Suggestions
Idioma
Guide for authors
Searcher
Journal Information
Vol. 35. Issue 6.
Pages 281-340 (November - December 2024)
Cite
Cite
Share
Download PDF
More article options
Visits
1000
Vol. 35. Issue 6.
Pages 281-340 (November - December 2024)
Clinical Research

Microsurgical clipping of unruptured intracranial aneurysms: Clinical and radiological outcomes

Aneurismas intracraneales no rotos tratados con microcirugía: análisis de resultados clínicos y radiológicos
Visits
1000
Silvia Vázquez Sufuentes
Corresponding author
, Loreto Esteban Estallo, Jesús Moles Herbera, Luis Manuel González Martínez, Jouke Sieds van Popta, Juan Casado Pellejero
Servicio de Neurocirugía, Hospital Universitario Miguel Servet, Zaragoza, Spain
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Abstract
Background and objectives

The prevalence of unruptured intracranial aneurysms is 1–3%. The annual rupture rate increases in patients with multiple aneurysms that presented a previous hemorrhage from another aneurysm.

Objectives

To evaluate outcomes of clipping unruptured aneurysms, comparing patients with single or multiple aneurysms clipped, describe the complications related to surgery and to identify risk factors predicting an unfavorable outcome.

Materials and methods

Retrospective study including patients who underwent clipping of unruptured aneurysms between 2020–2023 at our center. Occlusion rate, complications, and functional outcome were analyzed. Risk factors for poor prognosis are identified using univariate model.

Results

82 patients with 114 aneurysms were treated with microsurgery. Multiple aneurysms were clipped in 22 patients. A mini-open approach was used in 86,5% of cases. Complete occlusion in angio3D was found in 78.6% of clipped aneurysms. Complication rate was 12.2%, including asymptomatic cases. Mortality was 0%. The probability of 1 point mRS worsening was 7.3% and 2 or more points was 1.2%, with a good functional outcome in 98.9%. Clipping multiple aneurysms, miniopen approaches, or surgery in patients with previous subarachnoid hemorrhage did not increase the risk of complications. Posterior circulation aneurysms surgery increased the risk of ischemia.

Conclusions

The management for unruptured intracranial aneurysms should be multimodal and based on clinical and radiological outcomes. Microsurgery is a valid and safe technique, with 0% mortality and bleeding rates and 1,2% rate of severe morbidity in our series.

Keywords:
Clipping
Unruptured intracranial aneurysms
Multiple intracranial aneurysms
Outcomes
Complications
Abbreviations:
AINR
HSA
HTA
PHASES
ELAPSS
UIATS
TC
LSO
mRS
OR
ACM
ACI
A1
M1
AcoA
A2
AcoP
AB-ACS
ACA
AchoA
FD
MIS
Resumen
Antecedentes y objetivo

La prevalencia de aneurismas intracraneales no rotos es de un 1-3%. La tasa de ruptura anual aumenta en pacientes con aneurismas múltiples que han sufrido una hemorragia de uno de ellos. Los objetivos son evaluar los resultados quirúrgicos del clipaje de aneurismas no rotos, comparando pacientes en los que se clipa un único o varios y describir las complicaciones de las intervenciones de aneurismas no rotos estableciendo los factores de riesgo de un pronóstico desfavorable.

Materiales y métodos

Estudio retrospectivo que incluye pacientes intervenidos de aneurismas no rotos mediante microcirugía entre 2020-2023 en nuestro centro. Se analiza la tasa de cierre, las complicaciones y el resultado funcional de los pacientes. Se identifican los factores de riesgo de mal pronóstico con un modelo univariante.

Resultados

Se intervinieron 82 pacientes con 114 aneurismas. En 22 pacientes se clipó más de un aneurisma durante la intervención. El 86,5% de las intervenciones se realizaron mediante abordaje miniopen. El 78,6% de los aneurismas seguidos por arteriografía 3D presentan cierre completo. La tasa de complicaciones fue del 12,2%, incluyendo asintomáticas. La mortalidad fue del 0%. La probabilidad de empeorar el mRS 1 punto fue del 7,3% y 2 o más del 1,2%, con buen resultado funcional en el 98,9%. El clipaje de varios aneurismas en una misma intervención, empleo de minicraneotomías o la cirugía en pacientes con hemorragia subaracnoidea previa no incrementó el riesgo de complicaciones. La cirugía de aneurismas de circulación posterior aumentó el riesgo de isquemia.

Conclusiones

La indicación de cirugía de aneurismas intracraneales no rotos debe de ser consensuada multidisciplinarmente, conociendo resultados clínicos y radiológicos. La microcirugía es una técnica válida y segura, con una mortalidad 0% y una morbilidad severa del 1,2% en nuestra serie.

