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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nuestro objetivo fue el estudiar la correlaci&#243;n entre las maniobras anest&#233;sicas y la aparici&#243;n de CSWS en pacientes neuroquir&#250;rgicos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudiaron quinientas veintiuna craniotom&#237;as consecutivas&#44; excluyendo las relacionadas con el hipot&#225;lamo&#44; el tercer ventr&#237;culo o hip&#243;fisis y aquellos con patolog&#237;a renal&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Factores estudiados&#58; ingesta l&#237;quida&#44; diuresis&#44; hipertensi&#243;n intracraneal&#44; corticoides&#44; furosemida&#44; manitol&#44; hipn&#243;ticos&#44; opi&#225;ceos&#44; duraci&#243;n de la cirug&#237;a y tiempo hasta la extubaci&#243;n&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se observaron treinta y dos casos &#40;6&#44;14&#37;&#41; de Cerebral salt wasting syndrome &#40;CSWS&#41;&#46; Su aparici&#243;n s&#243;lo se vio relacionada con la administraci&#243;n de opi&#225;ceos&#46; Treinta de estos casos hab&#237;an recibido fentanilo &#62; 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg m&#225;s morfina &#62; 5<span class="elsevierStyleHsp" style=""></span>mg y los otros dos restantes fentanilo 0&#44;20<span class="elsevierStyleHsp" style=""></span>mg m&#225;s morfina 5<span class="elsevierStyleHsp" style=""></span>mg&#46; Ninguno de los 93 pacientes que recibieron fentanilo &#8804; 0&#44;15<span class="elsevierStyleHsp" style=""></span>mg y ninguna morfina desarrollaron CSWS&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La administraci&#243;n de dosis medias o altas de opi&#225;ceos &#40;fentanilo &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;25<span class="elsevierStyleHsp" style=""></span>mg y morfina &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#41; en el curso de cirug&#237;a cerebral parece de alg&#250;n modo predisponer a la aparici&#243;n de CSWS&#46;</p>"
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        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We aimed to study the relationship between the anaesthetic manoeuvres and the appearance of Cerebral salt wasting syndrome &#40;CSWS&#41; in neurosurgical patients&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Five-hundred and twenty-one consecutive craniotomies were studied&#44; excluding those related to the hypothalamus&#44; IIIrd ventricle and pituitary and those with kidney troubles&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Factors studied&#58; fluid intake&#44; diuresis&#44; intracranial hypertension&#44; corticoids&#44; furosemide&#44; mannitol&#44; hypnotic agents&#44; opioids&#44; anaesthetic gases&#44; duration of surgery&#44; and time to extubation&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Thirty-two cases &#40;6&#44;14&#37;&#41; of CSWS were seen&#46; Its appearance was related only to opioid administration&#46; Thirty of the cases had received fentanyl &#62; 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg plus morphine &#62; 5<span class="elsevierStyleHsp" style=""></span>mg and the other two fentanyl 0&#44;20<span class="elsevierStyleHsp" style=""></span>mg plus morphine 5<span class="elsevierStyleHsp" style=""></span>mg&#46; None of the 93 patients managed with fentanyl &#8804; 0&#44;15<span class="elsevierStyleHsp" style=""></span>mg and no morphine at alla developed CSWS&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The administration of medium&#47;large doses of opioids &#40;fentanyl &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;25<span class="elsevierStyleHsp" style=""></span>mg and morphine &#62;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mg&#41; during brain surgery seems to somehow predispose to CSWS&#46;</p>"
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                      "titulo" => "Hyponatremia&#44; convulsions&#44; respiratory arrest&#44; and permanent brain damage after elective surgery in healthy women"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
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                      "doi" => "10.1056/NEJM198606123142401"
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                        "tituloSerie" => "N Engl J Med"
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                        "volumen" => "314"
                        "paginaInicial" => "1529"
                        "paginaFinal" => "1534"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3713746"
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                      "titulo" => "Thiazide-induced hyponatremia associated with death or neurologic damage in outpatients"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                            2 => "A&#46;I&#46; Arieff"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1981"
                        "volumen" => "70"
                        "paginaInicial" => "1163"
                        "paginaFinal" => "1168"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7234886"
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                      "titulo" => "Changing concepts in treatment of severe symptomatic hyponatremia&#46; Rapid correction and possible relation to central pontine myelinolisis"
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                          "autores" => array:3 [
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                            2 => "A&#46;I&#46; Arieff"
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                        "tituloSerie" => "Am J Med"
                        "fecha" => "1985"
                        "volumen" => "78"
                        "paginaInicial" => "897"
                        "paginaFinal" => "902"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4014266"
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                          ]
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                    0 => array:2 [
                      "titulo" => "The syndrome of inappro priate secretion of antidiuretic hormone"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1967"
                        "volumen" => "42"
                        "paginaInicial" => "790"
                        "paginaFinal" => "806"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5337379"
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                        "paginaFinal" => "883"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5535947"
