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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetctives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Primary central nervous system lymphoma &#40;PCNSL&#41; is a rare patology and is most often seen in immunodeficient patients&#46; This article presents our casuistic of PCNSL in immunocompetent patients and make a literature review on this issue with focus on recent advances&#44; investigations&#44; and controversies in diagnosis and management of this patology&#46;</p> <span class="elsevierStyleSectionTitle">Matherial and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nine patients operated in the last years in our clinics are analysed in relation to sex&#44; age&#44; time of symptoms&#44; procedures and adjuvant treatment&#46; Posteriorly the results are compared with those in the preview literature&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The age ranged from 44&#8211;68 years &#40;middle of 66 years&#41;&#59; 62&#44;5&#37; of the patients were female&#46; The mean time of symptoms&#44; when the diagnostic was made&#44; was 3&#46;2 months &#40;range 1&#8211;6 months&#41;&#46; The most common symptoms were hemiparesis &#40;present in 75&#37; of the patients&#41; headache &#40;37&#46;5&#37;&#41; seizures &#40;25&#37;&#41; and ataxia &#40;25&#37;&#41;&#46; The most common localization was the parietal&#44; frontal and temporal lobe surface with 25&#37; of the patients for each localization&#46; Five patients &#40;50&#37;&#41; were treated with stereotactic biopsy&#44; three with surgery &#40;37&#46;5&#37;&#41; and one &#40;12&#46;5&#37;&#41; with both of them&#46; Five patients &#40;62&#44;5&#37;&#41; were submitted to pos-operative radiotherapy as adjuvant treatment&#46; In relation to the hystology&#44; the most common cell type was Difuse B Cells&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This study demonstrated that complete surgical ressection followed by radiotherapy have shown good results&#46; In opposition to the literature&#44; the authors regards chemotherapy as a secondary line treatment and recommends its use only in some selected cases&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En este trabajo presentamos nuestra casu&#237;stica de linfomas cerebrales primarios en pacientes immunocompetentes comparandolo con los datos previos de la literatura&#44; con especial enfoque en los recientes avaces&#44; investigaciones&#44; y controversias acerca del diagn&#243;stico y manejo terap&#233;utico de estas patolog&#237;as&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nueve pacientes operados el a&#241;o pasado en nuestra cl&#237;nica con diagn&#243;stico de PCNLS son analizados en relaci&#243;n al sexo&#44; edad&#44; tiempo de sintomatolog&#237;a&#44; procedimientos y tratamiento&#46; Posteriormente&#44; los resultados son comparados con los de la literatura&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La edad vari&#243; entre 44&#8211;68 a&#241;os &#40;media de 60&#44;6 a&#241;os&#41;&#59; 62&#44;5&#37; de los pacientes fueron del sexo femenino&#59; el tiempo medio de duraci&#243;n de los s&#237;ntomas antes del diagn&#243;stico de la enfermedad vari&#243; de 1&#8211;6 meses&#44; con un rango medio de 3&#44;2 meses&#46; Los s&#237;ntomas cl&#237;nicos m&#225;s frecuentes fueron&#58; hemiparesia &#40;75&#37;&#41;&#44; cefalea &#40;37&#44;5&#41;&#44; crisis convulsivas &#40;25&#37;&#41; y ataxia &#40;25&#37;&#41;&#46; Las localizaciones predominaron en las superficies de los l&#243;bulos parietal&#44; temporal y frontal con un 25&#37; para cada una de las localizaciones citadas&#46; Cinco pacientes &#40;50&#37;&#41; fueron tratados con biopsia estereot&#225;xica&#44; tres con cirug&#237;a &#40;37&#46;5&#37;&#41; y uno &#40;12&#46;5&#37;&#41; con ambas&#46; Cinco pacientes &#40;62&#44;5&#37;&#41; fueron sometidos a radioterapia postoperatoria como tratamiento adyuvante&#46; En relaci&#243;n con el tipo histol&#243;gico predomin&#243; el linfoma de c&#233;lulas difusas tipo B&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Este estudio demostr&#243; que la resecci&#243;n quir&#250;rgica&#44; combinada con biopsia por esterotaxia y la radioterapia dan buenos resultados&#46; Los autores recomiendan la quimioterapia solamente como segunda l&#237;nea de tratamiento&#44; en pacientes seleccionados&#46;</p>"
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Vol. 17. Núm. 1.
Páginas 46-53 (enero 2005)
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Vol. 17. Núm. 1.
Páginas 46-53 (enero 2005)
Primary central nervous system lymphomas in immunocompetent patients
Linfomas primarios del sistema nervioso central en pacientes immunocompetentes
Visitas
1609
T. Alécio-Mattei
, J. Alécio-Mattei, P.H. Aguiar
Pinheiros Neurosurgery Clinic. São Paulo. Brazil
R. Ramina*
* Institute of Neurology Curitiba. Brazil
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Abstract
Objetctives

