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junto con la necesidad de ser considerado un proceso cl&#237;nico con diferentes fases de actuaci&#243;n estandarizadas&#44; hace necesario un tratamiento especializado multidisciplinar&#46; Su manejo en la UCI y la participaci&#243;n del intensivista y el neurocirujano en conjunci&#243;n con otros especialistas forman parte del entorno de esta enfermedad<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a>&#46; Pero los resultados pobres que se obtienen a veces conducen a una sensaci&#243;n de futilidad de las actuaciones realizadas<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nuestro <span class="elsevierStyleItalic">objetivo</span> es analizar el cambio durante m&#225;s de 2<span class="elsevierStyleHsp" style=""></span>d&#233;cadas de asistencia de las caracter&#237;sticas de presentaci&#243;n&#44; la evoluci&#243;n y el tratamiento en la UCI&#44; as&#237; como la evoluci&#243;n del pron&#243;stico funcional a los 12 meses de las HICE atendidas en una UCI de un centro de referencia&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Estudio descriptivo&#44; retrospectivo&#44; en un hospital de tercer nivel&#44; referencia de pacientes neuroquir&#250;rgicos y donde solo se trata a pacientes con politraumatismos y neurocr&#237;ticos&#46; Se recogieron todos los ingresos de pacientes con HICE durante 3<span class="elsevierStyleHsp" style=""></span>periodos&#58; 1999-2001 &#40;periodo I&#41;&#44; 2015-2016 &#40;periodo II&#41; y 2020-2021 &#40;periodo III&#41;&#46; Se recogen las variables demogr&#225;ficas&#44; las caracter&#237;sticas basales de los pacientes&#44; las variables cl&#237;nicas y las caracter&#237;sticas de la hemorragia&#44; as&#237; como los datos evolutivos durante su estancia en la UCI&#46; 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Los pacientes seg&#250;n la GOS fueron clasificados como de mal pron&#243;stico &#40;GOS 1-3&#41; y buen pron&#243;stico<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0025" class="elsevierStylePara elsevierViewall">Las variables cuantitativas se expresaron como mediana &#40;rango intercuart&#237;lico&#41; y las variables categ&#243;ricas como recuento &#40;porcentaje&#41;&#46; Para comparar las variables categ&#243;ricas utilizamos la prueba de la chi al cuadrado&#46; Para comparar variables cuantitativas utilizamos an&#225;lisis de la variancia&#44; con an&#225;lisis post hoc utilizando la prueba de Bonferroni&#46; Se considera significativo todo valor de p &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Se ha obtenido la autorizaci&#243;n por parte del Comit&#233; &#201;tico de Investigaci&#243;n Cl&#237;nica de nuestro centro hospitalario&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0035" class="elsevierStylePara elsevierViewall">De forma global&#44; en nuestra unidad&#44; de todos los pacientes con politraumatismos y neurocr&#237;ticos&#44; durante estos 23 a&#241;os&#44; el 14&#44;4&#37; ingresa por HICE&#46; Suponen 300 pacientes ingresados&#44; distribuidos en los siguientes periodos&#58; I&#44; 86 &#40;28&#44;7&#37;&#41; pacientes&#59; II&#44; 109 &#40;36&#44;3&#37;&#41; y III&#44; 105 &#40;35&#37;&#41; pacientes&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En conjunto&#44; en estos 23 a&#241;os&#44; el 56&#44;7&#37; son varones&#44; con una edad de 66 &#40;55&#44;5-74&#41; a&#241;os&#46; El 42&#44;2&#37; se localiza en l&#243;bulos cerebrales&#44; el 35&#44;3&#37; en los ganglios basales&#44; el 15&#44;2&#37; son cerebelosas&#44; el 4&#44;2&#37; en el tronco y el 3&#44;1&#37; en otras localizaciones&#46; Existe extensi&#243;n intraventricular en el 55&#37;&#44; con colocaci&#243;n de DVE en el 21&#44;3&#37;&#46; La causa implicada fue en un 60&#44;9&#37; la hipertensiva&#44; seguida por 17&#44;7&#37; la atribuida a la toma de antiagregantes o anticoagulantes&#46; En el 38&#44;5&#37; se realiz&#243; cirug&#237;a evacuadora&#46; El score ICH fue de 2 &#40;1-3&#41;&#46; La ventilaci&#243;n mec&#225;nica se realiz&#243; en el 71&#44;8&#37; con necesidad de traqueostom&#237;a en el 22&#44;7&#37;&#46; La estancia global en la UCI fue de 5 &#40;2-14&#41; d&#237;as&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La mortalidad global en la UCI fue del 36&#44;8&#37;&#46; Evaluados al a&#241;o&#44; la escala GOS fue&#58; 1 &#40;muerte&#41; 51&#44;3&#37;&#44; 2 &#40;estado vegetativo persistente&#41; 1&#44;5&#37;&#44; 3 &#40;discapacidad grave&#41; 14&#44;5&#37;&#44; 4 &#40;discapacidad moderada&#41; 17&#44;8&#37; y 