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                      "titulo" => "Treating hyponatremia&#58; damned if we do and damned if we don&#39;t"
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                          "autores" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1990"
                        "volumen" => "37"
                        "paginaInicial" => "1006"
                        "paginaFinal" => "1018"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2179612"
                            "web" => "Medline"
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                          "autores" => array:5 [
                            0 => "J&#46; Born"
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                            2 => "S&#46; Smitz"
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                            4 => "S&#46; Kay"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Neurol"
                        "fecha" => "1985"
                        "volumen" => "23"
                        "paginaInicial" => "383"
                        "paginaFinal" => "387"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3975827"
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                          "autores" => array:2 [
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Trauma"
                        "fecha" => "1974"
                        "volumen" => "14"
                        "paginaInicial" => "134"
                        "paginaFinal" => "136"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4811660"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral salt wasting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Cort"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1954"
                        "volumen" => "1"
                        "paginaInicial" => "752"
                        "paginaFinal" => "754"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2882171"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral regulation of renal sodium excretion in sheep infused intravenously with hypertonic NaCl"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Chodobski"
                            1 => "M&#46;J&#46; McKinley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Physiol &#40;Lond&#41;"
                        "fecha" => "1989"
                        "volumen" => "418"
                        "paginaInicial" => "273"
                        "paginaFinal" => "291"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sodium and water regulation in a patient with cerebral salt wasting"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Diringer"
                            1 => "P&#46;W&#46; Ladenson"
                            2 => "C&#46; Borel"
                            3 => "G&#46;K&#46; Hart"
                            4 => "J&#46;R&#46; Kirsch"
                            5 => "D&#46;F&#46; Hanley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "1989"
                        "volumen" => "46"
                        "paginaInicial" => "928"
                        "paginaFinal" => "930"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2757534"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syndrome of inappropriate secretion of antidiuretic hormone &#40;SIADH&#41; after head injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; D&#243;czi"
                            1 => "J&#46; Tarjanyi"
                            2 => "E&#46; Huszka"
                            3 => "J&#46; Kiss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1982"
                        "volumen" => "10"
                        "paginaInicial" => "685"
                        "paginaFinal" => "687"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7110540"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of adrenocorticoids in the inappropriate antidiuretic hormone syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;P&#46; Fichman"
                            1 => "J&#46;E&#46; Bethune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1968"
                        "volumen" => "68"
                        "paginaInicial" => "806"
                        "paginaFinal" => "820"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5642964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of antidiuretic hormone secretion by dyphenylhydantoin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;P&#46; Fichman"
                            1 => "C&#46;R&#46; Kleeman"
                            2 => "J&#46;E&#46; Bethune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Neurol"
                        "fecha" => "1970"
                        "volumen" => "22"
                        "paginaInicial" => "45"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5409600"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of aldosterone in the syndrome of inappropriate antidiuretic hormone secretion &#40;SIADH&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;P&#46; Fichmand"
                            1 => "A&#46;M&#46; Michelakis"
                            2 => "P&#46; Horton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem-39-1-136"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1974"
                        "volumen" => "39"
                        "paginaInicial" => "136"
                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4365920"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neurosurgical hyponatremia&#58; the role of inappropriate diuresis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;L&#46; Fox"
                            1 => "J&#46;L&#46; Falik"
                            2 => "R&#46;J&#46; Shalhoun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1971.34.4.0506"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1971"
                        "volumen" => "34"
                        "paginaInicial" => "506"
                        "paginaFinal" => "514"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5554356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "SIADH following minor surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;M&#46; Fuhrman"
                            1 => "T&#46; Runyan"
                            2 => "T&#46; Reilley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03008690"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "1992"
