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array:23 [ "pii" => "S1130147397710297" "issn" => "11301473" "doi" => "10.1016/S1130-1473(97)71029-7" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "71029" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1997" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1997;8:183-98" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 9461 "formatos" => array:3 [ "EPUB" => 19 "HTML" => 3601 "PDF" => 5841 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147397710303" "issn" => "11301473" "doi" => "10.1016/S1130-1473(97)71030-3" "estado" => "S300" "fechaPublicacion" => "1997-01-01" "aid" => "71030" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1997;8:199-204" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 16979 "formatos" => array:3 [ "EPUB" => 20 "HTML" => 3315 "PDF" => 13644 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Daño axonal difuso: factores pronósticos clínico-epidemiológicos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "199" "paginaFinal" => "204" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diffuse axonal injury: clinical and epidemiological prognostic factors" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. 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"apellidos" => "Oya" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397710285?idApp=UINPBA00004B" "url" => "/11301473/0000000800000003/v1_201305151502/S1130147397710285/v1_201305151502/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Tumores de región pineal: manejo, tratamiento quirúrgico y seguimiento de 21 casos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "183" "paginaFinal" => "198" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "S. Pardo, J.M. Fernández Villa, J. Molet, B. Oliver, P. Tresserras, P. Parés, F. Bartumeus" "autores" => array:7 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "Pardo" ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Fernández Villa" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Molet" ] 3 => array:2 [ "nombre" => "B." "apellidos" => "Oliver" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Tresserras" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Parés" ] 6 => array:2 [ "nombre" => "F." "apellidos" => "Bartumeus" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital de la Santa Creu i Sant Pau. Universidad Autónoma de Barcelona" ] ] ] 1 => array:3 [ "autoresLista" => "Ll. Colomo" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Ll." "apellidos" => "Colomo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía patológica. Hospital de la Santa Creu i Sant Pau. Universidad Autónoma de Barcelona" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pineal region tumors. Management and outcome of 21 cases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163166" "palabras" => array:6 [ 0 => "Tumor pineal" 1 => "Radioterapia" 2 => "Quimioterapia" 3 => "Germinoma" 4 => "Marcadores tumorales" 5 => "Citología LCR" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163167" "palabras" => array:6 [ 0 => "Pineal tumors" 1 => "Radiation therapy" 2 => "Chemotherapy" 3 => "Germinoma" 4 => "Tumor markers" 5 => "CSF cytology" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Revisamos el tratamiento y los resultados de una serie de 21 pacientes con lesiones de región pineal. De los 21 casos en diecinueve se realizó cirugía abierta. Nuestra serie incluye: 5 germinomas, 1 teratoma atípico, 2 teratomas maduros, 1 tumor mixto, 3 pineoblastomas, 1 pineocitoma, 2 gliomas, 1 cordoma, 2 quistes aracnoideos y una metástasis. Los otros dos tumores fueron catalogados como germinomas.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El estudio preoperatorio debe incluir RM craneoespinal con y sin contraste, citología de LCR y valoración de marcadores tumorales en suero y LCR.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Nosotros pensamos que el manejo correcto de estas lesiones requiere abordaje quirúrgico para diagnóstico histológico. Dicho abordaje vendrá determinado por las imágenes de la RM preoperatoria y la extensión tumoral. El tratamiento postoperatorio debe basarse en la histología y la extensión de la lesión.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los procesos benignos deben tratarse únicamente con cirugía. La radioterapia craneoespinal y quimioterapia deben ser administradas en aquellos pacientes con lesiones altamente malignas, diseminación meníngea, metástasis extraneural o citología positiva.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En nuestra serie la mortalidad operatoria es nula y la morbilidad mínima.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The management and outcome of 21 patients with tumors in the pineal region are reviewed. Nineteen patients underwent direct surgical approach. The identified tumors included: 5 germinomas, 1 atypical teratoma, 2 mature teratomas, 1 mixed tumor, 3 pineoblastomas, 1 pineocytoma, 2 gliomas, 1 cordoma, 2 cyst and 1 metastasis. Two others were presumptively germinomas.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Preoperative staging should inCIude craniospinal MR imaging with and without gadolinium, CSF sampling for cytology, and measurement of tumor markers in serum and CSF.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The authors believe that the preferred treatment for pineal tumors requires surgery with a histological diagnosis. Surgical approach is determined by the results of preoperative MR and the extension of the tumor. Postoperative treatment is based on histopathology and extension of the disease.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Benign tumors are treated with surgery only. Craniospinal irradiation and systemic chemotherapy should be administered to those patients with malignant tumors, showing meningeal seeding, extraneural metastasis, or positive CSF cytology.</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">There were no operative deaths and morbidity was minimal in our 21 patients.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pardo, S.; Fernández Villa, J.M.; Molet, J.; Oliver, B.; Tresserras, P.; Parés, P.; Colomo, L.; Bartumeus, F.: Tumores de región pineal. Manejo, tratamiento quirúrgico y seguimiento de 21 casos. Neurocirugía 1997; 8: 183–198.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:85 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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