5 &#40;discapacidad m&#237;nima&#41; 14&#44;9&#37;&#46; La escala GOS fue de mal pron&#243;stico en el 67&#44;3&#37; y de buen pron&#243;stico en el 32&#44;7&#37;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran los resultados&#44; en los diferentes periodos estudiados&#44; en relaci&#243;n con las variables basales&#44; los antecedentes personales y los datos caracter&#237;sticos de la hemorragia intracraneal&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> se muestra&#44; en los 3<span class="elsevierStyleHsp" style=""></span>periodos&#44; las GCS de ingreso&#44; los datos evolutivos en la UCI y la evaluaci&#243;n de la escala GOS al a&#241;o del episodio&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> detallamos la evoluci&#243;n de la mortalidad en los 3<span class="elsevierStyleHsp" style=""></span>periodos&#44; en el grupo total&#44; as&#237; como en las hemorragias de ganglios basales y lobares&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> podemos ver la utilizaci&#243;n de la cirug&#237;a evacuadora en los 3<span class="elsevierStyleHsp" style=""></span>periodos en el total de pacientes y seg&#250;n el tipo de hemorragia&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> se describen los componentes de la GOS en la evaluaci&#243;n al a&#241;o en el total de pacientes y seg&#250;n la localizaci&#243;n de la hemorragia&#46; Hay que hacer notar que las hemorragias lobares y de tronco no tienen grupo 2&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0070" class="elsevierStylePara elsevierViewall">La atenci&#243;n al paciente neurocr&#237;tico ha experimentado un gran avance en las &#250;ltimas d&#233;cadas&#44; acompasados por un mejor tratamiento inicial&#44; una mejor monitorizaci&#243;n y un tratamiento m&#225;s dirigido&#44; centr&#225;ndose el proceso en un mejor conocimiento fisiopatol&#243;gico de los factores implicados<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;9</span></a>&#46; Esto ha llevado a una mejor especializaci&#243;n y&#44; en este tiempo&#44; en nuestro centro hospitalario&#44; hemos pasado de una atenci&#243;n de un Servicio de Medicina Intensiva Polivalente en el periodo I a un Servicio de Medicina Intensiva con una Unidad especializada en pacientes neurocr&#237;ticos &#40;periodos II y III&#41;&#46; De esta complejidad se deriva el alto porcentaje de pacientes derivados de otros centros&#44; buscando mejorar la complejidad del manejo y la toma de decisiones&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">El paciente con HICE representa el 10-15&#37; &#37; de los ACVA<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">10-12</span></a>&#46; En nuestra serie nos encontramos con cifras en este rango&#44; destacando la importancia de esta patolog&#237;a&#46; Pero la hemorragia intracraneal no es una entidad homog&#233;nea&#44; sino que viene determinada por las caracter&#237;sticas de la hemorragia&#46; Aunque en estos periodos no existe diferencias en la edad de los pacientes&#44; hay una tendencia clara a un progresivamente mayor papel de la mujer como paciente con HICE&#46; Recientemente se ha llamado la atenci&#243;n al estar las mujeres infrarrepresentadas en los ensayos cl&#237;nicos sobre HICE<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Durante los 3<span class="elsevierStyleHsp" style=""></span>periodos aumenta progresivamente la prevalencia de diabetes&#44; obesidad&#44; enfermedad previa de HICE y pacientes anticoagulados&#46; Esto se asocia peor pron&#243;stico&#44; haciendo especial hincapi&#233; en el uso de los anticoagulantes<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14&#44;15</span></a>&#46; Llamar la atenci&#243;n sobre que se tiende a tratar pacientes que han tenido ya una HICE previa y recientemente se ha asociado a mayor presencia de eventos cardiovasculares mayores durante el ingreso&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En relaci&#243;n con los datos relacionados con la hemorragia&#44; son derivadas a nuestra Unidad progresivamente mayor n&#250;mero de hemorragias cerebelosas &#40;probablemente por la indicaci&#243;n quir&#250;rgica m&#225;s clara&#41; y las hemorragias de tronco&#44; aunque estas son escasos pacientes&#46; En cambio&#44; hemos recibido menos hemorragia de ganglios de la base&#46; El ICH score va en aumento de forma significativa&#44; indicando mayor extensi&#243;n y gravedad de la hemorragia&#46; Aunque un tratamiento temprano ha sido asociado con una tendencia a una mejor supervivencia despu&#233;s de