                        "volumen" => "39"
                        "paginaInicial" => "97"
                        "paginaFinal" => "98"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1733545"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Human red cell sodium and potassium in metabolic alkalosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Funder"
                            1 => "J&#46;O&#46; Wieth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Lab Invest"
                        "fecha" => "1974"
                        "volumen" => "34"
                        "paginaInicial" => "49"
                        "paginaFinal" => "59"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral wasting in children&#58; the need for recognition and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;A&#46; Ganong"
                            1 => "M&#46;S&#46; Kappy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dis Child"
                        "fecha" => "1993"
                        "volumen" => "147"
                        "paginaInicial" => "167"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8427239"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyponatremia is associated with cerebral ischemia in patients with aneurysmal subarachnoid haemorrhage"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Hassan"
                            1 => "E&#46;F&#46;M&#46; Wijdicks"
                            2 => "M&#46; Vermeulen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ana.410270118"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Neurol"
                        "fecha" => "1990"
                        "volumen" => "27"
                        "paginaInicial" => "106"
                        "paginaFinal" => "108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2301918"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The syndrome of inappropriate secretion of antidiuretic hormone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46;B&#46; Haycock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Nephrol"
                        "fecha" => "1995"
                        "volumen" => "9"
                        "paginaInicial" => "375"
                        "paginaFinal" => "381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7632537"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The stress reponse to anesthesia and surgery&#58; Release mechanisms and modifying factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Kehlet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clinical Anesthesia"
                        "fecha" => "1984"
                        "volumen" => "2"
                        "paginaInicial" => "315"
                        "paginaFinal" => "319"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syndrome of inappropriate antidiuresis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Kovacs"
                            1 => "G&#46;L&#46; Robertson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Metab Clin North Am"
                        "fecha" => "1992"
                        "volumen" => "21"
                        "paginaInicial" => "859"
                        "paginaFinal" => "875"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1486879"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyponatremia in acute brain disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Kr&#246;ll"
                            1 => "M&#46; Juhler"
                            2 => "J&#46; Lindholm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "1992"
                        "volumen" => "232"
                        "paginaInicial" => "291"
                        "paginaFinal" => "297"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1328460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of acute post-operative inappropriate antidiuretic hormone secretion with diphenylhydantoin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46;M&#46; Landolt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Endocrinol"
                        "fecha" => "1974"
                        "volumen" => "76"
                        "paginaInicial" => "625"
                        "paginaFinal" => "627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4407890"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral oedema after subarachnoid haemorrhage&#46; Pathogenetic significance of vasopressin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;A&#46; L&#225;szl&#243;"
                            1 => "C&#46; Varga"
                            2 => "T&#46; D&#243;czi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1995"
                        "volumen" => "133"
                        "paginaInicial" => "122"
                        "paginaFinal" => "133"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute water loading as a diagnostic test for the inappropriate ADH syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;Y&#46; Lee"
                            1 => "H&#46;A&#46; Grumer"
                            2 => "D&#46; Bronsky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Lab Clin Med"
                        "fecha" => "1961"
                        "volumen" => "58"
                        "paginaInicial" => "937"
                        "paginaFinal" => "940"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of hypokalemia&#44; hyponatremia&#44; and acid base alterations on erythrocyte sodium transport"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;L&#46; Levin"
                            1 => "F&#46;C&#46; Rector"
                            2 => "D&#46;W&#46; Seldin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Sci"
                        "fecha" => "1972"
                        "volumen" => "43"
                        "paginaInicial" => "251"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5048308"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phenytoin in the management of severe acute SIADH &#91;letter&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;G&#46; Lowe"
                            1 => "B&#46;H&#46; Wilkins"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Paediatr Child Health"
                        "fecha" => "1995"
                        "volumen" => "31"
                        "paginaInicial" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7794621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of chronic hypotonic volume expansion on the renal regulation of acid-base equilibrium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46; Lowrance"
