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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Endoscopic transforaminal discectomy is a minimally invasive technique used for the surgical treatment of herniated discs&#46; This technique has advantages like suitability for outpatient surgery&#44; shorter operation time&#44; less exposure to anesthetic agents&#44; faster recovery and less postoperative pain&#46; Usage of volatile agents or intravenous anesthetics is a matter of choice and comorbidities usually play an important role in deciding on the type of anesthesia&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Indigocarmine &#40;5&#44;5&#8242; sodium salt of indigodisulphonic acid or indigotine&#41; is a blue colored dye which is widely used to identify the ureteral orifice in urologic procedures&#46; In endoscopic discectomies&#44; indigocarmine is absorbed by the degenerative nucleus pulposus while normal tissue is not stained&#46; Compared to direct visualization&#44; removal of the stained tissue enables the surgeon to perform a selective endoscopic discectomy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nowadays dyes such as indigocarmine are being used to visualize damaged tissue in transforaminal surgery&#46; The identification of disc space was done with assistance of fluoroscopy&#46; During the instillation of indigocarmine&#44; we employed continuous fluoroscopy shooting to avoid overstaining of epidural tissues&#46; It is enough to see the proper disc space with filling of indigocarmine&#46; We interrupted the instillation of indigocarmine when it attained the posterior margin of annulus fibrosus&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Indigocarmine is structurally similar to two serotonine molecules which are mirror images of each other and thus it has a known positive inotropic and chronotropic effect on the heart and a vasoconstrictive effect on peripheral vessels&#46; Hemodynamic effects such as hypotension and anaphylaxis<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">1&#44;2</span></a> in addition to hypertension&#44; bradycardia and atrioventricular block<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> have been reported in intravenous application of indigocarmine&#46; The hemodynamic disturbance observed in two cases reported here following transforaminal injection is of interest&#46; The aim of this case report is to prepare anesthesiologists for such cases and make them consider invasive blood pressure monitorization&#46; Both patients reported here have given written informed consent&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Case 1</span><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was referred to the neurosurgery clinic with back pain radiating to right leg and MRI findings of radiculopathy and elective endoscopic disc surgery was planned&#46; The patient was a hypertensive 59 years old female and had no known allergies and was using ACE inhibitor&#46; Induction was carried out with 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg propofol&#44; 1<span class="elsevierStyleHsp" style=""></span>mcg&#47;kg fentanyl and 0&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;kg rocuronium and the patient was turned prone following intubation&#46; Maintenance was carried out with total intravenous anesthesia &#40;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;h propofol and 1<span class="elsevierStyleHsp" style=""></span>mcg&#47;kg&#47;h remifentanil&#41; and 50&#37; oxygen&#8211;50&#37; air with BIS monitorization&#46; The foramen was accessed endoscopically using a 6<span class="elsevierStyleHsp" style=""></span>mm&#8211;1<span class="elsevierStyleHsp" style=""></span>cm incision made 13<span class="elsevierStyleHsp" style=""></span>cm laterally with a 45&#176; angle targeting the L4-5 foramen&#46; Following the identification of the disc space using fluoroscopy&#44; 3<span class="elsevierStyleHsp" style=""></span>ml of a sterile solution &#40;2<span class="elsevierStyleHsp" style=""></span>ml&#47;16<span class="elsevierStyleHsp" style=""></span>mg indigocarmine&#44; 2<span class="elsevierStyleHsp" style=""></span>ml normal saline&#44; 2<span class="elsevierStyleHsp" style=""></span>ml meglumine amidotrizoate&#41; was injected&#46; The patient was hemodynamically stable until the solution was injected&#44; approximately 1<span class="elsevierStyleHsp" style=""></span>min after the injection bigeminated