controlar la severidad &#40;ICH score&#41;&#44; es evidente que son los m&#225;s graves los que tienden a derivarse<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a> y&#44; en consonancia con los estudios que muestran que los pacientes no comatosos o que no necesitan ventilaci&#243;n mec&#225;nica invasiva en las primeras 24 h&#44; pueden ser monitorizados y tratados fuera de la UCI o en UCI no especializadas<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">16&#44;17</span></a>&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">En relaci&#243;n con los datos de la UCI&#44; en los diferentes periodos se observa una disminuci&#243;n significativa de la utilizaci&#243;n de la ventilaci&#243;n mec&#225;nica invasiva&#44; traqueostom&#237;a y estancia&#46; Aunque no podemos sacar conclusiones al respecto&#44; la progresiva mejor&#237;a del manejo de este tipo de pacientes en centros de referencia y de la ventilaci&#243;n mec&#225;nica ha demostrado influir en el manejo<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">18&#44;19</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Las indicaciones quir&#250;rgicas han sido una de las piedras angulares del tratamiento&#46; En nuestra serie observamos un descenso muy significativo de los pacientes que acaban requiriendo intervenci&#243;n quir&#250;rgica&#46; Este decreciente papel de la cirug&#237;a&#44; como podemos apreciar en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>&#44; va en sinton&#237;a con las conclusiones obtenidas en los &#250;ltimos 20 a&#241;os&#46; Ensayos de la talla del Surgical Trial in Intracerebral Haemorrhage &#40;STICH I&#41;&#44; Surgical Trial in Lobar Intracerebral Haemorrhage &#40;STICH II&#41;&#44; Minimally Invasive Surgery plus rt-PA for Intracerebral Hemorrhage Evacuation &#40;MISTIE&#41; o Clot Lysis&#58; Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III &#40;CLEAR III&#41; no han demostrado una mejor&#237;a funcional a medio y largo plazo estad&#237;sticamente significativa&#44; aunque s&#237; hay una inclinaci&#243;n a creer que reducen la fatalidad de la evoluci&#243;n neurol&#243;gica<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">20-22</span></a>&#59; esto determina que el manejo quir&#250;rgico ideal est&#225; todav&#237;a por ser determinado<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11&#44;23</span></a>&#46; No en vano&#44; a nivel te&#243;rico&#44; el drenaje del hematoma tiene muchos beneficios&#44; permitiendo disminuir el efecto masa y la herniaci&#243;n cerebral consecuente&#44; con el da&#241;o secundario producido mediante excitotoxicidad y neurotoxicidad de los productos sangu&#237;neos<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Pese a la ausencia de certezas sobre el beneficio de la neurocirug&#237;a&#44; existen evidencias suficientes para respaldar ciertas intervenciones quir&#250;rgicas&#44; como la colocaci&#243;n de drenajes ventriculares externos&#44; tanto para monitorizaci&#243;n&#44; como para control de la hidrocefalia relacionada con el volcado ventricular de la hemorragia&#59; entre el 51 y 58&#37; de los pacientes de nuestra serie presentaron hemorragia intraventricular&#44; que de por s&#237; es un factor independiente de mal pron&#243;stico&#46; Adem&#225;s&#44; la implantaci&#243;n del cat&#233;ter ventricular permite la instilaci&#243;n de fibrinol&#237;ticos para facilitar la disoluci&#243;n del co&#225;gulo<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Con respecto a las craneotom&#237;as&#44; dada la ausencia significativa de resultados en los estudios mencionados &#40;STICH I o II&#41;&#44; hemos constatado una disminuci&#243;n en las indicaciones&#44; atendiendo a una diferenciaci&#243;n clara entre HICE supra e infratentoriales&#46; En HICE infratentoriales&#44; la colocaci&#243;n de DVE&#44; junto con craneotom&#237;a de fosa posterior y evacuaci&#243;n&#44; se han demostrado como terapia efectiva&#44; especialmente en hemorragias cerebelosas de m&#225;s de 3<span class="elsevierStyleHsp" style=""></span>cm&#44; estando indicada la realizaci&#243;n precoz de la cirug&#237;a&#46; Con respecto a la indicaci&#243;n quir&#250;rgica evacuadora en HICE supratentoriales&#44; tendemos a la individualizaci&#243;n de los casos&#58; edad&#44; comorbilidades&#44; no dominancia&#44; efecto masa o distancia con la cortical son factores que se toman en cuenta para llevar a cabo una intervenci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;11</span></a>&#46; En