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y el riesgo acumulado en 5 a&#241;os del 3&#44;4&#37;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#44;3&#44;4</span></a>&#46; Estos porcentajes generales ascienden si el paciente presenta factores de riesgo como hipertensi&#243;n arterial &#40;HTA&#41;&#44; tabaquismo&#44; multiplicidad de aneurismas o presencia de hemorragia subaracnoidea &#40;HSA&#41; previa<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;5</span></a>&#46; Por otro lado el tratamiento de AINR conlleva una morbimortalidad baja&#44; pero no despreciable<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a>&#46; Existe controversia respecto al manejo de AINR&#44; ya que el tratamiento de los mismos podr&#237;a suponer un riesgo que superar&#237;a el beneficio de evitar una HSA&#44; en ocasiones devastadora pero poco probable&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">En nuestro centro los AINR son valorados en comit&#233; y la indicaci&#243;n de tratamiento se fundamenta en criterios cl&#237;nicos &#40;edad&#44; factores de riesgo de sangrado&#41; y radiol&#243;gicos &#40;localizaci&#243;n&#44; tama&#241;o&#44; morfolog&#237;a&#44; crecimiento&#41;&#46; Si se decide ofrecer tratamiento&#44; se opta por t&#233;cnicas endovasculares o microquir&#250;rgicas en dependencia de las caracter&#237;sticas del paciente&#44; la probabilidad de cierre completo y de complicaciones&#46; Si se indica de manera juiciosa una u otra t&#233;cnica de cierre&#44; la tasa de complicaciones disminuye y la seguridad para el paciente mejora&#46; La microcirug&#237;a aporta una elevada tasa de cierre con resultados duraderos<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Consideramos la presencia de aneurismas m&#250;ltiples un factor de riesgo relevante&#44; especialmente en pacientes que presentaron previamente una HSA&#46; Si uno de los AINR se considera quir&#250;rgico&#44; ofrecemos el clipaje de todos ellos mediante una minicraneotom&#237;a&#46; Para conocer si este manejo supone un mayor riesgo para el paciente pretendemos evaluar los resultados quir&#250;rgicos del clipaje de AINR&#44; comparando los resultados de los subgrupos de las cirug&#237;as en las que se clipa un &#250;nico aneurisma o m&#225;s de uno&#44; as&#237; como los factores de riesgo para el desarrollo de complicaciones posquir&#250;rgicas&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material y m&#233;todos</span><p id="par0025" class="elsevierStylePara elsevierViewall">Se trata de un estudio retrospectivo en el que se incluyeron pacientes intervenidos mediante microcirug&#237;a de AINR en nuestro centro en el per&#237;odo 2020-2023&#46; Los criterios de exclusi&#243;n fueron&#58; 1&#41; aneurismas traum&#225;ticos&#44; mic&#243;ticos o asociados a malformaciones vasculares&#44; 2&#41; pacientes intervenidos de AINR durante la cirug&#237;a de un aneurisma roto&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Tras aprobaci&#243;n por parte del comit&#233; de &#233;tica de nuestro hospital&#44; se llev&#243; a cabo la revisi&#243;n de la historia cl&#237;nica electr&#243;nica de los pacientes&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se dividi&#243; la muestra en pacientes en los que se clip&#243; un &#250;nico aneurisma o m&#225;s de uno en la misma cirug&#237;a&#46; Se incluyeron las siguientes variables&#58; edad&#44; sexo&#44; tabaquismo&#44; HTA&#44; HSA previa&#44; localizaci&#243;n del aneurisma&#44; tama&#241;o del aneurisma&#44; t&#233;cnica quir&#250;rgica&#44; abordaje&#44; control radiol&#243;gico posquir&#250;rgico y necesidad de retratamiento&#46; Consideramos abordaje <span class="elsevierStyleItalic">miniopen</span> al minipterional&#44; <span class="elsevierStyleItalic">lateral supraorbital approach</span>&#44; al <span class="elsevierStyleItalic">keyhole</span> supraorbitario transciliar o al abordaje interhemisf&#233;rico unilateral&#46; Fuera de este grupo se consider&#243; la craneotom&#237;a pterional cl&#225;sica y el abordaje interhemisf&#233;rico bifrontal&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se divideron las complicaciones en isqu&#233;micas&#44; hemorr&#225;gicas &#40;subaracnoidea y no subaracnoidea&#41;&#44; infecciosas y totales&#46; Se consider&#243; isquemia a toda hipodensidad posquir&#250;rgica en la tomograf&#237;a computarizada &#40;TC&#41; de control congruente con un territorio vascular&#44; sintom&#225;tica o no&#46; Describimos como complicaci&#243;n hemorr&#225;gica cualquier sangrado en TC de control sintom&#225;tico o no&#44; a excepci&#243;n de peque&#241;os vol&#250;menes asintom&#225;ticos en el lecho quir&#250;rgico&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se emplea la escala de Rankin modificada &#40;mRS&#41; para definir el estado funcional pre y posquir&#250;rgico de los pacientes durante el seguimiento&#46; Se considera pron&#243;stico desfavorable la aparici&#243;n de cualquier s&#237;ntoma posquir&#250;rgico mantenido &#62;<span class="elsevierStyleHsp" style=""></span>3 meses tras la intervenci&#243;n&#44; lo que se valora como un empeoramiento de la escala mRS en al menos un punto&#46; Esto incluye la afectaci&#243;n cognitiva referida por paciente o familiares&#44; la cefalea o s&#237;ntomas inespec&#237;ficos&#44; como mareos o v&#233;rtigos&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Para la realizaci&#243;n del an&#225;lisis estad&#237;stico se utiliza el Microsoft Excel y el programa IBM SPSS Statistics versi&#243;n 25&#46;0&#46; Para calcular la normalidad se utiliza la prueba Kolmog&#243;rov-Smirnov&#46; Se considera p-valor &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 estad&#237;sticamente significativo&#46; Para el an&#225;lisis univariante se usa para variables cualitativas chi-cuadrado y variables cuantitativas param&#233;tricas t de Student&#44; y no par&#225;metricas U-de Mann-Whitney&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">Se intervinieron 82 pacientes de AINR mediante microcirug&#237;a durante el per&#237;odo de 2020-2023&#44; con un total de 114 aneurismas tratados&#46; En 60 pacientes se clip&#243; un &#250;nico aneurisma durante la intervenci&#243;n y en 22 pacientes se cliparon dos o m&#225;s&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Estos 82 pacientes presentaron un total de 173 aneurismas diagnosticados&#46; De estos&#44; 145 recibieron tratamiento endovascular &#40;31&#41; o microquir&#250;rgico &#40;114&#41;&#46; Se trataron el 91&#44;8&#37; de los aneurismas en pacientes que hab&#237;an sufrido una HSA previa&#46; Recibieron un tratamiento mixto 24 pacientes&#44; siendo m&#225;s frecuente entre pacientes que hab&#237;an presentado una HSA &#40;17&#47;24&#58; 70&#44;8&#37;&#41; que entre los que se diagnosticaron de AINR m&#250;ltiples asintom&#225;ticos &#40;7&#47;24&#58; 29&#44;2&#37;&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Se aprecia una mayor tendencia a tratar aneurismas m&#250;ltiples en casos de HSA previa de otro aneurisma&#44; as&#237; como mayor probabilidad de que estos pacientes reciban un tratamiento mixto&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Se presenta en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> la localizaci&#243;n de los 114 AINR intervenidos&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> se muestra un an&#225;lisis descriptivo comparativo de cada uno de los dos grupos de pacientes a estudio&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Factores de riesgo</span><p id="par0080" class="elsevierStylePara elsevierViewall">Se aprecian dos grupos homog&#233;neos en cuanto a sexo y factores