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even with suitable treatment<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a>&#41;&#44; it is essential to achieve maximum resection intraoperatively to improve vital prognosis and disease-free survival in these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Today&#44; the best treatment for these tumours remains a matter of debate&#46; The goal is to offer a higher rate of resection and thus minimise intra-operative and post-operative morbidity and mortality&#46; The endoscopic technique&#44; developed in the last 15 years&#44; has achieved equal or better extents of resection and in addition has been associated with a lower rate of complications&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We present the experience at our centre in managing these tumours using surgery via an extended endonasal endoscopic approach performed by the same surgeons &#40;JE and IA&#41; between 2008 and 2016&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Grade <span class="elsevierStyleSmallCaps">1</span> chordomas and chondrosarcomas are histologically differentiated entities and therefore have different prognoses&#46; However&#44; like other authors&#44; we see fit to report them together<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3&#44;5&#44;6</span></a> as they have a very similar anatomical site and therefore receive the same surgical treatment&#46; In addition&#44; both undergo the same treatment with proton beam &#40;PB&#41; therapy or conventional radiotherapy&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">We performed a retrospective analysis of all cases of clival lesions diagnosed as grade <span class="elsevierStyleSmallCaps">1</span> chordomas or chondrosarcomas which underwent surgery via an extended endonasal endoscopic approach between 2008 and 2016&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The regimen offered to all patients was surgery followed by adjuvant treatment &#40;PB therapy or conventional radiotherapy&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">We collected data such as age&#44; sex&#44; clinical presentation&#44; prior surgical procedures&#44; tumour size and volume&#44; extent of resection&#44; histology&#44; complications&#44; adjuvant treatment&#44; follow-up time and recurrences&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All patients underwent magnetic resonance imaging &#40;General Electric SIGNA<span class="elsevierStyleSup">&#174;</span> TM Pioneer 3&#46;0<span class="elsevierStyleHsp" style=""></span>T&#41; both before surgery for local study of the tumour and after surgery for management of complications and follow-up&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Based on pre-operative imaging and intra-operative findings&#44; lesions were classified according to their location in relation to the affected third of the clivus &#40;superior&#44; medial or inferior&#41;&#46; The floor of the sella turcica and the lower limit of the sphenoidal sinus were considered arbitrary borders&#46; The presence or absence of intradural and intrasellar invasion was also evaluated&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">All surgical procedures were assisted by neuronavigation &#40;Medtronic&#44; StealthStation Surgical Navigation Systems<span class="elsevierStyleSup">&#174;</span> Louisville&#44; CO&#44; United States&#41; and Doppler imaging to locate major vessels &#40;Microdoppler Prove<span class="elsevierStyleSup">&#174;</span>&#41;&#44; as well as continuous neuromonitoring with motor and somatosensory evoked potentials&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The extent of post-operative resection was evaluated on the basis of an MRI performed on all patients 3 months after surgery&#46; Resection was deemed total when there was no evidence of tumour&#44; subtotal when the extent of tumour resection was greater than 90&#37; of the initial volume&#44; and partial when less than 90&#37;&#46; We collected data on intra-operative and post-operative complications&#46; The otorhinolaryngology team performed monitoring rhinoscopy 48<span class="elsevierStyleHsp" style=""></span>h after surgery to rule out the presence of a fistula&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Tumour volumes were calculated &#40;in cubic centimetres &#91;cc&#93;&#41; using the pre-operative MRI and compared to the extent of resection&#46; Intradural invasion was expressed in binomial terms &#40;1 for yes&#59; 0 for no&#41; and compared to the extent of resection&#46; Both comparisons were made using Fischer&#39;s exact test &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; performed with the software programme STATA<span class="elsevierStyleSup">&#174;</span> &#40;StataCorp&#44; United States&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients were followed up on an outpatient basis except for one&#44; who was followed up at a different centre&#46; Adjuvant treatment was administered by means of conventional radiotherapy or PB therapy&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Surgical technique</span><p id="par0075" class="elsevierStylePara elsevierViewall">All surgeries were performed by the same multidisciplinary team&#44; which consisted of a neurosurgeon &#40;JE&#41; and an otorhinolaryngologist &#40;IA&#41; as well as a neurophysiologist and a neuroanaesthetist&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">An extended endonasal endoscopic approach was performed with a classic exposure<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> through a bilateral medial turbinectomy or&#44; in some cases&#44; an inferior turbinectomy&#58; the Hadad&#8211;Bassagaisteguy flap<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> was obtained and placed inside the medial meatus to protect it&#44; and a posterior septectomy as well as an anterior and inferior bilateral sphenoidotomy were performed to achieve full exposure of the clivus&#46; A maxillectomy or ethmoidectomy had to be performed&#44; depending on whether the tumour had invaded these sinuses and whether tumour exposure required it&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; a partial or complete clivectomy was performed depending on tumour spread&#44; with subsequent exposure of the dura mater and intradural resection&#44; depending on the case&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Closure was performed with intradural fat and intradural autologous fascia lata&#44; and the mucosa was replaced using the Hadad&#8211;Bassagaisteguy flap obtained earlier&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In extended endoscopic approaches with a dural opening&#44; a lumbar drain was placed and maintained for 72<span class="elsevierStyleHsp" style=""></span>h after surgery&#46; Antibiotic prophylaxis was also administered during that time&#46; After 72<span class="elsevierStyleHsp" style=""></span>h&#44; fluorescein was injected through the lumbar drain and an endonasal endoscopic examination was performed&#46; If no leakage of cerebrospinal fluid &#40;CSF&#41; was seen&#44; the lumbar drain was removed&#46; If a low-flow fistula was seen&#44; the drain was maintained for three more days and another fluorescein test was performed&#46; If it was positive&#44; surgery was indicated&#46; If a high-flow fistula was seen&#44; immediate surgical review was indicated&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">In our series&#44; we found a preponderance of males&#44; who accounted for 9 cases &#40;64&#46;3&#37;&#41;&#46; The mean age was 49 years &#40;range 29&#8211;70&#41; for chordomas and 32 years &#40;range 20&#8211;58&#41; for chondrosarcomas&#46; The most common clinical presentation was diplopia&#44; which occurred in 11 cases &#40;78&#46;5&#37;&#41;&#44; followed by dysphagia in 4 cases &#40;28&#46;6&#37;&#41;&#44; and finally vertigo&#44; amaurosis and hemiparesis with the same number of cases&#58; 2 &#40;14&#46;2&#37;&#41;&#44; and headache in one case &#40;7&#46;1&#37;&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Of the 14 cases&#44; 10 &#40;71&#46;4&#37;&#41; were classified as chordomas &#40;21&#46;4&#37; chondroid chordoma and 50&#37; conventional chordoma&#41; and 4 &#40;28&#46;6&#37;&#41; were classified as chondrosarcomas&#44; all low-grade&#46; In 8 cases &#40;57&#46;1&#37;&#41; there was intradural invasion&#59; in 5 &#40;35&#46;7&#37;&#41; there was intrasellar invasion&#59; in 6 &#40;42&#46;8&#37;&#41; the tumour invaded two-thirds of the clivus&#59; in 5 &#40;35&#46;7&#37;&#41; it invaded the entire clivus&#59; and in 3 &#40;21&#46;5&#37;&#41; it invaded just one-third of the clivus&#46; There was invasion of the superior third in 71&#46;4&#37; of cases&#44; the medial third in 92&#46;9&#37; and the inferior third in 57&#46;1&#37;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In 