                            1 => "H&#46; Garfinkel"
                            2 => "W&#46; Schwartz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1172/JCI107117"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Invest"
                        "fecha" => "1972"
                        "volumen" => "51"
                        "paginaInicial" => "2928"
                        "paginaFinal" => "2940"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5080418"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inappropriate antidiuretic hormone secretion of unknown origin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46; Maldonado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1980"
                        "volumen" => "17"
                        "paginaInicial" => "554"
                        "paginaFinal" => "567"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6771455"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal function during anesthesia and surgery&#46; The effect of halothane anesthesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Mazze"
                            1 => "F&#46; Scwartz"
                            2 => "H&#46; Glocum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Anesthesiology"
                        "fecha" => "1966"
                        "volumen" => "24"
                        "paginaInicial" => "279"
                        "paginaFinal" => "284"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The relationship of antidiuretic hormone to surgical stress"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46;H&#46; Moran"
                            1 => "F&#46;W&#46; Miltenberger"
                            2 => "W&#46;A&#46; Shuayb"
                            3 => "B&#46; Zimmermann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1964"
                        "volumen" => "56"
                        "paginaInicial" => "99"
                        "paginaFinal" => "108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14175989"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sodium&#44; potassium and water metabolism in the syndrome of inappropriate antidiuretic hormone secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46; Nolph"
                            1 => "R&#46; Shrier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1970"
                        "volumen" => "49"
                        "paginaInicial" => "534"
                        "paginaFinal" => "545"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5477638"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "T&#46; Oyama"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "The influence of anesthesia on the endocrine system"
                        "paginaInicial" => "39"
                        "paginaFinal" => "42"
                        "serieFecha" => "1980"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasma levels of ADH in man during methoxyflurane anesthesia and surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Oyama"
                            1 => "K&#46; Sato"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anaesthesia"
                        "fecha" => "1970"
                        "volumen" => "25"
                        "paginaInicial" => "500"
                        "paginaFinal" => "507"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5469556"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Blood chemistry changes in head injured patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;D&#46; Parent"
                            1 => "G&#46;A&#46; Meyer"
                            2 => "G&#46;T&#46; Tindall"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurosurg Nursing"
                        "fecha" => "1972"
                        "volumen" => "4"
                        "paginaInicial" => "9"
                        "paginaFinal" => "20"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A salt-wasting syndrome associated with cerebral disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;P&#46; Peters"
                            1 => "K&#46;G&#46; Welt"
                            2 => "E&#46;A&#46;H&#46; Sims"
                            3 => "J&#46; Orloff"
                            4 => "J&#46; Needham"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Trans Assoc Am Physicians"
                        "fecha" => "1950"
                        "volumen" => "63"
                        "paginaInicial" => "57"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14855556"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022347610001885"
                          "estado" => "S300"
                          "issn" => "00223476"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syndrome of inappropriate antidiuretic hormone following appendedectomy&#58; case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Policastro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Milit Med"
                        "fecha" => "1983"
                        "volumen" => "148"
                        "paginaInicial" => "271"
                        "paginaFinal" => "272"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Renal tubular sodium and water metabolism in brain tumour patients submitted to craniotomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Ponce"
                            1 => "J&#46; Travassos"
                            2 => "J&#46; Cruz"
                            3 => "P&#46; Moreira"
                            4 => "P&#46; Melo Gomes"
                            5 => "J&#46;L&#46; Lobo Antunes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1993"
                        "volumen" => "125"
                        "paginaInicial" => "86"
                        "paginaFinal" => "91"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Administration of intravenous urea and normal saline for the treatment of hyponatremia in neurosurgical patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;F&#46; Reeder"
                            1 => "R&#46;E&#46; Harbaugh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1989.70.2.0201"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1989"
                        "volumen" => "70"