de riesgo&#44; con mayor n&#250;mero de pacientes j&#243;venes &#40;18&#44;3&#37; &#60;<span class="elsevierStyleHsp" style=""></span>46 a&#241;os&#41; en el grupo 1&#46; Un total de 22 pacientes &#40;26&#44;8&#37;&#41; presentaron previamente una HSA&#46; Cinco aneurismas del total de 114 eran de circulaci&#243;n posterior&#44; todos ellos en el grupo 2 &#40;p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;022&#41;&#46; Se aprecia m&#225;s tendencia a clipar aneurismas peque&#241;os en el grupo de aneurismas m&#250;ltiples&#46; El tama&#241;o medio entre los intervenidos fue de 7&#44;7<span class="elsevierStyleHsp" style=""></span>mm&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">T&#233;cnica quir&#250;rgica</span><p id="par0085" class="elsevierStylePara elsevierViewall">En el grupo 1 hubo 3 casos en los que no se consider&#243; seguro el clipaje y se llev&#243; a cabo un <span class="elsevierStyleItalic">wrapping</span>&#44; lo que supone un 2&#44;6&#37; del total&#46; Se realizaron cinco abordajes interhemisf&#233;ricos &#40;4 aneurismas de ACA distal y uno de AcoA&#41;&#44; uno de ellos doble abordaje interhemisf&#233;rico&#47;minipterional con una misma incisi&#243;n para clipar aneurismas m&#250;ltiples&#46; El resto fueron abordajes laterales&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Ambos grupos muestran un porcentaje similar de abordaje <span class="elsevierStyleItalic">miniopen</span> &#40;86&#44;6&#37; vs&#46; 86&#44;4&#41;&#46; La mayor&#237;a de los abordajes convencionales se realizaron en los primeros a&#241;os del estudio&#46; En la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> se ejemplifica la t&#233;cnica quir&#250;rgica&#46; Se aprecia m&#225;s tendencia a emplear clinoidectom&#237;a en los casos de clipaje m&#250;ltiple&#44; probablemente por&#58; 1&#41; los 5 aneurismas de circulaci&#243;n posterior se encuentran en el grupo 2 y se cliparon mediante minipterional o pterional con abordaje temporal anterior&#44; que suele requerir clinoidectom&#237;a anterior y en ocasiones tambi&#233;n posterior&#44; 2&#41; generalmente ante casos de aneurismas simples oft&#225;lmicos o paraclinoideos se ofrece tratamiento mediante <span class="elsevierStyleItalic">stent flow diverter</span> &#40;FD&#41;&#44; sin embargo ante la presencia de varios aneurismas es m&#225;s probable que llevemos a cabo el clipaje de todos ellos&#44; incluidos los paraclinoideos&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Oclusi&#243;n del aneurisma</span><p id="par0095" class="elsevierStylePara elsevierViewall">El 87&#44;3&#37; de los pacientes clipados tienen una prueba de imagen de control del cierre&#44; el 41&#44;8&#37; mediante angio-TC y el 58&#44;2&#37; mediante arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D&#46; El tiempo medio desde la cirug&#237;a al &#250;ltimo control fue de 10 meses &#40;1-37&#41;&#46; Se perdi&#243; el seguimiento en 2 pacientes y 8 tienen pendiente la realizaci&#243;n de la prueba&#46; Los 3 aneurismas tratados con <span class="elsevierStyleItalic">wrapping</span> han seguido controles mediante angio-RM&#44; sin crecimiento de los aneurismas&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Se apreci&#243; el cierre completo del 100&#37; de los aneurismas controlados mediante angio-TC y del 74&#44;3&#37; de los aneurismas seguidos mediante arteriograf&#237;a&#46; El 90&#44;3&#37; de los pacientes clipados seguidos por arteriograf&#237;a presentan un cuello &#60;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">La tasa de cierre completo entre ambos grupos es similar&#44; aunque ligeramente mayor en el grupo 1 &#40;83&#44;7 vs&#46; 77&#44;6&#37;&#41;&#44; debido a que la mayor parte de los pacientes controlados mediante angio-TC pertenecen al grupo 1&#46; Dos pacientes del grupo 1 y 5 del grupo 2 presentaron un cuello &#8805;2<span class="elsevierStyleHsp" style=""></span>mm &#40;2-5<span class="elsevierStyleHsp" style=""></span>mm&#41;&#44; sea por presencia de calcificaciones&#44; por salida de perforantes o riesgo de afectaci&#243;n de las mismas o por una t&#233;cnica de clipaje inadecuada&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Cuatro aneurismas intervenidos requirieron retratamiento &#40;3&#44;5&#37;&#41;&#44; ya que no se consider&#243; haber conseguido una prevenci&#243;n &#243;ptima de crecimiento o sangrado&#58; 1&#41; aneurisma fusosacular de A2 que recreci&#243; entre clips y fue tratado mediante <span class="elsevierStyleItalic">FD</span>&#44; 2&#41; aneurisma de arteria cerebral media &#40;ACM&#41; contralateral cerrado parcialmente por el clip&#44; tratado con coils&#44; 3&#41; aneurisma trilobulado de AcoA en el que se apreci&#243; persistencia del tet&#243;n posterosuperior&#44; tratado con <span class="elsevierStyleItalic">FD</span> y 4&#41; aneurisma de AcoA clipado por minipterional con resto de 2&#44;8<span class="elsevierStyleHsp" style=""></span>mm&#44; que requiri&#243; abordaje interhemisf&#233;rico&#46; Todos presentaron cierre completo tras el tratamiento&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Complicaciones y situaci&#243;n funcional &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;</span><p id="par0115" class="elsevierStylePara elsevierViewall">Se aprecia una tasa de sangrado&#47;resangrado y de mortalidad del 0&#37;&#44; con una morbilidad posquir&#250;rgica significativa &#40;empeoramiento de &#8805;2 puntos de mRS&#41; del 1&#44;2&#37;&#46; Por lo tanto&#44; durante el seguimiento el 98&#44;8&#37; de los pacientes presentaron una buena o muy buena situaci&#243;n funcional&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Seis pacientes &#40;7&#44;3&#37;&#41; presentaron un empeoramiento de un punto en la escala mRS&#58; d&#233;ficit neurol&#243;gico leve &#40;2&#41;&#44; mareos &#40;1&#41;&#44; empeoramiento cognitivo &#40;2&#41; y empeoramiento de cefalea previa &#40;1&#41;&#46; Tres pacientes &#40;3&#44;7&#37;&#41; mejoraron un punto debido a la disminuci&#243;n del efecto de masa&#46; Una paciente present&#243; mRS<span class="elsevierStyleHsp" style=""></span>&#62;2 despu&#233;s de la cirug&#237;a&#44; pasando de mRS 2 a mRS 5 tras presentar un infarto de ACM tras clipaje de aneurisma de ACI-oft&#225;lmica de 22<span class="elsevierStyleHsp" style=""></span>mm&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> se visualiza la situaci&#243;n funcional de los pacientes intervenidos&#46; Seis de los 8 pacientes que presentaban un mRS 2 prequir&#250;rgico hab&#237;an sufrido una HSA por otro aneurisma&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Se diagnosticaron adem&#225;s tres isquemias silentes &#40;3&#44;7&#37;&#41;&#44; todas ellas en circulaci&#243;n anterior &#40;<a class="elsevierStyleCrossRef" href="#fig0015">fig&#46; 3</a>&#41;&#46; Ninguno de los pacientes refiere afectaci&#243;n cognitiva pero solo un caso fue confirmado mediante test neuropsicol&#243;gicos&#46; Tres pacientes presentaron complicaciones hemorr&#225;gicas &#40;3&#44;7&#37;&#41;&#46; Ninguno requiri&#243; intervenci&#243;n quir&#250;rgica&#44; pero un paciente empeor&#243; su situaci&#243;n basal y requiri&#243; un ingreso prolongado &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0135" class="elsevierStylePara elsevierViewall">Dos pacientes &#40;2&#44;4&#37;&#41; presentaron una infecci&#243;n posquir&#250;rgica&#44; una de ellas superficial y otra intracraneal &#40;empiema&#41;&#59; ambos precisaron reintervenci&#243;n&#46; Otra paciente fue reintervenida con anestesia local para retirar un tapatr&#233;panos que le molestaba&#44; por lo que la tasa de reintervenci&#243;n por complicaciones