la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> se observa que todas las localizaciones se operan menos &#40;casi la mitad&#41;&#44; siendo las cerebelosas en las que la disminuci&#243;n es menor&#44; pues se tienen en consideraci&#243;n los hechos comentados&#58; presencia de hidrocefalia&#44; etc&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">El papel de la craniectom&#237;a descompresiva asociada a la evacuaci&#243;n es escaso&#44; asociado con casos de mal pron&#243;stico y mala situaci&#243;n cl&#237;nica &#40;GCS &#8804; 8&#41;&#44; si bien pueden prevenir hipertensiones intracraneales no controlables con medidas farmacol&#243;gicas&#44; con buenos resultados cl&#237;nicos y de forma segura&#44; asocian frecuentemente complicaciones relacionadas con la herida quir&#250;rgica y sus resultados se ven interferidos por la gravedad de los pacientes seleccionados<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a>&#46; Como asignatura pendiente en este hospital&#44; queda atender a t&#233;cnicas m&#237;nimamente invasivas que empiezan a imponerse en los grandes centros neuroquir&#250;rgicos a nivel mundial&#44; con el empleo de t&#233;cnicas de endoscopia o neuronavegaci&#243;n&#44; como el sistema SCUBA &#40;Stereotactic intracerebral hemorrhage underwater blood aspiration&#41;&#44; que tratan de minimizar la morbilidad asociada a la cirug&#237;a&#44; con tasas de evacuaci&#243;n satisfactorias<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a>&#46; La progresiva implementaci&#243;n de t&#233;cnicas menos invasivas puede que abran nuevas v&#237;as de exploraci&#243;n<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La mortalidad solo ha mejorado discretamente del I al II periodo&#44; de forma no significativa&#44; qued&#225;ndose en un tercio de los pacientes que fallecen en la UCI<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a>&#46; Aunque la mortalidad estar&#237;a dentro de lo descrito en la literatura&#44; muchos autores llaman la atenci&#243;n de que esta mortalidad precoz sigue situ&#225;ndose entre el 30-40&#37; sin ning&#250;n cambio desde hace m&#225;s de 20 a&#241;os<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">27&#44;28</span></a>&#46; Se debe observar que al a&#241;o la mortalidad es del 51&#44;3&#37;&#44; indicando la gravedad que conlleva&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Esta enfermedad tan devastadora no solo repercute a nivel de mortalidad&#44; sino tambi&#233;n de la situaci&#243;n funcional que provoca alteraciones importantes en la calidad de vida&#46; La utilizaci&#243;n de equipos de rehabilitaci&#243;n ayuda a mejorar no solo el pron&#243;stico funcional&#44; sino que tambi&#233;n tendr&#237;a una repercusi&#243;n sobre la mortalidad postalta<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a>&#46; Nuestros pacientes muestran una adecuada recuperaci&#243;n funcional que les permita llevar una vida razonablemente independiente &#40;GOS 4-5&#41; en el 32&#44;7&#37; al a&#241;o de evaluaci&#243;n&#44; estando en consonancia con lo publicado que se sit&#250;a entre el 30 y 40&#37;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a>&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> observamos como las hemorragias cerebelosas alcanzan una escala GOS 4-5 en el 38&#44;1&#37; al a&#241;o de evoluci&#243;n&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">El estudio presenta varias limitaciones&#44; no solo en la revisi&#243;n retrospectiva de los casos&#44; sino que establecer los periodos de estudio de un modo arbitrario podr&#237;a sin duda influir en los resultados&#44; aunque hemos tratado de ver m&#225;s una tendencia que unos puntos absolutos de corte&#46; Adem&#225;s&#44; los periodos no homog&#233;neos&#44; pues el primer periodo comprende 3 a&#241;os y los otros&#44; 2&#44; pero hemos querido aumentar el tama&#241;o de comparaci&#243;n del n&#250;mero de pacientes entre los periodos&#46; Adem&#225;s&#44; habr&#237;a variables con factor pron&#243;stico relevante que podr&#237;an haber sido consideradas como la evaluaci&#243;n del volumen de la hemorragia en cada localizaci&#243;n&#44; el desplazamiento de la l&#237;nea media o el estado de las cisternas de la base e incluso establecer diferentes an&#225;lisis seg&#250;n las distintas etiolog&#237;as distintivas &#40;coagulopat&#237;a&#44; causa vascular&#44; etc&#46;&#41;&#46; Pero hemos querido mostrar una visi&#243;n general de una enfermedad relevante en el devenir de los a&#241;os&#44; sin entrar en consideraciones que habr&#225; que