A very large proportion of human brain tumours show DNA alterations at the EGF-R gene
Read
1591
Timeswas read the article
618
Total PDF
973
Total HTML
Share statistics
array:23 [ "pii" => "S1130147392709026" "issn" => "11301473" "doi" => "10.1016/S1130-1473(92)70902-6" "estado" => "S300" "fechaPublicacion" => "1992-01-01" "aid" => "70902" "copyright" => "Sociedad Española de Neurocirugía" "copyrightAnyo" => "1992" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1992;3:13-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1597 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 970 "PDF" => 610 ] ] "itemSiguiente" => array:18 [ "pii" => "S1130147392709038" "issn" => "11301473" "doi" => "10.1016/S1130-1473(92)70903-8" "estado" => "S300" "fechaPublicacion" => "1992-01-01" "aid" => "70903" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1992;3:20-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6363 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 1308 "PDF" => 5037 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Infección de las derivaciones ventrículo-peritoneales sin repercusión en el líquido cefalorraquídeo" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "20" "paginaFinal" => "22" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "V. Vanaclocha, N. Saiz-Sapena" "autores" => array:2 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Vanaclocha" ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Saiz-Sapena" ] ] ] 1 => array:2 [ "autoresLista" => "M.C. Frades" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M.C." "apellidos" => "Frades" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392709038?idApp=UINPBA00004B" "url" => "/11301473/0000000300000001/v1_201305151416/S1130147392709038/v1_201305151416/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1130147392709014" "issn" => "11301473" "doi" => "10.1016/S1130-1473(92)70901-4" "estado" => "S300" "fechaPublicacion" => "1992-01-01" "aid" => "70901" "copyright" => "Sociedad Española de Neurocirugía" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Neurocirugia. 1992;3:7-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2352 "formatos" => array:3 [ "EPUB" => 17 "HTML" => 727 "PDF" => 1608 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Tratamiento alternativo de la hernia discal lumbo-sacra. Nuclectomía percutánea automatizada. Nuestra experiencia en 50 pacientes" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "7" "paginaFinal" => "12" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. San Emeterio Samperio, J. Ailagas de las Heras, J.M. Coca Martín, J.I. Díaz de Tuesta" "autores" => array:4 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "San Emeterio Samperio" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Ailagas de las Heras" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Coca Martín" ] 3 => array:2 [ "nombre" => "J.I." "apellidos" => "Díaz de Tuesta" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392709014?idApp=UINPBA00004B" "url" => "/11301473/0000000300000001/v1_201305151416/S1130147392709014/v1_201305151416/es/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "A very large proportion of human brain tumours show DNA alterations at the EGF-R gene" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "13" "paginaFinal" => "19" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "A. Del Arco, J. García, M. Izquierdo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Del Arco" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "García" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Izquierdo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Departamento de Bioquímica, Biología Molecular. Universidad Autónoma de Madrid" ] ] ] 1 => array:3 [ "autoresLista" => "J.M. Izquierdo, M.G. Blázquez" "autores" => array:2 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "Izquierdo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "M.G." "apellidos" => "Blázquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neurocirugía. Hospital Valdecilla (Santander)" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicio de Neurocirugía. Hospital La Paz (Madrid)" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162135" "palabras" => array:4 [ 0 => "Brain tumors" 1 => "Epidermal Grow Factor" 2 => "EGF-R gene" 3 => "DNA alterations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162136" "palabras" => array:4 [ 0 => "Tumores cerebrales" 1 => "Factor de crecimiento epidérmico" 2 => "Gen receptor del EGF" 3 => "Alteraciones del DNA" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">DNA alterations occurs frequently in sorne types of neoplasia such as retinoblastoma, and lung, breast and colorectal carcinoma, We have found that loses of restriction fragments at the epidermal growth factor receptor gene (EGEF-R) are present in as much as 82% of human brain tumours. Amplifications of fragments are present at a much lower proportion reaching only 10% of the samples examined. Two fragments of 9<span class="elsevierStyleHsp" style=""></span>kb and 3.6<span class="elsevierStyleHsp" style=""></span>kb are preferentially lost during tumorigenesis and the latter only is not present in 79% of the cases in which normal and tumoral samples from the same individual were compared. In all but one sample examined in which alterations are present, the 3.6<span class="elsevierStyleHsp" style=""></span>kb fragment was heterozygotic in normal