fue del 3&#44;7&#37;&#46; Tres pacientes &#40;3&#44;7&#37;&#41; presentaron un d&#233;ficit neurol&#243;gico &#40;cuadro cl&#237;nico completo de isquemia de ACM izquierda&#44; afectaci&#243;n parcial del III pc y cuadrantanopsia&#41; tras la intervenci&#243;n&#44; mientras que otros tres presentaron mejor&#237;a neurol&#243;gica al disminuir el efecto de masa &#40;resoluci&#243;n de la afectaci&#243;n del III pc y hemiparesia&#41; tras trombectom&#237;a intraaneurism&#225;tica&#46; El an&#225;lisis univariante de las complicaciones se puede observar en la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">An&#225;lisis estad&#237;stico</span><p id="par0140" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> no se aprecia mayor morbimortalidad en aquellas cirug&#237;as en las que se clipa m&#225;s de un aneurisma&#44; tampoco en las realizadas por t&#233;cnica <span class="elsevierStyleItalic">miniopen</span>&#44; ni en las que se realizan a pacientes que han sufrido previamente una HSA&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Se aprecian diferencias estad&#237;sticamente significativas en la probabilidad de isquemia posquir&#250;rgica en cirug&#237;as en las que se lleva a cabo el clipaje de un aneurisma de circulaci&#243;n posterior&#46; Esto no implica una mayor probabilidad de empeoramiento de la situaci&#243;n funcional&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discusi&#243;n</span><p id="par0150" class="elsevierStylePara elsevierViewall">El 30&#37; de los AINR se rompen a lo largo de la vida de un paciente<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; En los estudios ISUIA<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a> y UCAS<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> se describieron seis factores de riesgo independientes de rotura&#58; tama&#241;o&#44; localizaci&#243;n&#44; rotura de otro aneurisma previo&#44; edad&#44; HTA y origen geogr&#225;fico&#46; Se han identificado otros factores que favorecen el sangrado<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#44;2&#44;7&#44;10</span></a>&#58; tabaquismo&#44; multiplicidad de aneurismas&#44; HSA &#8805;2 familiares de primer grado y caracter&#237;sticas asociadas al propio aneurisma como irregularidad&#44; crecimiento&#44; mayor <span class="elsevierStyleItalic">aspect ratio&#44;</span> localizaci&#243;n en ACoP e inflamaci&#243;n de la pared&#46; El 9&#37; de los AINR presentan crecimiento en el seguimiento en 2&#44;8 a&#241;os y el 45&#37; en 19<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#44; lo que incrementa la probabilidad de rotura en un 0&#44;2-2&#44;4&#37;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">No existe un consenso sobre la actitud a tomar en pacientes con aneurismas m&#250;ltiples tras HSA&#44; aunque es conocido que ambos criterios de manera individual aumentan el riesgo de sangrado<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">10&#44;12&#44;13</span></a>&#46; La tasa de rotura en pacientes con aneurismas m&#250;ltiples y HSA previa es el doble que en pacientes con aneurismas simples &#40;3 vs&#46; 1&#44;5&#37;&#41;&#44; especialmente en aneurismas irregulares&#44; grandes y localizados en ACM<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#46; Por otro lado&#44; el tratamiento de aneurismas m&#250;ltiples en una misma intervenci&#243;n no parece aumentar el riesgo de complicaciones&#44; incluso con el uso de varias craneotom&#237;as<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a>&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Ni las gu&#237;as de manejo cl&#237;nico<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a> ni las escalas de decisi&#243;n<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">11&#44;16&#44;17</span></a> aportan evidencia suficiente para apoyar la toma de decisiones<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">1&#44;18&#44;19</span></a>&#46; Por dicho motivo&#44; es imprescindible individualizar el tratamiento de estos pacientes teniendo en cuenta los resultados obtenidos por cada unidad o centro&#46; Por un lado debe valorarse la capacidad de evitar el sangrado y por otro ha de tenerse en cuenta la morbilidad generada por el propio tratamiento&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">En nuestro estudio se establece una tasa de cierre completo del 81&#44;63&#37;&#44; que disminuye a 74&#44;32&#37; cuando se eval&#250;an solamente los casos controlados mediante arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">La mayor&#237;a de los art&#237;culos previos no consideran la arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D como prueba de control posquir&#250;rgico&#44; reportando tasas de cierre del 94&#44;7&#37;&#44; valoradas con angio-TC o arteriograf&#237;a 2<span class="elsevierStyleHsp" style=""></span>D<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">20&#44;21</span></a>&#46; Un estudio reciente<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">22</span></a> eval&#250;a las tasa de cierre mediante arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D&#44; consiguiendo un cierre completo en el 76&#44;9&#37; de los casos&#46; Describen que el 59&#37; de los cuellos remanentes no hab&#237;an sido visualizados en angiograf&#237;a 2<span class="elsevierStyleHsp" style=""></span>D&#46; Mientras que ning&#250;n aneurisma con cierre completo recreci&#243; o sangr&#243;&#44; el 11&#44;8&#37; de los aneurismas con cierre incompleto presentaron crecimiento durante el seguimiento&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">La heterogeneidad de los estudios no permite establecer qu&#233; se considera un cierre adecuado de un AINR<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">6</span></a> e incluso en series modernas se emplea la angio-TC para definir el cierre completo<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a>&#46; Sin embargo&#44; parece apropiada la realizaci&#243;n de un primer control posquir&#250;rgico mediante arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D para definir qu&#233; pacientes necesitar&#225;n seguimiento &#40;en torno a un 20&#37; de los mismos&#44; especialmente j&#243;venes y con aneurismas de mayor tama&#241;o&#41;&#46; En nuestra serie se observ&#243; un cierre completo mediante arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D del 74&#44;3&#37;&#44; mientras que mediante angio-TC del 100&#37;&#46; No obstante si consideramos un cierre adecuado persistencia de un cuello &#60;<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm&#44; el porcentaje de aneurismas con cierre completo o adecuado asciende al 90&#44;3&#37; de los pacientes clipados seguidos por arteriograf&#237;a y al 92&#44;9&#37; de los seguidos mediante ambas pruebas&#46; Por lo tanto&#44; seg&#250;n estos resultados se observa una mayor sensibilidad de la arteriograf&#237;a como t&#233;cnica para diagnosticar remanentes no ocluidos del aneurisma&#46; Este dato podr&#237;a ser analizado con mayor profundidad en pr&#243;ximos estudios&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">En nuestra serie&#44; el 3&#44;5&#37; de los AINR clipados requirieron retratamiento&#44; ninguno por crecimiento o sangrado&#46; El empleo de t&#233;cnicas endovasculares &#40;3&#47;4 casos&#41; no hace sino reforzar nuestro manejo multidisciplinar&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Por otro lado&#44; el objetivo de tratar AINR es evitar la rotura de los mismos&#46; La tasa de sangrado de pacientes clipados fue del 0&#37; en nuestra serie&#44; aunque se trata de un periodo corto de seguimiento&#46; Por ello&#44; se han