Diagnóstico diferencial de tumores cerebrales “in vitro” por espectroscopía de resonancia magnética de protón. Método de los cocientes espectrales
Differential diagnosis of brain tumors by proton magnetic resonance spectroscopy “in vitro”. The method of spectroscopic ratios
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López-Escobar Fernández, E. Gómez Cárdenas, A. Contreras Jiménez, C. Ramos Guillén" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "López-Escobar Fernández" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Gómez Cárdenas" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Contreras Jiménez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Ramos Guillén" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147398707158?idApp=UINPBA00004B" "url" => "/11301473/0000000900000001/v1_201305151507/S1130147398707158/v1_201305151507/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Diagnóstico diferencial de tumores cerebrales “in vitro” por espectroscopía de resonancia magnética de protón. Método de los cocientes espectrales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "10" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J.Mª. Pascual, F. Carceller, J.M. Roda" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.Mª." "apellidos" => "Pascual" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Carceller" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Roda" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía. Hospital Universitario La Paz. 28046 Madrid" ] ] ] 1 => array:3 [ "autoresLista" => "S. Cerdán" "autores" => array:1 [ 0 => array:3 [ "nombre" => "S." "apellidos" => "Cerdán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Instituto de Investigaciones Biomédicas del C.S.I.C. Madrid" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Differential diagnosis of brain tumors by proton magnetic resonance spectroscopy “in vitro”. The method of spectroscopic ratios" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Abreviaturas" "identificador" => "xpalclavsec163231" "palabras" => array:13 [ 0 => "Ala" 1 => "Cho" 2 => "Cr" 3 => "Glu" 4 => "Gln" 5 => "Gly" 6 => "Ino" 7 => "Lac" 8 => "NAA" 9 => "RMN" 10 => "SNC" 11 => "Tau" 12 => "TSP" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec163233" "palabras" => array:1 [ 0 => "Espectroscopía <span class="elsevierStyleSup">1</span>H RMN, tumores cerebrales, diagnóstico in vitro:" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec163232" "palabras" => array:1 [ 0 => "<span class="elsevierStyleSup">1</span>H NMR spectroscopy, brain tumors, in vitro diagnosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se han estudiado por espectroscopía de <span class="elsevierStyleSup">1</span>H RMN de alta resolución extractos de biopsias de cerebro humano normal (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5), de astrocitomas de bajo grado (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7), de astrocitomas de alto grado y glioblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16), de meningiomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>18), de oligodendrogliomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) y de meduloblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3). Los espectros obtenidos se compararon entre sí utilizando ocho cocientes de intensidad de resonancias específicas: colina/creatina, colina/N-acetilaspártico, creatina/N-acetilaspártico, colina/inositol, glutamina/glutamato, taurina/N-acetilaspártico, alanina/creatina y alanina/N-acetilaspártico. Estos cocientes permitieron realizar un, diagnóstico diferencial entre todos los tejidos estudiados con excepción de la comparación entre oligodendrogliomas y astrocitomas. Los tumores cerebrales pudieron diferenciarse del tejido cerebral normal por su menor contenido en N-acetilaspártico. Los meningiomas se caracterizaron por su alto contenido en alanina y los medulobiastomas por sus elevados contenidos en colina y taurina. En el caso de los astrocitomas fue posible discriminar entre los grados de malignidad bajo y alto en base al mayor valor del cociente colina/inositol y menor valor del cociente glutamina/glutamato en los astrocitomas de alto grado. Estos resultados indican que la aplicación de cocientes en la comparación de espectros de biopsias cerebrales constituye una herramienta útil en el diagnóstico diferencial de tumores por espectroscopía de’ <span class="elsevierStyleSup">1</span>H RMN.