Avances en el tratamiento de los traumatismos craneoencefálicos graves

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Romance, G. Sánchez Aniceto, R. Gutiérrez, R.D. Lobato, R. Alday, A. De La Lama, R. de la Mata" "autores" => array:7 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Romance" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Sánchez Aniceto" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Gutiérrez" ] 3 => array:2 [ "nombre" => "R.D." "apellidos" => "Lobato" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Alday" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "De La Lama" ] 6 => array:2 [ "nombre" => "R." "apellidos" => "de la Mata" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147399707980?idApp=UINPBA00004B" "url" => "/11301473/0000001000000003/v1_201305151012/S1130147399707980/v1_201305151012/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Avances en el tratamiento de los traumatismos craneoencefálicos graves" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "185" "paginaFinal" => "209" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "J. Sahuquillo, M.A. Poca, E. Rubio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Sahuquillo" ] 1 => array:2 [ "nombre" => "M.A." "apellidos" => "Poca" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Rubio" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neurocirugía, Hospitales Universitarios Vall d’Hebron. Barcelona" ] ] ] 1 => array:3 [ "autoresLista" => "F. Munar" "autores" => array:1 [ 0 => array:3 [ "nombre" => "F." "apellidos" => "Munar" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Unidad de Neurotraumatología, Hospitales Universitarios Vall d’Hebron. Barcelona" "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Advances in the management of severe head injury" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec156683" "palabras" => array:6 [ 0 => "Traumatismos craneoencefálicos" 1 => "Revisión" 2 => "Estrategias terapéuticas" 3 => "Corticosteroides" 4 => "Hiperventilación" 5 => "Medicina basada en la evidencia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec156684" "palabras" => array:6 [ 0 => "Head injury" 1 => "Review" 2 => "Management strategies" 3 => "Steroids" 4 => "Hyperventilation" 5 => "Evidence-based medicine" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Los fundamentos teóricos para el tratamiento de los pacientes con un traumatismo craneoencefálico (TCE) grave se derivan del concepto de lesión secundaria. En este trabajo actualizamos las pautas de tratamiento seguidas en el traumatismo craneoencefálico y de aquel subgrupo de pacientes que presentan hipertensión intracraneaI. Introducimos el nuevo paradigma denominado medicina basada en la evidencia haciendo énfasis en sus implicaciones presentes y futuras en el tratamiento de los traumatismos craneoencefálicoso Presentamos una revisión de las recomendaciones sugeridas por las Guías de práctica clínica recientemente publicadas bajo los auspicios de la Brain Trauma Foundation. En este artículo revisamos también los grupos específicos de drogas utilizados en el tratamiento de estos pacientes y que incluyen entre otras: Sedantes y analgésicos, bloqueantes musculares, barbitúricos, corticosteroides y soluciones hiperosmolares. Planteamos las controversias existentes en el uso de algunos tratamientos tales como el aumento de la presión de perfusión cerebral mediante drogas vasoactivas, la hiperventilación o el uso de drogas tales como la dihidroergotamina y la indometacina. También presentamos una revisión histórica y las controversias existentes sobre el uso de corticosteroides y se discuten los fundamentos y la potencial utilidad de ciertas drogas dirigidas a bloquear las cascadas neuroquímicas anómalas que se han demostrado en estos pacientes. Presentamos y discutimos también las bases teóricas sobre la utilización de los 21-aminoesteroides (Lazaroides), los antagonistas del calcio, algunos fármacos potenciales protectores de membrana y los inhibidores del glutamato en el tratamiento de estos pacientes." ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "The theoretical basis for treatment of severe head injury derives from the concept of secondary damage to the brain. This paper provides an overview of the current therapeutic approaches used in treating severe head injury and in particular those patients who develop high intracranial pressure. Special emphasis is given to the new paradigm of so-called evidence-based medicine and its influence on the present and future management of severe head injuries. A review of the recommendations suggested by the Guidelines for the Treatment of Severe Head Injury, recently published by the Brain Trauma Foundation are presented. Specific types of drugs covered in this review include sedatives, analgesics, paralytic agents, barbiturates, steroids and hyperosmolar solutions. The controversies surrounding certain treatments such as the increase of cerebral perfusion pressure with vasoactive drugs, hyperventilation, indomethacine or dihydroergotamine are outlined. We also review the historical background and the controversies over the use of steroids in these patients. The recentiy developed drugs capable of blocking the damaging neurochemical cascades identified in severe head injury are discussed. Finally, the rationale for using 21-aminosteroids (Lazaroids), calcium-antagonists, potential membrane-protectors and the different types of glutamate receptors is also presented." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Sahuquillo, J.; Poca, M.A.; Munar, F.; Rubio, E.: Avances en el tratamiento de los traumatismos craneoencefálicos graves. Neurocirugía 1999; 10: 185–209." ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:184 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emergency drug therapy of closed head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "CNS Drugs" "fecha" => "1995" "volumen" => "3" "paginaInicial" => "337" "paginaFinal" => "350" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular biology of the cell" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1989" "editorial" => "Garlan Publishing, lnc" "editorialLocalizacion" => "New York & London" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subtemporal decompression: radiological observations and current surgical experience" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Brit. J. Neurosurg" "fecha" => "1987" "volumen" => "1" "paginaInicial" => "427" "paginaFinal" => "433" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral carbohydrate metabolism during hypocarbia in man" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anesthesiology" "fecha" => "1965" "volumen" => "26" "paginaInicial" => "624" "paginaFinal" => "632" "link" => array:1 [ …1] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The intensive care management of patients with head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neurosurgical Intensive Careo" "paginaInicial" => "227" "paginaFinal" => "242" "serieFecha" => "1993" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lidocaine can reduce intracranial pressure associated with intracranial space-occupying lesions" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure VII" "paginaInicial" => "486" "paginaFinal" => "489" "serieFecha" => "1989" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J. Cereb. BIood Flow Metab" "fecha" => "1991" "volumen" => "11" "paginaInicial" => "380" "paginaFinal" => "387" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new therapy of post-trauma brain oedema based on haemodynamic principies for brain volume regulation" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Intens Care Med" "fecha" => "1994" "volumen" => "20" "paginaInicial" => "260" "paginaFinal" => "267" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral oxygen metabolism during hypotherrnic circulatory arrest in humans" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1993.79.6.0810" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1993" "volumen" => "79" "paginaInicial" => "810" "paginaFinal" => "815" "link" => array:1 [ …1] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A trial of the effect of nimodipine on outcome after head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Neurochir. (Wien)" "fecha" => "1991" "volumen" => "110" "paginaInicial" => "97" "paginaFinal" => "105" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mannitol infusion Part III The acute effect of the intravenous infusion of mannitol on blood and plasma volume" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM196105252642102" "Revista" => array:6 [ "tituloSerie" => "N. Engl. J. Med" "fecha" => "1961" "volumen" => "264" "paginaInicial" => "1.085" "paginaFinal" => "1.088" "link" => array:1 [ …1] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Control of intracranial pressure in severe head injury" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Intracranial Pressure" "paginaInicial" => "567" "paginaFinal" => "571" "serieFecha" => "1983" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Barbiturate therapy in the management of cerebral ischaemia" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anaesthesia" "fecha" => "1980" "volumen" => "35" "paginaInicial" => "271" "paginaFinal" => "278" "link" => array:1 [ …1] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertone lösungen zur behandlung des intrakkraniellen drucks" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "ZBL Chir" "fecha" => "1993" "volumen" => "118" "paginaInicial" => "237" "paginaFinal" => "244" "link" => array:1 [ …1] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1995.83.4.0627" "Revista" => array:6 [ "tituloSerie" => "J. Neurosurg" "fecha" => "1995" …4 ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant cerebral edema and intracranial hypertension" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etude des effets de l’ administration de cytidine diphosphocholine sur les conséquences hémodynamiques, fonctionelles et biochimiques du traumatisme craniocervical chez le rat" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1991.75.5.0685" "Revista" => array:6 [ …6] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.77.3.0360" "Revista" => array:7 [ …7] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demonstration of early ischemia after severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A multicenter trial of the efficacy of nimodipine on outcome after severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1994.80.5.0797" "Revista" => array:6 [ …6] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Megadose steroids in severe head injury Results of a prospective double-blind clinical trial" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1983.58.3.0326" "Revista" => array:6 [ …6] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemical Neurobiology" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ …3] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new 21-aminosteroid antioxidant lacking glucocorticoid activity simulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor (AtT-20) cells" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medicina basada en pruebas (Evidence-based Medicine)" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nimodipinje and calcium channel blockade for cerebral vasospasm" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detailed monitoring of the effects of mannitol following experimental head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1979.50.4.0423" "Revista" => array:6 [ …6] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mannitol and other diuretics in severe neurotrauma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for the Management of Severe Head Injury, The Brain Trauma Foundation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ …2] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experience with the glutamate antagonist CG 19755 in severe human head injury: Evidence for ICP lowering effect" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of CDP-choline on the recovery of patients with head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intracellular calcium homeostasis" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.bi.56.070187.002143" "Revista" => array:6 [ …6] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etude double insu du Réxort en neuro-traumatologie infantile" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical management of severe head. injury: present and future" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of secondary brain injury in determining outcome. from severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypothermia and hyperbaric oxygen as. treatment modalities for severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A phase II study of moderate hypothermia in severe brain injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/neu.1993.10.263" "Revista" => array:6 [ …6] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etude d’un précurseur. des phospholipides dans le traitement des comas. traumatiques graves" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does acute hyperventilation provoke cerebral. oliguemia in comatose patients after acute head injury?" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence based critical care medicine: What is it and what. can it do for us?" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dexamethasone and severe head injury. A prospective double-blind. study" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1979.51.3.0307" "Revista" => array:6 [ …6] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pituitary body and its disorders" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ …3] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C02 and indomethacin. vasoreactivity in patients with head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of high-dose dexamethasone. on outcome from severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1986.64.1.0081" "Revista" => array:6 [ …6] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects de la CDP-choline sur le rapport lactates/pyruvates prospective randomized double-blind multicenter trial (GUDHIS). dans le LCR en cas de souffrance cérébrale grave" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurons and networks" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ …4] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-dose dexamethasone therapy in head injury: a patient group that may benefit from therapy" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of three potentially preventable complications on outcome after severe closed head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1988.69.1.0015" "Revista" => array:6 [ …6] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Initial CT findings in 753 patients with severe head injury. A report from the NIH traumatic coma data bank" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1990.73.5.0688" "Revista" => array:7 [ …7] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emergency Care: Initial Evaluation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Etude de l’action de la CDP-choline dans les troubles de la vigilance post-traumatique" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of experimental intracranial hypertension by lidocaine" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dexamethason beim schweren schadel-hirn-trauma Ergebnisse einer Doppel-Blind-Studie" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regional cerebral blood flow and intraventricular pressure in acute head injuries" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current Concepts of Pathophysiology and Management of Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertonic saline lowers raised intracranial pressure in children after head trauma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib60" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bilateral Decompressive Craniectomy for Worsening Coma in Acute Subarachnoid Hemorrhage - Observations in Support of the Procedure" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib61" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertonic saline (7.5-percent) versus mannitol - a comparison for treatment of acute head injuries" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib62" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "“Ultrahigh” dexamethasone in acute brain injury Results from a German Ultrahigh Dexamethasone Head Injury Sudy Group. Zentralbl" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib63" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical rationale for the use of CDPcholine in traumatic brain injury: pharmacokinetics of the orally administered drug" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib64" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of fluid restriction, mannitol and frusemide in reducing ICP" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib65" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survey of critical care management of comatose, head-injured patients in the United States" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib66" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroprotection in brain ischemia: an update (part I)" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib67" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroprotection in brain ischemia: An update. Part II" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib68" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathophysiological mechanisms and therapeutic aspects in stroke and ischemic brain injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ …5] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib69" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anfallsprophylaze mit carbamazepin nach schweren schadelhirnverletzungen" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2008-1053615" "Revista" => array:6 [ …6] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib70" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prolonged paralysis after neuromuscular blockade" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib71" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebrovascular effects of dihydroergotamine" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib72" "etiqueta" => "72" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of Subtemporal Decompression in Severe Closed Head Injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib73" "etiqueta" => "73" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of selective neuronal vulnerability - bioenergetics and