Primary central nervous system lymphoma (PCNSL) is a rare patology and is most often seen in immunodeficient patients. This article presents our casuistic of PCNSL in immunocompetent patients and make a literature review on this issue with focus on recent advances, investigations, and controversies in diagnosis and management of this patology.

Matherial and methods

Nine patients operated in the last years in our clinics are analysed in relation to sex, age, time of symptoms, procedures and adjuvant treatment. Posteriorly the results are compared with those in the preview literature.

Results

The age ranged from 44–68 years (middle of 66 years); 62,5% of the patients were female. The mean time of symptoms, when the diagnostic was made, was 3.2 months (range 1–6 months). The most common symptoms were hemiparesis (present in 75% of the patients) headache (37.5%) seizures (25%) and ataxia (25%). The most common localization was the parietal, frontal and temporal lobe surface with 25% of the patients for each localization. Five patients (50%) were treated with stereotactic biopsy, three with surgery (37.5%) and one (12.5%) with both of them. Five patients (62,5%) were submitted to pos-operative radiotherapy as adjuvant treatment. In relation to the hystology, the most common cell type was Difuse B Cells.

Conclusions

This study demonstrated that complete surgical ressection followed by radiotherapy have shown good results. In opposition to the literature, the authors regards chemotherapy as a secondary line treatment and recommends its use only in some selected cases.

Key words:
Brain lymphoma
Immunocompetent
Malignant lymphoma
PCNLS
Abbreviations:
IICP
NHL
PCNSL
Resumen
Objetivos

En este trabajo presentamos nuestra casuística de linfomas cerebrales primarios en pacientes immunocompetentes comparandolo con los datos previos de la literatura, con especial enfoque en los recientes avaces, investigaciones, y controversias acerca del diagnóstico y manejo terapéutico de estas patologías.

Material y método

Nueve pacientes operados el año pasado en nuestra clínica con diagnóstico de PCNLS son analizados en relación al sexo, edad, tiempo de sintomatología, procedimientos y tratamiento. Posteriormente, los resultados son comparados con los de la literatura.

Resultados

La edad varió entre 44–68 años (media de 60,6 años); 62,5% de los pacientes fueron del sexo femenino; el tiempo medio de duración de los síntomas antes del diagnóstico de la enfermedad varió de 1–6 meses, con un rango medio de 3,2 meses. Los síntomas clínicos más frecuentes fueron: hemiparesia (75%), cefalea (37,5), crisis convulsivas (25%) y ataxia (25%). Las localizaciones predominaron en las superficies de los lóbulos parietal, temporal y frontal con un 25% para cada una de las localizaciones citadas. Cinco pacientes (50%) fueron tratados con biopsia estereotáxica, tres con cirugía (37.5%) y uno (12.5%) con ambas. Cinco pacientes (62,5%) fueron sometidos a radioterapia postoperatoria como tratamiento adyuvante. En relación con el tipo histológico predominó el linfoma de células difusas tipo B.

Conclusiones

Este estudio demostró que la resección quirúrgica, combinada con biopsia por esterotaxia y la radioterapia dan buenos resultados. Los autores recomiendan la quimioterapia solamente como segunda línea de tratamiento, en pacientes seleccionados.

Palabras clave:
Immunocompetente
Linfomas cerebrales
Linfomas malignos
PCNLS

Artículo

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