6 cases resection was total &#40;42&#46;8&#37;&#59; 4&#47;6 were chordomas and 2&#47;6 were chondrosarcomas&#41;&#44; in 3 resection was subtotal &#40;21&#46;5&#37;&#59; all were chordomas&#41; and in 5 resection was partial &#40;35&#46;7&#37;&#59; 3&#47;5 were chordomas and 2&#47;5 were chondrosarcomas&#41;&#46; Histology could not be correlated with extent of resection&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Complications appeared in 28&#46;6&#37; of cases as a CSF fistula &#40;three were low-flow and one was high-flow&#41;&#44; visualised on monitoring rhinoscopy after 72<span class="elsevierStyleHsp" style=""></span>h&#44; of which just one &#40;7&#46;1&#37;&#41; required surgical treatment&#46; The rest spontaneously resolved and delayed the removal of the 72<span class="elsevierStyleHsp" style=""></span>h drain&#46; There was a single case of meningitis in one of the patients with a fistula&#44; which resolved with antibiotic therapy&#46; There were no post-operative neurological deficits&#44; with the exception of one case of transient diplopia&#46; There were no deaths&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">We attempted to associate the extent of resection to the tumour volume &#40;with an arbitrary threshold at 20<span class="elsevierStyleHsp" style=""></span>cc&#41; and with the presence or absence of intradural invasion&#46; The volume did not significantly influence the extent of resection&#46; However&#44; we did find a significant relationship between the presence of dural invasion and a lower rate of total resections &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; 100&#37; &#40;5&#47;5&#41; of tumours with no dural invasion were totally resected&#44; versus 11&#46;1&#37; &#40;1&#47;9&#41; of tumours with dural invasion&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">To date&#44; the average length of follow-up for these patients was 53&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;9 months&#46; One patient went to a centre in another city and was lost to follow-up&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In partially resected lesions&#44; we found invasion of the cavernous sinus&#44; cerebellopontine angle&#44; sellar region&#44; parasellar region and retrosellar region&#44; as seen in <a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">They were treated with conventional radiotherapy in 21&#46;5&#37; of cases and PB therapy in 35&#46;8&#37; of cases&#59; 6 patients &#40;42&#46;8&#37;&#41; received no adjuvant treatment&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Among the patients in whom total resection was achieved&#44; one &#40;reported as having a chondrosarcoma&#41; had a recurrence in the nasal fossae prior to treatment with PB therapy and underwent further surgery by the otorhinolaryngology department&#46; Following this further surgery&#44; the patient was administered PB therapy and has exhibited no further changes&#46; Regarding the rest of the patients with total resection&#44; two &#40;both with chordomas&#41; received PB therapy&#44; and two others &#40;one with a chordoma and the other with a chondrosarcoma&#41; received no adjuvant treatment &#40;both refused it&#41;&#46; All other patients had no recurrences&#46; The clinical course of the latter is unknown due to failure to attend follow-up visits&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Among the patients with subtotal resection&#44; one received conventional radiotherapy before surgery and the other two received PB therapy after surgery&#46; None experienced subsequent tumour progression&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Concerning the patients in whom only partial resection could be achieved&#44; three received no adjuvant treatment &#40;two had chordomas and one had a chondrosarcoma&#41;&#44; and to date no tumour progression has been seen&#46; One patient had to undergo total resection via a retromastoid approach in a separate operation&#46; Another patient&#44; reported with a chondrosarcoma&#44; received treatment with conventional radiotherapy&#44; required another operation 4 years after the first due to growth of tumour remnants&#46; Following this&#44; that patient has remained stable&#46; Another patient with a very extended chordoma at the base of the skull has required 7 surgeries and was treated with radiotherapy following the fourth procedure&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Therefore&#44; a total of 3 patients &#40;21&#46;5&#37;&#41; experienced tumour progression&#58; two who did not receive adjuvant treatment &#40;one was treated with PB therapy and the other was treated with conventional radiotherapy a posteriori&#41;&#44; and one with a very extended tumour which had already progressed 3 times and which following radiotherapy progressed another three times &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">The objective of this study was to compile our experience in managing clival chordomas through endoscopic surgical treatment or adjuvant radiotherapy&#44; depending on the case&#46; The study consisted of retrospective evaluation of 14 patients&#44; whose clinical presentation&#44; histological type&#44; approach&#44; complications&#44; follow-up time and recurrences were collected&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">In this study&#44; we did not find any difference in terms of epidemiological patterns compared to other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2&#44;9&#8211;11</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">The main objective with the patients was to attempt a total resection&#44; followed or not by radiotherapy&#46; Four-hand surgery by neurosurgeons and otorhinolaryngologists enabled suitable care for nasal and sinus structures as well as central nervous system structures&#46; In our study&#44; there were no intra-operative complications in any of the cases&#44; nor was there post-operative neurological worsening in any of them&#44; except for one case of transient diplopia&#44; which resolved during the initial post-operative period &#40;72<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Clinical findings on admission included diplopia in 78&#46;5&#37; of cases&#46; This figure was similar to the 81&#46;8&#37; found by Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> and higher than the 36&#37; found by Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> There was dysphagia in 28&#46;6&#37; and hemiparesis in 14&#46;2&#37;&#59; these percentages could be attributed to the presence of more than 50&#37; intradural invasion and some degree of brainstem compression&#46; We found headache in 7&#46;1&#37;&#59; this figure was very different from the usual figures in the literature&#44; which range from 35&#37; to 45&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">This series laid bare the locally aggressive nature of this type of lesion&#44; since&#44; as noted in the results section&#44; it featured high percentages of intradural involvement and involvement of at least two-thirds of the clivus&#46; These data were not collected in any other series compared&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Factors that influence radical tumour resection are extremely important&#44; since both the recurrence rate and the long-term prognosis depend on them&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;12&#44;13</span></a> In our series&#44; we only found that the extent of resection could depend on intradural invasion&#59; we were unable to associated it with tumour volume&#46; Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> found in their series that the lateral spread of these lesions is associated with a lower rate of total resection&#46; Vaz-Guimaraes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> and Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> found the same in their series &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Other series&#44; such as that of Gui et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> also compared the tumour volume to the extent of resection&#59; in their case they set the threshold at 40<span class="elsevierStyleHsp" style=""></span>cc and found a significant association between a greater extent of resection &#40;total or subtotal&#41; and volumes below 40<span class="elsevierStyleHsp" style=""></span>cc&#46; A series by Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> found volumes above 20<span class="elsevierStyleHsp" style=""></span>cc to be associated with lower resection rates&#46; These authors were also among the few to associate the rate of resection with the rate of prior surgeries&#44; finding the latter to be lower&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Comparison with the latest meta-analysis published in 2016 by