excitotoxicity" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib74" "etiqueta" => "74" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomy and physiology of glutamate in the CNS" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib75" "etiqueta" => "75" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Failure of high dose steroid therapy to influence intracranial pressure in patients with severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1979.51.3.0301" "Revista" => array:6 [ …6] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib76" "etiqueta" => "76" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence-based medicine. A new approach to teaching the practice of medicine" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib77" "etiqueta" => "77" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A proposal for enhancing the quality of clinical teaching: results of a department of medicine’ s educationa1 retreat" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib78" "etiqueta" => "78" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized trial of nicardipine in subarachnoid hemorrhage: angiographic and transcranial doppler ultrasound results. A report of the cooperative aneurysm study" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1993.78.4.0548" "Revista" => array:6 [ …6] ] ] ] ] ] 78 => array:3 [ "identificador" => "bib79" "etiqueta" => "79" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage: A report of the cooperative aneurysm study" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1993.78.4.0537" "Revista" => array:6 [ …6] ] ] ] ] ] 79 => array:3 [ "identificador" => "bib80" "etiqueta" => "80" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The neuroprotective pharmacology of methylprednisolone" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.76.1.0013" "Revista" => array:6 [ …6] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib81" "etiqueta" => "81" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lazaroids: mechanisms of action and implications for disorders of the CNS" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib82" "etiqueta" => "82" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of tirilazad mesylate on postischemic brain lipid peroxidation and recovery of extracellular calcium in gerbils" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib83" "etiqueta" => "83" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactive oxygen species and the central nervous system" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib84" "etiqueta" => "84" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Traumatic subarachnoid hemorrhage and its treatment with nimodipine" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1996.85.1.0082" "Revista" => array:6 [ …6] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib85" "etiqueta" => "85" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Marked variability in the management of severe head injury at Trauma Centers inthe United States" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib86" "etiqueta" => "86" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemical studies of head injury and brain edema" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib87" "etiqueta" => "87" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic management of cerebral edema based on a new concept in severe head injury patients" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib88" "etiqueta" => "88" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurochemical changes in traumatic brain injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib89" "etiqueta" => "89" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adrenocorticotropic hormone; Adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib90" "etiqueta" => "90" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of moderate hypothermia on therapies for intracranial pressure control in severe traumatic brain injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib91" "etiqueta" => "91" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3% NaCl and 7,5% NaCl/dextran 70 in the resuscitation of severely injured patients" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib92" "etiqueta" => "92" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early, routine paralysis for intracranial pressure control in severe head injury: Is it necessary?" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib93" "etiqueta" => "93" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The molecular basis of brain injury and brain edema: The role of oxygen free radicals" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib94" "etiqueta" => "94" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain swelling and brain oedema in acute head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 94 => array:3 [ "identificador" => "bib95" "etiqueta" => "95" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ …3] ] ] ] ] ] 95 => array:3 [ "identificador" => "bib96" "etiqueta" => "96" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indomethacin (Confortid) in severe head injury and elevated intracranial pressure (lCP)" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 96 => array:3 [ "identificador" => "bib97" "etiqueta" => "97" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guías de práctica clínica" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 97 => array:3 [ "identificador" => "bib98" "etiqueta" => "98" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1996.84.2.0221" "Revista" => array:6 [ …6] ] ] ] ] ] 98 => array:3 [ "identificador" => "bib99" "etiqueta" => "99" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuron-glial interaction during injury and edema of the CNS" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 99 => array:3 [ "identificador" => "bib100" "etiqueta" => "100" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Studies in head injury Part I: and experimental model of closed head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 100 => array:3 [ "identificador" => "bib101" "etiqueta" => "101" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyperglycemia and neurological outcome in patients with