Case Report
Endothelial dysfunction and vascular abnormalities in acromegaly. A case report
Disfunción endotelial y anomalías vasculares en acromegalia. A propósito de un caso
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The navy blue line indicates the proportion of OPEN procedures, while the crimson line represents the ENDO procedures.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ignacio Arrese, Sergio García-García, Santiago Cepeda, Rosario Sarabia" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Ignacio" "apellidos" => "Arrese" ] 1 => array:2 [ "nombre" => "Sergio" "apellidos" => "García-García" ] 2 => array:2 [ "nombre" => "Santiago" "apellidos" => "Cepeda" ] 3 => array:2 [ "nombre" => "Rosario" "apellidos" => "Sarabia" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529849624000352?idApp=UINPBA00004B" "url" => "/25298496/unassign/S2529849624000352/v1_202407110420/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Endothelial dysfunction and vascular abnormalities in acromegaly. A case report" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ana Irigaray Echarri, M. Dolores Ollero García-Agulló, José Jorge Ortez Toro, Idoya Zazpe Cenoz" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Ana Irigaray" "apellidos" => "Echarri" "email" => array:1 [ 0 => "anairigarayecharri@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:4 [ "nombre" => "M." "apellidos" => "Dolores Ollero García-Agulló" "email" => array:1 [ 0 => "md.ollero.garciaagullo@navarra.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:4 [ "nombre" => "José" "apellidos" => "Jorge Ortez Toro" "email" => array:1 [ 0 => "josejorge.ortez.toro@navarra.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:4 [ "nombre" => "Idoya Zazpe" "apellidos" => "Cenoz" "email" => array:1 [ 0 => "idoyazazpecenoz@navarra.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Endocrinología y Nutrición, Hospital Universitario de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Sección de Endocrinología y Nutrición, Hospital Reina Sofía, Tudela, Navarra, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Neurocirugía, Hospital Universitario de Navarra, Pamplona, Navarra, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Disfunción endotelial y anomalías vasculares en acromegalia. A propósito de un caso" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2024-08-12" "fechaAceptado" => "2024-09-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1900050" "palabras" => array:4 [ 0 => "Pituitary" 1 => "acromegaly" 2 => "endothelial dysfunction" 3 => "growth hormone" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1900051" "palabras" => array:4 [ 0 => "Hipófisis" 1 => "acromegalia" 2 => "disfunción endotelial" 3 => "hormona de crecimiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In patients with acromegaly, the pleiotropic effects of GH and IGF-1 have been associated with the development of endothelial dysfunction and vascular abnormalities.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We present the case of a 45-year-old male diagnosed with acromegaly. Magnetic resonance imaging identified a marked dilatation and medialization of both cavernous internal carotid arteries (ICA), leading to a narrow intercarotid distance, a phenomenon known as “carotid kisses”.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This vascular alteration has been described in greater proportion in patients with acromegaly. The anomalies that are also present with greater prevalence in these patients are: aneurysms of the ICA, protrusion of the ICA into the sphenoid sinus, narrow intercarotid distance, fusiform dilatation of the ICA and dehiscence of this artery in the bony canal. The presence of such alterations increases the risk of injury to the ICA.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pre-surgical detection of such abnormalities is essential to ensure the safety of the surgical approach.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En pacientes con acromegalia, los efectos pleiotrópicos de la GH e IGF-1 se han asociado con el desarrollo de disfunción endotelial y anomalías vasculares.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de un varón de 45 años con diagnóstico de acromegalia. La resonancia magnética identificó una marcada dilatación de ambas arterias carótidas internas (ACI) cavernosas con medialización de las mismas condicionando una distancia intercarotídea estrecha, fenómeno conocido como “kissing carótidas”.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Esta alteración vascular se ha descrito en mayor proporción en pacientes con acromegalia. Las anomalías que también se presentan con mayor prevalencia en estos pacientes son: aneurismas de la ACI, protusión de la ACI en el seno esfenoidal, distancia intercarotídea estrecha, dilatación fusiforme de la ACI y la dehiscencia de tal arteria en el canal óseo. La presencial de tales alteraciones, aumenta el riesgo de lesión de la ACI.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La detección prequirúrgica de tales alteraciones es fundamental para garantizar la seguridad del abordaje quirúrgico.</p></span>" ] ] ] "idiomaDefecto" => "en" "url" => "/25298496/unassign/S2529849624000662/v1_202410291637/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/25298496/unassign/S2529849624000662/v1_202410291637/en/main.pdf?idApp=UINPBA00004B&text.app=https://revistaneurocirugia.com/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2529849624000662?idApp=UINPBA00004B" ]