revisado las 274 HSA aneurism&#225;ticas tratadas en nuestro hospital en el periodo 2017-2023&#44; observando que ninguna de ellas se produjo en pacientes previamente intervenidos por microcirug&#237;a&#44; ni tampoco en pacientes que hubieran presentado HSA previamente por otro aneurisma&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Las complicaciones secundarias al tratamiento microquir&#250;rgico de AINR han disminuido de manera considerable en las &#250;ltimas d&#233;cadas&#44; con tasas de mortalidad en torno al 0-1&#44;7&#37; y morbilidad del 4&#37;-10&#44;9&#37;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a>&#46; En un estudio multic&#233;ntrico<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> basado en 2245 casos tratados de una cohorte internacional se describe la tasa de resultados adecuados tras clipaje de AINR&#58; mRS &#8804;2 &#8805;95&#44;9&#37;&#44; complicaciones posquir&#250;rgicas &#8804;20&#44;7&#37;&#44; estancia hospitalaria &#8804;7&#44;7 d&#237;as&#44; infarto asintom&#225;tico &#8804;3&#44;6&#37;&#44; infecci&#243;n quir&#250;rgica &#8804;2&#44;7&#37;&#44; vasoespasmo &#8804;2&#44;5&#37; y focalidad neurol&#243;gica &#8804;5&#44;9&#37;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">En nuestro trabajo observamos una probabilidad de mRS &#8804;2 del 98&#44;9&#37;&#44; con una mortalidad del 0&#37;&#46; Sin embargo&#44; dado que los pacientes intervenidos de AINR se encuentran en su mayor&#237;a asintom&#225;ticos o paucisintom&#225;ticos antes de la cirug&#237;a&#44; consideramos m&#225;s apropiado medir cualquier empeoramiento en la situaci&#243;n funcional del paciente&#44; aunque sea leve&#46; Un 7&#44;3&#37; de nuestros pacientes presentaron un empeoramiento leve que no les impide las actividades habituales&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">Los factores asociados a complicaciones m&#225;s com&#250;nmente descritos en la literatura<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a> son&#58; edad<span class="elsevierStyleHsp" style=""></span>&#62;50 a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">26&#44;27</span></a>&#44; sexo femenino&#44; coagulopat&#237;a&#44; anticoagulaci&#243;n&#44; tabaquismo&#44; HTA<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a>&#44; DM <a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a>&#44; fallo card&#237;aco congestivo&#44; circulaci&#243;n posterior<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">20&#44;26&#44;27&#44;30</span></a>&#44; calcificaciones y tama&#241;o del aneurisma<span class="elsevierStyleHsp" style=""></span>&#62;12mm<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">26&#44;28</span></a>&#46; En la presente serie la tasa de complicaciones fue del 12&#44;2&#37;&#44; incluyendo las asintom&#225;ticas&#44; con necesidad de reintervenci&#243;n por las mismas del 3&#44;7&#37;&#46; Se aprecia una mayor probabilidad de complicaciones isqu&#233;micas en los casos intervenidos de aneurismas de circulaci&#243;n posterior&#44; aunque se trata en nuestro trabajo de 3 isquemias asintom&#225;ticas y de territorio ACM o ACA en el contexto del clipaje de otros aneurismas presentes&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Ni la cirug&#237;a en pacientes que previamente presentaron HSA&#44; ni el clipaje de varios aneurismas en la misma intervenci&#243;n&#44; ni el empleo de abordajes <span class="elsevierStyleItalic">miniopen</span> han supuesto una mayor probabilidad de complicaciones o empeoramiento funcional&#46; Los abordajes MIS ofrecen tasas de oclusi&#243;n aneurism&#225;tica similares a las craneotom&#237;as convencionales&#44; un menor tiempo quir&#250;rgico&#44; menor probabilidad de par&#225;lisis facial y atrofia temporal &#40;12&#37; vs&#46; 35&#37;&#41; y mayor satisfacci&#243;n del paciente&#44; calidad de vida y resultado est&#233;tico<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a>&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Es dif&#237;cil generalizar si los riesgos de la cirug&#237;a suponen un beneficio frente a la probabilidad de sangrado de AINR&#46; Cada caso debe ser evaluado de manera individual&#44; ya que riesgos no asumibles para un paciente con baja probabilidad de sangrado pueden ser adecuados en otro con un aneurisma m&#225;s inestable&#46; La toma de decisiones debe llevarse a cabo por un equipo multidisciplinar capaz de valorar las ventajas e inconvenientes de cada t&#233;cnica&#46;</p><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limitaciones</span><p id="par0215" class="elsevierStylePara elsevierViewall">El presente estudio est&#225; sujeto a limitaciones&#46; En primer lugar&#44; el car&#225;cter retrospectivo del mismo que ha podido generar datos perdidos&#46; En segundo lugar&#44; se trata de un estudio unic&#233;ntrico por lo que est&#225; basado solo en la serie de nuestro centro&#46; Finalmente&#44; no todos los pacientes de la serie ten&#237;an un control arteriogr&#225;fico posquir&#250;rgico y no se ha valorado la complejidad de los aneurismas&#46; Por ello podr&#237;a plantearse en un futuro la realizaci&#243;n de un estudio multic&#233;ntrico prospectivo en el que todos los pacientes fueran sometidos para evaluar la tasa de cierre a una arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D y se recogiera el grado de complejidad de los anuerismas&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusiones</span><p id="par0220" class="elsevierStylePara elsevierViewall">La selecci&#243;n de la t&#233;cnica de cierre en el tratamiento de AINR tiene que ser individualizada y para ello debemos conocer los resultados obtenidos por cada grupo&#46; Con una correcta selecci&#243;n de pacientes&#44; la microcirug&#237;a supone una opci&#243;n eficiente con una mortalidad y una probabilidad de sangrado aneurism&#225;tico del 0&#37; en nuestra serie y una probabilidad de morbilidad severa del 1&#44;2&#37;&#46; El clipaje de aneurismas m&#250;ltiples mediante minicraneotom&#237;a en pacientes que han sufrido previamente una HSA no supone un riesgo a&#241;adido&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Financiaci&#243;n</span><p id="par0230" class="elsevierStylePara elsevierViewall">La presente investigaci&#243;n no&#160;ha recibido ayudas espec&#237;ficas provenientes de agencias del sector p&#250;blico&#44; sector comercial o entidades sin &#225;nimo de lucro&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicto de intereses</span><p id="par0235" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
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              "titulo" => "Background and objectives"
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          "titulo" => "Introducci&#243;n"
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              "identificador" => "sec0020"
              "titulo" => "Factores de riesgo"
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            1 => array:2 [
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              "titulo" => "T&#233;cnica quir&#250;rgica"
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            2 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Oclusi&#243;n del aneurisma"
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              "titulo" => "Complicaciones y situaci&#243;n funcional &#40;tabla 3&#41;"
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              "titulo" => "An&#225;lisis estad&#237;stico"
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          "titulo" => "Conflicto de intereses"
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          "titulo" => "Bibliograf&#237;a"