realizar de forma individual&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Como <span class="elsevierStyleItalic">conclusi&#243;n</span> podemos decir que la HICE grave es una enfermedad con una complejidad de manejo y abordaje en unidades especializadas&#46; Durante las 2<span class="elsevierStyleHsp" style=""></span>&#250;ltimas d&#233;cadas ha ido modificando algunas caracter&#237;sticas de presentaci&#243;n en la UCI con mayor prevalencia en mujeres y mayor presencia de factores cardiovasculares&#59; aunque la etiolog&#237;a no ha cambiado&#44; la gravedad ha ido increment&#225;ndose y en cuanto a su localizaci&#243;n han ido aumentado la hemorragia cerebelosa y de troncoenc&#233;falo&#46; Aunque la gravedad ha sido mayor&#44; la estancia en la UCI&#44; la utilizaci&#243;n de ventilaci&#243;n mec&#225;nica invasiva y la traqueostom&#237;a son menores&#46; La cirug&#237;a abierta se ha disminuido su utilizaci&#243;n en un 50&#37;&#46; La mortalidad sigue siendo alta&#44; estancada en la UCI en el 35&#37;&#44; y conlleva un alto grado de discapacidad al a&#241;o de valoraci&#243;n&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Financiaci&#243;n</span><p id="par0135" class="elsevierStylePara elsevierViewall">No existen fuentes de financiaci&#243;n del trabajo provenientes de entidades p&#250;blicas&#44; privadas&#44; de investigaci&#243;n o fundaciones ni ninguna otra que se pueda considerar&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0140" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar el cambio de las caracter&#237;sticas de presentaci&#243;n&#44; evoluci&#243;n y tratamiento en UCI&#44; as&#237; como la evoluci&#243;n funcional a los 12 meses de las hemorragias intracraneales espont&#225;neas &#40;HICE&#41; atendidas en una UCI centro de referencia&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Pacientes y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo&#44; retrospectivo en Hospital de Referencia neurocr&#237;ticos&#46; Se estudian todos los ingresos de pacientes con HICE durante 3<span class="elsevierStyleHsp" style=""></span>periodos&#58; 1999-2001 &#40;I&#41;&#44; 2015-2016 &#40;II&#41; y 2020-2021 &#40;III&#41;&#46; Se estudian la evoluci&#243;n en los 3<span class="elsevierStyleHsp" style=""></span>periodos de variables demogr&#225;ficas&#44; las caracter&#237;sticas basales de los pacientes&#44; las variables cl&#237;nicas y las caracter&#237;sticas de la hemorragia&#44; y los datos evolutivos en UCI&#46; Al a&#241;o valoramos la escala Glasgow Outcome Score &#40;GOS&#41; seg&#250;n presentaban mal &#40;GOS 1-3&#41; o buen pron&#243;stico &#40;GOS 4-5&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Trescientos pacientes ingresados&#44; distribuidos en periodos&#58; I&#58; 28&#44;7&#37;&#44; II&#58; 36&#44;3&#37; y III&#58; 35&#37;&#46; 56&#44;7&#37; eran varones con una edad de 66 &#40;55&#44;5-74&#41; a&#241;os&#59; ICH score 2 &#40;1-3&#41;&#46; La estancia en la UCI fue de 5 &#40;2-14&#41; d&#237;as&#44; con una mortalidad del 36&#44;8&#37;&#46; Al a&#241;o&#44; GOS 1-3 en el 67&#44;3&#37; y GOS 4-5 en el 32&#44;7&#37;&#46; Comparando los 3<span class="elsevierStyleHsp" style=""></span>periodos observamos mayor prevalencia en mujeres y presencia de factores cardiovasculares&#59; sin cambios en la etiolog&#237;a&#59; con relaci&#243;n a la localizaci&#243;n&#44; aumenta la hemorragia cerebelosa y en el troncoenc&#233;falo&#46; Aunque la gravedad fue mayor&#44; la estancia en la UCI&#44; la utilizaci&#243;n de ventilaci&#243;n mec&#225;nica invasiva y la traqueostom&#237;a son menores&#46; La cirug&#237;a abierta ha disminuido su utilizaci&#243;n en un 50&#37;&#46; La mortalidad sigue siendo alta&#44; estancada en la UCI en el 35&#37;&#44; y conlleva un alto grado de discapacidad al a&#241;o de valoraci&#243;n&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La HICE grave es una enfermedad compleja que ha modificado algunas caracter&#237;sticas en las 2<span class="elsevierStyleHsp" style=""></span>&#250;ltimas d&#233;cadas&#44; con pacientes m&#225;s graves&#44; con m&#225;s antecedentes cardiovasculares y mayor predominancia de la hemorragia en tronco-enc&#233;falo y cerebelosa&#46; A pesar de aumento gravedad&#44; se observan mejores par&#225;metros en la estancia en la UCI&#44; con una cirug&#237;a abierta que se utiliza un 50&#37; menos&#46; La mortalidad sigue estancada en un 35&#37;&#44; con una alta discapacidad al a&#241;o&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objetivo"
