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array:23 [ "pii" => "S1130147305704218" "issn" => "11301473" "doi" => "10.1016/S1130-1473(05)70421-8" "estado" => "S300" "fechaPublicacion" => "2005-01-01" "aid" => "70421" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "2005" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 2005;16:158-68" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1808 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 970 "PDF" => 822 ] ] "itemSiguiente" => array:18 [ "pii" => "S113014730570422X" "issn" => "11301473" "doi" => "10.1016/S1130-1473(05)70422-X" "estado" => "S300" "fechaPublicacion" => "2005-01-01" "aid" => "70422" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 2005;16:169-72" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1606 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 991 "PDF" => 597 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Chordoma of the lumbar spine: a case report" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "169" "paginaFinal" => "172" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cordoma de la columna lumbar: caso clínico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "H. Tuna, M. Bozkurt, A. Attar" "autores" => array:3 [ 0 => array:3 [ "preGrado" => "MD" "nombre" => "H." "apellidos" => "Tuna" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Bozkurt" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Attar" ] ] ] 1 => array:2 [ "autoresLista" => "V. Aydin" "autores" => array:1 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Aydin" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014730570422X?idApp=UINPBA00004B" "url" => "/11301473/0000001600000002/v1_201305151236/S113014730570422X/v1_201305151236/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147305704206" "issn" => "11301473" "doi" => "10.1016/S1130-1473(05)70420-6" "estado" => "S300" "fechaPublicacion" => "2005-01-01" "aid" => "70420" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 2005;16:142-57" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2394 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 1092 "PDF" => 1285 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Papel de la cirugía en la enfermedad degenerativa espinal. Análisis de revisiones sistemáticas sobre tratamientos quirúrgicos y conservadores desde el punto de vista de la medicina basada en la evidencia" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "142" "paginaFinal" => "157" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Role of surgery in spinal degenerative disease. Analysis of systematic reviews on surgical and conservative treatments from an evidence-based approach" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P.D. Delgado-López, A. Rodríguez-Salazar, J.M. Castilla-Diez, V. Martín-Velasco, O. Fernández-Arconada" "autores" => array:5 [ 0 => array:2 [ "nombre" => "P.D." "apellidos" => "Delgado-López" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Rodríguez-Salazar" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Castilla-Diez" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Martín-Velasco" ] 4 => array:2 [ "nombre" => "O." "apellidos" => "Fernández-Arconada" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147305704206?idApp=UINPBA00004B" "url" => "/11301473/0000001600000002/v1_201305151236/S1130147305704206/v1_201305151236/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "Tratamiento de los gliomas mediante virus oncolíticos: revisión de la literatura" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "158" "paginaFinal" => "168" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "I. Arrese, P. González, P. Miranda, A. Pérez-Núñez, B. Pascual, R.D. Lobato" "autores" => array:6 [ 0 => array:3 [ "nombre" => "I." "apellidos" => "Arrese" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "P." "apellidos" => "González" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Miranda" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Pérez-Núñez" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Pascual" ] 5 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondencia postal: Servicio de Neurocirugía, Hospital Universitario 12 de Octubre, Avda de Córdoba s/n, 28041 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Oncolytic viral terapy of gliomas: review of the literature" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-05-20" "fechaAceptado" => "2004-06-22" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec158839" "palabras" => array:3 [ 0 => "Virus oncolíticos" 1 => "Glioma" 2 => "Biología molecular" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec158840" "palabras" => array:3 [ 0 => "Oncolytic viruses" 1 => "Glioma" 2 => "Molecular biology" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los gliomas son los tumores cerebrales primarios más frecuentes. Los tratamientos tradicionales se han basado en la cirugía, la radioterapia y la quimioterapia. Pese al avance en estas terapias, el pronóstico de estos tumores ha permanecido casi constante durante los últimos años. Dada la ausencia de mejoría en el pronóstico, los últimos avances en técnicas de biología molecular han abierto un nuevo campo de investigación para el desarrollo de nuevos tratamientos, y dentro de ellos, se ha evaluado el uso de virus oncolíticos en diferentes ensayos. En esta revisión discutimos los avances ocurridos en el uso de terapias basadas en estos agentes anticancerosos.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Gliomas are the most frequent primary tumors of the brain. The standard treatment includes surgery, radiotherapy and chemotherapy, but the outcomes of patients with these tumors have remained nearly unchanged for past years. Hopefully, recent advances in molecular biology are rising new clinical expectation for patients with brain tumors. Among the novel techniques in this new fleld of research a new fleld of research, the use of oncolytic viruses has been explored in different trials during last years. In the present review we analyze the advances in the understanding of the oncolytic viral therapy of gliomas.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Arrese, I; González, P.; Miranda, P.; Pérez-Núñez, A.; Pascual, B.; Lobato, R.D.: Tratamiento de los gliomas mediante viras oncolíticos: revisión de la literatura. Neurociragía 2005; 16: 158–168.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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