ventricular extrasystoles were observed and noninvasive blood pressure was 230&#47;120<span class="elsevierStyleHsp" style=""></span>mmHg while BIS was 24 while the heart rate was 42&#47;min&#46; Cardiac rhythm returned to normal following a 100<span class="elsevierStyleHsp" style=""></span>mg intravenous bolus of lidocaine and the patient was given 5<span class="elsevierStyleHsp" style=""></span>mg of nitroglycerine bolus twice&#46; Hemodynamics remained within normal limits throughout the remainder of the procedure&#46; The patient was returned to the supine position at the end of surgery and was extubated&#46; The patient was monitorized for 8<span class="elsevierStyleHsp" style=""></span>h in the ward&#46; Her vital signs and control ECG were within normal limits&#46; She was discharged on the second postoperateive day&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case 2</span><p id="par0030" class="elsevierStylePara elsevierViewall">Endoscopic disc surgery was planned for the patient who was referred to the neurosurgery clinic with back pain radiating to right foot and MRI findings of radiculopathy&#46; The patient was a 54 years old female who had allergic asthma but was not using any medications&#46; Anesthesia induction was carried out with 3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg propofol&#44; 1<span class="elsevierStyleHsp" style=""></span>mcg&#47;kg fentanyl and 0&#46;6<span class="elsevierStyleHsp" style=""></span>mg&#47;kg rocuronium and the patient was turned prone following intubation&#46; Maintenance was carried out using total intravenous anesthesia &#40;5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;h propofol and 1<span class="elsevierStyleHsp" style=""></span>mcg&#47;kg&#47;h remifentanil&#41; and 50&#37; oxygen&#8211;50&#37; air under BIS monitorization&#46; The foramen was accessed endoscopically using a 6<span class="elsevierStyleHsp" style=""></span>mm&#8211;1<span class="elsevierStyleHsp" style=""></span>cm incision made 13<span class="elsevierStyleHsp" style=""></span>cm laterally with a 45&#176; angle targeting the L4-5 foramen&#46; Following the identification of the disc space using fluoroscopy&#44; 3<span class="elsevierStyleHsp" style=""></span>ml of a sterile solution &#40;2<span class="elsevierStyleHsp" style=""></span>ml&#47;16<span class="elsevierStyleHsp" style=""></span>mg indigocarmine&#44; 2<span class="elsevierStyleHsp" style=""></span>ml normal saline&#44; 2<span class="elsevierStyleHsp" style=""></span>ml meglumine amidotrizoate&#41; was injected&#46; The patient was hemodynamically stable until the solution was injected&#44; approximately 2<span class="elsevierStyleHsp" style=""></span>min after the injection sinus tachycardia &#40;140<span class="elsevierStyleHsp" style=""></span>beats&#47;min&#41; was observed and non invasive blood pressure was measured as 220&#47;120<span class="elsevierStyleHsp" style=""></span>mmHg while BIS was 28&#46; Hemodynamic parameters returned to normal after 100<span class="elsevierStyleHsp" style=""></span>mg lidocaine and 5<span class="elsevierStyleHsp" style=""></span>mg nitroglycerine bolus which was given three times and remained within normal limits until the end of surgery&#46; The patient was returned to supine at the end of surgery and was extubated&#46; Vital signs and ECG were monitorized for 8<span class="elsevierStyleHsp" style=""></span>h in the ward and all values were within normal limits&#46; She was discharged on the second postoperative day&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Although its indications are more limited compared to open microdiscectomy&#44; endoscopic spinal surgery has become a technique that is more often chosen by neurosurgeons&#46; Sparing of the multifidus muscle during foraminal surgery maintains motion and negates or delays the need for fusion&#46; In this context&#44; it can be considered as completely minimally invasive&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">There are case reports in the literature concerning anaphylactic reactions resulting in deep hypotension which state that the exact pathological mechanism responsible is still not clear enough&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">6&#44;7</span></a> Although there are reports of anaphylaxis following the intravenous injection of indigocarmine&#44; the absence of hypotension&#44; bronchospasm&#44; wheezing or urticaria in our cases has made a diagnosis of anaphylaxis less