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Clinical Research
Available online 20 November 2021
Long-term survival of glioblastoma: A systematic analysis of literature about a case
Glioblastomas de larga supervivencia: un análisis sistemático de la literatura a propósito de un caso
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Luis Germán González Boneta,b,
Corresponding author
, Claudio Piqueras-Sánchezb, Esther Roselló-Sastreb,c, Ricardo Broseta-Torresd, Ramón de las Peñase
a Servicio de Neurocirugía, Hospital General Universitario de Castellón, Castellón, Spain
b Facultad de Ciencias de la Salud, Universidad Jaume I de Castellón, Castellón, Spain
c Servicio de Anatomía Patológica, Hospital General Universitario de Castellón, Castellón, Spain
d Ascires/Eresa, Castellón, Spain
e Servicio de Oncología Médica, Hospital Provincial de Castellón, Castellón, Spain
Received 05 January 2021. Accepted 05 May 2021
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Table 1. Studies meeting inclusion and exclusion criteria for the review.
Abstract
Introduction

In spite of the changes for the treatment of glioblastoma since 2005, we have not seen differences between long-survival patients of more than 10 years showing a value minor than 1%.

Material and method

We realize a systematic analysis and identify important factors for long survivor patients. We also show an own case with more of 20 years of survival. We make a new pathological study of the old paraffin block of this patient.

Results

The most important variable associated with long-survival between all multivariant studies is the age. When we try to find genetic and molecular alterations in glioblastoma associated with prolongated survival, the MGMT promoter methylation play the most important role. We find a correct diagnosis in the current analysis of our patient’s sample with very long survival.

Conclusions

Multiple variables are found that affect long survival of glioblastoma series but analyzed studies are very heterogeneous and it is very difficult comparation between them. Most articles we review are obtained from databases of different countries with hundreds of patients. It would be very interesting to promote the use of a single database in Spain that allows us to study these long-term glioblastoma survivors.

Keywords:
Glioblastoma
Long-term survival
Very long-term survival
Cure
Molecular profile
Resumen
Introducción

A pesar de las modificaciones introducidas en el tratamiento de los glioblastomas a partir del 2005, los pacientes supervivientes de más de 10 años se han mantenido constantes, siendo dicha cifra muy pobre e inferior al 1% en la mayoría de los estudios.

Material y métodos

Se realiza un análisis sistemático de la literatura identificando los factores que pueden influir en los pacientes de larga supervivencia. Se identifica un caso en nuestro medio de más de 20 años de supervivencia realizándose un análisis actual del bloque de parafina que se conservaba del paciente.

Resultados

La variable que más se asocia a la larga supervivencia en todos los análisis multivariantes es la edad, aunque, cuando se analiza las características genéticas y moleculares de los tumores, parecen existir otras variables como la metilación del promotor MGMT que juegan un papel muy importante. El análisis anatomo-patológico actual de la muestra comprueba la certeza del diagnóstico en nuestro paciente de muy larga supervivencia.

Conclusiones

Múltiples variables son encontradas que influencian la larga supervivencia en distintas series, si bien los estudios analizados son muy heterogéneos resultando muy difícil la comparación entre ellos. La mayoría de los estudios referenciados pertenecen a bases de datos nacionales de distintos países que engloban a cientos de pacientes. Sería interesante fomentar el uso de una única base de datos en Espa˜na que permita, entre otros, el análisis de estos pacientes de larga supervivencia afectos de glioblastoma.

Palabras clave:
Glioblastoma
Larga supervivencia
Muy larga supervivencia
Curación
Perfil molecular

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