Labidi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> revealed that the percentage of total resections &#40;39&#37; according to said series&#41; in our patients was similar to or even slightly higher than the mean&#46; Other series have found figures for total resection of 66&#46;7&#37; &#40;Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a>&#41;&#44; 62&#46;9&#37; &#40;Vaz-Guimaraes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> &#91;chondrosarcomas only&#93;&#41;&#44; 48&#37; &#40;Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a>&#41;&#44; 46&#37; &#40;Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a>&#41; and 24&#37; &#40;Gui et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a>&#41;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Regarding the choice of surgical technique&#44; a study by Jho and Carrau<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> included several series of clival tumours having undergone surgery exclusively by the endoscopic route&#46; The results reported in the study were similar to the results reported in series of clival tumours having undergone surgery by the traditional route&#44; but with lower rates of complications&#46; Komotar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a> also performed a comparison between an endoscopic approach and a transcranial approach in which they found a higher percentage of total resection&#44; fewer neurological deficits&#44; fewer post-operative complications and fewer recurrences in the endoscopic cohort&#46; Sen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">19</span></a> reported a rate of total resection of 53&#37; through a transcranial approach&#44; and Colli and al-Mefty&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> in their series on transcranial and transfacial approaches&#44; reported a rate of 49&#46;2&#37;&#46; Compared to endoscopic series such as those by Garzaro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> and Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> &#40;67&#37;&#41;&#44; Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> &#40;48&#37;&#41;&#44; and our own &#40;43&#37;&#41;&#44; this does not seem to represent an advantage with respect to extent of resection&#46; These things&#44; plus a lower incidence of intra-operative and post-operative complications&#44; lead to the conclusion that a team experienced in this type of approach should be used whenever possible&#46; As Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> specified in their study&#44; the most important predictive factor for total resection is the experience of the team that performs it and a proper learning curve&#46; In their series&#44; they compared patients having undergone surgery in the first four years to patients having undergone surgery in the last four years&#44; and found a rate of total resection of 36&#46;4&#37; in the first group versus 88&#46;9&#37; in the second group&#46; This reinforces the notion of attempting to centralise this type of disease at experienced centres&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">The most common complication which we found&#44; and one of the most common arguments for not indicating the transnasal endoscopic approach&#44; was a fistula&#46; We found a rate of fistulas of 28&#46;6&#37;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a>&#59; however&#44; only one patient &#40;7&#46;1&#37;&#41; required further surgery&#46; Series by Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> and Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> found rates of 18&#37; and 19&#37;&#44; respectively&#44; but did not specify whether further surgery was required&#46; We believe that&#44; especially in cases of dural invasion&#44; intra-operative reconstruction with a vascularised flap as reported by Hadad in 2006 is the treatment of choice to decrease the incidence of this complication&#46; In addition&#44; post-operative preventive lumbar drain placement plus antibiotics for 72<span class="elsevierStyleHsp" style=""></span>h and a fluorescein test with a rhinoscopy by otorhinolaryngology &#40;ORL&#41; is a safe and effective method for decreasing the incidence of fistula and the potential meningitis deriving therefrom&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Post-operative radiotherapy is extremely important in this type of tumour&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;21&#44;22</span></a> Therefore&#44; all patients were offered the option of proton beam adjuvant treatment &#40;those who chose this had to go to another country to get it&#44; as it is not yet available in Spain&#41;&#46; Given the current lack of a high level of evidence &#40;<span class="elsevierStyleSmallCaps">1</span>&#44; <span class="elsevierStyleSmallCaps">2</span>&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> they were also offered the option of taking a wait-and-see approach or&#44; if they preferred radiotherapy but could not go to another country&#44; receiving conventional radiotherapy&#46; In the end&#44; 5 patients received proton beam therapy&#44; 6 elected not to receive adjuvant treatment and 3 opted to be treated with conventional radiotherapy&#46; Our rate of tumour progression was 21&#46;5&#37; of cases&#46; This was comparable to that found by Yoneoka et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a> and higher than those reported by Dehdashti et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> and Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> It should be noted that the latter two series had a shorter follow-up time &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0210" class="elsevierStylePara elsevierViewall">The extended endonasal endoscopic approach by a team experienced in skull base diseases with a proper learning curve for this disease in particular is a good option for managing these lesions&#46; Intradural invasion could be associated with a higher risk of complications and greater clinical impairment on diagnosis&#44; as well as a lower rate of total resection&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interests</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We had fourteen patients &#40;male&#47;female 2&#58;1&#41;&#44; with a mean age of 49 years for chordoma and 32 for chondrosarcoma&#46; The most common clinical presentation was diplopia in 78&#46;5&#37; of cases&#44; followed by dysphagia in 28&#46;6&#37;&#46; Histologically&#44; 71&#46;4&#37; were chordomas and 28&#46;6&#37; were chondrosarcomas&#46; In addition&#44; invasion of at least two-thirds or more of the clivus was found in 81&#37; of the cases&#59; in 57&#46;1&#37; there was intradural invasion&#44; and in 35&#46;7&#37; invasion of the sella turcica&#46; In 42&#46;8&#37; of cases&#44; the degree of resection was total and in 21&#46;5&#37; subtotal&#46; The most common complication was CSF fistula&#44; occurring in 28&#46;6&#37; of the cases&#44; with only one case requiring surgery to repair it&#46; Adjuvant treatment with Proton Beam was performed in 35&#46;7&#37; of cases and with conventional radiotherapy in 21&#46;5&#37;&#46; Mean follow-up was 53&#46;5 months and tumour recurrence or progression was found in 21&#46;5&#37; of the cases&#44; two of which had not received adjuvant treatment&#46; There were no deaths&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The extended endoscopic endonasal approach &#40;EEEA&#41; performed by an experienced team is a good alternative for the management of these lesions&#46; Intradural invasion may be related to an increased risk of complications and worse clinical presentation&#44; in addition to a lower rate of total resection&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Method"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Reportar la experiencia del manejo de los cordomas y condrosarcomas por abordaje endosc&#243;pico endonasal extendido&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un an&#225;lisis retrospectivo de una serie de 14 pacientes afectos de cordomas o condrosarcomas clivales operados mediante un abordaje endosc&#243;pico endonasal extendido por un mismo equipo multidisciplinar&#44; en el intervalo de tiempo desde 2008 hasta 2016&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Catorce pacientes &#40;hombre&#47;mujer 2&#58;1&#41; con una media de edad de 49<span class="elsevierStyleHsp" style=""></span>a&#241;os en los cordomas y de 32<span class="elsevierStyleHsp" style=""></span>a&#241;os en los condrosarcomas&#46; La presentaci&#243;n cl&#237;nica m&#225;s frecuente fue la diplop&#237;a &#40;78&#44;5&#37; de los casos&#41;&#44; seguida de la disfagia &#40;28&#44;6&#37;&#41;&#46; Histol&#243;gicamente se reportaron como cordomas el 71&#44;4&#37; y como condrosarcomas el 28&#44;6&#37;&#46; Adem&#225;s&#44; se encontr&#243; en el 81&#37; de los casos invasi&#243;n