagonists attenuate subarachnoid hemorrhage-induced cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Stroke." "fecha" => "1998" "volumen" => "29" "paginaInicial" => "1924" "paginaFinal" => "1929" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib94" "etiqueta" => "94." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endothelin et-a and et-b receptors in subarachnoid hemorrhageinduced cerebral vasospasm" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J of Pharmacol." "fecha" => "1994" "volumen" => "259" "paginaInicial" => "R1" "paginaFinal" => "R2" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/11301473/0000001800000001/v1_201305151301/S1130147307703044/v1_201305151301/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000001800000001/v1_201305151301/S1130147307703044/v1_201305151301/es/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147307703044?idApp=UINPBA00004B" ]