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          1 => array:2 [
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            "titulo" => "Pacientes y m&#233;todo"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
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            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze the change in the characteristics of presentation&#44; evolution and treatment in the ICU&#44; as well as the functional evolution at 12 months of spontaneous intracranial hemorrhages &#40;ICHs&#41; treated in an ICU reference center&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Patient and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Descriptive&#44; retrospective study in a Neurocritical Reference Hospital&#46; All admissions of patients with HICE during 3<span class="elsevierStyleHsp" style=""></span>periods are studied&#58; 1999-2001 &#40;I&#41;&#44; 2015-2016 &#40;II&#41; and 2020-2021 &#40;III&#41;&#46; Evolution in the 3<span class="elsevierStyleHsp" style=""></span>periods of demographic variables&#44; baseline characteristics of the patients&#44; clinical variables and characteristics of bleeding&#44; evolutionary data in the ICU are studied&#46; At one year we assessed the GOS scale &#40;Glasgow Outcome Score&#41; according to whether they had a poor &#40;GOS 1-3&#41; or good &#40;GOS 4-5&#41; prognosis&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">300 admitted patients&#44; distributed in periods&#58; I&#58; 28&#46;7&#37;&#44; II&#58; 36&#46;3&#37; and III&#58; 35&#37;&#46; 56&#46;7&#37; were males aged 66 &#40;55&#46;5-74&#41; years&#59; ICH score 2 &#40;1-3&#41;&#46; The ICU stay was 5 &#40;2-14&#41; days with a mortality of 36&#46;8&#37;&#46; GOS 1-3 a year in 67&#46;3&#37; and GOS 4-5 in 32&#46;7&#37;&#46; Comparing the 3<span class="elsevierStyleHsp" style=""></span>periods&#44; we observed a higher prevalence in women&#44; and the presence of cardiovascular factors&#59; no changes in etiology&#59; in relation to the location&#44; it increases cerebellar hemorrhage and in the brainstem&#46; Although the severity was greater&#44; the stay in the ICU&#44; the use of invasive mechanical ventilation and tracheostomy were lower&#46; Open surgery has decreased its use by 50&#37;&#46; Mortality continues to be high&#44; stagnating in the ICU at 35&#37; and entails a high degree of disability one year after assessment&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Severe ICH is a complex pathology that has changed some characteristics in the last 2<span class="elsevierStyleHsp" style=""></span>decades&#44; with more severe patients&#44; with more cardiovascular history and a greater predominance of brainstem and cerebellar hemorrhage&#46; Despite the increase in severity&#44; better parameters during the ICU stay&#44; with open surgery used 50&#37; less&#46; Mortality remains stagnant at 35&#37; with high disability per year&#46;</p></span>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n de la mortalidad en UCI en los 3<span class="elsevierStyleHsp" style=""></span>periodos mostrando el total de las hemorragias&#44; las hemorragias lobares y en los ganglios basales &#40;ninguna presenta significaci&#243;n estad&#237;stica&#41;&#46;</p>"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Evoluci&#243;n del porcentaje de cirug&#237;a evacuadora realizada durante su ingreso en UCI en los 3<span class="elsevierStyleHsp" style=""></span>periodos mostrando el total de las hemorragias&#44; las hemorragias lobares&#44; en ganglios basales y cerebelosa&#46;</p>"
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        "etiqueta" => "Figura 3"
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        "mostrarFloat" => true
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n de los componentes de la GOS en la evaluaci&#243;n al a&#241;o en el total de pacientes y seg&#250;n la localizaci&#243;n de la hemorragia&#46;</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">HICE&#58; hemorragia intracraneal espont&#225;nea&#59; ICH&#58; intracerebral hemorragia&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Las variables cualitativas son expresadas como recuento &#40;porcentaje&#41; y las cuantitativas como mediana &#40;rango intercuart&#237;lico&#41;&#46;</p>"