                        "paginaInicial" => "201"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2913218"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Monitoring of the critically ill patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "W&#46;C&#46; Schoemaker"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "paginaInicial" => "105"
                        "paginaFinal" => "121"
                        "serieFecha" => "1984"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Schwartz"
                            1 => "W&#46; Bennett"
                            2 => "S&#46; Curelop"
                            3 => "F&#46; Bartter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1957"
                        "volumen" => "23"
                        "paginaInicial" => "529"
                        "paginaFinal" => "542"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13469824"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Restricted fluid intake&#58; Rational management of the neurosurgical patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;A&#46; Shenkin"
                            1 => "H&#46;S&#46; Bezier"
                            2 => "W&#46;F&#46; Bouzrth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1976.45.4.0432"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1976"
                        "volumen" => "45"
                        "paginaInicial" => "432"
                        "paginaFinal" => "436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/956879"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The analysis of body water compartments in postoperative craniotomy patients"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;A&#46; Shenkin"
                            1 => "W&#46;F&#46; Bouzart"
                            2 => "T&#46; Tatsumi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3171/jns.1968.28.5.0417"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurosurg"
                        "fecha" => "1968"
                        "volumen" => "28"
                        "paginaInicial" => "417"
                        "paginaFinal" => "428"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4873036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Management of neurosurgical patients with hyponatremia and natriuresis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Sivakumar"
                            1 => "V&#46; Rajshekhar"
                            2 => "M&#46; Chandy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neurosurgery"
                        "fecha" => "1994"
                        "volumen" => "34"
                        "paginaInicial" => "269"
                        "paginaFinal" => "274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8177388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary complications and water retention in prolonged mechanical ventilation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Sladen"
                            1 => "M&#46;B&#46; Laver"
                            2 => "H&#46; Pontoppidan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM196808292790902"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1968"
                        "volumen" => "279"
                        "paginaInicial" => "448"
                        "paginaFinal" => "453"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4874342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syndrome of inappropriate secretion of antidiuretic hormone &#40;SIADH&#41; in malignant disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;B&#46; Sorensen"
                            1 => "M&#46;K&#46; Andersen"
                            2 => "H&#46;H&#46; Hansen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "1995"
                        "volumen" => "238"
                        "paginaInicial" => "97"
                        "paginaFinal" => "110"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7629492"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Symptomatic hyponatraemia due to inappropriate antidiuretic hormone secretion following minor surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Soroker"
                            1 => "T&#46; Erzi"
                            2 => "S&#46;K&#46; Lurie"
                            3 => "S&#46; Feld"
                            4 => "I&#46; Savir"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/BF03008151"
                      "Revista" => array:6 [
                        "tituloSerie" => "Can J Anaesth"
                        "fecha" => "1991"
                        "volumen" => "38"
                        "paginaInicial" => "225"
                        "paginaFinal" => "226"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2021994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyponatremia and the syndrome of inappropriate antidiuretic hormone secretion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Spigset"
                            1 => "K&#46; Hedenmalm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Saf"
                        "fecha" => "1995"
                        "volumen" => "12"
                        "paginaInicial" => "209"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7619332"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Syndrome of inappropriate secretion of arginine vasopressin in patients with cancer of the head and neck"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46;P&#46; Talmi"
                            1 => "H&#46;T&#46; Hoffman"
                            2 => "B&#46;F&#46; McCabe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Otol Rhinol Laryngol"
                        "fecha" => "1992"
                        "volumen" => "101"
                        "paginaInicial" => "946"
                        "paginaFinal" => "949"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1332568"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term treatment of the syndrome of inappropriate antidiuretic hormone secretion wih phenytoin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Tanay"
                            1 => "I&#46; Yust"
                            2 => "G&#46; Peresecenschi"
                            3 => "A&#46;L&#46; Abramov"
                            4 => "A&#46; Aviram"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1979"
                        "volumen" => "90"
                        "paginaInicial" => "50"
