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array:23 [ "pii" => "S1130147392708811" "issn" => "11301473" "doi" => "10.1016/S1130-1473(92)70881-1" "estado" => "S300" "fechaPublicacion" => "1992-01-01" "aid" => "70881" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1992" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1992;3:206-11" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2000 "formatos" => array:3 [ "EPUB" => 14 "HTML" => 838 "PDF" => 1148 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147392708823" "issn" => "11301473" "doi" => "10.1016/S1130-1473(92)70882-3" "estado" => "S300" "fechaPublicacion" => "1992-01-01" "aid" => "70882" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1992;3:212-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1546 "formatos" => array:3 [ "EPUB" => 16 "HTML" => 779 "PDF" => 751 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Empiemas subdllrales intracraneales" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "212" "paginaFinal" => "216" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Isla, F. Alvarez, V. Pepín, M. García-Blázquez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Isla" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Alvarez" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Pepín" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "García-Blázquez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392708823?idApp=UINPBA00004B" "url" => "/11301473/0000000300000003/v1_201305151419/S1130147392708823/v1_201305151419/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S113014739270880X" "issn" => "11301473" "doi" => "10.1016/S1130-1473(92)70880-X" "estado" => "S300" "fechaPublicacion" => "1992-01-01" "aid" => "70880" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1992;3:197-205" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2480 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 1034 "PDF" => 1428 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Hemorragia subaracnoidea idiopática. Estudio clínico de una serie de 258 casos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "197" "paginaFinal" => "205" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P.A. Gómez, J.J. Rivas, R.D. Lobato, A. Cabrera, R. Alday, S. Castro, J.M. Ortega, H. Sandoval, E. Lamas" "autores" => array:9 [ 0 => array:2 [ "nombre" => "P.A." "apellidos" => "Gómez" ] 1 => array:2 [ "nombre" => "J.J." "apellidos" => "Rivas" ] 2 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Cabrera" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Alday" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Castro" ] 6 => array:2 [ "nombre" => "J.M." "apellidos" => "Ortega" ] 7 => array:2 [ "nombre" => "H." "apellidos" => "Sandoval" ] 8 => array:2 [ "nombre" => "E." "apellidos" => "Lamas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S113014739270880X?idApp=UINPBA00004B" "url" => "/11301473/0000000300000003/v1_201305151419/S113014739270880X/v1_201305151419/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Tumores cerebrales experimentales inducidos por etil-nitrosourea en la rata Wistar" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "206" "paginaFinal" => "211" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Vaquero, A. Arias, M. Zurita, S. Coca, S. Oya, C. Morales" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Arias" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Zurita" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Oya" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Morales" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Clínica Puerta de Hierro y Departamento de Biología Celular, Universidad Complutense, Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162261" "palabras" => array:6 [ 0 => "Tumores cerebrales experimentales" 1 => "ENU" 2 => "Tumores neuroectodérrnicos primitivos" 3 => "Sinaptofisina" 4 => "Schwanomas" 5 => "Oligodendrogliomas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162262" "palabras" => array:6 [ 0 => "Experimental brain tumors" 1 => "ENU" 2 => "Primitive neuroectoderrnal tumors" 3 => "Synaptophysin" 4 => "Schwannoma" 5 => "Oligodendroglioma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se muestra la experiencia obtenida en la inducción de tumores experimentales del Sistema Nervioso en la rata Wistar, tras la exposición a etil-nitrosourea (ENU) durante el período fetal. En las condiciones experimentales utilizadas (inyección IP de 50<span class="elsevierStyleHsp" style=""></span>mg/kg de ENU en el día 17 de gestación), se obtuvieron schwanomas, generalmente del trigémino y/o ganglio de Gasser, con una latencia que osciló entre 4 y 7 meses, y tumores intracerebrales con aspecto morfológico de oligodendrogliomas, tras una latencia que osciló entre 7 y 10 meses tras la exposición al carcinógeno. El estudio inmunohistoquímico de ambos tipos de tumores mostró una clara positividad a la sinaptofisina, y en menor grado a la vimentina, lo que sugiere que, independientemente de su aspecto histológico, las neoplasias experimentales inducidas por ENU deben ser consideradas como tumores neuroectodérmicos primitivos.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The experience with experimental brain tumors, induced in the Wistar rat after transplacental administration (50<span class="elsevierStyleHsp" style=""></span>mg/kg, 17 day of gestafion) of ethyl-nitrosourea (ENU) is presented. Malignant schwannomas, arising from the trigeminal nerves or Gasserian ganglia, were found after a latency between 4–7 months. Oligodendroglioma-like tumors appeared between 7–10 months after ENU administration. Imunohistochemical study of the ENU-induced tumors showed that most of them expressed strong positivity to synaptophysin and, to a lesser degree, to vimentin, suggesting their interpretation as primitive neuroectodermal tumors.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Vaquero, J.; Arias, A.; Zurita, M.; Coca, S.; Oya, S.; Morales, c.: Tumores cerebrales experimentales inducidos por etil-nitrosurea en la rata Wistar. Neurocirugía 1992; 3: 206–211.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Short and long-tenn effects of methyl-and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. II. 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