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    "fechaRecibido" => "2024-02-29"
    "fechaAceptado" => "2024-06-23"
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            0 => "Clipaje"
            1 => "Aneurismas intracraneales no rotos"
            2 => "Aneurismas m&#250;ltiples"
            3 => "Pron&#243;stico"
            4 => "Complicaciones"
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            0 => "Clipping"
            1 => "Unruptured intracranial aneurysms"
            2 => "Multiple intracranial aneurysms"
            3 => "Outcomes"
            4 => "Complications&#46;"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de aneurismas intracraneales no rotos es de un 1-3&#37;&#46; La tasa de rotura anual aumenta en pacientes con aneurismas m&#250;ltiples que han sufrido una hemorragia de uno de ellos&#46; Los objetivos son evaluar los resultados quir&#250;rgicos del clipaje de aneurismas no rotos&#44; comparando pacientes en los que se clipa un &#250;nico o varios y describir las complicaciones de las intervenciones de aneurismas no rotos estableciendo los factores de riesgo de un pron&#243;stico desfavorable&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materiales y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo que incluye pacientes intervenidos de aneurismas no rotos mediante microcirug&#237;a entre 2020-2023 en nuestro centro&#46; Se analiza la tasa de cierre&#44; las complicaciones y el resultado funcional de los pacientes&#46; Se identifican los factores de riesgo de mal pron&#243;stico con un modelo univariante&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se intervinieron 82 pacientes con 114 aneurismas&#46; En 22 pacientes se clip&#243; m&#225;s de un aneurisma durante la intervenci&#243;n&#46; El 86&#44;5&#37; de las intervenciones se realizaron mediante abordaje <span class="elsevierStyleItalic">miniopen&#46;</span> El 78&#44;6&#37; de los aneurismas seguidos por arteriograf&#237;a 3<span class="elsevierStyleHsp" style=""></span>D presentan cierre completo&#46; La tasa de complicaciones fue del 12&#44;2&#37;&#44; incluyendo asintom&#225;ticas&#46; La mortalidad fue del 0&#37;&#46; La probabilidad de empeorar el mRS 1 punto fue del 7&#44;3&#37; y 2 o m&#225;s del 1&#44;2&#37;&#44; con buen resultado funcional en el 98&#44;9&#37;&#46; El clipaje de varios aneurismas en una misma intervenci&#243;n&#44; empleo de minicraneotom&#237;as o la cirug&#237;a en pacientes con hemorragia subaracnoidea previa no increment&#243; el riesgo de complicaciones&#46; La cirug&#237;a de aneurismas de circulaci&#243;n posterior aument&#243; el riesgo de isquemia&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La indicaci&#243;n de cirug&#237;a de aneurismas intracraneales no rotos debe de ser consensuada multidisciplinarmente&#44; conociendo resultados cl&#237;nicos y radiol&#243;gicos&#46; La microcirug&#237;a es una t&#233;cnica v&#225;lida y segura&#44; con una mortalidad 0&#37; y una morbilidad severa del 1&#44;2&#37; en nuestra serie&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
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          1 => array:2 [
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            "titulo" => "Materiales y m&#233;todos"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The prevalence of unruptured intracranial aneurysms is 1-3&#37;&#46; The annual rupture rate increases in patients with multiple aneurysms that presented a previous hemorrhage from another aneurysm&#46; Objectives were evaluate outcomes of clipping unruptured aneurysms&#44; comparing patients with single or multiple aneurysms clipped&#44; describe the complications related to surgery and to identify risk factors predicting an unfavorable outcome&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Materials and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Retrospective study including patients who underwent clipping of unruptured aneurysms between 2020-2023 at our center&#46; Occlusion rate&#44; complications&#44; and functional outcome were analyzed&#46; Risk factors for poor prognosis are identified using univariate model&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">82 patients with 114 aneurysms were treated wit microsurgery&#46; Multiple aneurysms were clipped in 22 patients&#46; A mini-open approach was used in 86&#44;5&#37; of cases&#46; Complete occlusion in angio3D was found in 78&#46;6&#37; of clipped aneurysms&#46; Complication rate was 12&#46;2&#37;&#44; including asymptomatic cases&#46; Mortality was 0&#37;&#46; The probability of 1 point mRS worsening was 7&#46;3&#37; and 2 or more points was 1&#46;2&#37;&#44; with a good functional outcome in 98&#46;9&#37;&#46; Clipping multiple aneurysms&#44; miniopen approaches&#44; or surgery in patients with previous subarachnoid hemorrhage did not increase the risk of complications&#46; Posterior circulation aneurysms surgery increased the risk of ischemia&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The management for unruptured intracranial aneurysms should be multimodal and based on clinical and radiological outcomes&#46; Microsurgery is a valid and safe technique&#44; with 0&#37; mortality and bleeding rates and 1&#44;2&#37; rate of severe morbidity in our serie&#46;</p></span>"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">A y B&#41; T&#233;cnica de abordaje minipterional con separaci&#243;n roma de las fibras del m&#250;sculo temporal&#46; C y D&#41; T&#233;cnicas m&#225;s empleadas de clipaje de aneurismas de ACM mediante minicraneotom&#237;a para evitar las &#171;orejas de perro&#187;&#44; siguiendo el concepto de <span class="elsevierStyleItalic">ideal closure line</span>&#46; E y F&#41; Ejemplos de clipaje de aneurismas m&#250;ltiples mediante minicraneotom&#237;a&#58; E&#41; clipaje de aneurisma de AcoA y ACM mediante abordaje lateral supraorbitario derecho&#44; F&#41; clipaje de aneurisma de AchoA derecha&#44; A1 izquierda y top de la basilar mediante abordaje minipterional derecho&#46;</p>"
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Complicaciones isqu&#233;micas y hemorr&#225;gicas&#46; A&#41; Isquemia en cabeza de caudado&#46; B&#41; Isquemia en regi&#243;n cortical anterior de ACM&#46; C&#41; Isquemia en regi&#243;n cortical lateral de ACM&#46; D&#41; Isquemia sintom&#225;tica en territorio ACM izquierda&#46; E&#41; Hemorragia cerebelosa &#40;signo de la cebra&#41; sintom&#225;tica&#46; F&#41; L&#225;mina subdural aguda izquierda&#46; G&#41; Hematoma subdural cr&#243;nico derecho&#46;</p>"
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                  \t\t\t\t">19&#47;114 &#40;16&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">AB-ACS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#47;114 &#40;2&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">ACI oft&#47;paraclinoideo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3&#47;114 &#40;2&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                0 => """