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We have studied high resolution 1H NMR spectra of extracts from biopsies of normal brain (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5), low grade astrocytomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7), high grade astrocytomas and glioblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>16), meningiomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>18), oligodendrogliomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4) and medulloblastomas (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3). The spectra were compared using eight different intensity ratios. of specific resonances: choline/creatine, choline/N-acetyl-aspartic, creatine/N-acetilaspartic, choline/inositol; glutamine/glutamate, turine/N-acetylaspartic, alanine/creatine and alanine/N-acetylaspartic. These ratios allowed a differential diagnosis for each of the tissue samples studied, with the exception of the comparison between oligodendrogliomas and astrocytomas. Brain tumors contained always less N-acetylaspartic than the normal brain. Meningiomas were characterized by their high content in alanine and medulloblastomas by their high content in choline and taurineo High grade astrocytomas and glioblastomas could be distinguished from low grade astrocytomas by their higher choline/inositol ratio and lower glutamine/glutamate ratio. These results indicate that comparisons between intensity ratios in spectra of cerebral biopsies provide a useful tool for the differential diagnosis of brain tumors by high resolution <span class="elsevierStyleSup">1</span>H NMR.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Pascual, J.Mª.; Carceller, F.; Cerdán, S.; Roda, J.M.: Diagnóstico diferencial de tumores cerebrales “in vitro” por espectroscopía de resonancia magnética de protón. Método de cocientes espectrales. Neurocirugía 1998; 9: 4–10.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2023 March | 2 | 3 | 5 |
| 2018 November | 1 | 2 | 3 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 21 | 7 | 28 |
| 2018 January | 29 | 18 | 47 |
| 2017 December | 34 | 27 | 61 |
| 2017 November | 54 | 50 | 104 |
| 2017 October | 46 | 42 | 88 |
| 2017 September | 25 | 53 | 78 |
| 2017 August | 24 | 62 | 86 |
| 2017 July | 30 | 54 | 84 |
| 2017 June | 31 | 72 | 103 |
| 2017 May | 35 | 84 | 119 |
| 2017 April | 20 | 106 | 126 |
| 2017 March | 15 | 96 | 111 |
| 2017 February | 18 | 106 | 124 |
| 2017 January | 13 | 53 | 66 |
| 2016 December | 36 | 52 | 88 |
| 2016 November | 33 | 84 | 117 |
| 2016 October | 52 | 82 | 134 |
| 2016 September | 95 | 134 | 229 |
| 2016 August | 149 | 143 | 292 |
| 2016 July | 66 | 135 | 201 |
| 2015 December | 4 | 0 | 4 |
| 2015 September | 1 | 0 | 1 |
| 2015 July | 4 | 8 | 12 |
| 2015 June | 14 | 86 | 100 |
| 2015 May | 22 | 112 | 134 |
| 2015 April | 10 | 114 | 124 |
| 2015 March | 17 | 105 | 122 |
| 2015 February | 15 | 110 | 125 |
| 2015 January | 13 | 101 | 114 |
| 2014 December | 15 | 73 | 88 |
| 2014 November | 14 | 101 | 115 |
| 2014 October | 21 | 97 | 118 |
| 2014 September | 19 | 127 | 146 |
| 2014 August | 15 | 120 | 135 |
| 2014 July | 21 | 77 | 98 |
| 2014 June | 25 | 80 | 105 |
| 2014 May | 25 | 90 | 115 |
| 2014 April | 12 | 69 | 81 |
| 2014 March | 18 | 51 | 69 |
| 2014 February | 19 | 64 | 83 |
| 2014 January | 12 | 68 | 80 |
| 2013 December | 9 | 51 | 60 |
| 2013 November | 14 | 53 | 67 |
| 2013 October | 16 | 76 | 92 |
| 2013 September | 16 | 98 | 114 |
| 2013 August | 15 | 58 | 73 |
| 2013 July | 18 | 75 | 93 |
| 2013 June | 15 | 68 | 83 |
| 2013 May | 9 | 70 | 79 |
| 2013 April | 13 | 54 | 67 |
| 2013 March | 10 | 40 | 50 |
| 2013 February | 8 | 29 | 37 |
| 2013 January | 14 | 25 | 39 |
| 2012 December | 11 | 27 | 38 |
| 2012 November | 1 | 21 | 22 |
| 2012 October | 0 | 1 | 1 |
| 2012 September | 0 | 2 | 2 |
| 2012 January | 8 | 0 | 8 |
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