head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1991.75.4.0545" "Revista" => array:6 [ …6] ] ] ] ] ] 101 => array:3 [ "identificador" => "bib102" "etiqueta" => "102" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CT, NMR, and emission tomography in the diagnosis and management of brain swelling and intracranial hypertension" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 102 => array:3 [ "identificador" => "bib103" "etiqueta" => "103" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brain extracellular pH: the main factor controlling cerebral blood flow" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/00365516809167060" "Revista" => array:6 [ …6] ] ] ] ] ] 103 => array:3 [ "identificador" => "bib104" "etiqueta" => "104" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of postconcussional symptons with CDP-choline" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 104 => array:3 [ "identificador" => "bib105" "etiqueta" => "105" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Excitatory amino acids as a final common pathway for neurologic disorders" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199403033300907" "Revista" => array:6 [ …6] ] ] ] ] ] 105 => array:3 [ "identificador" => "bib106" "etiqueta" => "106" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of disease" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199403033300907" "Revista" => array:6 [ …6] ] ] ] ] ] 106 => array:3 [ "identificador" => "bib107" "etiqueta" => "107" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CDP-choline in the treatment of cranioencephalic traumata" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 107 => array:3 [ "identificador" => "bib108" "etiqueta" => "108" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of stable xenonenhanced computed tomographic studies of cerebral blood flow to define changes in cerebral carbon dioxide vasoresponsivity caused by asevere head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 108 => array:3 [ "identificador" => "bib109" "etiqueta" => "109" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of traumatic brain injury with moderate hypothermia" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199702203360803" "Revista" => array:6 [ …6] ] ] ] ] ] 109 => array:3 [ "identificador" => "bib110" "etiqueta" => "110" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early effects of mannitol in patients with head injuries assessed using bedside multimodality monitoring - Comments" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ …4] ] ] ] ] ] 110 => array:3 [ "identificador" => "bib111" "etiqueta" => "111" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical management of head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 111 => array:3 [ "identificador" => "bib112" "etiqueta" => "112" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medical management of intracranial pressure" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 112 => array:3 [ "identificador" => "bib113" "etiqueta" => "113" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacologic therapy: promising clinical investigation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 113 => array:3 [ "identificador" => "bib114" "etiqueta" => "114" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mannitol dose requirements in brain-injured patients" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1978.48.2.0169" "Revista" => array:6 [ …6] ] ] ] ] ] 114 => array:3 [ "identificador" => "bib115" "etiqueta" => "115" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new class of compounds for stroke and trauma: Effects of 21-aminosteroids on lipid peroxidation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 115 => array:3 [ "identificador" => "bib116" "etiqueta" => "116" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of mannitol on increased intracranial pressure" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 116 => array:3 [ "identificador" => "bib117" "etiqueta" => "117" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of the intracranial response to mannitol and furosemide" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 117 => array:3 [ "identificador" => "bib118" "etiqueta" => "118" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low risk of late post-traumatic seizures following severe head injury: implications for clinical trials of prophylaxis" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 118 => array:3 [ "identificador" => "bib119" "etiqueta" => "119" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Xenon-133-CBF measurements in severe head injury and subarachnoid haemorrhage" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 119 => array:3 [ "identificador" => "bib120" "etiqueta" => "120" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Significance of intracranial hypertension in severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1977.47.4.0503" "Revista" => array:6 [ …6] ] ] ] ] ] 120 => array:3 [ "identificador" => "bib121" "etiqueta" => "121" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Further experience in the management of severe head injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1981.54.3.0289" "Revista" => array:6 [ …6] ] ] ] ] ] 121 => array:3 [ "identificador" => "bib122" "etiqueta" => "122" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early insults to the injured brain" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 122 => array:3 [ "identificador" => "bib123" "etiqueta" => "123" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of mannitol on intracranial pressure and cerebral blood flow and correlation with pressure autoregulation in severely head-injured patients" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1984.61.4.0700" "Revista" => array:6 [ …6] ] ] ] ] ] 123 => array:3 [ "identificador" => "bib124" "etiqueta" => "124" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1991.75.5.0731" "Revista" => array:6 [ …6] ] ] ] ] ] 124 => array:3 [ "identificador" => "bib125" "etiqueta" => "125" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pial arteriolar vessel diameter and C02 reactivity during prolonged hyperventilation in the rabbit" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1988.69.6.0923" "Revista" => array:6 [ …6] ] ] ] ] ] 125 => array:3 [ "identificador" => "bib126" "etiqueta" => "126" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebra1 autorregulation and flow/metabolism coupling during cardio-pulmonary bypass: the influence of Pa C02" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 126 => array:3 [ "identificador" => "bib127" "etiqueta" => "127" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Steroids in trauma patients: Right or wrong?" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 127 => array:3 [ "identificador" => "bib128" "etiqueta" => "128" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cerebral vasoconstriction by indomethacin in intracrania1 hypertension - An experimental investigation in pigs" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 128 => array:3 [ "identificador" => "bib129" "etiqueta" => "129" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study of mannitol and glycero1 on the reduction of raised intracranial pressure on their rebound phenomenon" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ …4] ] ] ] ] ] 129 => array:3 [ "identificador" => "bib130" "etiqueta" => "130" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Raised intracranial pressure. A clinical guide" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ …3] ] ] ] ] ] 130 => array:3 [ "identificador" => "bib131" "etiqueta" => "131" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "(S)-emopami1 attenuates regional cerebral blood flow reduction following experimental brain injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/neu.1994.11.83" "Revista" => array:6 [ …6] ] ] ] ] ] 131 => array:3 [ "identificador" => "bib132" "etiqueta" => "132" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "(S)emopamil attenuates regional cerebral blood flow reduction following experimental brain injury" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1992.77.4.0607" "Revista" => array:6 [ …6] ] ] ] ] ] 132 => array:3 [ "identificador" => "bib133" "etiqueta" => "133" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurotoxicity of NMDA receptor antagonists: an overview" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 133 => array:3 [ "identificador" => "bib134" "etiqueta" => "134" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is Continuous Neuromuscular Blockade Necessary in Head-Injured Patients?" 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"host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 178 => array:3 [ "identificador" => "bib179" "etiqueta" => "179" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of potential risks associated with 7,5% Sodium Chloride resuscitation of traumatic shock" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 179 => array:3 [ "identificador" => "bib180" "etiqueta" => "180" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bifrontal decompressive craniectomy in the management of head trauma" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3171/jns.1975.42.4.0429" "Revista" => array:6 [ …6] ] ] ] ] ] 180 => array:3 [ "identificador" => "bib181" "etiqueta" => "181" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indomethacin abolishes cerebral blood flow increase in response to acetazolamide- induced extracellular acidosis: a mechanism for its effect on hypercapnia" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/jcbfm.1993.92" "Revista" => array:6 [ …6] ] ] ] ] ] 181 => array:3 [ "identificador" => "bib182" "etiqueta" => "182" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of posttraumatic cerebral blood flow velocities by transcranial Doppler ultrasonography" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 182 => array:3 [ "identificador" => "bib183" "etiqueta" => "183" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of resistant intracranial hypertension with hypertonic saline. 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Advances in the management of severe head injury

J. Sahuquillo, M.A. Poca, E. Rubio

Servicio de Neurocirugía, Hospitales Universitarios Vall d’Hebron. Barcelona

F. Munar*

* Unidad de Neurotraumatología, Hospitales Universitarios Vall d’Hebron. Barcelona

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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los fundamentos te&#243;ricos para el tratamiento de los pacientes con un traumatismo craneoencef&#225;lico &#40;TCE&#41; grave se derivan del concepto de lesi&#243;n secundaria&#46; En este trabajo actualizamos las pautas de tratamiento seguidas en el traumatismo craneoencef&#225;lico y de aquel subgrupo de pacientes que presentan hipertensi&#243;n intracraneaI&#46; Introducimos el nuevo paradigma denominado medicina basada en la evidencia haciendo &#233;nfasis en sus implicaciones presentes y futuras en el tratamiento de los traumatismos craneoencef&#225;licoso Presentamos una revisi&#243;n de las recomendaciones sugeridas por las Gu&#237;as de pr&#225;ctica cl&#237;nica recientemente publicadas bajo los auspicios de la Brain Trauma Foundation&#46; En este art&#237;culo revisamos tambi&#233;n los grupos espec&#237;ficos de drogas utilizados en el tratamiento de estos pacientes y que incluyen entre otras&#58; Sedantes y analg&#233;sicos&#44; bloqueantes musculares&#44; barbit&#250;ricos&#44; corticosteroides y soluciones hiperosmolares&#46; Planteamos las controversias existentes en el uso de algunos tratamientos tales como el aumento de la presi&#243;n de perfusi&#243;n cerebral mediante drogas vasoactivas&#44; la hiperventilaci&#243;n o el uso de drogas tales como la dihidroergotamina y la indometacina&#46; Tambi&#233;n presentamos una revisi&#243;n hist&#243;rica y las controversias existentes sobre el uso de corticosteroides y se discuten los fundamentos y la potencial utilidad de ciertas drogas dirigidas a bloquear las cascadas neuroqu&#237;micas an&#243;malas que se han demostrado en estos pacientes&#46; Presentamos y discutimos tambi&#233;n las bases te&#243;ricas sobre la utilizaci&#243;n de los 21-aminoesteroides &#40;Lazaroides&#41;&#44; los antagonistas del calcio&#44; algunos f&#225;rmacos potenciales protectores de membrana y los inhibidores del glutamato en el tratamiento de estos pacientes&#46;</p>"
