Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado
Effects of tetracycline derivates as inhibitors of tumor angiogenesis (C.N.S.). Experimental study on an undifferentiated neuroectodermal tumor
J. Vaquero, M. Zurita, S. Coca, S. Oya
Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina. Laboratorio de Neuro-oncología experimental del Servicio de Neurocirugía del Hospital Universitario Clínica Puerta de HielTo. Madrid
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Bini" "autores" => array:1 [ 0 => array:2 [ "nombre" => "W." "apellidos" => "Bini" ] ] ] 1 => array:2 [ "autoresLista" => "O. Speck, Th. Thiel, J. Hennig" "autores" => array:3 [ 0 => array:2 [ "nombre" => "O." "apellidos" => "Speck" ] 1 => array:2 [ "nombre" => "Th." "apellidos" => "Thiel" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Hennig" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147397710273?idApp=UINPBA00004B" "url" => "/11301473/0000000800000003/v1_201305151502/S1130147397710273/v1_201305151502/en/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "178" "paginaFinal" => "182" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "J. Vaquero, M. Zurita, S. Coca, S. Oya" "autores" => array:4 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Vaquero" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Zurita" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Coca" ] 3 => array:2 [ "nombre" => "S." "apellidos" => "Oya" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Investigación en Neurociencias de la Fundación Mapfre-Medicina. Laboratorio de Neuro-oncología experimental del Servicio de Neurocirugía del Hospital Universitario Clínica Puerta de HielTo. Madrid" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Effects of tetracycline derivates as inhibitors of tumor angiogenesis (C.N.S.). Experimental study on an undifferentiated neuroectodermal tumor" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163160" "palabras" => array:4 [ 0 => "Tetraciclina" 1 => "Minociclina" 2 => "Tumor cerebral experimental" 3 => "Angiogénesis tumoral" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163161" "palabras" => array:4 [ 0 => "Tetracycline" 1 => "Minocycline" 2 => "Experimental brain tumor" 3 => "Tumor angiogenesis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un estudio experimental sobre un modelo de tumor neuroectodérmico indiferenciado, con el propósito de conocer el posible efecto antitumoral de un derivado de la tetraciclina (minociclina) con capacidad para inducir una inhibición de la angiogénesis tumoral. La administración intratumoral de minociclina sobre el tumor experimental IL-7, durante 4 semanas, no modificó el crecimiento del tumor ni su patrón de angiogénesis. Estos resultados sugieren la escasa utilidfld de líneas de investigación que traten de controlar el crecimiento de neoplasias indiferenciadas del Sistema Nervioso basándose en una supuesta inhibición de la angiogénesis tumoral inducida por derivados de la tetraciclina.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An experimental study on a model of undifferentiated neuroectodermal tumor has been accomplished in order to know the possible antitumor effect of a tetracycline derivative (minocycline), with capacity to induce an inhibition of the tumor angiogenesis. The intratumoral administration of minocycline on the experimental tumor IL-7, during 4 weeks, it did not modify the growth of the tumor neither its pattern of angiogenesis. These results suggest the scarce usefulness of research that try of controlling the growth of undifferentiated neoplasias of the Nervous System by means of a supposed inhibition of tumor angiogenesis induced by tetracycline derivatives.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Vaquero, J.; Zurita, M.; Coca, S.; Oya, S.: Utilidad de los derivados de la tetraciclina como inhibidores de la angiogénesis tumoral en neoplasias del sistema nervioso. Estudio experimental sobre un tumor neuroectodérmico indiferenciado. Neurocirugía 1997; 8: 178–182.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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