tissues and was not present in the tumour. Normal tissue surrounding the tumour was analyzed in a few examples and already showed a certain degree of alteration but normally not as much as the tumour itself. This will suggest that an accumulation ofseveral DNA aberrations might be responsible for determining the tumour biological propertieso Restriction fragment length polymorphism (RFLP), irrelevant to tumorigenesis, was found in about 22% of the cases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Alteraciones en las cadenas de DNA han sido detectadas en algunos tipos tumorales, como retinoblastomas y carcinomas de pulmón, mama y colon. Por nuestra parte, hemos observado que en el 82% de los tumores cerebrales examinados existen pérdidas de fragmentos de DNA en el gen del receptor del factor de crecimiento epidérmico, así como amplificación de otros fragmentos en el 10% de los tumores. Los fragmentos que más frecuentemente faltan son dos, uno de 9<span class="elsevierStyleHsp" style=""></span>kb (kilobase) y otro de 3,6. Este último no se encontró en el 79% de los casos en los que existía en el tejido normal del mismo paciente. En todos los casos excepto en uno, este fragmento era heterozigoto en el tejido normal y faltaba en el tumoral. El tejido aparentemente normal que rodea al tumor fue analizado en algunos casos, observándose en él algunas anomalías, aunque no tantas como en el propio tumor. Esto sugiere que probablemente sean necesarias varias alteraciones del DNA para que aparezcan las propiedades tumorales. Polimorfismo en la longitud de los fragmentos de restricción fue observado en el 22% de los casos.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genetic model for colorectal tumorige nesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.R. Fearon" 1 => "B. Vogelstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1990" "volumen" => "61" "paginaInicial" => "759" "paginaFinal" => "767" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2188735" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human EGF receptor gene: structure the 110<span class="elsevierStyleHsp" style=""></span>kb locus and identification sequences regulating its transcriptions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Haley" 1 => "N. Whittle" 2 => "P. Bennett" 3 => "D. Kinchington" 4 => "A. Ullrich" 5 => "M. Waterfleld" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Oncongen Research" "fecha" => "1987" "volumen" => "1" "paginaInicial" => "375" "paginaFinal" => "396" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic of cancer predisposition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.F. Hansen" 1 => "W.K. Cavenee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1987" "volumen" => "47" "paginaInicial" => "5518" "paginaFinal" => "5527" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2889524" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clonal genomic alterations in glioma malignancy stages" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C.D. James" 1 => "E. Carlbam" 2 => "J.P. Dumanski" 3 => "M. Hansen" 4 => "M. Nordenskjold" 5 => "P. Colllns" 6 => "W.K. Cavenee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1988" "volumen" => "48" "paginaInicial" => "5546" "paginaFinal" => "5551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2901288" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of stability and synthesis of EGF receptor mRNAs encoding for intact and truncated receptor forms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Kesavan" 1 => "P. Das" 2 => "J. Kern" 3 => "M. Das" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1990" "volumen" => "5" "paginaInicial" => "483" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2326077" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Truncation of the human EGF receptor leads to differential lransforming potentials in primary avian fibroblasts and erythroblasts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "K. Khazaie" 1 => "T.J. Dull" 2 => "T. Graf" 3 => "J. Schelssinger" 4 => "A. Ullrich" 5 => "H. Beug" 6 => "B. Vennstrom" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "EMBO J" "fecha" => "1988" "volumen" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2468488" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unique allelic restriction fragments of the human Ha-ras locus in leucocyte and tumour DNAs of cancer patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T.G. Krontiris" 1 => "N.A. Di martino" 2 => "M. Colb" 3 => "D.R. Parkinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nafure" "fecha" => "1985" "volumen" => "313" "paginaInicial" => "369" "paginaFinal" => "374" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Lee" 1 => "T.J. Dull" 2 => "I. Lax" 3 => "J. Schlessinger" 4 => "A. Ullrich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "EMBO J" "fecha" => "1989" "volumen" => "8" "paginaInicial" => "421" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2785915" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508502001750" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amplification, enhanced expressions and possible rearragement of EGF receptor gene in primary human brain tumours of glial origin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:10 [ 0 => "T.A. Libermann" 1 => "H.R. Nusbaum" 2 => "N. Razon" 3 => "R. Kris" 4 => "J. Lax" 5 => "H. Soreq" 6 => "N. Whittles" 7 => "M.D. Waterfields" 8 => "A. Ullrich" 9 => "J. Schelessinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1985" "volumen" => "313" "paginaInicial" => "144" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2981413" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Selective amplification on the cyloplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I.T. Malden" 1 => "V. Novac" 2 => "A.H. Kaye" 3 => "A.W. Buges" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "1988" "volumen" => "48" "paginaInicial" => "2711" "paginaFinal" => "2714" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2834047" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic analysis of hyperproduction of epidermal growth factor receptors in human epidermoid carcinoma As431 cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Shimizu" 1 => "I. Kondo" 2 => "M.A. Gamou" 3 => "A. Behzadian" 4 => "Y. Shimizu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Somatic Cell Mol. Genet." "fecha" => "1984" "volumen" => "10" "paginaInicial" => "45" "paginaFinal" => "53" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Signal transduction by receptors with tyrosine kinase activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Ullrich" 1 => "J. Schlessinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "1990" "volumen" => "61" "paginaInicial" => "203" "paginaFinal" => "212" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2158859" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The PUC plasmids, and M13 mp7 derived system for insertions mutagenesis and sequencing with synlhetic universal primers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Vieira" 1 => "J. Messing" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gene" "fecha" => "1982" "volumen" => "19" "paginaInicial" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6295879" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allelotype of colorectal carcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "B. Vogelstein" 1 => "E.E. Fearon" 2 => "S.E. Kern" 3 => "S.R. Hamilton" 4 => "A.C. Preisinoer" 5 => "Y. Nakamura" 6 => "R. White" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1989" "volumen" => "244" "paginaInicial" => "207" "paginaFinal" => "210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2565047" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ligand-induced transformation by a noninternalizing epidermal growth factor receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Wells" 1 => "J.B. Welsh" 2 => "C.S. Lazar" 3 => "H.S. Wiley" 4 => "G.N. Gill" 5 => "M.G. Rosenfedl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "1990" "volumen" => "247" "paginaInicial" => "962" "paginaFinal" => "964" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2305263" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human epidermal growth factor receptor cDNA is homologous to a variety of RNAa overproduced in A431 carcinoma cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "Y. Xu" 1 => "S. Ishil" 2 => "A.J.L. Clark" 3 => "M. Sulllvan" 4 => "R.K. Wilson" 5 => "D.P. Ma" 6 => "B.A. Roe" 7 => "G.T. Merllno" 8 => "I. Pastan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1984" "volumen" => "309" "paginaInicial" => "806" "paginaFinal" => "810" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6330563" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/11301473/0000000300000001/v1_201305151416/S1130147392709026/v1_201305151416/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/11301473/0000000300000001/v1_201305151416/S1130147392709026/v1_201305151416/en/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147392709026?idApp=UINPBA00004B" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2023 August | 0 | 1 | 1 |
| 2023 March | 3 | 7 | 10 |
| 2018 February | 13 | 3 | 16 |
| 2018 January | 15 | 5 | 20 |
| 2017 December | 18 | 13 | 31 |
| 2017 November | 15 | 46 | 61 |
| 2017 October | 17 | 10 | 27 |
| 2017 September | 12 | 8 | 20 |
| 2017 August | 17 | 7 | 24 |
| 2017 July | 12 | 8 | 20 |
| 2017 June | 24 | 3 | 27 |
| 2017 May | 17 | 12 | 29 |
| 2017 April | 15 | 7 | 22 |
| 2017 March | 15 | 24 | 39 |
| 2017 February | 2 | 3 | 5 |
| 2017 January | 10 | 6 | 16 |
| 2016 December | 36 | 13 | 49 |
| 2016 November | 33 | 13 | 46 |
| 2016 October | 50 | 12 | 62 |
| 2016 September | 24 | 3 | 27 |
| 2016 August | 0 | 4 | 4 |
| 2016 July | 0 | 12 | 12 |
| 2015 December | 3 | 0 | 3 |
| 2015 July | 0 | 7 | 7 |
| 2015 June | 21 | 6 | 27 |
| 2015 May | 21 | 14 | 35 |
| 2015 April | 25 | 15 | 40 |
| 2015 March | 28 | 24 | 52 |
| 2015 February | 20 | 12 | 32 |
| 2015 January | 19 | 11 | 30 |
| 2014 December | 18 | 14 | 32 |
| 2014 November | 20 | 9 | 29 |
| 2014 October | 28 | 14 | 42 |
| 2014 September | 23 | 16 | 39 |
| 2014 August | 21 | 13 | 34 |
| 2014 July | 17 | 14 | 31 |
| 2014 June | 28 | 23 | 51 |
| 2014 May | 27 | 14 | 41 |
| 2014 April | 17 | 13 | 30 |
| 2014 March | 11 | 13 | 24 |
| 2014 February | 22 | 18 | 40 |
| 2014 January | 20 | 12 | 32 |
| 2013 December | 9 | 8 | 17 |
| 2013 November | 24 | 6 | 30 |
| 2013 October | 34 | 10 | 44 |
| 2013 September | 23 | 9 | 32 |
| 2013 August | 25 | 26 | 51 |
| 2013 July | 15 | 8 | 23 |
| 2013 June | 18 | 10 | 28 |
| 2013 May | 13 | 17 | 30 |
| 2013 April | 15 | 6 | 21 |
| 2013 March | 15 | 5 | 20 |
| 2013 February | 11 | 5 | 16 |
| 2013 January | 18 | 6 | 24 |
| 2012 December | 16 | 14 | 30 |
| 2012 November | 0 | 4 | 4 |
| 2012 September | 0 | 2 | 2 |
Show all