de al menos dos o m&#225;s tercios del clivus&#44; en el 57&#44;1&#37; invasi&#243;n intradural y en el 35&#44;7&#37; invasi&#243;n sellar&#46; En el 42&#44;8&#37; de los casos el grado de resecci&#243;n fue total y en el 21&#44;5&#37;&#44; subtotal&#46; La complicaci&#243;n m&#225;s frecuente fue la f&#237;stula de LCR&#44; que se present&#243; en el 28&#44;6&#37; de los casos&#44; habiendo que intervenir solo a un paciente&#46; En el 35&#44;7&#37; de los casos se indic&#243; tratamiento coadyuvante con <span class="elsevierStyleItalic">Proton Beam</span> y en el 21&#44;5&#37; radioterapia convencional&#46; La media de seguimiento fue de 53&#44;5<span class="elsevierStyleHsp" style=""></span>meses&#44; y se encontr&#243; recurrencia o progresi&#243;n tumoral en el 21&#44;5&#37; de los casos&#44; dos de los cuales no hab&#237;a recibido coadyuvancia&#46; No hubo fallecimientos&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El abordaje endosc&#243;pico endonasal extendido&#44; realizado por un equipo experimentado&#44; es una buena alternativa de manejo para estas lesiones&#46; La invasi&#243;n intradural podr&#237;a estar relacionada con un mayor riesgo de complicaciones y una mayor afectaci&#243;n cl&#237;nica al diagn&#243;stico&#44; as&#237; como con una menor tasa de resecci&#243;n total&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Culebras D&#44; Torales J&#44; Reyes LA&#44; Zapata L&#44; Garc&#237;a S&#44; Rold&#225;n P&#46; Cirug&#237;a endosc&#243;pica endonasal extendida para cordomas y condrosarcomas de clivus&#58; nuestra experiencia en 14 casos&#46; Neurocirug&#237;a&#46; 2018&#59;29&#58;201&#8211;208&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 2147
            "Ancho" => 2000
            "Tamanyo" => 345065
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Pre- and post-treatment axial and sagittal slices of chordoma invading the dura mater&#44; sellar and parasellar regions&#44; cavernous sinus&#44; medial fossa&#44; and prepontine region&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2148
            "Ancho" => 2000
            "Tamanyo" => 337906
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Pre- and post-treatment axial and sagittal slices of clival chordoma invading the lower third of the clivus and exhibiting posterior and lateral spread towards the cerebellopontine region&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">AP&#58; anteroposterior&#59; CC&#58; craniocaudal&#59; LL&#58; latero-lateral&#59; F&#58; female&#59; PB&#58; proton beam&#59; M&#58; male&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;years&#41;&#47;sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Size &#40;AP<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>LL<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CC mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Intradural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Intrasellar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Resection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&#44; hemiparesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>34<br>&#40;20&#46;3<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chondroid chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; hemiparesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>35<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>33<br>&#40;23&#46;1<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chondroid chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VI&#44; VII&#44; VIII&#44; dysphagia&#44; tumour bleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>33<br>&#40;11&#46;0<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>16<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>13<br>&#40;1&#46;87<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<br>&#40;11&#46;9<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chondroid chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Subtotal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>24<br>&#40;12&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>21<br>&#40;7&#46;2<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>30<br>&#40;14&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; LE amaurosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>41<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>32<br>&#40;27&#46;6<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LE amaurosis&#44; III&#44; V&#44; VII&#44; VIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>21<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>27<br>&#40;10&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Subtotal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Headache&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>30<br>&#40;13&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>20<br>&#40;3&#46;7<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Subtotal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&#47;meningitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>58<br>&#40;40&#46;4<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Transient diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hyposmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>37<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>31<br>&#40;22&#46;9<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors and year of publication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Patients&#44; n &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Approach&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total resection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Rate of complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Recurrences&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ense&#241;at et al&#46;&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;2008&#8211;2016&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;5 &#40;2&#8211;112&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Koutourousiou et al&#46;&#44; 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;2003&#8211;2011&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;8 &#40;1&#8211;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#37; in total resection&#59; 60&#37; in all others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vaz-Guimaraes et al&#46;&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35 &#40;2004&#8211;2013&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#46;9&#37; &#40;chondrosarcomas only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#46;6 &#40;13&#8211;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Garzaro et al&#46;&#44; 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;2012&#8211;2013&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vellutini et al&#46;&#44; 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38 &#40;2000&#8211;2011&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Matteo Soli et al&#46;&#44; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;1998&#8211;2015&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52 &#40;7&#8211;159&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yoneoka et al&#46;&#44; 2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;1982&#8211;2002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">122 &#40;37&#8211;268&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gui et al&#46;&#44; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">161 &#40;2007&#8211;2013&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;4 &#40;8&#8211;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Frank et al&#46;&#44; 2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;1998&#8211;2004&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;15&#8211;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Al-Mefty et al&#46;&#44; 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109 &#40;1990&#8211;2006&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48 &#40;1&#8211;191&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dehdashti et al&#46;&#44; 2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;2005&#8211;2007&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;4&#8211;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Samii et al&#46;&#44; 2007<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;1979&#8211;2002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63 &#40;5&#8211;134&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Review of endoscopic and microscopic series&#46;</p>"
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Clinical Research
Extended endoscopic endonasal surgery for clival chordoma and chondrosarcoma: Our experience in 14 cases
Cirugía endoscópica endonasal extendida para cordomas y condrosarcomas de clivus: nuestra experiencia en 14 casos
Diego Culebrasa,
Corresponding author
Culebras.palao@gmail.com

Corresponding author.