likely&#46; Drugs used in both cases were checked for past expiry date&#46; On the other hand&#44; indigocarmine has been held responsible from a rise in blood pressure followed by a bradycardic reflex due to its chemical structure which is similar to serotonine&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Hypertension and bradyarrhythmia was observed in the first case while hypertension and sinus tachycardia was observed in the second of two cases&#46; These two distinctly different clinical pictures support the notion that indigocarmine causes this hemodynamic deterioration via an unknown mechanism&#46; Moreover&#44; we believe that intradiscal injection of indigocarmine may have caused sympathetic activation of pain pathways even though preemptive analgesia was employed&#44; total intravenous anesthesia under BIS monitorization was used and the disturbance resolved rapidly after lidocaine injection&#46; In fact&#44; recent studies reveal sensory innervation of the intervertebral discs that also show ingrowth to the inner layers<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> which support formation of pain due to intervertebral injection&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In this case report hypertension and arryhthmia have been treated symptomatically&#46; Nitroglycerin&#44; which is a weak arteriolar vasodilator primarily effecting venous capacitance vessels&#44; has been preferred because of its short duration of action and easy titrability for intraoperative hypertension&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> Lidocaine has been preferred because it decreases activity in spinal cord neurons and post-synaptic depolarization mediated by NMDA and neurokinin receptors and thus has an intraoperative analgesic activity&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0055" class="elsevierStylePara elsevierViewall">Considering that transforaminal discectomy operations are going to become more frequent&#44; we believe that anesthesiologists should keep in mind that indigocarmine can cause serious hemodynamic disturbances not only in intravenous but also in transforaminal injection and invasive blood pressure monitorization should be considered and necessary precautions taken for emergency interventions prior to indigocarmine usage&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have not received funding of any kind for this manuscript&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conflict of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interests&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La discectom&#237;a endosc&#243;pica transforaminal es una t&#233;cnica m&#237;nimamente invasiva utilizada para el tratamiento quir&#250;rgico de discos herniados&#46; Indigocarmine es un tinte que se usa ampliamente para identificar el orificio ureteral en procedimientos urol&#243;gicos&#46; Se han informado efectos hemodin&#225;micos como hipotensi&#243;n y anafilaxia adem&#225;s de hipertensi&#243;n&#44; bradicardia y bloqueo auriculoventricular en la aplicaci&#243;n intravenosa de indigocarmina&#46; El objetivo de este informe de caso es preparar a los anestesi&#243;logos para tales casos y hacer que consideren la monitorizaci&#243;n invasiva de la presi&#243;n sangu&#237;nea&#46; Ambos pacientes ten&#237;an dolor radicular que irradiaba a la pierna y se programaron para recibir una discectom&#237;a endosc&#243;pica transforaminal&#46; Los signos vitales intraoperatorios se encontraron dentro de los l&#237;mites normales&#44; sin embargo&#44; la hipertensi&#243;n severa y la taquiarritmia se desarrollaron despu&#233;s de la inyecci&#243;n&#46; La hemodin&#225;mica en ambos pacientes volvi&#243; a la normalidad despu&#233;s de la inyecci&#243;n de lidoca&#237;na y nitroglicerina&#46;</p></span>"
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Case Report
Severe hypertension and tachycardia during transforaminal endoscopic discectomy – Is indigocarmine to blame?
Hipertensión severa y taquicardia durante la discectomía endoscópica transforaminal: ¿se puede culpar a la indigocarmina?
Baturay Kansu Kazbeka,
Autor para correspondencia
bkkazbek@gmail.com

Corresponding author.
, Hakan Yılmaza, Burak Kazancıb, Perihan Ekmekçia, Hakan Sabuncuoğlub
a Ufuk University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Turkey
b Ufuk University, Faculty of Medicine, Department of Neurosurgery, Turkey

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