Función del eje hipotálamo-hipofisario en la muerte cerebral
J.M. Rabanal Llevot
Servicios de Anestesiología, Hospital Universitario «Marqués de Valdecilla». Santander
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Amado Señaris" "autores" => array:4 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Vázquez Barquero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "J.R." "apellidos" => "Carda Llop" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.M." "apellidos" => "Izquierdo Rojo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J.A." "apellidos" => "Amado Señaris" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicios de Neurocirugía, Hospital Universitario «Marqués de Valdecilla». Santander" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Servicios de Endocrinología. Hospital Universitario «Marqués de Valdecilla». Santander" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec162402" "palabras" => array:4 [ 0 => "Hormonas hipofisarias" 1 => "Muerte cerebral" 2 => "Función endocrina" 3 => "Hipofisis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec162403" "palabras" => array:4 [ 0 => "Pituitary hormones" 1 => "Brain death" 2 => "Endocrine function" 3 => "Hypophysis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La evolución de un paciente neurológico grave a la situación de muerte cerebral (MC) se produce como consecuencia de procesos que originan una isquemia cerebral generalizada con pérdida irreversible de todas las funciones encefálicas incluidas las troncoencefálicas. La isquemia del eje hipotálamo-hipofisario en la MC condicionaría un panhipopituitarismo universal que podría ser responsable del deterioro metabólico y hemodinámico de los donantes de órganos en MC.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hemos realizado un estudio prospectivo en quince pacientes en MC en los que determinamos los niveles de hormonas hipofisarias y la incidencia de diabetes insípida, practicando también un test de la TRH. Los cambios endocrinos hallados ponen de manifiesto una insuficiencia hipofisaria bien anatómica o funcional tras la MC, con escasa reserva funcional para responder al estímulo de la TRH.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Evolution to brain death of seriously ill neurologic patients is the consequence of cerebral isquemia. Isquemia of hypothalamic-hypophysis axis in brain death can be responsable of haemodynamic and metabolic disorders, in organ donors.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We performed a prospective study in fifteen brain death organ donors assesing hypophysis hormone leveIs and diabetes insipidus incidence. A TRH stimulation test was also performed.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The endocrine changes found in our study are characteristics of hypophyseal insufficiency (anatomic or functional), with little response to TRH stimulation.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Rabanal, J.M.; Vázquez, A.; Carda, J.R.; Izquierdo, J.M. y Amado, J.A.: Función del eje hípotálamo-hípofisario en la muerte cerebral. Neurocirugía 1993; 4: 63–66.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physiologic and hormonal changes in experimentally induced brain death dogs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Finkelstein" 1 => "L. Toledo-Pereira" 2 => "J. Castellanos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Transplant Proc" "fecha" => "1987" "volumen" => "5" "paginaInicial" => "4156" "paginaFinal" => "4158" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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