, Jorge Toralesa, Luis Alberto Reyesa, Luis Zapatac, Sergio Garcíaa, Pedro Roldána, Cristóbal Langdonb, Issam Alobidb, Joaquim Enseñata
a Servicio de Neurocirugía, Unidad de Cirugía de Base de Cráneo, Hospital Clínic, Barcelona, Spain
b Servicio de Otorrinolaringología, Unidad de Cirugía de Base de Cráneo, Hospital Clínic, Barcelona, Spain
c Servicio de Neurocirugía, Hospital Militar Alejandro Dávila Bolaños, Managua, Nicaragua
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Pre- and post-treatment axial and sagittal slices of chordoma invading the dura mater&#44; sellar and parasellar regions&#44; cavernous sinus&#44; medial fossa&#44; and prepontine region&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Clival chordomas and chondrosarcomas comprise the second least common category of intracranial tumours&#44; accounting for around 1&#8211;4&#37;&#46; Their overall incidence in Spain is 0&#46;51 cases per million&#46; Chordomas and chondrosarcomas appear in the same anatomical sites and share many clinical and radiological characteristics&#46; The essential differences between them are microscopic&#59; each tumour type has its own histological and immunohistochemical characteristics&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Given the high rate of recurrence of this type of lesion &#40;up to 42&#37; in some series&#44; even with suitable treatment<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">2</span></a>&#41;&#44; it is essential to achieve maximum resection intraoperatively to improve vital prognosis and disease-free survival in these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3&#44;4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Today&#44; the best treatment for these tumours remains a matter of debate&#46; The goal is to offer a higher rate of resection and thus minimise intra-operative and post-operative morbidity and mortality&#46; The endoscopic technique&#44; developed in the last 15 years&#44; has achieved equal or better extents of resection and in addition has been associated with a lower rate of complications&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We present the experience at our centre in managing these tumours using surgery via an extended endonasal endoscopic approach performed by the same surgeons &#40;JE and IA&#41; between 2008 and 2016&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Grade <span class="elsevierStyleSmallCaps">1</span> chordomas and chondrosarcomas are histologically differentiated entities and therefore have different prognoses&#46; However&#44; like other authors&#44; we see fit to report them together<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">3&#44;5&#44;6</span></a> as they have a very similar anatomical site and therefore receive the same surgical treatment&#46; In addition&#44; both undergo the same treatment with proton beam &#40;PB&#41; therapy or conventional radiotherapy&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">We performed a retrospective analysis of all cases of clival lesions diagnosed as grade <span class="elsevierStyleSmallCaps">1</span> chordomas or chondrosarcomas which underwent surgery via an extended endonasal endoscopic approach between 2008 and 2016&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The regimen offered to all patients was surgery followed by adjuvant treatment &#40;PB therapy or conventional radiotherapy&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">We collected data such as age&#44; sex&#44; clinical presentation&#44; prior surgical procedures&#44; tumour size and volume&#44; extent of resection&#44; histology&#44; complications&#44; adjuvant treatment&#44; follow-up time and recurrences&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">All patients underwent magnetic resonance imaging &#40;General Electric SIGNA<span class="elsevierStyleSup">&#174;</span> TM Pioneer 3&#46;0<span class="elsevierStyleHsp" style=""></span>T&#41; both before surgery for local study of the tumour and after surgery for management of complications and follow-up&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Based on pre-operative imaging and intra-operative findings&#44; lesions were classified according to their location in relation to the affected third of the clivus &#40;superior&#44; medial or inferior&#41;&#46; The floor of the sella turcica and the lower limit of the sphenoidal sinus were considered arbitrary borders&#46; The presence or absence of intradural and intrasellar invasion was also evaluated&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">All surgical procedures were assisted by neuronavigation &#40;Medtronic&#44; StealthStation Surgical Navigation Systems<span class="elsevierStyleSup">&#174;</span> Louisville&#44; CO&#44; United States&#41; and Doppler imaging to locate major vessels &#40;Microdoppler Prove<span class="elsevierStyleSup">&#174;</span>&#41;&#44; as well as continuous neuromonitoring with motor and somatosensory evoked potentials&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The extent of post-operative resection was evaluated on the basis of an MRI performed on all patients 3 months after surgery&#46; Resection was deemed total when there was no evidence of tumour&#44; subtotal when the extent of tumour resection was greater than 90&#37; of the initial volume&#44; and partial when less than 90&#37;&#46; We collected data on intra-operative and post-operative complications&#46; The otorhinolaryngology team performed monitoring rhinoscopy 48<span class="elsevierStyleHsp" style=""></span>h after surgery to rule out the presence of a fistula&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Tumour volumes were calculated &#40;in cubic centimetres &#91;cc&#93;&#41; using the pre-operative MRI and compared to the extent of resection&#46; Intradural invasion was expressed in binomial terms &#40;1 for yes&#59; 0 for no&#41; and compared to the extent of resection&#46; Both comparisons were made using Fischer&#39;s exact test &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; performed with the software programme STATA<span class="elsevierStyleSup">&#174;</span> &#40;StataCorp&#44; United States&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">All patients were followed up on an outpatient basis except for one&#44; who was followed up at a different centre&#46; Adjuvant treatment was administered by means of conventional radiotherapy or PB therapy&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Surgical technique</span><p id="par0075" class="elsevierStylePara elsevierViewall">All surgeries were performed by the same multidisciplinary team&#44; which consisted of a neurosurgeon &#40;JE&#41; and an otorhinolaryngologist &#40;IA&#41; as well as a neurophysiologist and a neuroanaesthetist&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">An extended endonasal endoscopic approach was performed with a classic exposure<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">7</span></a> through a bilateral medial turbinectomy or&#44; in some cases&#44; an inferior turbinectomy&#58; the Hadad&#8211;Bassagaisteguy flap<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">8</span></a> was obtained and placed inside the medial meatus to protect it&#44; and a posterior septectomy as well as an anterior and inferior bilateral sphenoidotomy were performed to achieve full exposure of the clivus&#46; A maxillectomy or ethmoidectomy had to be performed&#44; depending on whether the tumour had invaded these sinuses and whether tumour exposure required it&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Finally&#44; a partial or complete clivectomy was performed depending on tumour spread&#44; with subsequent exposure of the dura mater and intradural resection&#44; depending on the case&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Closure was performed with intradural fat and intradural autologous fascia lata&#44; and the mucosa was replaced using the Hadad&#8211;Bassagaisteguy flap obtained earlier&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">In extended endoscopic approaches with a dural opening&#44; a lumbar drain was placed and maintained for 72<span class="elsevierStyleHsp" style=""></span>h after surgery&#46; Antibiotic prophylaxis was also administered during that time&#46; After 72<span class="elsevierStyleHsp" style=""></span>h&#44; fluorescein was injected through the lumbar drain and an endonasal endoscopic examination was performed&#46; If no leakage of cerebrospinal fluid &#40;CSF&#41; was seen&#44; the lumbar drain was removed&#46; If a low-flow fistula was seen&#44; the drain was maintained for three more days and another fluorescein test was performed&#46; If it was positive&#44; surgery was indicated&#46; If a high-flow fistula was seen&#44; immediate surgical review was indicated&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0100" class="elsevierStylePara elsevierViewall">In our series&#44; we found a preponderance of males&#44; who accounted for 9 cases &#40;64&#46;3&#37;&#41;&#46; The mean age was 49 years &#40;range 29&#8211;70&#41; for chordomas and 32 years &#40;range 20&#8211;58&#41; for chondrosarcomas&#46; The most common clinical presentation was diplopia&#44; which occurred in 11 cases &#40;78&#46;5&#37;&#41;&#44; followed by dysphagia in 4 cases &#40;28&#46;6&#37;&#41;&#44; and finally vertigo&#44; amaurosis and hemiparesis with the same number of cases&#58; 2 &#40;14&#46;2&#37;&#41;&#44; and headache in one case &#40;7&#46;1&#37;&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Of the 14 cases&#44; 10 &#40;71&#46;4&#37;&#41; were classified as chordomas &#40;21&#46;4&#37; chondroid chordoma and 50&#37; conventional chordoma&#41; and 4 &#40;28&#46;6&#37;&#41; were classified as chondrosarcomas&#44; all low-grade&#46; In 8 cases &#40;57&#46;1&#37;&#41; there was intradural invasion&#59; in 5 &#40;35&#46;7&#37;&#41; there was intrasellar invasion&#59; in 6 &#40;42&#46;8&#37;&#41; the tumour invaded two-thirds of the clivus&#59; in 5 &#40;35&#46;7&#37;&#41; it invaded the entire clivus&#59; and in 3 &#40;21&#46;5&#37;&#41; it