Palabras clave:
Clipaje
Aneurismas intracraneales no rotos
Aneurismas múltiples
Pronóstico
Complicaciones

Article

These are the options to access the full texts of the publication Neurocirugía (English edition)
Member
Member of the Sociedad Española de Neurocirugía

If it is the first time you have accessed you can obtain your credentials by contacting Elsevier Spain in suscripciones@elsevier.com or by calling our Customer Service at902 88 87 40 if you are calling from Spain or at +34 932 418 800 (from 9 to 18h., GMT + 1) if you are calling outside of Spain.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option ¿I have forgotten my password¿.

Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to
Neurocirugía (English edition)
Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
References
[1]
K.A.M. Hackenberg, D. Hänggi, N. Etminan.
Unruptured intracranial aneurysms.
Stroke, 49 (2018), pp. 2268-2275
[2]
S. Renowden, R. Nelson.
Management of incidental unruptured intracranial aneurysms.
Pract Neurol, 20 (2020), pp. 347-355
[3]
H. Matsukawa, H. Kamiyama, T. Tsuboi, K. Noda, N. Ota, S. Miyata, et al.
Subarachnoid hemorrhage after surgical treatment of unruptured intracranial aneurysms.
J Neurosurg, 129 (2018), pp. 490-497
[4]
N. Etminan, A. Dörfler, H. Steinmetz.
Unruptured intracranial aneurysms- pathogenesis and individualized management.
Dtsch Arztebl Int, 117 (2020), pp. 235-242
[5]
P.D. Delgado Lopez, J.M. Castilla Díez, V. Martín Velasco.
Aneurismas cerebrales no rotos: controversias sobre el cribado poblacional.
Neurocirugia (Astur), 27 (2016), pp. 237-244
[6]
M. Kotowski, O. Naggara, T.E. Darsaut, S. Nolet, G. Gevry, E. Kouznetsov, et al.
Safety and occlusion rates of surgical treatment of unruptured intracranial aneurysms : a systematic review and meta-analysis of the literature from 1990 to 2011.
J Neurol Neurosurg Psychiatry, 84 (2013), pp. 42-48
[7]
M. Korja, H. Lehto, S. Juvela.
Lifelong rupture risk of intracranial aneurysms depends on risk factors: a prospective Finnish cohort study.
Stroke, 45 (2014), pp. 1958-1963
[8]
D.O. Wiebers, J.P. Whisnant, J. Huston 3rd, I. Meissner, R.D. Brown Jr, D.G. Piepgras, et al.
Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment.
[9]
A. Morita, A. Morita, T. Kirino, K. Hashi, N. Aoki, S. Fukuhara, N. Hashimoto, UCAS Japan Investigators, et al.
The natural course of unruptured cerebral aneurysms in a Japanese cohort.
N Engl J Med, 366 (2012), pp. 2474-2482
[10]
J. Liu, Y. Zhang, M.R. Levitt, M. Mossa-Basha, C. Wang, M. Turhon, et al.
Risk of unruptured aneurysms in subarachnoid hemorrhage patients with multiple intracranial aneurysms: a multicenter, longitudinal, comparative study from China.
J Neurointerv Surg, 3 (2024),
[11]
D. Backes, G.J.E. Rinkel, J.P. Greving, B.K. Velthuis, Y. Murayama, H. Takao, et al.
ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms.
Neurology, 88 (2017), pp. 1600-1608
[12]
L. Rigante, H.D. Boogaarts, R.H.M.A. Bartels, P. Vart, R. Aquarius, J.A. Grotenhuis, et al.
Factors associated with subsequent subarachnoid hemorrhages in patients with multiple intracranial aneurysms.
World Neurosurg, 154 (2021), pp. e185-e198
[13]
M.M. McDowell, Y. Zhao, C.P. Kellner, S.M. Barton, E. Sussman, J. Claassen, et al.
Demographic and clinical predictors of multiple intracranial aneurysms in patients with subarachnoid hemorrhage.
J Neurosurg, 128 (2018), pp. 961-968
[14]
M.K. Morgan, M. Wiedmann, N.N. Assaad, G.Z. Heller.
Complication-effectiveness analysis for unruptured intracranial aneurysm surgery: a prospective cohort study.
Neurosurgery, 78 (2016), pp. 648-659
[15]
S. Sanchez, J.M. Miller, E.A. Samaniego.
Clinical scales in aneurysm rupture prediction.
Stroke Vasc Interv Neurol, 4 (2024),
[16]
J.P. Greving, M.J. Wermer, R.D. Brown Jr, A. Morita, S. Juvela, M. Yonekura, et al.
Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms : a pooled analysis of six prospective cohort studies.
Lancet Neurol, 13 (2014), pp. 59-66
[17]
N. Etminan, R.D. Brown Jr, K. Beseoglu, S. Juvela, J. Raymond, A. Morita, et al.
The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus.
Neurology, 85 (2015), pp. 881-889
[18]
B.G. Thompson, R.D. Brown Jr, S. Amin-hanjani, J.P. Broderick, K.M. Cockroft, E.S. Connolly Jr, et al.
Guidelines for the management of patients with unruptured intracranial aneurysms: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
Stroke, 46 (2015), pp. 2368-2400
[19]
T. Wende, J. Kasper, F. Wilhelmy, G. Prasse, U. Quäschling, A. Haase, et al.
Comparison of the unruptured intracranial aneurysm treatment score recommendations with clinical treatment results - a series of 322 aneurysms.
J Clin Neurosci, 98 (2022), pp. 104-108
[20]
R. Drexler, T. Sauvigny, T.F. Pantel, F.L. Ricklefs, J.S. Catapano, J.E. Wanebo, et al.
Global outcomes for microsurgical clipping of unruptured. Intracranial aneurysms: a benchmark analysis of 2245 cases.
Neurosurgery, 94 (2024), pp. 369-378
[21]
R. Jabbarli, K.H. Wrede, D. Pierscianek, P. Dammann, N. El Hindy, N. Özkan, et al.
Outcome after clipping of unruptured intracranial aneurysms depends on caseload.
World Neurosurg, 89 (2016), pp. 666-671.e1
[22]
S. Marbacher, B.E. Grüter, S. Wanderer, L. Andereggen, M. Cattaneo, P. Trost, et al.
Risk of intracranial aneurysm recurrence after microsurgical clipping based on 3D digital subtraction angiography.
J Neurosurg, 138 (2022), pp. 717-723
[23]
T.E. Darsaut, J.M. Findlay, M.W. Bojanowski, C. Chalaala, D. Iancu, D. Roy, et al.
A pragmatic randomized trial comparing surgical clipping and endovascular treatment of unruptured intracranial aneurysms.
AJNR Am J Neuroradiol, 44 (2023), pp. 634-640
[24]
N. Ajiboye, N. Chalouhi, R.M. Starke, M. Zanaty, R. Bell.
Unruptured cerebral aneurysms: evaluation and management.
Sci World J, 2015 (2015),
[25]
A.M. Algra, A. Lindgren, M.D.I. Vergouwen, J.P. Greving, I.C. van der Schaaf, T.P.C. van Doormaal, et al.
Procedural clinical complications, case-fatality risks, and risk factors in endovascular and neurosurgical treatment of unruptured intracranial aneurysms: a systematic review and meta-analysis.
JAMA Neurol, 76 (2019), pp. 282-293
[26]
J.A. Kosty, N.O. Andaluz, Y.M. Gozal, B.M. Krueger, J. Scoville, M. Zuccarello.
Microsurgical treatment for unruptured intracranial aneurysms : a modern single surgeon series surgeon series.
Br J Neurosurg, 33 (2019), pp. 322-327
[27]
C.S. Ogilvy, N.J. Jordan, L.C. Ascanio, A.A. Enriquez-Marulanda, M.M. Salem, J.M. Moore, et al.
Surgical and endovascular comprehensive treatment outcomes of unruptured intracranial aneurysms: reduction of treatment bias.
World Neurosurg, 126 (2019), pp. e878-e887
[28]
J. Sauvigny, R. Drexler, T.F. Pantel, F.L. Ricklefs, J.S. Catapano, J.E. Wanebo, et al.
Microsurgical clipping of unruptured anterior circulation aneurysms-a global multicenter investigation of perioperative outcomes.
[29]
P. Kerezoudis, B.A. Mccutcheon, M. Murphy, T. Rayan, H. Gilder, L. Rinaldo, et al.
Predictors of 30-day perioperative morbidity and mortality of unruptured intracranial aneurysm surgery.
Clin Neurol Neurosurg, 149 (2016), pp. 75-80
[30]
J. Song, B. Kim, Y.S. Shin.
Treatment outcomes of unruptured intracranial aneurysm; experience of 1231 consecutive aneurysms.
Acta Neurochir (Wien), 157 (2015), pp. 1303-1311
[31]
M. Mandel, R. Tutihashi, Y. Li, J. Rosi Jr, B.C. Ping Jeng, M.J. Teixeira, et al.
MISIAN (minimally invasive surgery for treatment of unruptured intracranial aneurysms): a prospective randomized single-center clinical trial with long-term follow-up comparing different minimally invasive surgery techniques with standard open surgery.
World Neurosurg, 151 (2021), pp. e533-e544
Idiomas
Neurocirugía (English edition)
Article options
Tools