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupo 1&#46; Pacientes en los que se trata un solo aneurisma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">60&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;717&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujeres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#47;60 &#40;73&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#47;22 &#40;77&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hombres&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#47;60 &#40;26&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;22 &#40;22&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tabaquismo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#47;60 &#40;53&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;22 &#40;54&#44;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;922&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HTA</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#47;60 &#40;35&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#47;22 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HSA previa</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#47;60 &#40;23&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#47;22 &#40;36&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;238&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Localizaci&#243;n del aneurisma &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">aneurismas&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;022</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Circulaci&#243;n anterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#47;60 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#47;54 &#40;90&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Circulaci&#243;n posterior&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;60 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;54 &#40;9&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tama&#241;o del aneurisma &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">aneurismas&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;011</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peque&#241;o &#60;<span class="elsevierStyleHsp" style=""></span>7mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#47;60 &#40;60&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#47;54 &#40;85&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mediano 7-12mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#47;60 &#40;28&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#47;54 &#40;14&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Grande 13-24mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;60 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;54 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gigante<span class="elsevierStyleHsp" style=""></span>&#62;24<span class="elsevierStyleHsp" style=""></span>mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#47;60 &#40;6&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;54 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">T&#233;cnica quir&#250;rgica &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">aneurismas&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;245&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ClippingClip sobre coil previo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#47;60 &#40;95&#37;&#41;2&#47;60 &#40;3&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#47;54 &#40;100&#37;&#41;5&#47;54 &#40;9&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Wrapping&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;60 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;54 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abordajes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Miniopen</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#47;60 &#40;86&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#47;22 &#40;86&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Clinoidectom&#237;as&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;60 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#47;22 &#40;18&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Control radiol&#243;gico general &#40;N</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">aneurismas controlados por imagen&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;602&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cierre completo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#47;49 &#40;83&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#47;49 &#40;77&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Control por arteriograf&#237;a &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>aneurismas controlados por arteriograf&#237;a&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;542&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cierre completo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#47;27 &#40;70&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#47;47 &#40;76&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cuello &#60;<span class="elsevierStyleHsp" style=""></span>2mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;27 &#40;22&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;47 &#40;12&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cuello &#8805;2mm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;27 &#40;7&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;47 &#40;10&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Necesidad de retratamiento &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>aneurismas totales&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;60 &#40;3&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;54 &#40;3&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab3715518.png"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis descriptivo entre pacientes en los que se trat&#243; un aneurisma o m&#225;s de un aneurisma en la misma intervenci&#243;n</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Complicaciones&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sobre total de pacientes &#40;N<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Isqu&#233;micas &#40;incluye asintom&#225;ticas&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#47;82 &#40;4&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemorr&#225;gicas no HSA &#40;incluye asintom&#225;ticas&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;82 &#40;3&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Resangrado aneurism&#225;tico &#40;HSA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;82 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Infecciosas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;82 &#40;2&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cualquier tipo de complicaci&#243;n &#40;incluye asintom&#225;ticas&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#47;82 &#40;12&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Reintervenci&#243;n por complicaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;82 &#40;3&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">mRS &#8804; 2 en el seguimiento&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Nuevo d&#233;ficit neurol&#243;gico focal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Mejor&#237;a neurol&#243;gica focal &#40;gigantes&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Mortalidad&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8804;65 a&#241;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ausente&nbsp;\t\t\t\t\t\t\n
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Vol. 35. Núm. 6.
Páginas 289-298 (noviembre - diciembre 2024)
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Visitas
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Vol. 35. Núm. 6.
Páginas 289-298 (noviembre - diciembre 2024)
Investigación clínica
Aneurismas intracraneales no rotos tratados con microcirugía: análisis de resultados clínicos y radiológicos
Microsurgical clipping of unruptured intracranial aneurysms: clinical and radiological outcomes
Visitas
4
Silvia Vázquez Sufuentes
Autor para correspondencia
silviavazquezsufuentes@gmail.com