invaded just one-third of the clivus&#46; There was invasion of the superior third in 71&#46;4&#37; of cases&#44; the medial third in 92&#46;9&#37; and the inferior third in 57&#46;1&#37;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">In 6 cases resection was total &#40;42&#46;8&#37;&#59; 4&#47;6 were chordomas and 2&#47;6 were chondrosarcomas&#41;&#44; in 3 resection was subtotal &#40;21&#46;5&#37;&#59; all were chordomas&#41; and in 5 resection was partial &#40;35&#46;7&#37;&#59; 3&#47;5 were chordomas and 2&#47;5 were chondrosarcomas&#41;&#46; Histology could not be correlated with extent of resection&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Complications appeared in 28&#46;6&#37; of cases as a CSF fistula &#40;three were low-flow and one was high-flow&#41;&#44; visualised on monitoring rhinoscopy after 72<span class="elsevierStyleHsp" style=""></span>h&#44; of which just one &#40;7&#46;1&#37;&#41; required surgical treatment&#46; The rest spontaneously resolved and delayed the removal of the 72<span class="elsevierStyleHsp" style=""></span>h drain&#46; There was a single case of meningitis in one of the patients with a fistula&#44; which resolved with antibiotic therapy&#46; There were no post-operative neurological deficits&#44; with the exception of one case of transient diplopia&#46; There were no deaths&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">We attempted to associate the extent of resection to the tumour volume &#40;with an arbitrary threshold at 20<span class="elsevierStyleHsp" style=""></span>cc&#41; and with the presence or absence of intradural invasion&#46; The volume did not significantly influence the extent of resection&#46; However&#44; we did find a significant relationship between the presence of dural invasion and a lower rate of total resections &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; 100&#37; &#40;5&#47;5&#41; of tumours with no dural invasion were totally resected&#44; versus 11&#46;1&#37; &#40;1&#47;9&#41; of tumours with dural invasion&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">To date&#44; the average length of follow-up for these patients was 53&#46;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;9 months&#46; One patient went to a centre in another city and was lost to follow-up&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In partially resected lesions&#44; we found invasion of the cavernous sinus&#44; cerebellopontine angle&#44; sellar region&#44; parasellar region and retrosellar region&#44; as seen in <a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">They were treated with conventional radiotherapy in 21&#46;5&#37; of cases and PB therapy in 35&#46;8&#37; of cases&#59; 6 patients &#40;42&#46;8&#37;&#41; received no adjuvant treatment&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Among the patients in whom total resection was achieved&#44; one &#40;reported as having a chondrosarcoma&#41; had a recurrence in the nasal fossae prior to treatment with PB therapy and underwent further surgery by the otorhinolaryngology department&#46; Following this further surgery&#44; the patient was administered PB therapy and has exhibited no further changes&#46; Regarding the rest of the patients with total resection&#44; two &#40;both with chordomas&#41; received PB therapy&#44; and two others &#40;one with a chordoma and the other with a chondrosarcoma&#41; received no adjuvant treatment &#40;both refused it&#41;&#46; All other patients had no recurrences&#46; The clinical course of the latter is unknown due to failure to attend follow-up visits&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Among the patients with subtotal resection&#44; one received conventional radiotherapy before surgery and the other two received PB therapy after surgery&#46; None experienced subsequent tumour progression&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Concerning the patients in whom only partial resection could be achieved&#44; three received no adjuvant treatment &#40;two had chordomas and one had a chondrosarcoma&#41;&#44; and to date no tumour progression has been seen&#46; One patient had to undergo total resection via a retromastoid approach in a separate operation&#46; Another patient&#44; reported with a chondrosarcoma&#44; received treatment with conventional radiotherapy&#44; required another operation 4 years after the first due to growth of tumour remnants&#46; Following this&#44; that patient has remained stable&#46; Another patient with a very extended chordoma at the base of the skull has required 7 surgeries and was treated with radiotherapy following the fourth procedure&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Therefore&#44; a total of 3 patients &#40;21&#46;5&#37;&#41; experienced tumour progression&#58; two who did not receive adjuvant treatment &#40;one was treated with PB therapy and the other was treated with conventional radiotherapy a posteriori&#41;&#44; and one with a very extended tumour which had already progressed 3 times and which following radiotherapy progressed another three times &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discussion</span><p id="par0160" class="elsevierStylePara elsevierViewall">The objective of this study was to compile our experience in managing clival chordomas through endoscopic surgical treatment or adjuvant radiotherapy&#44; depending on the case&#46; The study consisted of retrospective evaluation of 14 patients&#44; whose clinical presentation&#44; histological type&#44; approach&#44; complications&#44; follow-up time and recurrences were collected&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">In this study&#44; we did not find any difference in terms of epidemiological patterns compared to other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2&#44;9&#8211;11</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">The main objective with the patients was to attempt a total resection&#44; followed or not by radiotherapy&#46; Four-hand surgery by neurosurgeons and otorhinolaryngologists enabled suitable care for nasal and sinus structures as well as central nervous system structures&#46; In our study&#44; there were no intra-operative complications in any of the cases&#44; nor was there post-operative neurological worsening in any of them&#44; except for one case of transient diplopia&#44; which resolved during the initial post-operative period &#40;72<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Clinical findings on admission included diplopia in 78&#46;5&#37; of cases&#46; This figure was similar to the 81&#46;8&#37; found by Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> and higher than the 36&#37; found by Zhang et al&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">6</span></a> There was dysphagia in 28&#46;6&#37; and hemiparesis in 14&#46;2&#37;&#59; these percentages could be attributed to the presence of more than 50&#37; intradural invasion and some degree of brainstem compression&#46; We found headache in 7&#46;1&#37;&#59; this figure was very different from the usual figures in the literature&#44; which range from 35&#37; to 45&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">This series laid bare the locally aggressive nature of this type of lesion&#44; since&#44; as noted in the results section&#44; it featured high percentages of intradural involvement and involvement of at least two-thirds of the clivus&#46; These data were not collected in any other series compared&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Factors that influence radical tumour resection are extremely important&#44; since both the recurrence rate and the long-term prognosis depend on them&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;12&#44;13</span></a> In our series&#44; we only found that the extent of resection could depend on intradural invasion&#59; we were unable to associated it with tumour volume&#46; Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> found in their series that the lateral spread of these lesions is associated with a lower rate of total resection&#46; Vaz-Guimaraes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> and Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> found the same in their series &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Other series&#44; such as that of Gui et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a> also compared the tumour volume to the extent of resection&#59; in their case they set the threshold at 40<span class="elsevierStyleHsp" style=""></span>cc and found a significant association between a greater extent of resection &#40;total or subtotal&#41; and volumes below 40<span class="elsevierStyleHsp" style=""></span>cc&#46; A series by Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> found volumes above 20<span class="elsevierStyleHsp" style=""></span>cc to be associated with lower resection rates&#46; These authors were also among the few to associate the rate of resection with the rate of prior surgeries&#44; finding the latter to be lower&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Comparison with the latest meta-analysis published in 2016 by Labidi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a> revealed that the percentage of total resections &#40;39&#37; according to said series&#41; in our patients was similar to or even slightly higher than the mean&#46; Other series have found figures for total resection of 66&#46;7&#37; &#40;Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a>&#41;&#44; 62&#46;9&#37; &#40;Vaz-Guimaraes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a> &#91;chondrosarcomas only&#93;&#41;&#44; 48&#37; &#40;Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a>&#41;&#44; 46&#37; &#40;Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a>&#41; and 24&#37; &#40;Gui et al&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a>&#41;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Regarding the choice of surgical technique&#44; a study by Jho and Carrau<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a> included several