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array:23 [ "pii" => "S1130147399707748" "issn" => "11301473" "doi" => "10.1016/S1130-1473(99)70774-8" "estado" => "S300" "fechaPublicacion" => "1999-01-01" "aid" => "70774" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1999" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1999;10:350-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2806 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 1099 "PDF" => 1689 ] ] "itemSiguiente" => array:18 [ "pii" => "S113014739970775X" "issn" => "11301473" "doi" => "10.1016/S1130-1473(99)70775-X" "estado" => "S300" "fechaPublicacion" => "1999-01-01" "aid" => "70775" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Neurocirugia. 1999;10:358" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 7405 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 3708 "PDF" => 3678 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Comentario" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "358" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jaime Domínguez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Jaime" "apellidos" => "Domínguez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739970775X?idApp=UINPBA00004B" "url" => "/11301473/0000001000000005/v1_201305151016/S113014739970775X/v1_201305151016/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147399707736" "issn" => "11301473" "doi" => "10.1016/S1130-1473(99)70773-6" "estado" => "S300" "fechaPublicacion" => "1999-01-01" "aid" => "70773" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1999;10:345-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1450 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 679 "PDF" => 753 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Doentes com traumatismo crânio-encefálico em coma operados. Factores de morbilidade e mortalidade" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "345" "paginaFinal" => "349" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Surgically treated severe head injury patients. Factors influencing morbility and mortality" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.L. Reís, C. Pinheiro, V. Martins, E. Carvalho" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Reís" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Pinheiro" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Martins" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Carvalho" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147399707736?idApp=UINPBA00004B" "url" => "/11301473/0000001000000005/v1_201305151016/S1130147399707736/v1_201305151016/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Tratamiento con radiocirugía estereotáxica del glioma cerebral primario de alto grado" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "350" "paginaFinal" => "357" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "D. Ortiz de Urbina, M. Santos, J. Samblás, J.M. Delgado, J.C. Bustos, J.A. Gutiérrez-Díaz, I. García-Berrocal, S. Rodríguez, M.C. Rubio, G. Donckaster, F. Sansivirini, F.A. Calvo" "autores" => array:12 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Ortiz de Urbina" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Santos" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Samblás" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Delgado" ] 4 => array:2 [ "nombre" => "J.C." "apellidos" => "Bustos" ] 5 => array:2 [ "nombre" => "J.A." "apellidos" => "Gutiérrez-Díaz" ] 6 => array:2 [ "nombre" => "I." "apellidos" => "García-Berrocal" ] 7 => array:2 [ "nombre" => "S." "apellidos" => "Rodríguez" ] 8 => array:2 [ "nombre" => "M.C." "apellidos" => "Rubio" ] 9 => array:2 [ "nombre" => "G." "apellidos" => "Donckaster" ] 10 => array:2 [ "nombre" => "F." "apellidos" => "Sansivirini" ] 11 => array:2 [ "nombre" => "F.A." "apellidos" => "Calvo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Sanatorio San Francisco de Asís. Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Stereotactic radiosurgery in primary high grade malignat glioma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156767" "palabras" => array:2 [ 0 => "Radiocirugía estereotáxica" 1 => "Glioma cerebral de alto grado" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156766" "palabras" => array:2 [ 0 => "Stereotactic Radiosurgety" 1 => "High grade glioma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar en un estudio fase II el control local, tiempo a progresión y supervivencia (SPV) de pacientes con glioma cerebral primario de alto grado tratados con radiocirugía estereotáxica (RC), como tratamiento de intensificación local.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dieciocho pacientes, 8 astrocitomas anaplásicos y 10 glioblastomas multiformes de diámetro máximo menor o igual a 5<span class="elsevierStyleHsp" style=""></span>cm, han sido tratados con RC, administrándose una dosis margen que incluye el volumen tumoral de 10–20 Gy (mediana: 15 Gy), alcanzando una dosis máxima intratumoral de 12.5–40 Gy (mediana 17 Gy). Catorce pacientes (78%) recibieron radioterapia externa fraccionada (mediana de dosis: 60 Gy).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La mediana de SPV ha sido 11.5 meses y la SPV actuarial a 1 y 2 años de 42.5% y 10.6% respectivamente. Diez de 18 pacientes (55%) presentaron progresión tumoral con una mediana de tiempo a progresión de 10 meses (límites: 1–14 meses). Sólo 1 paciente (5.5%) desarrolló toxicidad severa.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La RC es una atractiva modalidad de tratamiento de intensificación local en glioma maligno cerebral de tamaño menor o igual a 5<span class="elsevierStyleHsp" style=""></span>cm, tolerable y factible.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze in a phase II clinical trial the local control, time to progression and survival of patients with primary malignant glioma treated with stereotactic radiosurgery (SRS) as a treatment boost.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Methods and material A total of 18 patients, with anaplastic astrocytomas (8 cases) and glioblastoma multiformes (10 cases) (maximum diameter=<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>cm) have been treated with SRS, receiving a single marginal tumor dose of 10–20 Gy (median: 15 Gy), at 90% isodose line, and achieving a maximun tumor dose of 12.5–40 Gy (median: 17 Gy). Fourteen patients (78%) were treated with external beam radiotherapy (median dose: 60 Gy).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The median survival time was 11.5 months, and the 1 -and 2-year actuarial survival were 42.5% and 10.6% respectively. Ten out of 18 patients (55%) had tumor progression and the median time to tumor progression was 10 months (range: 1–14 months). One patient (5.5%) developed severe toxicity.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">SRS is an attractive, feasible and tolerable treatment modality for local intensification in malignant glioma, lesser o equal than 5<span class="elsevierStyleHsp" style=""></span>cm in size.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Ortiz de Urbina, D.; Santos, M.; Samblas, J.; Delgado, J.M.; Bustos, J.C.; Gutiérrez-Díaz, J.A., García-Berrocal, I.; Rodríguez, S.; Rubio, M.C.; Donckaster, G.; Sansivirini, F.; Calvo, F.A.: Tratamiento con radiocirugía estereotáxica del glioma cerebral primario de alto grado. 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