Autor para correspondencia.
, Loreto Esteban Estallo, Jesús Moles Herbera, Luis Manuel González Martínez, Jouke Sieds van Popta, Juan Casado Pellejero
Servicio de Neurocirugía, Hospital Universitario Miguel Servet, Zaragoza, España
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Estadísticas
Figuras (3)
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Tablas (4)
Tabla 1. Localización de los aneurismas no rotos tratados mediante microcirugía
Tabla 2. Análisis descriptivo entre pacientes en los que se trató un aneurisma o más de un aneurisma en la misma intervención
Tabla 3. Complicaciones y situación funcional al final del estudio en pacientes intervenidos de aneurismas no rotos mediante microcirugía
Tabla 4. Análisis univariante de las complicaciones isquémicas, totales y situación funcional postoperatoria
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Resumen
Antecedentes y objetivo

La prevalencia de aneurismas intracraneales no rotos es de un 1-3%. La tasa de rotura anual aumenta en pacientes con aneurismas múltiples que han sufrido una hemorragia de uno de ellos. Los objetivos son evaluar los resultados quirúrgicos del clipaje de aneurismas no rotos, comparando pacientes en los que se clipa un único o varios y describir las complicaciones de las intervenciones de aneurismas no rotos estableciendo los factores de riesgo de un pronóstico desfavorable.