series of clival tumours having undergone surgery exclusively by the endoscopic route&#46; The results reported in the study were similar to the results reported in series of clival tumours having undergone surgery by the traditional route&#44; but with lower rates of complications&#46; Komotar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">18</span></a> also performed a comparison between an endoscopic approach and a transcranial approach in which they found a higher percentage of total resection&#44; fewer neurological deficits&#44; fewer post-operative complications and fewer recurrences in the endoscopic cohort&#46; Sen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">19</span></a> reported a rate of total resection of 53&#37; through a transcranial approach&#44; and Colli and al-Mefty&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a> in their series on transcranial and transfacial approaches&#44; reported a rate of 49&#46;2&#37;&#46; Compared to endoscopic series such as those by Garzaro et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">20</span></a> and Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> &#40;67&#37;&#41;&#44; Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> &#40;48&#37;&#41;&#44; and our own &#40;43&#37;&#41;&#44; this does not seem to represent an advantage with respect to extent of resection&#46; These things&#44; plus a lower incidence of intra-operative and post-operative complications&#44; lead to the conclusion that a team experienced in this type of approach should be used whenever possible&#46; As Koutourousiou et al&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> specified in their study&#44; the most important predictive factor for total resection is the experience of the team that performs it and a proper learning curve&#46; In their series&#44; they compared patients having undergone surgery in the first four years to patients having undergone surgery in the last four years&#44; and found a rate of total resection of 36&#46;4&#37; in the first group versus 88&#46;9&#37; in the second group&#46; This reinforces the notion of attempting to centralise this type of disease at experienced centres&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">The most common complication which we found&#44; and one of the most common arguments for not indicating the transnasal endoscopic approach&#44; was a fistula&#46; We found a rate of fistulas of 28&#46;6&#37;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">4</span></a>&#59; however&#44; only one patient &#40;7&#46;1&#37;&#41; required further surgery&#46; Series by Vellutini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">14</span></a> and Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> found rates of 18&#37; and 19&#37;&#44; respectively&#44; but did not specify whether further surgery was required&#46; We believe that&#44; especially in cases of dural invasion&#44; intra-operative reconstruction with a vascularised flap as reported by Hadad in 2006 is the treatment of choice to decrease the incidence of this complication&#46; In addition&#44; post-operative preventive lumbar drain placement plus antibiotics for 72<span class="elsevierStyleHsp" style=""></span>h and a fluorescein test with a rhinoscopy by otorhinolaryngology &#40;ORL&#41; is a safe and effective method for decreasing the incidence of fistula and the potential meningitis deriving therefrom&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Post-operative radiotherapy is extremely important in this type of tumour&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">4&#44;21&#44;22</span></a> Therefore&#44; all patients were offered the option of proton beam adjuvant treatment &#40;those who chose this had to go to another country to get it&#44; as it is not yet available in Spain&#41;&#46; Given the current lack of a high level of evidence &#40;<span class="elsevierStyleSmallCaps">1</span>&#44; <span class="elsevierStyleSmallCaps">2</span>&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a> they were also offered the option of taking a wait-and-see approach or&#44; if they preferred radiotherapy but could not go to another country&#44; receiving conventional radiotherapy&#46; In the end&#44; 5 patients received proton beam therapy&#44; 6 elected not to receive adjuvant treatment and 3 opted to be treated with conventional radiotherapy&#46; Our rate of tumour progression was 21&#46;5&#37; of cases&#46; This was comparable to that found by Yoneoka et al&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a> and higher than those reported by Dehdashti et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> and Frank et al&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">5</span></a> It should be noted that the latter two series had a shorter follow-up time &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="par0210" class="elsevierStylePara elsevierViewall">The extended endonasal endoscopic approach by a team experienced in skull base diseases with a proper learning curve for this disease in particular is a good option for managing these lesions&#46; Intradural invasion could be associated with a higher risk of complications and greater clinical impairment on diagnosis&#44; as well as a lower rate of total resection&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interests</span><p id="par0215" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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            0 => "Skull base"
            1 => "Endoscopic endonasal surgery"
            2 => "Clivus"
            3 => "Chordoma"
            4 => "Chondrosarcoma"
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          "clase" => "keyword"
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            0 => "Base de cr&#225;neo"
            1 => "Cirug&#237;a endonasal endosc&#243;pica"
            2 => "Clivus"
            3 => "Cordomas"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To report our experience in the management of chordoma and chondrosarcoma with extended endoscopic endonasal surgery&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We performed a retrospective analysis of a series of 14 patients with clival chordoma or chondrosarcoma who had extended endoscopic endonasal surgery from 2008 to 2016 performed by the same multidisciplinary team&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We had fourteen patients &#40;male&#47;female 2&#58;1&#41;&#44; with a mean age of 49 years for chordoma and 32 for chondrosarcoma&#46; The most common clinical presentation was diplopia in 78&#46;5&#37; of cases&#44; followed by dysphagia in 28&#46;6&#37;&#46; Histologically&#44; 71&#46;4&#37; were chordomas and 28&#46;6&#37; were chondrosarcomas&#46; In addition&#44; invasion of at least two-thirds or more of the clivus was found in 81&#37; of the cases&#59; in 57&#46;1&#37; there was intradural invasion&#44; and in 35&#46;7&#37; invasion of the sella turcica&#46; In 42&#46;8&#37; of cases&#44; the degree of resection was total and in 21&#46;5&#37; subtotal&#46; The most common complication was CSF fistula&#44; occurring in 28&#46;6&#37; of the cases&#44; with only one case requiring surgery to repair it&#46; Adjuvant treatment with Proton Beam was performed in 35&#46;7&#37; of cases and with conventional radiotherapy in 21&#46;5&#37;&#46; Mean follow-up was 53&#46;5 months and tumour recurrence or progression was found in 21&#46;5&#37; of the cases&#44; two of which had not received adjuvant treatment&#46; There were no deaths&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The extended endoscopic endonasal approach &#40;EEEA&#41; performed by an experienced team is a good alternative for the management of these lesions&#46; Intradural invasion may be related to an increased risk of complications and worse clinical presentation&#44; in addition to a lower rate of total resection&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Reportar la experiencia del manejo de los cordomas y condrosarcomas por abordaje endosc&#243;pico endonasal extendido&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un an&#225;lisis retrospectivo de una serie de 14 pacientes afectos de cordomas o condrosarcomas clivales operados mediante un abordaje endosc&#243;pico endonasal extendido por un mismo equipo multidisciplinar&#44; en el intervalo de tiempo desde 2008 hasta 2016&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Catorce pacientes &#40;hombre&#47;mujer 2&#58;1&#41; con una media de edad de 49<span class="elsevierStyleHsp" style=""></span>a&#241;os en los cordomas y de 32<span class="elsevierStyleHsp" style=""></span>a&#241;os en los condrosarcomas&#46; La presentaci&#243;n cl&#237;nica m&#225;s frecuente fue la diplop&#237;a &#40;78&#44;5&#37; de los casos&#41;&#44; seguida de la disfagia &#40;28&#44;6&#37;&#41;&#46; Histol&#243;gicamente se reportaron como cordomas el 71&#44;4&#37; y como condrosarcomas el 28&#44;6&#37;&#46; Adem&#225;s&#44; se encontr&#243; en el 81&#37; de los casos invasi&#243;n de al menos dos o m&#225;s tercios del clivus&#44; en el 57&#44;1&#37; invasi&#243;n intradural y en el 35&#44;7&#37; invasi&#243;n sellar&#46; En el 42&#44;8&#37; de los casos el grado de resecci&#243;n fue total y en el 21&#44;5&#37;&#44; subtotal&#46; La complicaci&#243;n m&#225;s frecuente fue la f&#237;stula de LCR&#44; que se present&#243; en el 28&#44;6&#37; de los casos&#44; habiendo que intervenir solo a un paciente&#46; En el 35&#44;7&#37; de los casos se indic&#243; tratamiento coadyuvante con <span class="elsevierStyleItalic">Proton Beam</span> y en el 21&#44;5&#37; radioterapia convencional&#46; La media de seguimiento fue de 53&#44;5<span class="elsevierStyleHsp" style=""></span>meses&#44; y se encontr&#243; recurrencia o progresi&#243;n tumoral en el 21&#44;5&#37; de los casos&#44; dos de los cuales no hab&#237;a recibido coadyuvancia&#46; No hubo fallecimientos&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El abordaje endosc&#243;pico endonasal extendido&#44; realizado por un equipo experimentado&#44; es una buena alternativa de