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array:23 [ "pii" => "S1130147393708441" "issn" => "11301473" "doi" => "10.1016/S1130-1473(93)70844-1" "estado" => "S300" "fechaPublicacion" => "1993-01-01" "aid" => "70844" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1993" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1993;4:177-82" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1771 "formatos" => array:3 [ "EPUB" => 26 "HTML" => 843 "PDF" => 902 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147393708453" "issn" => "11301473" "doi" => "10.1016/S1130-1473(93)70845-3" "estado" => "S300" "fechaPublicacion" => "1993-01-01" "aid" => "70845" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1993;4:183-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1887 "formatos" => array:3 [ "EPUB" => 31 "HTML" => 906 "PDF" => 950 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Estudio experimental de la inducción ósea mediante implantes de duramadre humana pretratada en defectos craneales" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "183" "paginaFinal" => "190" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Ravina Cabrera, L. González Feria, L. Díaz-Flores, A. Alareó Hernández, R. Gutiérrez García, F. Valladares Parrilla" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Ravina Cabrera" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "González Feria" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Díaz-Flores" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Alareó Hernández" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Gutiérrez García" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Valladares Parrilla" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147393708453?idApp=UINPBA00004B" "url" => "/11301473/0000000400000003/v1_201305151427/S1130147393708453/v1_201305151427/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S113014739370843X" "issn" => "11301473" "doi" => "10.1016/S1130-1473(93)70843-X" "estado" => "S300" "fechaPublicacion" => "1993-01-01" "aid" => "70843" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1993;4:172-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1665 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 684 "PDF" => 946 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Desarrollo y planificación de las unidades asistenciales y docentes en Neurocirugía" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "172" "paginaFinal" => "176" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Albert, J.M. Izquierdo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Albert" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Izquierdo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739370843X?idApp=UINPBA00004B" "url" => "/11301473/0000000400000003/v1_201305151427/S113014739370843X/v1_201305151427/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Revisión de algunos conceptos básicos de neuro-onco-biología. Oncogenes y gliomas" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "177" "paginaFinal" => "182" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "M. Pérez-Espejo, M. Poza y Poza" "autores" => array:2 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Pérez-Espejo" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Poza y Poza" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio Regional de Neurocirugía. Hospital Universitario «Virgen de la Arrixaca». Murcia" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec162476" "palabras" => array:4 [ 0 => "Oncogene" 1 => "Growth Factor" 2 => "Gliomas" 3 => "Cytogenetics" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec162477" "palabras" => array:4 [ 0 => "Oncogen" 1 => "Factores de crecimiento" 2 => "Gliomas" 3 => "Citogenética" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El trabajo que presentamos, dirigido esencialmente al lector clínico, constituye una revisión sucinta de los conceptos de oncogen, protooncogen, antioncogen y gen modulador, así como de sus relaciones con los factores de crecimiento y de transformación celular (EGF, TGF, FGF, PDGF) y sus receptores. Asimismo se apuntan los mecanismos de secreción protéica intracelular -autocrinia- y las «señales» que desencadenan las reacciones biocinéticas que conducirán a la creación de poblaciones celulares autónomas en relación con el tejido circundante; todo ello con especial referencia a los gliomas cerebrales. Finalmente se exponen algunas de las alteraciones cromosómicas o reagrupamientos de material genético más frecuentemente halladas en este tipo de tumores.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This article is a brief review, fundamentally adressed to the clinicians readers, on the moderns concepts of oncogenes, protooncogenes, antioncogenes, modulator genes and their relationships with the cell growth and transforming factors (EGF, TGF, FGF, PDGF) and their receptors. The mechanisms of protein secretion into the cell -autocrinia- and the biological «signals » which promote biocynetics reactions and subsequent rise of autonomous celular populations are also remarked, focusing all of these events in the particular field of brain gliomas. Finally some of the most usual chromosomal alterations or genetic material gains or deletions in these tumors are exposed.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pérez-Espejo, M.; Poza y Poza, M.: Revisión de algunos conceptos básicos de neuro-onco-biología. Oncogenes y gliomas. Neurocirugía 1993; 4: 177–182.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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