Primary central nervous system lymphomas in immunocompetent patients
Linfomas primarios del sistema nervioso central en pacientes immunocompetentes
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Lagares" "autores" => array:1 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Lagares" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1130147306703682?idApp=UINPBA00004B" "url" => "/11301473/0000001700000001/v1_201305151250/S1130147306703682/v1_201305151250/es/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Primary central nervous system lymphomas in immunocompetent patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "53" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "T. Alécio-Mattei, J. Alécio-Mattei, P.H. Aguiar" "autores" => array:3 [ 0 => array:3 [ "nombre" => "T." "apellidos" => "Alécio-Mattei" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Alécio-Mattei" ] 2 => array:2 [ "nombre" => "P.H." "apellidos" => "Aguiar" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Pinheiros Neurosurgery Clinic. São Paulo. Brazil" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence to: Rua Capote Valente 725 ap. 302. CEP (postal-code) 05409-002 São Paulo - SP - Brazil." ] ] ] 1 => array:3 [ "autoresLista" => "R. Ramina" "autores" => array:1 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Ramina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Institute of Neurology Curitiba. Brazil" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfomas primarios del sistema nervioso central en pacientes immunocompetentes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-08-18" "fechaAceptado" => "2005-05-19" "PalabrasClave" => array:2 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec159154" "palabras" => array:4 [ 0 => "Brain lymphoma" 1 => "Immunocompetent" 2 => "Malignant lymphoma" 3 => "PCNLS" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abbreviations" "identificador" => "xpalclavsec159155" "palabras" => array:3 [ 0 => "IICP" 1 => "NHL" 2 => "PCNSL" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec159153" "palabras" => array:4 [ 0 => "Immunocompetente" 1 => "Linfomas cerebrales" 2 => "Linfomas malignos" 3 => "PCNLS" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objetctives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Primary central nervous system lymphoma (PCNSL) is a rare patology and is most often seen in immunodeficient patients. This article presents our casuistic of PCNSL in immunocompetent patients and make a literature review on this issue with focus on recent advances, investigations, and controversies in diagnosis and management of this patology.</p> <span class="elsevierStyleSectionTitle">Matherial and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nine patients operated in the last years in our clinics are analysed in relation to sex, age, time of symptoms, procedures and adjuvant treatment. Posteriorly the results are compared with those in the preview literature.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The age ranged from 44–68 years (middle of 66 years); 62,5% of the patients were female. The mean time of symptoms, when the diagnostic was made, was 3.2 months (range 1–6 months). The most common symptoms were hemiparesis (present in 75% of the patients) headache (37.5%) seizures (25%) and ataxia (25%). The most common localization was the parietal, frontal and temporal lobe surface with 25% of the patients for each localization. Five patients (50%) were treated with stereotactic biopsy, three with surgery (37.5%) and one (12.5%) with both of them. Five patients (62,5%) were submitted to pos-operative radiotherapy as adjuvant treatment. In relation to the hystology, the most common cell type was Difuse B Cells.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This study demonstrated that complete surgical ressection followed by radiotherapy have shown good results. In opposition to the literature, the authors regards chemotherapy as a secondary line treatment and recommends its use only in some selected cases.