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                        "paginaFinal" => "433"
                      ]
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                      "titulo" => "Cerebral carbohydrate metabolism during hypocarbia in man"
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                        "paginaInicial" => "624"
                        "paginaFinal" => "632"
                        "link" => array:1 [ …1]
                      ]
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                      "titulo" => "The intensive care management of patients with head injury"
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                      "titulo" => "Cerebral oxygen metabolism during hypotherrnic circulatory arrest in humans"
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                        "paginaFinal" => "815"
                        "link" => array:1 [ …1]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mannitol infusion Part III The acute effect of the intravenous infusion of mannitol on blood and plasma volume"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "N&#46; Engl&#46; J&#46; Med"
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                        "paginaInicial" => "1&#46;085"
                        "paginaFinal" => "1&#46;088"
                        "link" => array:1 [ …1]
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Control of intracranial pressure in severe head injury"
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                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Intracranial Pressure"
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                    ]
                  ]
                ]
              ]
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              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Barbiturate therapy in the management of cerebral ischaemia"
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                        0 => array:2 [ …2]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anaesthesia"
                        "fecha" => "1980"
                        "volumen" => "35"
                        "paginaInicial" => "271"
                        "paginaFinal" => "278"
                        "link" => array:1 [ …1]
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              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hypertone l&#246;sungen zur behandlung des intrakkraniellen drucks"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "ZBL Chir"
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                        "paginaInicial" => "237"
                        "paginaFinal" => "244"
                        "link" => array:1 [ …1]
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                    0 => array:2 [
                      "titulo" => "Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment&#58; preliminary report"
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                    0 => array:2 [
                      "titulo" => "Malignant cerebral edema and intracranial hypertension"
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                    0 => array:1 [
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                      "Revista" => array:7 [ …7]
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                      "titulo" => "Demonstration of early ischemia after severe head injury"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                      "titulo" => "A multicenter trial of the efficacy of nimodipine on outcome after severe head injury"
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                      "doi" => "10.3171/jns.1994.80.5.0797"
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                      "titulo" => "Megadose steroids in severe head injury Results of a prospective double-blind clinical trial"
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                      "doi" => "10.3171/jns.1983.58.3.0326"
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                    0 => array:2 [
                      "titulo" => "Chemical Neurobiology"
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                    0 => array:1 [
                      "LibroEditado" => array:3 [ …3]
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                      "titulo" => "A new 21-aminosteroid antioxidant lacking glucocorticoid activity simulates adrenocorticotropin secretion and blocks arachidonic acid release from mouse pituitary tumor &#40;AtT-20&#41; cells"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                    0 => array:2 [
                      "titulo" => "Medicina basada en pruebas &#40;Evidence-based Medicine&#41;"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                    0 => array:2 [
                      "titulo" => "Nimodipinje and calcium channel blockade for cerebral vasospasm"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                      "titulo" => "Detailed monitoring of the effects of mannitol following experimental head injury"
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                    0 => array:2 [
                      "doi" => "10.3171/jns.1979.50.4.0423"
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                    0 => array:2 [
                      "titulo" => "Mannitol and other diuretics in severe neurotrauma"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                      "titulo" => "Guidelines for the Management of Severe Head Injury&#44; The Brain Trauma Foundation"
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                    0 => array:1 [
                      "Revista" => array:2 [ …2]
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                      "titulo" => "Experience with the glutamate antagonist CG 19755 in severe human head injury&#58; Evidence for ICP lowering effect"
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                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of CDP-choline on the recovery of patients with head injury"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracellular calcium homeostasis"
