Enfermedad de Creutzfeldt-Jakob en Neurocirugía: una revisión de riesgos y medidas de prevención
Creutzfeldt-Jakob disease in neurosurgery: a review of risks and prevention measures
J.E. Martínez-Lage, M. Poza
Serv. de Neurocirugía, Hospital Universitario Virgen de la Arrixaca, Murcia
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"apellidos" => "Ruiz Bremón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "de Pedro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Laboratory of Central Nervous System Studies, National Institute of Neurological Disorder and Stroke, Bethesda, MD" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] 1 => array:3 [ "entidad" => "Centro de Vigilancia Epidemiológica, Inst. de Salud Carlos IlI, Madrid" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Creutzfeldt-Jakob disease in neurosurgery: a review of risks and prevention measures" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec163203" "palabras" => array:6 [ 0 => "Complicaciones en Neurocirugía" 1 => "Encefalopatía espongiforme" 2 => "Enfermedad de Creutzfeldt-Jakob yatrógena" 3 => "Enfermedades por priones" 4 => "Infección por virus lentos" 5 => "Injertos de duramadre" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163204" "palabras" => array:6 [ 0 => "Complications in Neurosurgery" 1 => "Dura mater grafts" 2 => "Iatrogenic Creutzfeldt-Jakob disease" 3 => "Prion infection" 4 => "Slow-virus infection" 5 => "Spongiform encephalopathy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">De 1988 a 1996 se han publicado al menos 17 casos de enfermedad de Creutzfeldt-Jakob (ECJ) relacionada con la colocación de injertos de duramadre obtenida de cadáveres en el curso de operaciones de Neurocirugía. El conocimiento de las formas de transmisión en el medio neuroquirúrgico, el cambio introducido en los métodos de obtención y esterilización de los injertos de origen humano, y sobre todo el mayor empleo de tejidos autólogos parecen haber puesto fin a una complicación de la neurocirugía: la ECJ yatrógena, terminando así con una pesadilla, de la cual ya solo cabe esperar la aparición de casos esporádicos. Los autores revisan su experiencia personal, así como los casos publicados (y no publicados) conocidos, y los métodos en uso para la erradicación de una enfermedad en la que el neurocirujano ha sido protagonista y, a la vez, vector involuntario. Del mismo modo, los neurocirujanos han contribuido a la investigación de los casos y a detener el desarrollo de esta enfermedad en el medio quirúrgico.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">From 1988 to 1996 there have been at least 17 reports on Creutzfeldt-Jakob disease (CJD) related to the placement of dura mater grafts of cadaveric origin during the course of neurosurgical procedures. The knowledge of means of transmission in the neurosurgical milieu, the changes introduced in the procurement and sterilization of grafts of human origin, and especially the widespread utilization of autologous tissues in dural repair, seems to have put to an end to this feared neurosurgical complication. Probably, we will see in the future only sporadic and infrequent cases of this entity. The authors review their personal experience, published and unpublished data on iatrogenic CJD cases, and the methods in use for eradication of this disease, in which the neurosurgeons have been involuntary protagonists and vectors. We also note the role played by neurosurgeons in the active investigation of most cases, and in contributing to halt CJD spread in the surgical environment.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Martínez-Lage, J.F.; Poza, M.; Brown, P.; Cervenáková, L.; Ruiz Bremón, A.; De Pedro, J.: Enfermedad de Creutzfeldt-Jakob en Neurocirugía: Una revisión de riesgos y medidas de prevención. Neurocirugía 1997; 8: 284–293.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:48 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2023 March | 1 | 3 | 4 |
| 2018 March | 0 | 3 | 3 |
| 2018 February | 13 | 10 | 23 |
| 2018 January | 13 | 7 | 20 |
| 2017 December | 9 | 8 | 17 |
| 2017 November | 44 | 32 | 76 |
| 2017 October | 7 | 12 | 19 |
| 2017 September | 9 | 8 | 17 |
| 2017 August | 9 | 14 | 23 |
| 2017 July | 9 | 10 | 19 |
| 2017 June | 10 | 7 | 17 |
| 2017 May | 12 | 11 | 23 |
| 2017 April | 13 | 3 | 16 |
| 2017 March | 10 | 7 | 17 |
| 2017 February | 6 | 1 | 7 |
| 2017 January | 11 | 2 | 13 |
| 2016 December | 28 | 6 | 34 |
| 2016 November | 23 | 8 | 31 |
| 2016 October | 28 | 21 | 49 |
| 2016 September | 36 | 12 | 48 |
| 2016 August | 30 | 8 | 38 |
| 2016 July | 25 | 15 | 40 |
| 2015 December | 4 | 0 | 4 |
| 2015 July | 5 | 4 | 9 |
| 2015 June | 12 | 10 | 22 |
| 2015 May | 24 | 11 | 35 |
| 2015 April | 12 | 17 | 29 |
| 2015 March | 23 | 17 | 40 |
| 2015 February | 15 | 23 | 38 |
| 2015 January | 15 | 16 | 31 |
| 2014 December | 18 | 13 | 31 |
| 2014 November | 13 | 12 | 25 |
| 2014 October | 22 | 19 | 41 |
| 2014 September | 17 | 21 | 38 |
| 2014 August | 15 | 16 | 31 |
| 2014 July | 19 | 14 | 33 |
| 2014 June | 30 | 19 | 49 |
| 2014 May | 24 | 21 | 45 |
| 2014 April | 22 | 12 | 34 |
| 2014 March | 16 | 18 | 34 |
| 2014 February | 25 | 13 | 38 |
| 2014 January | 20 | 16 | 36 |
| 2013 December | 15 | 15 | 30 |
| 2013 November | 17 | 13 | 30 |
| 2013 October | 17 | 12 | 29 |
| 2013 September | 25 | 16 | 41 |
| 2013 August | 19 | 21 | 40 |
| 2013 July | 28 | 23 | 51 |
| 2013 June | 8 | 28 | 36 |
| 2013 May | 16 | 21 | 37 |
| 2013 April | 9 | 17 | 26 |
| 2013 March | 15 | 15 | 30 |
| 2013 February | 6 | 14 | 20 |
| 2013 January | 14 | 13 | 27 |
| 2012 December | 14 | 20 | 34 |
| 2012 November | 0 | 20 | 20 |
| 2012 October | 0 | 1 | 1 |
| 2012 September | 0 | 2 | 2 |
| 2012 January | 10 | 0 | 10 |
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