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En este trabajo presentamos nuestra casuística de linfomas cerebrales primarios en pacientes immunocompetentes comparandolo con los datos previos de la literatura, con especial enfoque en los recientes avaces, investigaciones, y controversias acerca del diagnóstico y manejo terapéutico de estas patologías.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nueve pacientes operados el año pasado en nuestra clínica con diagnóstico de PCNLS son analizados en relación al sexo, edad, tiempo de sintomatología, procedimientos y tratamiento. Posteriormente, los resultados son comparados con los de la literatura.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La edad varió entre 44–68 años (media de 60,6 años); 62,5% de los pacientes fueron del sexo femenino; el tiempo medio de duración de los síntomas antes del diagnóstico de la enfermedad varió de 1–6 meses, con un rango medio de 3,2 meses. Los síntomas clínicos más frecuentes fueron: hemiparesia (75%), cefalea (37,5), crisis convulsivas (25%) y ataxia (25%). Las localizaciones predominaron en las superficies de los lóbulos parietal, temporal y frontal con un 25% para cada una de las localizaciones citadas. Cinco pacientes (50%) fueron tratados con biopsia estereotáxica, tres con cirugía (37.5%) y uno (12.5%) con ambas. Cinco pacientes (62,5%) fueron sometidos a radioterapia postoperatoria como tratamiento adyuvante. En relación con el tipo histológico predominó el linfoma de células difusas tipo B.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Este estudio demostró que la resección quirúrgica, combinada con biopsia por esterotaxia y la radioterapia dan buenos resultados. Los autores recomiendan la quimioterapia solamente como segunda línea de tratamiento, en pacientes seleccionados.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Alécio-Mattei, T.; Alécio-Mattei, J.; Aguiar, P.H.; Ramina, R.: Primary central nervous system lymphomas in immunocompetent patients. Neurocirugía 2006; 17: 46–53.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2023 Marzo | 1 | 0 | 1 |
| 2018 Febrero | 9 | 4 | 13 |
| 2018 Enero | 10 | 4 | 14 |
| 2017 Diciembre | 18 | 9 | 27 |
| 2017 Noviembre | 62 | 17 | 79 |
| 2017 Octubre | 11 | 15 | 26 |
| 2017 Septiembre | 12 | 14 | 26 |
| 2017 Agosto | 12 | 6 | 18 |
| 2017 Julio | 8 | 6 | 14 |
| 2017 Junio | 20 | 5 | 25 |
| 2017 Mayo | 13 | 10 | 23 |
| 2017 Abril | 12 | 41 | 53 |
| 2017 Marzo | 14 | 6 | 20 |
| 2017 Febrero | 3 | 2 | 5 |
| 2017 Enero | 9 | 4 | 13 |
| 2016 Diciembre | 45 | 7 | 52 |
| 2016 Noviembre | 23 | 11 | 34 |
| 2016 Octubre | 40 | 7 | 47 |
| 2016 Septiembre | 27 | 6 | 33 |
| 2016 Agosto | 0 | 15 | 15 |
| 2016 Julio | 0 | 10 | 10 |
| 2015 Diciembre | 2 | 0 | 2 |
| 2015 Julio | 2 | 0 | 2 |
| 2015 Junio | 15 | 4 | 19 |
| 2015 Mayo | 22 | 8 | 30 |
| 2015 Abril | 23 | 11 | 34 |
| 2015 Marzo | 20 | 9 | 29 |
| 2015 Febrero | 10 | 16 | 26 |
| 2015 Enero | 17 | 11 | 28 |
| 2014 Diciembre | 26 | 9 | 35 |
| 2014 Noviembre | 8 | 11 | 19 |
| 2014 Octubre | 16 | 9 | 25 |
| 2014 Septiembre | 15 | 19 | 34 |
| 2014 Agosto | 15 | 14 | 29 |
| 2014 Julio | 17 | 14 | 31 |
| 2014 Junio | 24 | 17 | 41 |
| 2014 Mayo | 26 | 16 | 42 |
| 2014 Abril | 16 | 10 | 26 |
| 2014 Marzo | 24 | 12 | 36 |
| 2014 Febrero | 19 | 14 | 33 |
| 2014 Enero | 19 | 12 | 31 |
| 2013 Diciembre | 25 | 8 | 33 |
| 2013 Noviembre | 25 | 11 | 36 |
| 2013 Octubre | 26 | 11 | 37 |
| 2013 Septiembre | 35 | 12 | 47 |
| 2013 Agosto | 32 | 16 | 48 |
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| 2013 Junio | 25 | 16 | 41 |
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| 2013 Abril | 32 | 10 | 42 |
| 2013 Marzo | 22 | 9 | 31 |
| 2013 Febrero | 18 | 9 | 27 |
| 2013 Enero | 24 | 4 | 28 |
| 2012 Diciembre | 24 | 16 | 40 |
| 2012 Noviembre | 1 | 0 | 1 |
| 2012 Octubre | 0 | 2 | 2 |
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| 2012 Enero | 7 | 0 | 7 |
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