                        "paginaFinal" => "52"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/420461"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inappropriate antidiuretic hormone secretion after cataract extraction under local anesthesia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;T&#46; Tichy"
                            1 => "M&#46;A&#46; Dougal"
                            2 => "L&#46;S&#46; Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Ophthalmol"
                        "fecha" => "1985"
                        "volumen" => "18"
                        "paginaInicial" => "231"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3752849"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neuroendocrinology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;T&#46; Tindall"
                            1 => "D&#46;K&#46; Barrow"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Disorders of pituitary"
                        "paginaInicial" => "23"
                        "paginaFinal" => "63"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inappropriate secretion of antidiuretic hormone after open-heart surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ting"
                            1 => "E&#46; Eshaghpoor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Dis Child"
                        "fecha" => "1980"
                        "volumen" => "134"
                        "paginaInicial" => "873"
                        "paginaFinal" => "874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7416115"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of visceral afferent pathways on vasopressin secretion and urinary excretory patterns during surgical stress"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Ukai"
                            1 => "W&#46; Moran"
                            2 => "B&#46; Zimmermann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg"
                        "fecha" => "1968"
                        "volumen" => "168"
                        "paginaInicial" => "16"
                        "paginaFinal" => "28"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5244576"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Le syndrome de secretion inappopriee de l&#39;hormone antidiuretique &#40;SIADH&#41; d&#39;origine medicamenteuse&#46; Revue de la literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46; Verstraeten"
                            1 => "B&#46; Dewier"
                            2 => "C&#46; Montjoie"
                            3 => "A&#46; Hassoun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pharm Belg"
                        "fecha" => "1993"
                        "volumen" => "48"
                        "paginaInicial" => "227"
                        "paginaFinal" => "232"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8410627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyponatremia hypoosmolarity in neurosurgical patients&#46; Appropriate secretion of ADH and cerebral salt wasting syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "F&#46;A&#46; Vingerhoets"
                            1 => "N&#46; De Tribolet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1988"
                        "volumen" => "91"
                        "paginaInicial" => "50"
                        "paginaFinal" => "54"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of the central nervous system in metabolism of electrolytes and water"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46;G&#46; Welt"
                            1 => "D&#46;W&#46; Seldin"
                            2 => "W&#46;P&#46; Nelson"
                            3 => "W&#46;J&#46; German"
                            4 => "J&#46;P&#46; Peters"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1952"
                        "volumen" => "90"
                        "paginaInicial" => "355"
                        "paginaFinal" => "378"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib60"
              "etiqueta" => "60&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;L&#46; Wise"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Fluid and electrolytes in Neurological Surgery"
                        "paginaInicial" => "43"
                        "paginaFinal" => "47"
                        "serieFecha" => "1965"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib61"
              "etiqueta" => "61&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cerebral salt wasting syndrome distinct from the syndrome of inappropriate secretion of antidiuretic hormone &#40;SIADH&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Yamaki"
                            1 => "A&#46; Tano-Oka"
                            2 => "T&#46; Takahashi"
                            3 => "K&#46; Imaizumi"
                            4 => "K&#46; Suetake"
                            5 => "K&#46; Hashi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Neurochir &#40;Wien&#41;"
                        "fecha" => "1992"
                        "volumen" => "115"
                        "paginaInicial" => "156"
                        "paginaFinal" => "162"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib62"
              "etiqueta" => "62&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of indomethacin and adrenocorticotropic hormone on renal fuction in man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Zasman"
                            1 => "J&#46; Vinci"
                            2 => "R&#46; Bourden"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1979"
                        "volumen" => "15"
                        "paginaInicial" => "62"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/226768"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
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Vol. 10. Issue 1.
Pages 61-66 (January 1999)
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Vol. 10. Issue 1.
Pages 61-66 (January 1999)
Cerebral salt wasting syndrome and brain surgery: intraoperative predisposing factors
El síndrome de la pérdida cerebral de sal y la cirugía cerebral: Factores intraoperatorios predisponentes
N. Saiz-Sapena
Servicios de Anestesiología Clínica Universitaria, Universidad de Navarra. Pamplona
V. Vanaclocha*, P. Irimia**, F. Panta*
* Servicios de Neurocirugía Clínica Universitaria, Universidad de Navarra. Pamplona
** Servicios de Neurología Clínica Universitaria, Universidad de Navarra. Pamplona
Article information
Abstract
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Resumen