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes personales</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">53 &#40;61&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">64 &#40;61&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;725&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes mellitus&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">33 &#40;31&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipidemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesidad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">-&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;9&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;281&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cardiopat&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;18&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;039&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HICE&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;3&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;10&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;190&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ictus&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18 &#40;20&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;5&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;004&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Medicaci&#243;n basal</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antiagregaci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;22&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;22&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25 &#40;23&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;949&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulaci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;9&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15 &#40;15&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;15&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;413&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Datos hemorragia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Etiolog&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">62 &#40;72&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">53 &#40;55&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46 &#40;54&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">12 &#40;12&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">14 &#40;16&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>GCS motor ingreso&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Datos evolutivos UCI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Estancia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;6 &#40;3-11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ventilaci&#243;n mec&#225;nica invasiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Drenaje ventricular externo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cirug&#237;a evacuadora&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Evoluci&#243;n UCI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fallecimiento&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">35 &#40;40&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">35 &#40;35&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">37 &#40;35&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otros hospitales&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;5&#44;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;2&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Motivo de fallecimiento</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>SDMO&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>LTSV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Muerte encef&#225;lica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HTIC refractaria&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Comparaci&#243;n de las variables evolutivas durante el ingreso en la UCI y al a&#241;o en los 3<span class="elsevierStyleHsp" style=""></span>periodos de estudio evaluados</p>"
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Vol. 35. Núm. 4.
Páginas 169-176 (julio - agosto 2024)
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Vol. 35. Núm. 4.
Páginas 169-176 (julio - agosto 2024)
Investigación clínica
Evaluación de las últimas 2 décadas en las características de presentación, manejo y pronóstico de las hemorragias cerebrales espontáneas graves en un hospital de tercer nivel
Evaluation of the last 2 decades in the characteristics of presentation, management and prognosis of serious spontaneous intracerebral hemorrhage in a third level hospital
Visitas
341
Francisco Javier Morán Gallegoa, Marcelino Sanchez Casadoa,
Autor para correspondencia
mmsc16@gmail.com