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                    0 => array:2 [
                      "doi" => "10.1146/annurev.bi.56.070187.002143"
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                ]
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            34 => array:3 [
              "identificador" => "bib35"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Etude double insu du R&#233;xort en neuro-traumatologie infantile"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [ …4]
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                      "titulo" => "Medical management of severe head&#46; injury&#58; present and future"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                    0 => array:2 [
                      "titulo" => "The role of secondary brain injury in determining outcome&#46; from severe head injury"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                    0 => array:2 [
                      "titulo" => "Hypothermia and hyperbaric oxygen as&#46; treatment modalities for severe head injury"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A phase II study of moderate hypothermia in severe brain injury"
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                    0 => array:2 [
                      "doi" => "10.1089/neu.1993.10.263"
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              ]
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              "identificador" => "bib40"
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                      "titulo" => "Etude d&#8217;un pr&#233;curseur&#46; des phospholipides dans le traitement des comas&#46; traumatiques graves"
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                    0 => array:1 [
                      "Revista" => array:6 [ …6]
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                      "titulo" => "Does acute hyperventilation provoke cerebral&#46; oliguemia in comatose patients after acute head injury&#63;"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                    0 => array:2 [
                      "titulo" => "Evidence based critical care medicine&#58; What is it and what&#46; can it do for us&#63;"
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                    0 => array:1 [
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                      "titulo" => "Dexamethasone and severe head injury&#46; A prospective double-blind&#46; study"
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                      "doi" => "10.3171/jns.1979.51.3.0307"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pituitary body and its disorders"
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                    0 => array:1 [
                      "Libro" => array:3 [ …3]
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                    0 => array:2 [
                      "titulo" => "C02 and indomethacin&#46; vasoreactivity in patients with head injury"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                    0 => array:2 [
                      "titulo" => "Effect of high-dose dexamethasone&#46; on outcome from severe head injury"
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                      "doi" => "10.3171/jns.1986.64.1.0081"
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                      "titulo" => "Effects de la CDP-choline sur le rapport lactates&#47;pyruvates prospective randomized double-blind multicenter trial &#40;GUDHIS&#41;&#46; dans le LCR en cas de souffrance c&#233;r&#233;brale grave"
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                    0 => array:2 [
                      "titulo" => "Neurons and networks"
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                      "Libro" => array:4 [ …4]
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                      "titulo" => "High-dose dexamethasone therapy in head injury&#58; a patient group that may benefit from therapy"
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                    0 => array:1 [
                      "Revista" => array:5 [ …5]
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                    0 => array:2 [
                      "titulo" => "The effects of three potentially preventable complications on outcome after severe closed head injury"
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                    0 => array:1 [
                      "LibroEditado" => array:4 [ …4]
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                      "titulo" => "High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury"
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                      "titulo" => "Initial CT findings in 753 patients with severe head injury&#46; A report from the NIH traumatic coma data bank"
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                      "titulo" => "Emergency Care&#58; Initial Evaluation"
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                      "titulo" => "Reduction of experimental intracranial hypertension by lidocaine"
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                      "titulo" => "Dexamethason beim schweren schadel-hirn-trauma Ergebnisse einer Doppel-Blind-Studie"
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                      "titulo" => "Role of Subtemporal Decompression in Severe Closed Head Injury"
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                      "titulo" => "Failure of high dose steroid therapy to influence intracranial pressure in patients with severe head injury"
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                      "titulo" => "Evidence-based medicine&#46; A new approach to teaching the practice of medicine"
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Article information

ISSN: 11301473
Original language: Spanish

DOI:10.1016/S1130-1473(99)70797-9

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2015 March	23	35	58
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