manejo para estas lesiones&#46; La invasi&#243;n intradural podr&#237;a estar relacionada con un mayor riesgo de complicaciones y una mayor afectaci&#243;n cl&#237;nica al diagn&#243;stico&#44; as&#237; como con una menor tasa de resecci&#243;n total&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Culebras D&#44; Torales J&#44; Reyes LA&#44; Zapata L&#44; Garc&#237;a S&#44; Rold&#225;n P&#46; Cirug&#237;a endosc&#243;pica endonasal extendida para cordomas y condrosarcomas de clivus&#58; nuestra experiencia en 14 casos&#46; Neurocirug&#237;a&#46; 2018&#59;29&#58;201&#8211;208&#46;</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">AP&#58; anteroposterior&#59; CC&#58; craniocaudal&#59; LL&#58; latero-lateral&#59; F&#58; female&#59; PB&#58; proton beam&#59; M&#58; male&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Age &#40;years&#41;&#47;sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Size &#40;AP<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>LL<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>CC mm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Intradural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Intrasellar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Resection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">III&#44; hemiparesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>34<br>&#40;20&#46;3<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chondroid chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; hemiparesis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>35<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>33<br>&#40;23&#46;1<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chondroid chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VI&#44; VII&#44; VIII&#44; dysphagia&#44; tumour bleeding&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>33<br>&#40;11&#46;0<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>16<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>13<br>&#40;1&#46;87<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<br>&#40;11&#46;9<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Chondroid chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Subtotal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>26<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>24<br>&#40;12&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>22<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>21<br>&#40;7&#46;2<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>30<br>&#40;14&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Low-grade chondrosarcoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Diplopia&#44; LE amaurosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>41<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>32<br>&#40;27&#46;6<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">58&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">LE amaurosis&#44; III&#44; V&#44; VII&#44; VIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>21<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>27<br>&#40;10&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Subtotal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#47;F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Headache&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>23<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>30<br>&#40;13&#46;5<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Partial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>20<br>&#40;3&#46;7<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Subtotal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fistula&#47;meningitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dysphagia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>58<br>&#40;40&#46;4<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Transient diplopia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#47;M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hyposmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>37<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>31<br>&#40;22&#46;9<span class="elsevierStyleHsp" style=""></span>cc&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Conventional chordoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors and year of publication&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Patients&#44; n &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Approach&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total resection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Rate of complications&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Follow-up time&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Recurrences&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ense&#241;at et al&#46;&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;2008&#8211;2016&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;5 &#40;2&#8211;112&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Koutourousiou et al&#46;&#44; 2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60 &#40;2003&#8211;2011&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;8 &#40;1&#8211;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20&#37; in total resection&#59; 60&#37; in all others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vaz-Guimaraes et al&#46;&#44; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35 &#40;2004&#8211;2013&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">62&#46;9&#37; &#40;chondrosarcomas only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44&#46;6 &#40;13&#8211;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Garzaro et al&#46;&#44; 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;2012&#8211;2013&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vellutini et al&#46;&#44; 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38 &#40;2000&#8211;2011&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Matteo Soli et al&#46;&#44; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;1998&#8211;2015&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52 &#40;7&#8211;159&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Yoneoka et al&#46;&#44; 2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;1982&#8211;2002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">122 &#40;37&#8211;268&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Gui et al&#46;&#44; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">161 &#40;2007&#8211;2013&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;4 &#40;8&#8211;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Frank et al&#46;&#44; 2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;1998&#8211;2004&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Endonasal endoscopic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;15&#8211;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Al-Mefty et al&#46;&#44; 2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109 &#40;1990&#8211;2006&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">83&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48 &#40;1&#8211;191&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dehdashti et al&#46;&#44; 2008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;2005&#8211;2007&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">EE and microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;4&#8211;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Samii et al&#46;&#44; 2007<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;1979&#8211;2002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Microsurgical&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">63 &#40;5&#8211;134&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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      "titulo" => "References"
      "seccion" => array:1 [
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          "identificador" => "bibs0015"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cordoma&#46; Sus variantes y diagn&#243;stico diferencial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46;J&#46; Mart&#237;nez Tello"
                            1 => "E&#46; Conde Gallego"
                            2 => "P&#46; Manj&#243;n Luengo"
                            3 => "J&#46;R&#46; Ricoy Campo"
                            4 => "A&#46; P&#233;rez Barrios"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
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                        "tituloSerie" => "Rev Esp Patol"
                        "fecha" => "2007"
                        "volumen" => "40"
                        "paginaInicial" => "135"
                        "paginaFinal" => "145"
                      ]
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                    0 => array:2 [
                      "titulo" => "Chordoma and chondrosarcoma&#58; similar&#44; but quite different&#44; skull base tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Almefty"
                            1 => "S&#46; Pravdenkova"
                            2 => "B&#46;O&#46; Colli"
                            3 => "O&#46; al-Mefty"
                            4 => "M&#46; Gokden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cncr.23073"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2007"
                        "volumen" => "110"
                        "paginaInicial" => "2457"
                        "paginaFinal" => "2467"
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        "identificador" => "xack353186"
        "titulo" => "Acknowledgements"
        "texto" => "<p id="par0220" class="elsevierStylePara elsevierViewall">We would like to thank the Neurosurgery and Otorhinolaryngology department at Hospital Cl&#237;nic de Barcelona&#44; the Skull Base Surgery unit&#44; the Neuroscience Institute at Hospital Cl&#237;nic de Barcelona and the surgical teams who treated the patients&#46;</p>"
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ISSN: 25298496
Original language: English
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