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Case Report
Available online 5 March 2022
Brain lymphoma development related to a long lasting epidermoid cyst
Desarrollo de un linfoma cerebral con relación a un quiste epidermoide de larga evolución
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Angel Horcajadas Almansaa,
Corresponding author
angel.horcajadas@gmail.com

Corresponding author.
, Ana M. Jorques Infantea, Clara E. Chamorro Santosb, Ana M. Román Cutillasa
a Servicio de Neurocirugía, Hospital Virgen de las Nieves, Granada, Spain
b Servicio de Anatomía Patológica, Hospital Virgen de las Nieves, Granada, Spain
Received 30 October 2020. Accepted 12 February 2021
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Abstract
Introduction

Epidermoid cysts (EC) are benign and slow growing lesions. A primary brain lymphoma development related to a EC is presented, second case described in literature.

Case presentation

A woman 40 years old, harbouring a EC for more than 20 years, develops a fast growing brain lesion next to the EC. Surgery was performed and diagnosis was primary diffuse B cells lymphoma.

Discussion

Malignant transformation of EC has been described, usually to squamous cells carcinoma, and much less frequently, to another tumours. Inflammatory mechanisms have been advocated to explain this evolution. Chronic inflammation and lymphoma genesis are related, and this could be the mechanism behind this rare evolution of an EC.

Conclusions

Even being benign lesions, EC can develop malignant tumours due to the chronic inflammation secondary to them.

Keywords:
Epidermoid cyst
Brain lymphoma
Malignant transformation
Resumen
Introducción

Los quistes epidermoides (QE) son lesiones de lento crecimiento y naturaleza benigna. Se presenta un caso de un desarrollo de un linfoma cerebral (LC) en relación a un tumor epidermoide, segundo caso descrito en la literatura.

Presentacion del caso

Mujer de 40 años con QE intracraneal de larga evolución que desarrolla una lesión intraaxial rápidamente progresiva en relación con dicho tumor. Tras la resección el diagnóstico es de linfoma primario difuso de células B.

Discusión

La transformación de QE a carcinomas de células escamosas ha sido reportado en contadas ocasiones, siendo el desarrollo de otras lesiones malignas en relación con este proceso, absolutamente excepcional. Se han invocado mecanismos inflamatorios como la causa de dicha transformación. En la génesis de los linfomas están involucrados estos mecanismos y en el caso que nos ocupa, podría haber jugado un papel en el desarrollo del tumor.

Conclusiones

Aún siendo lesiones benignas, los QE tienen cierto potencial de malignización secundario a mecanismos de inflamación crónica.

Palabras clave:
Quiste epidermoide
Linfoma cerebral
Transformación maligna

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