Materiales y métodos

Estudio retrospectivo que incluye pacientes intervenidos de aneurismas no rotos mediante microcirugía entre 2020-2023 en nuestro centro. Se analiza la tasa de cierre, las complicaciones y el resultado funcional de los pacientes. Se identifican los factores de riesgo de mal pronóstico con un modelo univariante.

Resultados

Se intervinieron 82 pacientes con 114 aneurismas. En 22 pacientes se clipó más de un aneurisma durante la intervención. El 86,5% de las intervenciones se realizaron mediante abordaje miniopen. El 78,6% de los aneurismas seguidos por arteriografía 3D presentan cierre completo. La tasa de complicaciones fue del 12,2%, incluyendo asintomáticas. La mortalidad fue del 0%. La probabilidad de empeorar el mRS 1 punto fue del 7,3% y 2 o más del 1,2%, con buen resultado funcional en el 98,9%. El clipaje de varios aneurismas en una misma intervención, empleo de minicraneotomías o la cirugía en pacientes con hemorragia subaracnoidea previa no incrementó el riesgo de complicaciones. La cirugía de aneurismas de circulación posterior aumentó el riesgo de isquemia.

Conclusiones

La indicación de cirugía de aneurismas intracraneales no rotos debe de ser consensuada multidisciplinarmente, conociendo resultados clínicos y radiológicos. La microcirugía es una técnica válida y segura, con una mortalidad 0% y una morbilidad severa del 1,2% en nuestra serie.

Palabras clave:
Clipaje
Aneurismas intracraneales no rotos
Aneurismas múltiples
Pronóstico
Complicaciones
Abstract
Background and objectives

The prevalence of unruptured intracranial aneurysms is 1-3%. The annual rupture rate increases in patients with multiple aneurysms that presented a previous hemorrhage from another aneurysm. Objectives were evaluate outcomes of clipping unruptured aneurysms, comparing patients with single or multiple aneurysms clipped, describe the complications related to surgery and to identify risk factors predicting an unfavorable outcome.

Materials and methods

Retrospective study including patients who underwent clipping of unruptured aneurysms between 2020-2023 at our center. Occlusion rate, complications, and functional outcome were analyzed. Risk factors for poor prognosis are identified using univariate model.

Results

82 patients with 114 aneurysms were treated wit microsurgery. Multiple aneurysms were clipped in 22 patients. A mini-open approach was used in 86,5% of cases. Complete occlusion in angio3D was found in 78.6% of clipped aneurysms. Complication rate was 12.2%, including asymptomatic cases. Mortality was 0%. The probability of 1 point mRS worsening was 7.3% and 2 or more points was 1.2%, with a good functional outcome in 98.9%. Clipping multiple aneurysms, miniopen approaches, or surgery in patients with previous subarachnoid hemorrhage did not increase the risk of complications. Posterior circulation aneurysms surgery increased the risk of ischemia.

Conclusions

The management for unruptured intracranial aneurysms should be multimodal and based on clinical and radiological outcomes. Microsurgery is a valid and safe technique, with 0% mortality and bleeding rates and 1,2% rate of severe morbidity in our serie.

Keywords:
Clipping
Unruptured intracranial aneurysms
Multiple intracranial aneurysms
Outcomes
Complications.

Artículo

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