Autor para correspondencia.
, Ismael López de Toro Martín Consuegraa, Luis Marina Martineza, Javier Alvarez Fernandezb, María José Sánchez Carreteroa
a Servicio Medicina Intensiva, Hospital Universitario de Toledo, Toledo, España
b Servicio Neurocirugía, Hospital Universitario de Toledo, Toledo, España
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Tabla 1. Comparación de variables basales, antecedentes personales y datos de la hemorragia en los 3periodos de estudio comparados
Tabla 2. Comparación de las variables evolutivas durante el ingreso en la UCI y al año en los 3periodos de estudio evaluados
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Resumen
Objetivo

Analizar el cambio de las características de presentación, evolución y tratamiento en UCI, así como la evolución funcional a los 12 meses de las hemorragias intracraneales espontáneas (HICE) atendidas en una UCI centro de referencia.

Pacientes y método

Estudio descriptivo, retrospectivo en Hospital de Referencia neurocríticos. Se estudian todos los ingresos de pacientes con HICE durante 3periodos: 1999-2001 (I), 2015-2016 (II) y 2020-2021 (III). Se estudian la evolución en los 3periodos de variables demográficas, las características basales de los pacientes, las variables clínicas y las características de la hemorragia, y los datos evolutivos en UCI. Al año valoramos la escala Glasgow Outcome Score (GOS) según presentaban mal (GOS 1-3) o buen pronóstico (GOS 4-5).

Resultados

Trescientos pacientes ingresados, distribuidos en periodos: I: 28,7%, II: 36,3% y III: 35%. 56,7% eran varones con una edad de 66 (55,5-74) años; ICH score 2 (1-3). La estancia en la UCI fue de 5 (2-14) días, con una mortalidad del 36,8%. Al año, GOS 1-3 en el 67,3% y GOS 4-5 en el 32,7%. Comparando los 3periodos observamos mayor prevalencia en mujeres y presencia de factores cardiovasculares; sin cambios en la etiología; con relación a la localización, aumenta la hemorragia cerebelosa y en el troncoencéfalo. Aunque la gravedad fue mayor, la estancia en la UCI, la utilización de ventilación mecánica invasiva y la traqueostomía son menores. La cirugía abierta ha disminuido su utilización en un 50%. La mortalidad sigue siendo alta, estancada en la UCI en el 35%, y conlleva un alto grado de discapacidad al año de valoración.

Conclusiones

La HICE grave es una enfermedad compleja que ha modificado algunas características en las 2últimas décadas, con pacientes más graves, con más antecedentes cardiovasculares y mayor predominancia de la hemorragia en tronco-encéfalo y cerebelosa. A pesar de aumento gravedad, se observan mejores parámetros en la estancia en la UCI, con una cirugía abierta que se utiliza un 50% menos. La mortalidad sigue estancada en un 35%, con una alta discapacidad al año.

Palabras clave:
Hemorragia intracraneal espontánea
Neurocirugía
Glasgow Outcome Score
UCI
Abstract
Objective

To analyze the change in the characteristics of presentation, evolution and treatment in the ICU, as well as the functional evolution at 12 months of spontaneous intracranial hemorrhages (ICHs) treated in an ICU reference center.

Patient and methods

Descriptive, retrospective study in a Neurocritical Reference Hospital. All admissions of patients with HICE during 3periods are studied: 1999-2001 (I), 2015-2016 (II) and 2020-2021 (III). Evolution in the 3periods of demographic variables, baseline characteristics of the patients, clinical variables and characteristics of bleeding, evolutionary data in the ICU are studied. At one year we assessed the GOS scale (Glasgow Outcome Score) according to whether they had a poor (GOS 1-3) or good (GOS 4-5) prognosis.

Results

300 admitted patients, distributed in periods: I: 28.7%, II: 36.3% and III: 35%. 56.7% were males aged 66 (55.5-74) years; ICH score 2 (1-3). The ICU stay was 5 (2-14) days with a mortality of 36.8%. GOS 1-3 a year in 67.3% and GOS 4-5 in 32.7%. Comparing the 3periods, we observed a higher prevalence in women, and the presence of cardiovascular factors; no changes in etiology; in relation to the location, it increases cerebellar hemorrhage and in the brainstem. Although the severity was greater, the stay in the ICU, the use of invasive mechanical ventilation and tracheostomy were lower. Open surgery has decreased its use by 50%. Mortality continues to be high, stagnating in the ICU at 35% and entails a high degree of disability one year after assessment.

Conclusions

Severe ICH is a complex pathology that has changed some characteristics in the last 2decades, with more severe patients, with more cardiovascular history and a greater predominance of brainstem and cerebellar hemorrhage. Despite the increase in severity, better parameters during the ICU stay, with open surgery used 50% less. Mortality remains stagnant at 35% with high disability per year.

Keywords:
Spontaneous intracerebral hemorrhage
Neurosurgery
Glasgow Outcome Score
ICU

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