Nuestro objetivo fue el estudiar la correlación entre las maniobras anestésicas y la aparición de CSWS en pacientes neuroquirúrgicos.

Se estudiaron quinientas veintiuna craniotomías consecutivas, excluyendo las relacionadas con el hipotálamo, el tercer ventrículo o hipófisis y aquellos con patología renal.

Factores estudiados: ingesta líquida, diuresis, hipertensión intracraneal, corticoides, furosemida, manitol, hipnóticos, opiáceos, duración de la cirugía y tiempo hasta la extubación.

Se observaron treinta y dos casos (6,14%) de Cerebral salt wasting syndrome (CSWS). Su aparición sólo se vio relacionada con la administración de opiáceos. Treinta de estos casos habían recibido fentanilo > 0,25mg más morfina > 5mg y los otros dos restantes fentanilo 0,20mg más morfina 5mg. Ninguno de los 93 pacientes que recibieron fentanilo ≤ 0,15mg y ninguna morfina desarrollaron CSWS.

Conclusión

La administración de dosis medias o altas de opiáceos (fentanilo >0,25mg y morfina >5mg) en el curso de cirugía cerebral parece de algún modo predisponer a la aparición de CSWS.

Palabras clave:
Síndrome pierde-sal
Hiponatremia
Natriuresis
Síndrome de secreción inadecuada de hormona antidiurética
Tratamiento: hiponatremia. Balance hidroelectrolítico: fisiología
Summary

We aimed to study the relationship between the anaesthetic manoeuvres and the appearance of Cerebral salt wasting syndrome (CSWS) in neurosurgical patients.

Five-hundred and twenty-one consecutive craniotomies were studied, excluding those related to the hypothalamus, IIIrd ventricle and pituitary and those with kidney troubles.

Factors studied: fluid intake, diuresis, intracranial hypertension, corticoids, furosemide, mannitol, hypnotic agents, opioids, anaesthetic gases, duration of surgery, and time to extubation.

Thirty-two cases (6,14%) of CSWS were seen. Its appearance was related only to opioid administration. Thirty of the cases had received fentanyl > 0,25mg plus morphine > 5mg and the other two fentanyl 0,20mg plus morphine 5mg. None of the 93 patients managed with fentanyl ≤ 0,15mg and no morphine at alla developed CSWS.

Conclusión

The administration of medium/large doses of opioids (fentanyl >0,25mg and morphine >5mg) during brain surgery seems to somehow predispose to CSWS.

Key words:
Cerebral salt wasting
Hyponatremia
Natriuresis
Syndrome of inappropriate antidiuretic hormone secretion
Hyponatremia therapy
Water Electrolyte Balance physiology

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